This term is obsolete.

GO:0046922 JSON

peptide-O-fucosyltransferase activity

Molecular Function

Definition (GO:0046922 GONUTS page)

Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.

5,580 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
GDP-fucose:polypeptide fucosyltransferase activity related
GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity related
GDP-L-fucose:polypeptide fucosyltransferase activity related
GDP-fucose protein O-fucosyltransferase activity related

Ancestor Chart

Ancestor chart for GO:0046922
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016757 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A6KJI3 10116 A6KJI3_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6KJI3 10116 A6KJI3_RAT GO:0006486 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D6WQD5 7070 D6WQD5_TRICA GO:0070085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein D6WQD5 7070 D6WQD5_TRICA GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O00469 9606 PLOD2_HUMAN GO:0006493 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10934207
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q02809 9606 PLOD1_HUMAN GO:0006493 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10934207
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.4.1.221
InterPro IPR039922 GDP-fucose protein O-fucosyltransferase 1
InterPro IPR045130 GDP-fucose protein O-fucosyltransferase 2-like
MetaCyc 2.4.1.221-RXN
Reactome R-HSA-1912349
Reactome R-HSA-5173192

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0046922 based on ALL annotations
The top 100 of 189 co-occurring terms
Co-occurring Term PR S% #Together #Compared
peptide-O-fucosyltransferase activity
35,887.11 100.00 5,432 5,432
protein O-linked fucosylation
35,023.14 97.59 5,432 5,566
regulation of Notch signaling pathway
4,382.24 8.11 1,057 8,656
fucose metabolic process
2,566.52 7.13 5,237 73,228
Notch signaling pathway
906.45 2.40 1,813 71,778
positive regulation of protein folding
33,126.56 1.54 84 91
regulation of epithelial to mesenchymal transition
2,637.07 1.09 69 939
negative regulation of gibberellic acid mediated signaling pathway
7,897.94 1.01 57 259
regulation of secretion
720.31 0.88 84 4,185
somitogenesis
481.96 0.79 102 7,595
Totals 33409 70827538
No co-occurrence statistics for GO:0046922 based on MANUAL annotations
The top 38 of 38 co-occurring terms
Co-occurring Term PR S% #Together #Compared
peptide-O-fucosyltransferase activity
9,786.36 100.00 132 132
protein O-linked fucosylation
3,890.96 18.13 33 83
regulation of Notch signaling pathway
760.11 5.76 24 309
positive regulation of protein folding
2,935.91 2.16 3 10
fucosyltransferase activity
262.37 2.02 10 373
regulation of secretion
407.76 1.49 3 72
regulation of epithelial to mesenchymal transition
214.30 1.13 3 137
O-glycan processing
174.76 1.01 3 168
mesoderm formation
106.76 0.74 3 275
protein N-acetylglucosaminyltransferase activity
296.56 0.61 1 33
Totals 288 653026

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM GDP-L-fucose:polypeptide fucosyltransferase activity
2020-10-08 Added SYNONYM GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity
2020-10-08 Added SYNONYM GDP-L-fucose:polypeptide fucosyltransferase activity
2020-10-08 Deleted SYNONYM GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity
2020-10-08 Added SYNONYM GDP-fucose:polypeptide fucosyltransferase activity
2020-10-08 Added SYNONYM GDP-fucose protein O-fucosyltransferase activity
2020-10-08 Deleted SYNONYM GDP-fucose protein O-fucosyltransferase activity
2020-10-08 Deleted SYNONYM GDP-fucose:polypeptide fucosyltransferase activity
2019-04-01 Added XREF Reactome:R-HSA-1912349
2019-04-01 Added XREF Reactome:R-HSA-5173192
Timestamp Action Category Detail
2003-05-02 Updated TERM peptide-O-fucosyltransferase activity
2003-05-01 Added TERM peptide-O-fucosyltransferase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM GDP-L-fucose:polypeptide fucosyltransferase activity
2020-10-08 Added SYNONYM GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity
2020-10-08 Added SYNONYM GDP-L-fucose:polypeptide fucosyltransferase activity
2020-10-08 Deleted SYNONYM GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity
2020-10-08 Added SYNONYM GDP-fucose:polypeptide fucosyltransferase activity
2020-10-08 Added SYNONYM GDP-fucose protein O-fucosyltransferase activity
2020-10-08 Deleted SYNONYM GDP-fucose protein O-fucosyltransferase activity
2020-10-08 Deleted SYNONYM GDP-fucose:polypeptide fucosyltransferase activity
2008-05-13 Added DEFINITION Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.
2007-11-08 Added SYNONYM GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity
2007-09-06 Added SYNONYM GDP-fucose:polypeptide fucosyltransferase activity
2007-09-06 Added SYNONYM GDP-fucose protein O-fucosyltransferase activity
2007-09-06 Added SYNONYM GDP-L-fucose:polypeptide fucosyltransferase activity
2003-05-01 Added DEFINITION Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.
Timestamp Action Category Detail
2017-09-19 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2011-12-18 Added RELATION part of GO:0036066 (protein O-linked fucosylation)
2008-04-01 Updated RELATION is a GO:0008417 (fucosyltransferase activity)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-1912349
2019-04-01 Added XREF Reactome:R-HSA-5173192
2019-04-01 Deleted XREF reactome:R-HSA-1912349
2019-04-01 Deleted XREF reactome:R-HSA-5173192
2018-12-11 Added XREF reactome:R-HSA-1912349
2018-12-11 Added XREF reactome:R-HSA-5173192
2003-10-27 Added XREF MetaCyc:2.4.1.221-RXN
2003-05-01 Added XREF EC:2.4.1.221
Timestamp Action Category Detail
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