GO:0046922
JSON
peptide-O-fucosyltransferase activity
Molecular Function
Definition (GO:0046922 GONUTS page)
Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
GDP-fucose:polypeptide fucosyltransferase activity | related |
GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity | related |
GDP-L-fucose:polypeptide fucosyltransferase activity | related |
GDP-fucose protein O-fucosyltransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016757 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A6KJI3 | 10116 | A6KJI3_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6KJI3 | 10116 | A6KJI3_RAT | GO:0006486 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D6WQD5 | 7070 | D6WQD5_TRICA | GO:0070085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | D6WQD5 | 7070 | D6WQD5_TRICA | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O00469 | 9606 | PLOD2_HUMAN | GO:0006493 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10934207 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q02809 | 9606 | PLOD1_HUMAN | GO:0006493 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10934207 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.4.1.221 | |
InterPro | IPR039922 | GDP-fucose protein O-fucosyltransferase 1 |
InterPro | IPR045130 | GDP-fucose protein O-fucosyltransferase 2-like |
MetaCyc | 2.4.1.221-RXN | |
Reactome | R-HSA-1912349 | |
Reactome | R-HSA-5173192 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0046922 based on ALL annotations
The top 100 of 189 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
peptide-O-fucosyltransferase activity
|
35,887.11 | 100.00 | 5,432 | 5,432 |
protein O-linked fucosylation
|
35,023.14 | 97.59 | 5,432 | 5,566 |
regulation of Notch signaling pathway
|
4,382.24 | 8.11 | 1,057 | 8,656 |
fucose metabolic process
|
2,566.52 | 7.13 | 5,237 | 73,228 |
Notch signaling pathway
|
906.45 | 2.40 | 1,813 | 71,778 |
positive regulation of protein folding
|
33,126.56 | 1.54 | 84 | 91 |
regulation of epithelial to mesenchymal transition
|
2,637.07 | 1.09 | 69 | 939 |
negative regulation of gibberellic acid mediated signaling pathway
|
7,897.94 | 1.01 | 57 | 259 |
regulation of secretion
|
720.31 | 0.88 | 84 | 4,185 |
somitogenesis
|
481.96 | 0.79 | 102 | 7,595 |
Totals | 33409 | 70827538 |
No co-occurrence statistics for GO:0046922 based on MANUAL annotations
The top 38 of 38 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
peptide-O-fucosyltransferase activity
|
9,786.36 | 100.00 | 132 | 132 |
protein O-linked fucosylation
|
3,890.96 | 18.13 | 33 | 83 |
regulation of Notch signaling pathway
|
760.11 | 5.76 | 24 | 309 |
positive regulation of protein folding
|
2,935.91 | 2.16 | 3 | 10 |
fucosyltransferase activity
|
262.37 | 2.02 | 10 | 373 |
regulation of secretion
|
407.76 | 1.49 | 3 | 72 |
regulation of epithelial to mesenchymal transition
|
214.30 | 1.13 | 3 | 137 |
O-glycan processing
|
174.76 | 1.01 | 3 | 168 |
mesoderm formation
|
106.76 | 0.74 | 3 | 275 |
protein N-acetylglucosaminyltransferase activity
|
296.56 | 0.61 | 1 | 33 |
Totals | 288 | 653026 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | GDP-L-fucose:polypeptide fucosyltransferase activity |
2020-10-08 | Added | SYNONYM | GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity |
2020-10-08 | Added | SYNONYM | GDP-L-fucose:polypeptide fucosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity |
2020-10-08 | Added | SYNONYM | GDP-fucose:polypeptide fucosyltransferase activity |
2020-10-08 | Added | SYNONYM | GDP-fucose protein O-fucosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | GDP-fucose protein O-fucosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | GDP-fucose:polypeptide fucosyltransferase activity |
2019-04-01 | Added | XREF | Reactome:R-HSA-1912349 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5173192 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-05-02 | Updated | TERM | peptide-O-fucosyltransferase activity |
2003-05-01 | Added | TERM | peptide-O-fucosyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | GDP-L-fucose:polypeptide fucosyltransferase activity |
2020-10-08 | Added | SYNONYM | GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity |
2020-10-08 | Added | SYNONYM | GDP-L-fucose:polypeptide fucosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity |
2020-10-08 | Added | SYNONYM | GDP-fucose:polypeptide fucosyltransferase activity |
2020-10-08 | Added | SYNONYM | GDP-fucose protein O-fucosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | GDP-fucose protein O-fucosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | GDP-fucose:polypeptide fucosyltransferase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor. |
2007-11-08 | Added | SYNONYM | GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity |
2007-09-06 | Added | SYNONYM | GDP-fucose:polypeptide fucosyltransferase activity |
2007-09-06 | Added | SYNONYM | GDP-fucose protein O-fucosyltransferase activity |
2007-09-06 | Added | SYNONYM | GDP-L-fucose:polypeptide fucosyltransferase activity |
2003-05-01 | Added | DEFINITION | Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-09-19 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2011-12-18 | Added | RELATION | part of GO:0036066 (protein O-linked fucosylation) |
2008-04-01 | Updated | RELATION | is a GO:0008417 (fucosyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-1912349 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5173192 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1912349 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5173192 |
2018-12-11 | Added | XREF | reactome:R-HSA-1912349 |
2018-12-11 | Added | XREF | reactome:R-HSA-5173192 |
2003-10-27 | Added | XREF | MetaCyc:2.4.1.221-RXN |
2003-05-01 | Added | XREF | EC:2.4.1.221 |
Timestamp | Action | Category | Detail |
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