GO:0047058
JSON
vitamin-K-epoxide reductase (warfarin-insensitive) activity
Molecular Function
Definition (GO:0047058 GONUTS page)
Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
vitamin K 2,3-epoxide reductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.17.4.5 | |
MetaCyc | 1.1.4.2-RXN | |
RHEA | 21560 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:18298 | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone |
has_participant | CHEBI | CHEBI:15759 | 2,3-epoxyphylloquinone |
has_participant | CHEBI | CHEBI:41837 | (4S,5S)-1,2-dithiane-4,5-diol |
has_participant | CHEBI | CHEBI:18320 | 1,4-dithiothreitol |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0047058 based on ALL annotations
The top 18 of 18 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
vitamin-K-epoxide reductase (warfarin-insensitive) activity
|
2,707,483.20 | 100.00 | 72 | 72 |
positive regulation of coagulation
|
407,578.12 | 14.43 | 56 | 372 |
peptidyl-glutamic acid carboxylation
|
1,160,349.90 | 3.95 | 3 | 7 |
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
|
84,940.65 | 3.14 | 72 | 2,295 |
vitamin-K-epoxide reductase (warfarin-sensitive) activity
|
81,941.48 | 3.03 | 72 | 2,379 |
vitamin K metabolic process
|
70,912.62 | 2.62 | 72 | 2,749 |
bone development
|
15,356.94 | 0.57 | 56 | 9,873 |
regulation of blood coagulation
|
8,972.60 | 0.31 | 4 | 1,207 |
xenobiotic metabolic process
|
4,557.84 | 0.17 | 71 | 42,176 |
blood coagulation
|
4,492.51 | 0.17 | 72 | 43,392 |
Totals | 916 | 66780956 |
No co-occurrence statistics for GO:0047058 based on MANUAL annotations
The top 13 of 13 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
vitamin-K-epoxide reductase (warfarin-insensitive) activity
|
645,899.50 | 100.00 | 2 | 2 |
peptidyl-glutamic acid carboxylation
|
184,542.70 | 28.57 | 2 | 7 |
positive regulation of coagulation
|
58,718.13 | 8.33 | 1 | 11 |
vitamin-K-epoxide reductase (warfarin-sensitive) activity
|
25,835.98 | 4.00 | 2 | 50 |
regulation of blood coagulation
|
21,529.98 | 3.23 | 1 | 30 |
vitamin K metabolic process
|
12,790.09 | 1.98 | 2 | 101 |
bone development
|
2,956.06 | 0.46 | 2 | 437 |
blood coagulation
|
2,826.69 | 0.44 | 2 | 457 |
response to organic cyclic compound
|
1,216.38 | 0.19 | 1 | 531 |
xenobiotic metabolic process
|
1,147.25 | 0.18 | 2 | 1,126 |
Totals | 21 | 86399 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-10 | Added | RELATION | is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor) |
2022-05-10 | Deleted | RELATION | is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor) |
2021-05-22 | Deleted | XREF | EC:1.1.4.2 |
2021-05-22 | Added | XREF | EC:1.17.4.5 |
2021-05-22 | Deleted | SYNONYM | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | vitamin K 2,3-epoxide reductase activity |
2020-10-08 | Added | SYNONYM | vitamin K 2,3-epoxide reductase activity |
2020-10-08 | Added | SYNONYM | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2018-07-13 | Added | XREF | RHEA:21560 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-08-19 | Added | TERM | vitamin-K-epoxide reductase (warfarin-insensitive) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-22 | Deleted | SYNONYM | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | vitamin K 2,3-epoxide reductase activity |
2020-10-08 | Added | SYNONYM | vitamin K 2,3-epoxide reductase activity |
2020-10-08 | Added | SYNONYM | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
2007-11-08 | Added | SYNONYM | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2007-09-06 | Added | SYNONYM | vitamin K 2,3-epoxide reductase activity |
2004-08-06 | Updated | DEFINITION | Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
2003-08-19 | Added | DEFINITION | Catalysis of the reaction: H2O + oxidized-dithiothreitol + 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone = 14-dithiothreitol + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-10 | Added | RELATION | is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor) |
2022-05-10 | Deleted | RELATION | is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor) |
2008-04-01 | Updated | RELATION | is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-22 | Deleted | XREF | EC:1.1.4.2 |
2021-05-22 | Added | XREF | EC:1.17.4.5 |
2018-07-13 | Added | XREF | RHEA:21560 |
2018-07-13 | Deleted | XREF | RHEA:21563 |
2011-09-16 | Added | XREF | RHEA:21563 |
2003-10-27 | Added | XREF | MetaCyc:1.1.4.2-RXN |
2003-08-19 | Added | XREF | EC:1.1.4.2 |
Timestamp | Action | Category | Detail |
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