This term is obsolete.

GO:0047058 JSON

vitamin-K-epoxide reductase (warfarin-insensitive) activity

Molecular Function

Definition (GO:0047058 GONUTS page)

Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.

75 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
vitamin K 2,3-epoxide reductase activity related

Ancestor Chart

Ancestor chart for GO:0047058
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.17.4.5
MetaCyc 1.1.4.2-RXN
RHEA 21560

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:18298 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone
has_participant CHEBI CHEBI:15759 2,3-epoxyphylloquinone
has_participant CHEBI CHEBI:41837 (4S,5S)-1,2-dithiane-4,5-diol
has_participant CHEBI CHEBI:18320 1,4-dithiothreitol

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0047058 based on ALL annotations
The top 18 of 18 co-occurring terms
Co-occurring Term PR S% #Together #Compared
vitamin-K-epoxide reductase (warfarin-insensitive) activity
2,707,483.20 100.00 72 72
positive regulation of coagulation
407,578.12 14.43 56 372
peptidyl-glutamic acid carboxylation
1,160,349.90 3.95 3 7
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
84,940.65 3.14 72 2,295
vitamin-K-epoxide reductase (warfarin-sensitive) activity
81,941.48 3.03 72 2,379
vitamin K metabolic process
70,912.62 2.62 72 2,749
bone development
15,356.94 0.57 56 9,873
regulation of blood coagulation
8,972.60 0.31 4 1,207
xenobiotic metabolic process
4,557.84 0.17 71 42,176
blood coagulation
4,492.51 0.17 72 43,392
Totals 916 66780956
No co-occurrence statistics for GO:0047058 based on MANUAL annotations
The top 13 of 13 co-occurring terms
Co-occurring Term PR S% #Together #Compared
vitamin-K-epoxide reductase (warfarin-insensitive) activity
645,899.50 100.00 2 2
peptidyl-glutamic acid carboxylation
184,542.70 28.57 2 7
positive regulation of coagulation
58,718.13 8.33 1 11
vitamin-K-epoxide reductase (warfarin-sensitive) activity
25,835.98 4.00 2 50
regulation of blood coagulation
21,529.98 3.23 1 30
vitamin K metabolic process
12,790.09 1.98 2 101
bone development
2,956.06 0.46 2 437
blood coagulation
2,826.69 0.44 2 457
response to organic cyclic compound
1,216.38 0.19 1 531
xenobiotic metabolic process
1,147.25 0.18 2 1,126
Totals 21 86399

Change Log

Timestamp Action Category Detail
2022-05-10 Added RELATION is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor)
2022-05-10 Deleted RELATION is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)
2021-05-22 Deleted XREF EC:1.1.4.2
2021-05-22 Added XREF EC:1.17.4.5
2021-05-22 Deleted SYNONYM 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2020-10-08 Deleted SYNONYM 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2020-10-08 Deleted SYNONYM vitamin K 2,3-epoxide reductase activity
2020-10-08 Added SYNONYM vitamin K 2,3-epoxide reductase activity
2020-10-08 Added SYNONYM 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2018-07-13 Added XREF RHEA:21560
Timestamp Action Category Detail
2003-08-19 Added TERM vitamin-K-epoxide reductase (warfarin-insensitive) activity
Timestamp Action Category Detail
2021-05-22 Deleted SYNONYM 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2020-10-08 Deleted SYNONYM 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2020-10-08 Deleted SYNONYM vitamin K 2,3-epoxide reductase activity
2020-10-08 Added SYNONYM vitamin K 2,3-epoxide reductase activity
2020-10-08 Added SYNONYM 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2007-11-08 Added SYNONYM 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2007-09-06 Added SYNONYM vitamin K 2,3-epoxide reductase activity
2004-08-06 Updated DEFINITION Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2003-08-19 Added DEFINITION Catalysis of the reaction: H2O + oxidized-dithiothreitol + 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone = 14-dithiothreitol + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone.
Timestamp Action Category Detail
2022-05-10 Added RELATION is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor)
2022-05-10 Deleted RELATION is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)
2008-04-01 Updated RELATION is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)
Timestamp Action Category Detail
2021-05-22 Deleted XREF EC:1.1.4.2
2021-05-22 Added XREF EC:1.17.4.5
2018-07-13 Added XREF RHEA:21560
2018-07-13 Deleted XREF RHEA:21563
2011-09-16 Added XREF RHEA:21563
2003-10-27 Added XREF MetaCyc:1.1.4.2-RXN
2003-08-19 Added XREF EC:1.1.4.2
Timestamp Action Category Detail
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