This term is obsolete.

GO:0047280 JSON

nicotinamide phosphoribosyltransferase activity

Molecular Function

Definition (GO:0047280 GONUTS page)

Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide.

6,176 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
nicotinamide mononucleotide synthetase activity related
NMN diphosphorylase activity related
NMN synthetase activity related
nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity related
NMN pyrophosphorylase activity related
nicotinamide mononucleotide pyrophosphorylase activity related

Ancestor Chart

Ancestor chart for GO:0047280
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016757 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A6KJI3 10116 A6KJI3_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D6WQD5 7070 D6WQD5_TRICA GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q6AYL7 10116 Q6AYL7_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7JRM5 7227 Q7JRM5_DROME GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 2.4.2.12
KEGG_REACTION R01271
MetaCyc 2.4.2.12-RXN
RHEA 16149
Reactome R-HSA-197250

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:14649 NMN(-)
has_participant CHEBI CHEBI:17154 nicotinamide
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:58017 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0047280 based on ALL annotations
The top 96 of 96 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nicotinamide phosphoribosyltransferase activity
32,241.27 100.00 6,146 6,146
circadian regulation of gene expression
1,045.36 2.84 1,153 35,561
pyridine nucleotide biosynthetic process
779.13 2.41 5,926 245,223
NAD biosynthetic process
666.02 2.07 6,141 297,281
rhythmic process
545.23 1.57 1,146 67,767
nicotinate phosphoribosyltransferase activity
408.62 1.10 460 36,295
cytokine activity
216.14 0.65 1,146 170,944
circadian rhythm
113.84 0.28 84 23,791
positive regulation of ERK1 and ERK2 cascade
82.63 0.22 90 35,119
glycosyltransferase activity
60.20 0.19 5,930 3,176,052
Totals 35845 260099240
No co-occurrence statistics for GO:0047280 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nicotinamide phosphoribosyltransferase activity
32,826.35 100.00 43 43
NAD biosynthetic process
2,520.59 7.68 43 560
response to D-galactose
16,413.17 2.27 1 2
regulation of lung blood pressure
4,103.29 2.00 1 8
response to host
2,525.10 1.82 1 13
heterocyclic compound binding
746.05 1.16 1 44
nicotinate phosphoribosyltransferase activity
407.78 0.99 2 161
NAD biosynthetic process via the salvage pathway
397.90 0.97 2 165
adipose tissue development
329.91 0.83 2 199
NAD biosynthesis via nicotinamide riboside salvage pathway
410.33 0.82 1 80
Totals 146 753910

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide.
2020-10-08 Deleted SYNONYM nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
2020-10-08 Deleted SYNONYM nicotinamide mononucleotide synthetase activity
2020-10-08 Deleted SYNONYM nicotinamide mononucleotide pyrophosphorylase activity
2020-10-08 Deleted SYNONYM NMN synthetase activity
2020-10-08 Deleted SYNONYM NMN pyrophosphorylase activity
2020-10-08 Deleted SYNONYM NMN diphosphorylase activity
2020-10-08 Added SYNONYM nicotinamide mononucleotide pyrophosphorylase activity
2020-10-08 Added SYNONYM NMN synthetase activity
Timestamp Action Category Detail
2003-08-19 Added TERM nicotinamide phosphoribosyltransferase activity
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide.
2020-10-08 Deleted SYNONYM nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
2020-10-08 Deleted SYNONYM nicotinamide mononucleotide synthetase activity
2020-10-08 Deleted SYNONYM nicotinamide mononucleotide pyrophosphorylase activity
2020-10-08 Deleted SYNONYM NMN synthetase activity
2020-10-08 Deleted SYNONYM NMN pyrophosphorylase activity
2020-10-08 Deleted SYNONYM NMN diphosphorylase activity
2020-10-08 Added SYNONYM nicotinamide mononucleotide pyrophosphorylase activity
2020-10-08 Added SYNONYM NMN synthetase activity
2020-10-08 Added SYNONYM NMN pyrophosphorylase activity
2020-10-08 Added SYNONYM nicotinamide mononucleotide synthetase activity
2020-10-08 Added SYNONYM nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
2020-10-08 Added SYNONYM NMN diphosphorylase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide.
2008-05-13 Added DEFINITION Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide.
2007-11-08 Added SYNONYM nicotinamide mononucleotide pyrophosphorylase activity
2007-11-08 Added SYNONYM NMN synthetase activity
2007-11-08 Added SYNONYM nicotinamide mononucleotide synthetase activity
2007-11-08 Added SYNONYM nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
2007-09-06 Added SYNONYM NMN diphosphorylase activity
2007-09-06 Added SYNONYM NMN pyrophosphorylase activity
2003-08-19 Added DEFINITION Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016763 (pentosyltransferase activity)
Timestamp Action Category Detail
2019-06-20 Added XREF KEGG_REACTION:R01271
2019-06-20 Deleted XREF KEGG:R01271
2019-04-01 Added XREF Reactome:R-HSA-197250
2019-04-01 Deleted XREF reactome:R-HSA-197250
2018-12-11 Added XREF reactome:R-HSA-197250
2018-07-13 Added XREF RHEA:16149
2018-07-13 Deleted XREF RHEA:16152
2010-10-11 Added XREF RHEA:16152
2010-10-11 Added XREF KEGG:R01271
2003-10-27 Added XREF MetaCyc:2.4.2.12-RXN
2003-08-19 Added XREF EC:2.4.2.12
Timestamp Action Category Detail
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