GO:0047280
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nicotinamide phosphoribosyltransferase activity
Molecular Function
Definition (GO:0047280 GONUTS page)
Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
nicotinamide mononucleotide synthetase activity | related |
NMN diphosphorylase activity | related |
NMN synthetase activity | related |
nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity | related |
NMN pyrophosphorylase activity | related |
nicotinamide mononucleotide pyrophosphorylase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016757 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A6KJI3 | 10116 | A6KJI3_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D6WQD5 | 7070 | D6WQD5_TRICA | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q6AYL7 | 10116 | Q6AYL7_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7JRM5 | 7227 | Q7JRM5_DROME | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.4.2.12 | |
KEGG_REACTION | R01271 | |
MetaCyc | 2.4.2.12-RXN | |
RHEA | 16149 | |
Reactome | R-HSA-197250 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:14649 | NMN(-) |
has_participant | CHEBI | CHEBI:17154 | nicotinamide |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:58017 | 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0047280 based on ALL annotations
The top 96 of 96 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nicotinamide phosphoribosyltransferase activity
|
32,241.27 | 100.00 | 6,146 | 6,146 |
circadian regulation of gene expression
|
1,045.36 | 2.84 | 1,153 | 35,561 |
pyridine nucleotide biosynthetic process
|
779.13 | 2.41 | 5,926 | 245,223 |
NAD biosynthetic process
|
666.02 | 2.07 | 6,141 | 297,281 |
rhythmic process
|
545.23 | 1.57 | 1,146 | 67,767 |
nicotinate phosphoribosyltransferase activity
|
408.62 | 1.10 | 460 | 36,295 |
cytokine activity
|
216.14 | 0.65 | 1,146 | 170,944 |
circadian rhythm
|
113.84 | 0.28 | 84 | 23,791 |
positive regulation of ERK1 and ERK2 cascade
|
82.63 | 0.22 | 90 | 35,119 |
glycosyltransferase activity
|
60.20 | 0.19 | 5,930 | 3,176,052 |
Totals | 35845 | 260099240 |
No co-occurrence statistics for GO:0047280 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nicotinamide phosphoribosyltransferase activity
|
32,826.35 | 100.00 | 43 | 43 |
NAD biosynthetic process
|
2,520.59 | 7.68 | 43 | 560 |
response to D-galactose
|
16,413.17 | 2.27 | 1 | 2 |
regulation of lung blood pressure
|
4,103.29 | 2.00 | 1 | 8 |
response to host
|
2,525.10 | 1.82 | 1 | 13 |
heterocyclic compound binding
|
746.05 | 1.16 | 1 | 44 |
nicotinate phosphoribosyltransferase activity
|
407.78 | 0.99 | 2 | 161 |
NAD biosynthetic process via the salvage pathway
|
397.90 | 0.97 | 2 | 165 |
adipose tissue development
|
329.91 | 0.83 | 2 | 199 |
NAD biosynthesis via nicotinamide riboside salvage pathway
|
410.33 | 0.82 | 1 | 80 |
Totals | 146 | 753910 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide. |
2020-10-08 | Deleted | SYNONYM | nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | nicotinamide mononucleotide synthetase activity |
2020-10-08 | Deleted | SYNONYM | nicotinamide mononucleotide pyrophosphorylase activity |
2020-10-08 | Deleted | SYNONYM | NMN synthetase activity |
2020-10-08 | Deleted | SYNONYM | NMN pyrophosphorylase activity |
2020-10-08 | Deleted | SYNONYM | NMN diphosphorylase activity |
2020-10-08 | Added | SYNONYM | nicotinamide mononucleotide pyrophosphorylase activity |
2020-10-08 | Added | SYNONYM | NMN synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-08-19 | Added | TERM | nicotinamide phosphoribosyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide. |
2020-10-08 | Deleted | SYNONYM | nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | nicotinamide mononucleotide synthetase activity |
2020-10-08 | Deleted | SYNONYM | nicotinamide mononucleotide pyrophosphorylase activity |
2020-10-08 | Deleted | SYNONYM | NMN synthetase activity |
2020-10-08 | Deleted | SYNONYM | NMN pyrophosphorylase activity |
2020-10-08 | Deleted | SYNONYM | NMN diphosphorylase activity |
2020-10-08 | Added | SYNONYM | nicotinamide mononucleotide pyrophosphorylase activity |
2020-10-08 | Added | SYNONYM | NMN synthetase activity |
2020-10-08 | Added | SYNONYM | NMN pyrophosphorylase activity |
2020-10-08 | Added | SYNONYM | nicotinamide mononucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity |
2020-10-08 | Added | SYNONYM | NMN diphosphorylase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide. |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide. |
2007-11-08 | Added | SYNONYM | nicotinamide mononucleotide pyrophosphorylase activity |
2007-11-08 | Added | SYNONYM | NMN synthetase activity |
2007-11-08 | Added | SYNONYM | nicotinamide mononucleotide synthetase activity |
2007-11-08 | Added | SYNONYM | nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity |
2007-09-06 | Added | SYNONYM | NMN diphosphorylase activity |
2007-09-06 | Added | SYNONYM | NMN pyrophosphorylase activity |
2003-08-19 | Added | DEFINITION | Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016763 (pentosyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R01271 |
2019-06-20 | Deleted | XREF | KEGG:R01271 |
2019-04-01 | Added | XREF | Reactome:R-HSA-197250 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-197250 |
2018-12-11 | Added | XREF | reactome:R-HSA-197250 |
2018-07-13 | Added | XREF | RHEA:16149 |
2018-07-13 | Deleted | XREF | RHEA:16152 |
2010-10-11 | Added | XREF | RHEA:16152 |
2010-10-11 | Added | XREF | KEGG:R01271 |
2003-10-27 | Added | XREF | MetaCyc:2.4.2.12-RXN |
2003-08-19 | Added | XREF | EC:2.4.2.12 |
Timestamp | Action | Category | Detail |
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