GO:0047429
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nucleoside triphosphate diphosphatase activity
Molecular Function
Definition (GO:0047429 GONUTS page)
Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
nucleoside-triphosphate pyrophosphatase activity | exact |
nucleoside-triphosphate diphosphatase activity | exact |
nucleoside-triphosphate diphosphohydrolase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0047429
Child Term | Relationship to GO:0047429 |
---|---|
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
|
is_a |
dCTP diphosphatase activity
|
is_a |
dATP diphosphatase activity
|
is_a |
2-hydroxy-ATP hydrolase activity
|
is_a |
dITP diphosphatase activity
|
is_a |
ITP diphosphatase activity
|
is_a |
2-hydroxy-dATP hydrolase activity
|
is_a |
8-oxo-(d)RTP hydrolase activity
|
is_a |
XTP diphosphatase activity
|
is_a |
UTP diphosphatase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.6.1.9 | |
InterPro | IPR002637 | RdgB/HAM1 |
InterPro | IPR003697 | Nucleoside triphosphate pyrophosphatase Maf-like protein |
InterPro | IPR025984 | dCTP pyrophosphatase 1 |
InterPro | IPR027502 | Inosine triphosphate pyrophosphatase |
InterPro | IPR048011 | MazG-like, C-terminal domain |
MetaCyc | NUCLEOTIDE-PYROPHOSPHATASE-RXN | |
RHEA | 23996 | |
RHEA | 44644 | |
Reactome | R-HSA-9755030 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0047429 based on ALL annotations
The top 100 of 1,006 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nucleoside triphosphate diphosphatase activity
|
1,248.94 | 100.00 | 156,084 | 156,084 |
nucleoside triphosphate catabolic process
|
1,222.66 | 41.11 | 64,735 | 66,126 |
nucleotide metabolic process
|
372.44 | 24.67 | 91,817 | 307,900 |
purine nucleoside triphosphate catabolic process
|
1,248.94 | 24.29 | 37,910 | 37,910 |
8-oxo-(d)RTP hydrolase activity
|
1,241.77 | 23.06 | 36,046 | 36,254 |
dTTP catabolic process
|
1,248.94 | 20.63 | 32,202 | 32,202 |
TTP catabolic process
|
1,248.94 | 20.63 | 32,200 | 32,200 |
UTP catabolic process
|
1,245.03 | 20.62 | 32,200 | 32,301 |
dATP catabolic process
|
1,241.72 | 20.61 | 32,200 | 32,387 |
pyrophosphatase activity
|
421.23 | 19.10 | 47,724 | 141,501 |
Totals | 1189556 | 89394479 |
No co-occurrence statistics for GO:0047429 based on MANUAL annotations
The top 100 of 323 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nucleoside triphosphate diphosphatase activity
|
2,956.06 | 100.00 | 437 | 437 |
nucleoside triphosphate catabolic process
|
2,592.24 | 37.09 | 171 | 195 |
dTTP catabolic process
|
2,956.06 | 6.41 | 28 | 28 |
TTP catabolic process
|
2,956.06 | 5.95 | 26 | 26 |
UTP catabolic process
|
2,329.02 | 5.86 | 26 | 33 |
dATP catabolic process
|
1,921.44 | 5.76 | 26 | 40 |
dUTP catabolic process
|
365.99 | 4.19 | 26 | 210 |
dGTP catabolic process
|
281.99 | 4.07 | 29 | 304 |
nucleoside triphosphate metabolic process
|
2,791.84 | 3.88 | 17 | 18 |
ribonucleoside triphosphate phosphatase activity
|
197.62 | 3.11 | 24 | 359 |
Totals | 1318 | 16243 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Added | XREF | MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN |
2023-08-11 | Deleted | XREF | MetaCyc:3.6.1.19-RXN |
2023-04-02 | Added | XREF | Reactome:R-HSA-9755030 |
2022-06-12 | Deleted | SYNONYM | nucleoside-triphosphate diphosphohydrolase activity |
2022-06-12 | Deleted | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2022-06-12 | Updated | TERM | nucleoside triphosphate diphosphatase activity |
2022-06-12 | Added | SYNONYM | nucleoside-triphosphate diphosphohydrolase activity |
2022-06-12 | Added | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2022-06-12 | Added | SYNONYM | nucleoside-triphosphate diphosphatase activity |
2022-06-12 | Added | DEFINITION | Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-12 | Updated | TERM | nucleoside triphosphate diphosphatase activity |
2003-08-19 | Added | TERM | nucleoside-triphosphate diphosphatase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-12 | Deleted | SYNONYM | nucleoside-triphosphate diphosphohydrolase activity |
2022-06-12 | Deleted | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2022-06-12 | Added | SYNONYM | nucleoside-triphosphate diphosphohydrolase activity |
2022-06-12 | Added | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2022-06-12 | Added | SYNONYM | nucleoside-triphosphate diphosphatase activity |
2022-06-12 | Added | DEFINITION | Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. |
2022-06-12 | Deleted | DEFINITION | Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. |
2020-10-08 | Added | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2020-10-08 | Deleted | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2020-10-08 | Deleted | SYNONYM | nucleoside-triphosphate diphosphohydrolase activity |
2020-10-08 | Added | SYNONYM | nucleoside-triphosphate diphosphohydrolase activity |
2010-10-08 | Deleted | DEFINITION | Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide. |
2010-10-08 | Added | DEFINITION | Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide. |
2007-11-08 | Added | SYNONYM | nucleoside-triphosphate diphosphohydrolase activity |
2007-08-09 | Added | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2007-08-09 | Deleted | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2004-04-19 | Added | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2004-04-16 | Deleted | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2003-10-31 | Updated | DEFINITION | Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide. |
2003-10-27 | Added | SYNONYM | nucleoside-triphosphate pyrophosphatase activity |
2003-10-24 | Updated | DEFINITION | Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + A nucleotide. |
2003-08-19 | Added | DEFINITION | Catalysis of the reaction: H2O + A nucleoside triphosphate = pyrophosphate + A nucleotide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016462 (pyrophosphatase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Added | XREF | MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN |
2023-08-11 | Deleted | XREF | MetaCyc:3.6.1.19-RXN |
2023-04-02 | Added | XREF | Reactome:R-HSA-9755030 |
2022-06-12 | Added | XREF | RHEA:23996 |
2022-06-12 | Added | XREF | RHEA:44644 |
2019-09-30 | Added | XREF | EC:3.6.1.9 |
2019-09-30 | Deleted | XREF | EC:3.6.1.19 |
2003-10-27 | Added | XREF | MetaCyc:3.6.1.19-RXN |
2003-08-19 | Added | XREF | EC:3.6.1.19 |
Timestamp | Action | Category | Detail |
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