This term is obsolete.

GO:0047429 JSON

nucleoside triphosphate diphosphatase activity

Molecular Function

Definition (GO:0047429 GONUTS page)

Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate.

438,529 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
nucleoside-triphosphate diphosphatase activity exact
nucleoside-triphosphate diphosphohydrolase activity exact
nucleoside-triphosphate pyrophosphatase activity exact

Ancestor Chart

Ancestor chart for GO:0047429
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0047429

Child Term Relationship to
GO:0047429
ATP diphosphatase activity
is_a
dATP diphosphatase activity
is_a
dCTP diphosphatase activity
is_a
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
is_a
dUTP diphosphatase activity
is_a
2-hydroxy-dATP hydrolase activity
is_a
UTP diphosphatase activity
is_a
8-oxo-(d)RTP hydrolase activity
is_a
dITP diphosphatase activity
is_a
ITP diphosphatase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.6.1.9
InterPro IPR002637 RdgB/HAM1
InterPro IPR003697 Nucleoside triphosphate pyrophosphatase Maf-like protein
InterPro IPR025984 dCTP pyrophosphatase 1
InterPro IPR027502 Inosine triphosphate pyrophosphatase
InterPro IPR048011 MazG-like, C-terminal domain
MetaCyc NUCLEOTIDE-PYROPHOSPHATASE-RXN
RHEA 23996
RHEA 44644
Reactome R-HSA-9755030

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0047429 based on ALL annotations
The top 100 of 1,000 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nucleoside triphosphate diphosphatase activity
1,249.57 100.00 158,578 158,578
nucleoside triphosphate catabolic process
1,223.47 41.21 65,936 67,343
nucleotide metabolic process
373.88 24.71 93,003 310,832
purine nucleoside triphosphate catabolic process
1,249.57 24.21 38,389 38,389
8-oxo-(d)RTP hydrolase activity
1,242.31 22.41 35,577 35,785
dTTP catabolic process
1,249.57 20.60 32,662 32,662
TTP catabolic process
1,249.57 20.60 32,660 32,660
UTP catabolic process
1,245.72 20.58 32,660 32,761
dATP catabolic process
1,242.46 20.57 32,660 32,847
pyrophosphatase activity
417.13 18.91 48,180 144,331
Totals 1202689 89378091
No co-occurrence statistics for GO:0047429 based on MANUAL annotations
The top 100 of 315 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nucleoside triphosphate diphosphatase activity
3,029.04 100.00 466 466
nucleoside triphosphate catabolic process
2,645.08 37.73 186 213
dTTP catabolic process
3,029.04 5.79 27 27
TTP catabolic process
3,029.04 5.36 25 25
UTP catabolic process
2,366.44 5.29 25 32
dATP catabolic process
1,941.69 5.21 25 39
dUTP catabolic process
336.56 3.75 25 225
dGTP catabolic process
268.40 3.71 28 316
nucleoside triphosphate metabolic process
2,860.76 3.64 17 18
ribonucleoside triphosphate phosphatase activity
215.72 3.08 24 337
Totals 1332 15886

Change Log

Timestamp Action Category Detail
2023-08-11 Deleted XREF MetaCyc:3.6.1.19-RXN
2023-08-11 Added XREF MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN
2023-04-02 Added XREF Reactome:R-HSA-9755030
2022-06-12 Added XREF RHEA:23996
2022-06-12 Added XREF RHEA:44644
2022-06-12 Updated TERM nucleoside triphosphate diphosphatase activity
2022-06-12 Deleted SYNONYM nucleoside-triphosphate diphosphohydrolase activity
2022-06-12 Deleted DEFINITION Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
2022-06-12 Added DEFINITION Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate.
2022-06-12 Added SYNONYM nucleoside-triphosphate diphosphatase activity
Timestamp Action Category Detail
2022-06-12 Updated TERM nucleoside triphosphate diphosphatase activity
2003-08-19 Added TERM nucleoside-triphosphate diphosphatase activity
Timestamp Action Category Detail
2022-06-12 Deleted SYNONYM nucleoside-triphosphate diphosphohydrolase activity
2022-06-12 Deleted DEFINITION Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
2022-06-12 Added DEFINITION Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate.
2022-06-12 Added SYNONYM nucleoside-triphosphate diphosphatase activity
2022-06-12 Added SYNONYM nucleoside-triphosphate pyrophosphatase activity
2022-06-12 Added SYNONYM nucleoside-triphosphate diphosphohydrolase activity
2022-06-12 Deleted SYNONYM nucleoside-triphosphate pyrophosphatase activity
2020-10-08 Added SYNONYM nucleoside-triphosphate diphosphohydrolase activity
2020-10-08 Deleted SYNONYM nucleoside-triphosphate diphosphohydrolase activity
2020-10-08 Deleted SYNONYM nucleoside-triphosphate pyrophosphatase activity
2020-10-08 Added SYNONYM nucleoside-triphosphate pyrophosphatase activity
2010-10-08 Added DEFINITION Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
2010-10-08 Deleted DEFINITION Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide.
2008-05-13 Added DEFINITION Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide.
2007-11-08 Added SYNONYM nucleoside-triphosphate diphosphohydrolase activity
2007-08-09 Added SYNONYM nucleoside-triphosphate pyrophosphatase activity
2007-08-09 Deleted SYNONYM nucleoside-triphosphate pyrophosphatase activity
2004-04-19 Added SYNONYM nucleoside-triphosphate pyrophosphatase activity
2004-04-16 Deleted SYNONYM nucleoside-triphosphate pyrophosphatase activity
2003-10-31 Updated DEFINITION Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide.
2003-10-27 Added SYNONYM nucleoside-triphosphate pyrophosphatase activity
2003-10-24 Updated DEFINITION Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + A nucleotide.
2003-08-19 Added DEFINITION Catalysis of the reaction: H2O + A nucleoside triphosphate = pyrophosphate + A nucleotide.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016462 (pyrophosphatase activity)
Timestamp Action Category Detail
2023-08-11 Deleted XREF MetaCyc:3.6.1.19-RXN
2023-08-11 Added XREF MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN
2023-04-02 Added XREF Reactome:R-HSA-9755030
2022-06-12 Added XREF RHEA:23996
2022-06-12 Added XREF RHEA:44644
2019-09-30 Deleted XREF EC:3.6.1.19
2019-09-30 Added XREF EC:3.6.1.9
2003-10-27 Added XREF MetaCyc:3.6.1.19-RXN
2003-08-19 Added XREF EC:3.6.1.19
Timestamp Action Category Detail
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