This term is obsolete.

GO:0047676 JSON

arachidonate-CoA ligase activity

Molecular Function

Definition (GO:0047676 GONUTS page)

Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+.

2,958 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
arachidonate:CoA ligase (AMP-forming) related
arachidonoyl-CoA synthetase activity related

Ancestor Chart

Ancestor chart for GO:0047676
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1LN46 10116 CPT1C_RAT GO:0006631 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:24222496
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8BGD5 10090 CPT1C_MOUSE GO:0006631 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
EC 6.2.1.15
KEGG_REACTION R01598
MetaCyc ARACHIDONATE--COA-LIGASE-RXN
RHEA 19713

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:32395 arachidonate
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:456215 adenosine 5'-monophosphate(2-)
has_participant CHEBI CHEBI:57287 coenzyme A(4-)
has_participant CHEBI CHEBI:57368 arachidonoyl-CoA(4-)
has_participant CHEBI CHEBI:33019 diphosphate(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0047676 based on ALL annotations
The top 100 of 152 co-occurring terms
Co-occurring Term PR S% #Together #Compared
arachidonate-CoA ligase activity
68,024.33 100.00 2,913 2,913
positive regulation of long-chain fatty acid import across plasma membrane
68,024.33 44.73 1,303 1,303
long-chain fatty-acyl-CoA biosynthetic process
21,438.65 23.07 1,347 4,274
long-chain fatty-acyl-CoA metabolic process
3,783.61 5.27 1,454 26,141
very long-chain fatty acid-CoA ligase activity
4,634.45 2.61 118 1,732
long-chain fatty acid metabolic process
1,608.63 2.36 2,904 122,802
embryonic process involved in female pregnancy
9,981.00 1.98 65 443
oleoyl-CoA ligase activity
2,499.26 1.82 101 2,749
lipid droplet
916.43 1.33 1,462 108,521
long-chain fatty acid-CoA ligase activity
846.57 1.23 1,455 116,914
Totals 28962 58575385
No co-occurrence statistics for GO:0047676 based on MANUAL annotations
The top 83 of 83 co-occurring terms
Co-occurring Term PR S% #Together #Compared
arachidonate-CoA ligase activity
15,016.31 100.00 94 94
long-chain fatty-acyl-CoA biosynthetic process
12,355.19 60.19 65 79
positive regulation of long-chain fatty acid import across plasma membrane
15,016.31 22.34 21 21
very long-chain fatty acid metabolic process
4,197.11 21.43 45 161
long-chain fatty acid metabolic process
1,980.17 12.68 72 546
phytanate-CoA ligase activity
10,010.87 4.17 4 6
oleoyl-CoA ligase activity
1,472.19 3.57 5 51
long-chain fatty-acyl-CoA metabolic process
481.44 2.88 21 655
very long-chain fatty acid-CoA ligase activity
1,407.78 2.44 3 32
long-chain fatty acid-CoA ligase activity
331.69 2.06 22 996
Totals 730 836389

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+).
2020-11-26 Deleted RELATION is a GO:0016405 (CoA-ligase activity)
2020-11-26 Added RELATION is a GO:0004467 (long-chain fatty acid-CoA ligase activity)
2020-11-26 Deleted RELATION is a GO:0016878 (acid-thiol ligase activity)
2020-10-08 Deleted SYNONYM arachidonoyl-CoA synthetase activity
2020-10-08 Deleted SYNONYM arachidonate:CoA ligase (AMP-forming)
2020-10-08 Added SYNONYM arachidonoyl-CoA synthetase activity
2020-10-08 Added SYNONYM arachidonate:CoA ligase (AMP-forming)
2019-06-20 Added XREF KEGG_REACTION:R01598
Timestamp Action Category Detail
2003-08-28 Added TERM arachidonate-CoA ligase activity
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+).
2020-10-08 Deleted SYNONYM arachidonoyl-CoA synthetase activity
2020-10-08 Deleted SYNONYM arachidonate:CoA ligase (AMP-forming)
2020-10-08 Added SYNONYM arachidonoyl-CoA synthetase activity
2020-10-08 Added SYNONYM arachidonate:CoA ligase (AMP-forming)
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA.
2010-10-11 Added DEFINITION Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA.
2007-11-08 Added SYNONYM arachidonate:CoA ligase (AMP-forming)
2007-09-06 Added SYNONYM arachidonoyl-CoA synthetase activity
2003-08-28 Added DEFINITION Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA.
Timestamp Action Category Detail
2020-11-26 Deleted RELATION is a GO:0016405 (CoA-ligase activity)
2020-11-26 Added RELATION is a GO:0004467 (long-chain fatty acid-CoA ligase activity)
2020-11-26 Deleted RELATION is a GO:0016878 (acid-thiol ligase activity)
2018-02-09 Added RELATION is a GO:0016405 (CoA-ligase activity)
2008-04-01 Updated RELATION is a GO:0016878 (acid-thiol ligase activity)
Timestamp Action Category Detail
2019-06-20 Added XREF KEGG_REACTION:R01598
2019-06-20 Deleted XREF KEGG:R01598
2018-07-13 Added XREF RHEA:19713
2018-07-13 Deleted XREF RHEA:19716
2010-10-11 Added XREF RHEA:19716
2010-10-11 Added XREF KEGG:R01598
2003-10-27 Added XREF MetaCyc:ARACHIDONATE--COA-LIGASE-RXN
2003-08-28 Added XREF EC:6.2.1.15
Timestamp Action Category Detail
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