GO:0047676
JSON
arachidonate-CoA ligase activity
Molecular Function
Definition (GO:0047676 GONUTS page)
Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
arachidonate:CoA ligase (AMP-forming) | related |
arachidonoyl-CoA synthetase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1LN46 | 10116 | CPT1C_RAT | GO:0006631 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:24222496 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8BGD5 | 10090 | CPT1C_MOUSE | GO:0006631 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.2.1.15 | |
KEGG_REACTION | R01598 | |
MetaCyc | ARACHIDONATE--COA-LIGASE-RXN | |
RHEA | 19713 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:32395 | arachidonate |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:456215 | adenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:57287 | coenzyme A(4-) |
has_participant | CHEBI | CHEBI:57368 | arachidonoyl-CoA(4-) |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0047676 based on ALL annotations
The top 100 of 152 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
arachidonate-CoA ligase activity
|
68,024.33 | 100.00 | 2,913 | 2,913 |
positive regulation of long-chain fatty acid import across plasma membrane
|
68,024.33 | 44.73 | 1,303 | 1,303 |
long-chain fatty-acyl-CoA biosynthetic process
|
21,438.65 | 23.07 | 1,347 | 4,274 |
long-chain fatty-acyl-CoA metabolic process
|
3,783.61 | 5.27 | 1,454 | 26,141 |
very long-chain fatty acid-CoA ligase activity
|
4,634.45 | 2.61 | 118 | 1,732 |
long-chain fatty acid metabolic process
|
1,608.63 | 2.36 | 2,904 | 122,802 |
embryonic process involved in female pregnancy
|
9,981.00 | 1.98 | 65 | 443 |
oleoyl-CoA ligase activity
|
2,499.26 | 1.82 | 101 | 2,749 |
lipid droplet
|
916.43 | 1.33 | 1,462 | 108,521 |
long-chain fatty acid-CoA ligase activity
|
846.57 | 1.23 | 1,455 | 116,914 |
Totals | 28962 | 58575385 |
No co-occurrence statistics for GO:0047676 based on MANUAL annotations
The top 83 of 83 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
arachidonate-CoA ligase activity
|
15,016.31 | 100.00 | 94 | 94 |
long-chain fatty-acyl-CoA biosynthetic process
|
12,355.19 | 60.19 | 65 | 79 |
positive regulation of long-chain fatty acid import across plasma membrane
|
15,016.31 | 22.34 | 21 | 21 |
very long-chain fatty acid metabolic process
|
4,197.11 | 21.43 | 45 | 161 |
long-chain fatty acid metabolic process
|
1,980.17 | 12.68 | 72 | 546 |
phytanate-CoA ligase activity
|
10,010.87 | 4.17 | 4 | 6 |
oleoyl-CoA ligase activity
|
1,472.19 | 3.57 | 5 | 51 |
long-chain fatty-acyl-CoA metabolic process
|
481.44 | 2.88 | 21 | 655 |
very long-chain fatty acid-CoA ligase activity
|
1,407.78 | 2.44 | 3 | 32 |
long-chain fatty acid-CoA ligase activity
|
331.69 | 2.06 | 22 | 996 |
Totals | 730 | 836389 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). |
2020-11-26 | Deleted | RELATION | is a GO:0016405 (CoA-ligase activity) |
2020-11-26 | Added | RELATION | is a GO:0004467 (long-chain fatty acid-CoA ligase activity) |
2020-11-26 | Deleted | RELATION | is a GO:0016878 (acid-thiol ligase activity) |
2020-10-08 | Deleted | SYNONYM | arachidonoyl-CoA synthetase activity |
2020-10-08 | Deleted | SYNONYM | arachidonate:CoA ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | arachidonoyl-CoA synthetase activity |
2020-10-08 | Added | SYNONYM | arachidonate:CoA ligase (AMP-forming) |
2019-06-20 | Added | XREF | KEGG_REACTION:R01598 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-08-28 | Added | TERM | arachidonate-CoA ligase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). |
2020-10-08 | Deleted | SYNONYM | arachidonoyl-CoA synthetase activity |
2020-10-08 | Deleted | SYNONYM | arachidonate:CoA ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | arachidonoyl-CoA synthetase activity |
2020-10-08 | Added | SYNONYM | arachidonate:CoA ligase (AMP-forming) |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA. |
2007-11-08 | Added | SYNONYM | arachidonate:CoA ligase (AMP-forming) |
2007-09-06 | Added | SYNONYM | arachidonoyl-CoA synthetase activity |
2003-08-28 | Added | DEFINITION | Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-26 | Deleted | RELATION | is a GO:0016405 (CoA-ligase activity) |
2020-11-26 | Added | RELATION | is a GO:0004467 (long-chain fatty acid-CoA ligase activity) |
2020-11-26 | Deleted | RELATION | is a GO:0016878 (acid-thiol ligase activity) |
2018-02-09 | Added | RELATION | is a GO:0016405 (CoA-ligase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016878 (acid-thiol ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R01598 |
2019-06-20 | Deleted | XREF | KEGG:R01598 |
2018-07-13 | Added | XREF | RHEA:19713 |
2018-07-13 | Deleted | XREF | RHEA:19716 |
2010-10-11 | Added | XREF | RHEA:19716 |
2010-10-11 | Added | XREF | KEGG:R01598 |
2003-10-27 | Added | XREF | MetaCyc:ARACHIDONATE--COA-LIGASE-RXN |
2003-08-28 | Added | XREF | EC:6.2.1.15 |
Timestamp | Action | Category | Detail |
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