GO:0047805
JSON
cytidylate cyclase activity
Molecular Function
Definition (GO:0047805 GONUTS page)
Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming) | related |
3',5'-cyclic-CMP synthase activity | related |
3'5'-cyclic-CMP synthase activity | related |
CTP diphosphate-lyase (cyclizing) | related |
cytidyl cyclase activity | related |
cytidylyl cyclase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 4.6.1.6 | |
KEGG_REACTION | R00574 | |
MetaCyc | CYTIDYLATE-CYCLASE-RXN | |
RHEA | 14737 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58003 | 3',5'-cyclic CMP(1-) |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:37563 | CTP(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0047805 based on ALL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cytidylate cyclase activity
|
38,987,756.00 | 100.00 | 5 | 5 |
trans-synaptic signaling by nitric oxide, modulating synaptic transmission
|
38,987,756.00 | 20.00 | 1 | 1 |
retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
|
419,223.22 | 1.03 | 1 | 93 |
cellular response to nitric oxide
|
323,998.00 | 0.83 | 3 | 361 |
nitric oxide binding
|
170,438.28 | 0.44 | 4 | 915 |
positive regulation of nitric oxide mediated signal transduction
|
147,680.90 | 0.37 | 1 | 264 |
nitric oxide mediated signal transduction
|
146,295.53 | 0.37 | 2 | 533 |
nitric oxide-cGMP-mediated signaling
|
89,370.22 | 0.23 | 4 | 1,745 |
relaxation of vascular associated smooth muscle
|
89,627.02 | 0.23 | 1 | 435 |
guanylate cyclase complex, soluble
|
17,970.85 | 0.05 | 4 | 8,678 |
Totals | 100 | 75436464 |
No co-occurrence statistics for GO:0047805 based on MANUAL annotations
The top 28 of 28 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cytidylate cyclase activity
|
645,899.50 | 100.00 | 2 | 2 |
trans-synaptic signaling by nitric oxide, modulating synaptic transmission
|
645,899.50 | 50.00 | 1 | 1 |
retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
|
322,949.75 | 33.33 | 1 | 2 |
positive regulation of nitric oxide mediated signal transduction
|
71,766.61 | 10.00 | 1 | 9 |
nitric oxide binding
|
36,908.54 | 5.71 | 2 | 35 |
nitric oxide-cGMP-mediated signaling
|
21,177.03 | 3.28 | 2 | 61 |
relaxation of vascular associated smooth muscle
|
13,742.54 | 2.08 | 1 | 47 |
response to herbicide
|
13,456.24 | 2.04 | 1 | 48 |
guanylate cyclase complex, soluble
|
8,498.68 | 1.32 | 2 | 152 |
cellular response to nitric oxide
|
8,280.76 | 1.27 | 1 | 78 |
Totals | 40 | 149158 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+. |
2020-10-08 | Deleted | SYNONYM | 3',5'-cyclic-CMP synthase activity |
2020-10-08 | Deleted | SYNONYM | 3'5'-cyclic-CMP synthase activity |
2020-10-08 | Deleted | SYNONYM | cytidylyl cyclase activity |
2020-10-08 | Added | SYNONYM | 3',5'-cyclic-CMP synthase activity |
2020-10-08 | Added | SYNONYM | cytidylyl cyclase activity |
2020-10-08 | Added | SYNONYM | CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming) |
2020-10-08 | Added | SYNONYM | 3'5'-cyclic-CMP synthase activity |
2020-10-08 | Added | SYNONYM | CTP diphosphate-lyase (cyclizing) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-08-29 | Added | TERM | cytidylate cyclase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+. |
2020-10-08 | Deleted | SYNONYM | 3',5'-cyclic-CMP synthase activity |
2020-10-08 | Deleted | SYNONYM | 3'5'-cyclic-CMP synthase activity |
2020-10-08 | Deleted | SYNONYM | cytidylyl cyclase activity |
2020-10-08 | Added | SYNONYM | 3',5'-cyclic-CMP synthase activity |
2020-10-08 | Added | SYNONYM | cytidylyl cyclase activity |
2020-10-08 | Added | SYNONYM | CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming) |
2020-10-08 | Added | SYNONYM | 3'5'-cyclic-CMP synthase activity |
2020-10-08 | Added | SYNONYM | CTP diphosphate-lyase (cyclizing) |
2020-10-08 | Added | SYNONYM | cytidyl cyclase activity |
2020-10-08 | Deleted | SYNONYM | CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming) |
2020-10-08 | Deleted | SYNONYM | cytidyl cyclase activity |
2020-10-08 | Deleted | SYNONYM | CTP diphosphate-lyase (cyclizing) |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate. |
2007-11-08 | Added | SYNONYM | CTP diphosphate-lyase (cyclizing) |
2007-11-08 | Added | SYNONYM | 3',5'-cyclic-CMP synthase activity |
2007-11-08 | Added | SYNONYM | CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming) |
2007-09-06 | Added | SYNONYM | cytidylyl cyclase activity |
2007-09-06 | Added | SYNONYM | 3'5'-cyclic-CMP synthase activity |
2007-09-06 | Added | SYNONYM | cytidyl cyclase activity |
2003-08-29 | Added | DEFINITION | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-03-30 | Added | RELATION | part of GO:0009190 (cyclic nucleotide biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0016849 (phosphorus-oxygen lyase activity) |
2008-04-01 | Updated | RELATION | is a GO:0009975 (cyclase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R00574 |
2019-06-20 | Deleted | XREF | KEGG:R00574 |
2018-07-13 | Added | XREF | RHEA:14737 |
2018-07-13 | Deleted | XREF | RHEA:14740 |
2010-10-11 | Added | XREF | KEGG:R00574 |
2010-10-11 | Added | XREF | RHEA:14740 |
2003-10-27 | Added | XREF | MetaCyc:CYTIDYLATE-CYCLASE-RXN |
2003-08-29 | Added | XREF | EC:4.6.1.6 |
Timestamp | Action | Category | Detail |
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