GO:0047988
JSON
hydroxyacid-oxoacid transhydrogenase activity
Molecular Function
Definition (GO:0047988 GONUTS page)
Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity | related |
transhydrogenase, hydroxy acid-oxo acid | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.99.24 | |
MetaCyc | HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN | |
Reactome | R-HSA-880002 | |
Reactome | R-HSA-880033 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0047988 based on ALL annotations
The top 32 of 32 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
hydroxyacid-oxoacid transhydrogenase activity
|
65,371.83 | 100.00 | 2,982 | 2,982 |
glutamate catabolic process via 2-hydroxyglutarate
|
59,225.76 | 3.54 | 106 | 117 |
alcohol dehydrogenase (NAD+) activity
|
1,664.23 | 2.55 | 2,981 | 117,095 |
mitochondrion
|
22.78 | 0.03 | 1,833 | 5,259,736 |
oxidoreductase activity
|
16.37 | 0.03 | 2,982 | 11,906,003 |
metal ion binding
|
8.20 | 0.01 | 2,981 | 23,771,070 |
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
|
4.83 | 0.01 | 3 | 40,589 |
cellular_component
|
3.13 | 0.00 | 3 | 62,739 |
biological_process
|
0.98 | 0.00 | 1 | 66,439 |
2-oxoglutarate metabolic process
|
0.73 | 0.00 | 1 | 89,095 |
Totals | 13943 | 168902808 |
No co-occurrence statistics for GO:0047988 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate catabolic process via 2-hydroxyglutarate
|
92,271.35 | 100.00 | 14 | 14 |
hydroxyacid-oxoacid transhydrogenase activity
|
92,271.35 | 100.00 | 14 | 14 |
alcohol dehydrogenase (NAD+) activity
|
847.50 | 0.91 | 8 | 871 |
2-oxoglutarate metabolic process
|
215.59 | 0.23 | 1 | 428 |
mitochondrion
|
28.21 | 0.03 | 14 | 45,791 |
mitochondrial matrix
|
23.52 | 0.03 | 1 | 3,923 |
cellular_component
|
1.47 | 0.00 | 1 | 62,739 |
biological_process
|
1.39 | 0.00 | 1 | 66,439 |
Totals | 54 | 180219 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | transhydrogenase, hydroxy acid-oxo acid |
2020-10-08 | Added | SYNONYM | (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity |
2020-10-08 | Added | SYNONYM | transhydrogenase, hydroxy acid-oxo acid |
2019-04-01 | Added | XREF | Reactome:R-HSA-880033 |
2019-04-01 | Added | XREF | Reactome:R-HSA-880002 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-880002 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-880033 |
2018-12-11 | Added | XREF | reactome:R-HSA-880002 |
2018-12-11 | Added | XREF | reactome:R-HSA-880033 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-08-29 | Added | TERM | hydroxyacid-oxoacid transhydrogenase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | transhydrogenase, hydroxy acid-oxo acid |
2020-10-08 | Added | SYNONYM | (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity |
2020-10-08 | Added | SYNONYM | transhydrogenase, hydroxy acid-oxo acid |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. |
2007-11-08 | Added | SYNONYM | (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity |
2007-11-08 | Added | SYNONYM | transhydrogenase, hydroxy acid-oxo acid |
2003-08-29 | Added | DEFINITION | Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-880033 |
2019-04-01 | Added | XREF | Reactome:R-HSA-880002 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-880002 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-880033 |
2018-12-11 | Added | XREF | reactome:R-HSA-880002 |
2018-12-11 | Added | XREF | reactome:R-HSA-880033 |
2003-10-27 | Added | XREF | MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN |
2003-08-29 | Added | XREF | EC:1.1.99.24 |
Timestamp | Action | Category | Detail |
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