This term is obsolete.

GO:0047988 JSON

hydroxyacid-oxoacid transhydrogenase activity

Molecular Function

Definition (GO:0047988 GONUTS page)

Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.

2,998 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity related
transhydrogenase, hydroxy acid-oxo acid related

Ancestor Chart

Ancestor chart for GO:0047988
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.1.99.24
MetaCyc HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN
Reactome R-HSA-880002
Reactome R-HSA-880033

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0047988 based on ALL annotations
The top 32 of 32 co-occurring terms
Co-occurring Term PR S% #Together #Compared
hydroxyacid-oxoacid transhydrogenase activity
65,371.83 100.00 2,982 2,982
glutamate catabolic process via 2-hydroxyglutarate
59,225.76 3.54 106 117
alcohol dehydrogenase (NAD+) activity
1,664.23 2.55 2,981 117,095
mitochondrion
22.78 0.03 1,833 5,259,736
oxidoreductase activity
16.37 0.03 2,982 11,906,003
metal ion binding
8.20 0.01 2,981 23,771,070
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
4.83 0.01 3 40,589
cellular_component
3.13 0.00 3 62,739
biological_process
0.98 0.00 1 66,439
2-oxoglutarate metabolic process
0.73 0.00 1 89,095
Totals 13943 168902808
No co-occurrence statistics for GO:0047988 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate catabolic process via 2-hydroxyglutarate
92,271.35 100.00 14 14
hydroxyacid-oxoacid transhydrogenase activity
92,271.35 100.00 14 14
alcohol dehydrogenase (NAD+) activity
847.50 0.91 8 871
2-oxoglutarate metabolic process
215.59 0.23 1 428
mitochondrion
28.21 0.03 14 45,791
mitochondrial matrix
23.52 0.03 1 3,923
cellular_component
1.47 0.00 1 62,739
biological_process
1.39 0.00 1 66,439
Totals 54 180219

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM transhydrogenase, hydroxy acid-oxo acid
2020-10-08 Added SYNONYM (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity
2020-10-08 Deleted SYNONYM (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity
2020-10-08 Added SYNONYM transhydrogenase, hydroxy acid-oxo acid
2019-04-01 Added XREF Reactome:R-HSA-880033
2019-04-01 Added XREF Reactome:R-HSA-880002
2019-04-01 Deleted XREF reactome:R-HSA-880002
2019-04-01 Deleted XREF reactome:R-HSA-880033
2018-12-11 Added XREF reactome:R-HSA-880002
2018-12-11 Added XREF reactome:R-HSA-880033
Timestamp Action Category Detail
2003-08-29 Added TERM hydroxyacid-oxoacid transhydrogenase activity
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM transhydrogenase, hydroxy acid-oxo acid
2020-10-08 Added SYNONYM (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity
2020-10-08 Deleted SYNONYM (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity
2020-10-08 Added SYNONYM transhydrogenase, hydroxy acid-oxo acid
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.
2007-11-08 Added SYNONYM (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity
2007-11-08 Added SYNONYM transhydrogenase, hydroxy acid-oxo acid
2003-08-29 Added DEFINITION Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-880033
2019-04-01 Added XREF Reactome:R-HSA-880002
2019-04-01 Deleted XREF reactome:R-HSA-880002
2019-04-01 Deleted XREF reactome:R-HSA-880033
2018-12-11 Added XREF reactome:R-HSA-880002
2018-12-11 Added XREF reactome:R-HSA-880033
2003-10-27 Added XREF MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN
2003-08-29 Added XREF EC:1.1.99.24
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.