This term is obsolete.

GO:0048143 JSON

astrocyte activation

Biological Process

Definition (GO:0048143 GONUTS page)

A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. PMID:10526094 PMID:10695728 PMID:12529254 PMID:12580336 PMID:9585813

1,551 annotations

Ancestor Chart

Ancestor chart for GO:0048143
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0048143

Child Term Relationship to
GO:0048143
regulation of astrocyte activation
regulates
negative regulation of astrocyte activation
negatively_regulates
astrocyte activation involved in immune response
is_a
positive regulation of astrocyte activation
positively_regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0048143 astrocyte activation Only in Taxon 7742 Vertebrata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q54NG5 44689 Q54NG5_DICDI GO:0007417 To remove over-annotation from InterPro entries. Reported by Typhaine from InterPro on 08/06/2020 IPR034968
IEA Review protein Q54NG6 44689 Q54NG6_DICDI GO:0007417 To remove over-annotation from InterPro entries. Reported by Typhaine from InterPro on 08/06/2020 IPR034968
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P0CI71 10116 K0319_RAT GO:0022008 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q2EI20 7955 REST_DANRE GO:0022008 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22951640
NOT-qualified manual protein Q5SZV5 10090 K0319_MOUSE GO:0022008 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27510895

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CL CL:0000127 astrocyte

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0048143 based on ALL annotations
The top 100 of 1,322 co-occurring terms
Co-occurring Term PR S% #Together #Compared
astrocyte activation
147,457.47 100.00 1,322 1,322
microglial cell activation
69,190.68 29.56 587 1,251
positive regulation of axon regeneration
72,031.28 26.62 488 999
ciliary neurotrophic factor receptor binding
37,265.28 17.65 488 1,931
ciliary neurotrophic factor-mediated signaling pathway
34,897.79 16.85 488 2,062
astrocyte activation involved in immune response
142,634.10 15.58 207 214
positive regulation of amyloid fibril formation
98,782.20 14.54 207 309
smooth endoplasmic reticulum calcium ion homeostasis
101,409.35 13.89 196 285
regulation of spontaneous synaptic transmission
103,458.06 12.46 174 248
cell surface receptor signaling pathway via STAT
27,734.29 10.68 262 1,393
Totals 14504 70416
No co-occurrence statistics for GO:0048143 based on MANUAL annotations
The top 100 of 1,160 co-occurring terms
Co-occurring Term PR S% #Together #Compared
astrocyte activation
15,563.84 100.00 83 83
microglial cell activation
5,187.95 23.23 36 108
ciliary neurotrophic factor-mediated signaling pathway
6,299.65 15.74 17 42
ciliary neurotrophic factor receptor binding
4,899.73 14.17 17 54
neuroinflammatory response
5,082.07 13.79 16 49
complement-mediated synapse pruning
8,093.20 13.68 13 25
multivesicular body, internal vesicle lumen
14,266.86 13.10 11 12
negative regulation of cardiocyte differentiation
14,266.86 13.10 11 12
response to hydroxyisoflavone
14,266.86 13.10 11 12
positive regulation of prolactin secretion
13,169.41 12.94 11 13
Totals 1131 3903

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2022-01-12 Added RELATION is a GO:0061900 (glial cell activation)
2022-01-12 Deleted RELATION is a GO:0001775 (cell activation)
2020-11-03 Deleted RELATION is a GO:0061900 (glial cell activation)
2020-11-03 Added RELATION is a GO:0001775 (cell activation)
2017-06-15 Added RELATION is a GO:0061900 (glial cell activation)
2017-06-15 Deleted RELATION is a GO:0001775 (cell activation)
2008-05-13 Added DEFINITION A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2008-05-12 Deleted DEFINITION A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2008-04-01 Updated RELATION is a GO:0001775 (cell activation)
Timestamp Action Category Detail
2003-07-21 Added TERM astrocyte activation
Timestamp Action Category Detail
2008-05-13 Added DEFINITION A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2008-05-12 Deleted DEFINITION A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2003-11-11 Updated DEFINITION A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2003-07-22 Added DEFINITION A change in morphology and behavior of an astrocyte cell resulting from exposure to a mitogen or to an antigen to which they have been primed.
Timestamp Action Category Detail
2022-01-12 Added RELATION is a GO:0061900 (glial cell activation)
2022-01-12 Deleted RELATION is a GO:0001775 (cell activation)
2020-11-03 Deleted RELATION is a GO:0061900 (glial cell activation)
2020-11-03 Added RELATION is a GO:0001775 (cell activation)
2017-06-15 Added RELATION is a GO:0061900 (glial cell activation)
2017-06-15 Deleted RELATION is a GO:0001775 (cell activation)
2008-04-01 Updated RELATION is a GO:0001775 (cell activation)
2008-04-01 Updated RELATION part of GO:0014002 (astrocyte development)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
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