GO:0050415
JSON
formimidoylglutamase activity
Molecular Function
Definition (GO:0050415 GONUTS page)
Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
formiminoglutamase activity | exact |
formiminoglutamate hydrolase activity | related |
N-formimino-L-glutamate formiminohydrolase activity | related |
N-formiminoglutamate hydrolase activity | related |
N-formimidoyl-L-glutamate formimidoylhydrolase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.5.3.8 | |
InterPro | IPR005923 | Formiminoglutamase |
KEGG_REACTION | R02285 | |
MetaCyc | FORMIMINOGLUTAMASE-RXN | |
RHEA | 22492 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:16397 | formamide |
has_participant | CHEBI | CHEBI:58928 | N-formimidoyl-L-glutamate(1-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:29985 | L-glutamate(1-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0050415 based on ALL annotations
The top 31 of 31 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
formimidoylglutamase activity
|
36,396.34 | 100.00 | 5,356 | 5,356 |
putrescine biosynthetic process from arginine, using agmatinase
|
3,778.75 | 10.34 | 5,161 | 49,710 |
agmatinase activity
|
3,772.83 | 10.33 | 5,161 | 49,788 |
L-histidine catabolic process to glutamate and formamide
|
2,592.80 | 7.08 | 4,967 | 69,724 |
L-histidine metabolic process
|
2,108.07 | 5.77 | 5,026 | 86,775 |
L-histidine catabolic process to glutamate and formate
|
2,154.32 | 5.76 | 3,644 | 61,564 |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
|
2,045.44 | 5.60 | 5,002 | 89,005 |
manganese ion binding
|
329.61 | 0.90 | 4,265 | 470,951 |
L-histidine catabolic process
|
73.36 | 0.19 | 142 | 70,452 |
N-formylglutamate deformylase activity
|
85.24 | 0.06 | 4 | 1,708 |
Totals | 49294 | 212807575 |
No co-occurrence statistics for GO:0050415 based on MANUAL annotations
The top 4 of 4 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
formimidoylglutamase activity
|
1,291,799.00 | 100.00 | 1 | 1 |
putrescine biosynthetic process from arginine, using agmatinase
|
9,097.18 | 0.70 | 1 | 142 |
agmatinase activity
|
9,097.18 | 0.70 | 1 | 142 |
L-histidine catabolic process
|
7,424.13 | 0.57 | 1 | 174 |
Totals | 4 | 459 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide. |
2020-10-08 | Deleted | SYNONYM | N-formimidoyl-L-glutamate formimidoylhydrolase activity |
2020-10-08 | Added | SYNONYM | formiminoglutamate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | N-formiminoglutamate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | formiminoglutamate hydrolase activity |
2020-10-08 | Added | SYNONYM | N-formimino-L-glutamate formiminohydrolase activity |
2020-10-08 | Deleted | SYNONYM | N-formimino-L-glutamate formiminohydrolase activity |
2020-10-08 | Added | SYNONYM | N-formiminoglutamate hydrolase activity |
2020-10-08 | Added | SYNONYM | N-formimidoyl-L-glutamate formimidoylhydrolase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-08-30 | Added | TERM | formimidoylglutamase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide. |
2020-10-08 | Deleted | SYNONYM | N-formimidoyl-L-glutamate formimidoylhydrolase activity |
2020-10-08 | Added | SYNONYM | formiminoglutamate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | N-formiminoglutamate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | formiminoglutamate hydrolase activity |
2020-10-08 | Added | SYNONYM | N-formimino-L-glutamate formiminohydrolase activity |
2020-10-08 | Deleted | SYNONYM | N-formimino-L-glutamate formiminohydrolase activity |
2020-10-08 | Added | SYNONYM | N-formiminoglutamate hydrolase activity |
2020-10-08 | Added | SYNONYM | N-formimidoyl-L-glutamate formimidoylhydrolase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide. |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. |
2007-11-08 | Added | SYNONYM | N-formimidoyl-L-glutamate formimidoylhydrolase activity |
2007-11-08 | Added | SYNONYM | N-formiminoglutamate hydrolase activity |
2007-11-08 | Added | SYNONYM | N-formimino-L-glutamate formiminohydrolase activity |
2007-09-06 | Added | SYNONYM | formiminoglutamate hydrolase activity |
2007-08-09 | Deleted | SYNONYM | formiminoglutamase activity |
2007-08-09 | Added | SYNONYM | formiminoglutamase activity |
2004-04-19 | Added | SYNONYM | formiminoglutamase activity |
2004-04-16 | Deleted | SYNONYM | formiminoglutamase activity |
2003-10-27 | Added | SYNONYM | formiminoglutamase activity |
2003-08-30 | Added | DEFINITION | Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016813 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R02285 |
2019-06-20 | Added | XREF | KEGG_REACTION:R02285 |
2018-07-13 | Added | XREF | RHEA:22492 |
2018-07-13 | Deleted | XREF | RHEA:22495 |
2010-10-11 | Added | XREF | RHEA:22495 |
2010-10-11 | Added | XREF | KEGG:R02285 |
2003-10-27 | Added | XREF | MetaCyc:FORMIMINOGLUTAMASE-RXN |
2003-08-30 | Added | XREF | EC:3.5.3.8 |
Timestamp | Action | Category | Detail |
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