This term is obsolete.

GO:0050439 JSON

2-hydroxy-3-oxoadipate synthase activity

Molecular Function

Definition (GO:0050439 GONUTS page)

Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2.

331 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) related
oxoglutarate:glyoxylate carboligase activity related
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity related
alpha-ketoglutaric-glyoxylic carboligase activity related
2-hydroxy-3-oxoadipate synthetase activity related
oxoglutarate: glyoxylate carboligase activity related

Ancestor Chart

Ancestor chart for GO:0050439
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.2.1.5
KEGG_REACTION R00474
MetaCyc 2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN
RHEA 14341

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:16526 carbon dioxide
has_participant CHEBI CHEBI:36655 glyoxylate
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:16810 2-oxoglutarate(2-)
has_participant CHEBI CHEBI:57712 2-hydroxy-3-oxoadipate(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0050439 based on ALL annotations
The top 23 of 23 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-hydroxy-3-oxoadipate synthase activity
590,723.60 100.00 330 330
2-oxoglutarate decarboxylase activity
246,824.64 41.68 328 785
dihydrolipoyllysine-residue succinyltransferase activity
5,970.63 1.01 324 32,056
oxoglutarate dehydrogenase (succinyl-transferring) activity
4,622.96 0.78 328 41,912
oxoglutarate dehydrogenase complex
2,729.06 0.46 324 70,132
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
1,898.85 0.32 326 101,417
thiamine pyrophosphate binding
488.11 0.08 324 392,110
carboxy-lyase activity
286.62 0.05 323 665,708
tricarboxylic acid cycle
281.17 0.05 326 684,903
acyltransferase activity
76.27 0.01 329 2,548,217
Totals 4576 91419151
No co-occurrence statistics for GO:0050439 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-oxoglutarate decarboxylase activity
1,291,799.00 100.00 1 1
2-hydroxy-3-oxoadipate synthase activity
1,291,799.00 100.00 1 1
succinate metabolic process
14,514.60 1.12 1 89
oxoglutarate dehydrogenase (succinyl-transferring) activity
5,871.81 0.45 1 220
pyruvate dehydrogenase complex
3,867.66 0.30 1 334
2-oxoglutarate metabolic process
3,018.22 0.23 1 428
oxoglutarate dehydrogenase complex
1,804.19 0.14 1 716
peptidoglycan-based cell wall
1,633.12 0.13 1 791
tricarboxylic acid cycle
545.98 0.04 1 2,366
magnesium ion binding
440.74 0.03 1 2,931
Totals 14 275072

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2).
2022-09-01 Added DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2.
2020-10-08 Added SYNONYM 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
2020-10-08 Added SYNONYM alpha-ketoglutaric-glyoxylic carboligase activity
2020-10-08 Added SYNONYM oxoglutarate:glyoxylate carboligase activity
2020-10-08 Deleted SYNONYM 2-hydroxy-3-oxoadipate synthetase activity
2020-10-08 Deleted SYNONYM 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity
2020-10-08 Deleted SYNONYM oxoglutarate:glyoxylate carboligase activity
2020-10-08 Deleted SYNONYM 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
2020-10-08 Deleted SYNONYM oxoglutarate: glyoxylate carboligase activity
Timestamp Action Category Detail
2003-09-03 Added TERM 2-hydroxy-3-oxoadipate synthase activity
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2).
2022-09-01 Added DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2.
2020-10-08 Added SYNONYM 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
2020-10-08 Added SYNONYM alpha-ketoglutaric-glyoxylic carboligase activity
2020-10-08 Added SYNONYM oxoglutarate:glyoxylate carboligase activity
2020-10-08 Deleted SYNONYM 2-hydroxy-3-oxoadipate synthetase activity
2020-10-08 Deleted SYNONYM 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity
2020-10-08 Deleted SYNONYM oxoglutarate:glyoxylate carboligase activity
2020-10-08 Deleted SYNONYM 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
2020-10-08 Deleted SYNONYM oxoglutarate: glyoxylate carboligase activity
2020-10-08 Added SYNONYM 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity
2020-10-08 Added SYNONYM 2-hydroxy-3-oxoadipate synthetase activity
2020-10-08 Added SYNONYM oxoglutarate: glyoxylate carboligase activity
2020-10-08 Deleted SYNONYM alpha-ketoglutaric-glyoxylic carboligase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2.
2010-10-11 Added DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2).
2010-09-15 Added DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2.
2010-09-15 Deleted DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 .
2008-05-13 Added DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 .
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 .
2007-11-08 Added SYNONYM 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
2007-11-08 Added SYNONYM oxoglutarate:glyoxylate carboligase activity
2007-09-06 Added SYNONYM 2-hydroxy-3-oxoadipate synthetase activity
2007-09-06 Added SYNONYM alpha-ketoglutaric-glyoxylic carboligase activity
2007-09-06 Added SYNONYM oxoglutarate: glyoxylate carboligase activity
2007-09-06 Added SYNONYM 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity
2003-09-03 Added DEFINITION Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 .
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016744 (transketolase or transaldolase activity)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R00474
2019-06-20 Added XREF KEGG_REACTION:R00474
2018-07-13 Deleted XREF RHEA:14344
2018-07-13 Added XREF RHEA:14341
2010-10-11 Added XREF RHEA:14344
2010-10-11 Added XREF KEGG:R00474
2003-10-27 Added XREF MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN
2003-09-03 Added XREF EC:2.2.1.5
Timestamp Action Category Detail
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