GO:0050439
JSON
2-hydroxy-3-oxoadipate synthase activity
Molecular Function
Definition (GO:0050439 GONUTS page)
Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) | related |
oxoglutarate:glyoxylate carboligase activity | related |
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity | related |
alpha-ketoglutaric-glyoxylic carboligase activity | related |
2-hydroxy-3-oxoadipate synthetase activity | related |
oxoglutarate: glyoxylate carboligase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.2.1.5 | |
KEGG_REACTION | R00474 | |
MetaCyc | 2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN | |
RHEA | 14341 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:16526 | carbon dioxide |
has_participant | CHEBI | CHEBI:36655 | glyoxylate |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:16810 | 2-oxoglutarate(2-) |
has_participant | CHEBI | CHEBI:57712 | 2-hydroxy-3-oxoadipate(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0050439 based on ALL annotations
The top 23 of 23 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-hydroxy-3-oxoadipate synthase activity
|
590,723.60 | 100.00 | 330 | 330 |
2-oxoglutarate decarboxylase activity
|
246,824.64 | 41.68 | 328 | 785 |
dihydrolipoyllysine-residue succinyltransferase activity
|
5,970.63 | 1.01 | 324 | 32,056 |
oxoglutarate dehydrogenase (succinyl-transferring) activity
|
4,622.96 | 0.78 | 328 | 41,912 |
oxoglutarate dehydrogenase complex
|
2,729.06 | 0.46 | 324 | 70,132 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
|
1,898.85 | 0.32 | 326 | 101,417 |
thiamine pyrophosphate binding
|
488.11 | 0.08 | 324 | 392,110 |
carboxy-lyase activity
|
286.62 | 0.05 | 323 | 665,708 |
tricarboxylic acid cycle
|
281.17 | 0.05 | 326 | 684,903 |
acyltransferase activity
|
76.27 | 0.01 | 329 | 2,548,217 |
Totals | 4576 | 91419151 |
No co-occurrence statistics for GO:0050439 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-oxoglutarate decarboxylase activity
|
1,291,799.00 | 100.00 | 1 | 1 |
2-hydroxy-3-oxoadipate synthase activity
|
1,291,799.00 | 100.00 | 1 | 1 |
succinate metabolic process
|
14,514.60 | 1.12 | 1 | 89 |
oxoglutarate dehydrogenase (succinyl-transferring) activity
|
5,871.81 | 0.45 | 1 | 220 |
pyruvate dehydrogenase complex
|
3,867.66 | 0.30 | 1 | 334 |
2-oxoglutarate metabolic process
|
3,018.22 | 0.23 | 1 | 428 |
oxoglutarate dehydrogenase complex
|
1,804.19 | 0.14 | 1 | 716 |
peptidoglycan-based cell wall
|
1,633.12 | 0.13 | 1 | 791 |
tricarboxylic acid cycle
|
545.98 | 0.04 | 1 | 2,366 |
magnesium ion binding
|
440.74 | 0.03 | 1 | 2,931 |
Totals | 14 | 275072 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2. |
2020-10-08 | Added | SYNONYM | 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) |
2020-10-08 | Added | SYNONYM | alpha-ketoglutaric-glyoxylic carboligase activity |
2020-10-08 | Added | SYNONYM | oxoglutarate:glyoxylate carboligase activity |
2020-10-08 | Deleted | SYNONYM | 2-hydroxy-3-oxoadipate synthetase activity |
2020-10-08 | Deleted | SYNONYM | 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity |
2020-10-08 | Deleted | SYNONYM | oxoglutarate:glyoxylate carboligase activity |
2020-10-08 | Deleted | SYNONYM | 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) |
2020-10-08 | Deleted | SYNONYM | oxoglutarate: glyoxylate carboligase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-03 | Added | TERM | 2-hydroxy-3-oxoadipate synthase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2. |
2020-10-08 | Added | SYNONYM | 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) |
2020-10-08 | Added | SYNONYM | alpha-ketoglutaric-glyoxylic carboligase activity |
2020-10-08 | Added | SYNONYM | oxoglutarate:glyoxylate carboligase activity |
2020-10-08 | Deleted | SYNONYM | 2-hydroxy-3-oxoadipate synthetase activity |
2020-10-08 | Deleted | SYNONYM | 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity |
2020-10-08 | Deleted | SYNONYM | oxoglutarate:glyoxylate carboligase activity |
2020-10-08 | Deleted | SYNONYM | 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) |
2020-10-08 | Deleted | SYNONYM | oxoglutarate: glyoxylate carboligase activity |
2020-10-08 | Added | SYNONYM | 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity |
2020-10-08 | Added | SYNONYM | 2-hydroxy-3-oxoadipate synthetase activity |
2020-10-08 | Added | SYNONYM | oxoglutarate: glyoxylate carboligase activity |
2020-10-08 | Deleted | SYNONYM | alpha-ketoglutaric-glyoxylic carboligase activity |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2). |
2010-09-15 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2. |
2010-09-15 | Deleted | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 . |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 . |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 . |
2007-11-08 | Added | SYNONYM | 2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) |
2007-11-08 | Added | SYNONYM | oxoglutarate:glyoxylate carboligase activity |
2007-09-06 | Added | SYNONYM | 2-hydroxy-3-oxoadipate synthetase activity |
2007-09-06 | Added | SYNONYM | alpha-ketoglutaric-glyoxylic carboligase activity |
2007-09-06 | Added | SYNONYM | oxoglutarate: glyoxylate carboligase activity |
2007-09-06 | Added | SYNONYM | 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity |
2003-09-03 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 . |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016744 (transketolase or transaldolase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R00474 |
2019-06-20 | Added | XREF | KEGG_REACTION:R00474 |
2018-07-13 | Deleted | XREF | RHEA:14344 |
2018-07-13 | Added | XREF | RHEA:14341 |
2010-10-11 | Added | XREF | RHEA:14344 |
2010-10-11 | Added | XREF | KEGG:R00474 |
2003-10-27 | Added | XREF | MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN |
2003-09-03 | Added | XREF | EC:2.2.1.5 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link