GO:0050464
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nitrate reductase (NADPH) activity
Molecular Function
Definition (GO:0050464 GONUTS page)
Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
nitrate reductase (NADPH2) | related |
nitrate reductase (NADPH(2)) activity | related |
assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity | related |
triphosphopyridine nucleotide-nitrate reductase activity | related |
NADPH:nitrate oxidoreductase activity | related |
NADPH:nitrate reductase activity | related |
assimilatory nitrate reductase activity | broad |
assimilatory NADPH-nitrate reductase activity | related |
nitrite:NADP+ oxidoreductase activity | related |
NADPH-nitrate reductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.7.1.3 | |
InterPro | IPR012137 | Nitrate reductase NADH dependent |
MetaCyc | NITRATE-REDUCTASE-NADPH-RXN | |
RHEA | 19061 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:16301 | nitrite |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:17632 | nitrate |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0050464 based on ALL annotations
The top 79 of 79 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nitrate reductase (NADPH) activity
|
75,091.98 | 100.00 | 2,596 | 2,596 |
nitric oxide biosynthetic process
|
12,561.75 | 15.40 | 1,714 | 10,246 |
sulfite oxidase activity
|
6,636.48 | 8.78 | 2,422 | 27,405 |
nitrate reductase (NADH) activity
|
15,392.08 | 5.30 | 173 | 844 |
sulfur compound metabolic process
|
1,657.73 | 2.20 | 2,422 | 109,712 |
nitrate assimilation
|
1,548.28 | 2.05 | 2,203 | 106,846 |
molybdenum ion binding
|
1,264.90 | 1.68 | 2,577 | 152,986 |
molybdopterin cofactor binding
|
1,104.10 | 1.47 | 2,567 | 174,586 |
organelle membrane
|
167.88 | 0.20 | 55 | 24,601 |
nitrate reductase [NAD(P)H] activity
|
18,773.00 | 0.12 | 3 | 12 |
Totals | 24549 | 235384568 |
No co-occurrence statistics for GO:0050464 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nitrate reductase (NADPH) activity
|
258,359.80 | 100.00 | 5 | 5 |
molybdopterin cofactor biosynthetic process
|
25,002.56 | 9.09 | 3 | 31 |
molybdopterin synthase activity
|
9,936.92 | 3.64 | 2 | 52 |
molybdopterin synthase complex
|
8,201.90 | 3.03 | 2 | 63 |
molybdopterin adenylyltransferase complex
|
2,969.65 | 1.10 | 1 | 87 |
Mo-molybdopterin cofactor biosynthetic process
|
2,184.86 | 0.84 | 4 | 473 |
molybdenum ion binding
|
2,034.33 | 0.76 | 1 | 127 |
GTP 3',8'-cyclase activity
|
1,928.06 | 0.72 | 1 | 134 |
cyclic pyranopterin monophosphate synthase activity
|
1,913.78 | 0.72 | 1 | 135 |
molybdopterin molybdotransferase activity
|
1,575.36 | 0.60 | 1 | 164 |
Totals | 28 | 329155 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | nitrite:NADP+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | nitrate reductase (NADPH(2)) activity |
2020-10-08 | Added | SYNONYM | NADPH:nitrate oxidoreductase activity |
2020-10-08 | Added | SYNONYM | assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | triphosphopyridine nucleotide-nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | nitrate reductase (NADPH(2)) activity |
2020-10-08 | Deleted | SYNONYM | assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | assimilatory NADPH-nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | NADPH:nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | NADPH:nitrate oxidoreductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-03 | Added | TERM | nitrate reductase (NADPH) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | nitrite:NADP+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | nitrate reductase (NADPH(2)) activity |
2020-10-08 | Added | SYNONYM | NADPH:nitrate oxidoreductase activity |
2020-10-08 | Added | SYNONYM | assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | triphosphopyridine nucleotide-nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | nitrate reductase (NADPH(2)) activity |
2020-10-08 | Deleted | SYNONYM | assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | assimilatory NADPH-nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | NADPH:nitrate reductase activity |
2020-10-08 | Deleted | SYNONYM | NADPH:nitrate oxidoreductase activity |
2020-10-08 | Added | SYNONYM | nitrate reductase (NADPH2) |
2020-10-08 | Deleted | SYNONYM | nitrate reductase (NADPH2) |
2020-10-08 | Added | SYNONYM | assimilatory NADPH-nitrate reductase activity |
2020-10-08 | Added | SYNONYM | NADPH-nitrate reductase activity |
2020-10-08 | Added | SYNONYM | NADPH:nitrate reductase activity |
2020-10-08 | Added | SYNONYM | nitrite:NADP+ oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NADPH-nitrate reductase activity |
2020-10-08 | Added | SYNONYM | triphosphopyridine nucleotide-nitrate reductase activity |
2010-09-15 | Deleted | DEFINITION | Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+. |
2010-09-15 | Added | DEFINITION | Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+. |
2007-11-08 | Added | SYNONYM | nitrate reductase (NADPH2) |
2007-11-08 | Added | SYNONYM | nitrite:NADP+ oxidoreductase activity |
2007-09-06 | Added | SYNONYM | NADPH-nitrate reductase activity |
2007-09-06 | Added | SYNONYM | NADPH:nitrate oxidoreductase activity |
2007-09-06 | Added | SYNONYM | NADPH:nitrate reductase activity |
2007-09-06 | Added | SYNONYM | assimilatory NADPH-nitrate reductase activity |
2007-09-06 | Added | SYNONYM | assimilatory nitrate reductase activity |
2007-09-06 | Added | SYNONYM | assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity |
2007-09-06 | Added | SYNONYM | triphosphopyridine nucleotide-nitrate reductase activity |
2007-09-06 | Added | SYNONYM | nitrate reductase (NADPH(2)) activity |
2006-02-04 | Updated | DEFINITION | Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+. |
2003-10-30 | Updated | DEFINITION | Catalysis of the reaction: NO2(-) (nitrite) + NADP+ + H2O = NO3(-) (nitrate) + NADPH + H+. |
2003-09-03 | Added | DEFINITION | Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-07-13 | Deleted | RELATION | is a GO:0008940 (nitrate reductase activity) |
2019-07-13 | Deleted | RELATION | is a GO:0046857 (oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor) |
2019-07-13 | Added | RELATION | is a GO:0050463 (nitrate reductase [NAD(P)H] activity) |
2008-04-01 | Updated | RELATION | is a GO:0046857 (oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor) |
2008-04-01 | Updated | RELATION | is a GO:0008940 (nitrate reductase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-13 | Deleted | XREF | RHEA:19064 |
2018-07-13 | Added | XREF | RHEA:19061 |
2011-09-16 | Added | XREF | RHEA:19064 |
2009-05-21 | Deleted | XREF | MetaCyc:NITRATE-REDUCTASE-(NADPH)-RXN |
2009-05-21 | Added | XREF | MetaCyc:NITRATE-REDUCTASE-NADPH-RXN |
2003-10-27 | Added | XREF | MetaCyc:NITRATE-REDUCTASE-(NADPH)-RXN |
2003-09-03 | Added | XREF | EC:1.7.1.3 |
Timestamp | Action | Category | Detail |
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