This term is obsolete.

GO:0050464 JSON

nitrate reductase (NADPH) activity

Molecular Function

Definition (GO:0050464 GONUTS page)

Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+.

2,600 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
nitrate reductase (NADPH2) related
nitrate reductase (NADPH(2)) activity related
assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity related
triphosphopyridine nucleotide-nitrate reductase activity related
NADPH:nitrate oxidoreductase activity related
NADPH:nitrate reductase activity related
assimilatory nitrate reductase activity broad
assimilatory NADPH-nitrate reductase activity related
nitrite:NADP+ oxidoreductase activity related
NADPH-nitrate reductase activity related

Ancestor Chart

Ancestor chart for GO:0050464
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.7.1.3
InterPro IPR012137 Nitrate reductase NADH dependent
MetaCyc NITRATE-REDUCTASE-NADPH-RXN
RHEA 19061

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:16301 nitrite
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:17632 nitrate
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0050464 based on ALL annotations
The top 79 of 79 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nitrate reductase (NADPH) activity
75,091.98 100.00 2,596 2,596
nitric oxide biosynthetic process
12,561.75 15.40 1,714 10,246
sulfite oxidase activity
6,636.48 8.78 2,422 27,405
nitrate reductase (NADH) activity
15,392.08 5.30 173 844
sulfur compound metabolic process
1,657.73 2.20 2,422 109,712
nitrate assimilation
1,548.28 2.05 2,203 106,846
molybdenum ion binding
1,264.90 1.68 2,577 152,986
molybdopterin cofactor binding
1,104.10 1.47 2,567 174,586
organelle membrane
167.88 0.20 55 24,601
nitrate reductase [NAD(P)H] activity
18,773.00 0.12 3 12
Totals 24549 235384568
No co-occurrence statistics for GO:0050464 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nitrate reductase (NADPH) activity
258,359.80 100.00 5 5
molybdopterin cofactor biosynthetic process
25,002.56 9.09 3 31
molybdopterin synthase activity
9,936.92 3.64 2 52
molybdopterin synthase complex
8,201.90 3.03 2 63
molybdopterin adenylyltransferase complex
2,969.65 1.10 1 87
Mo-molybdopterin cofactor biosynthetic process
2,184.86 0.84 4 473
molybdenum ion binding
2,034.33 0.76 1 127
GTP 3',8'-cyclase activity
1,928.06 0.72 1 134
cyclic pyranopterin monophosphate synthase activity
1,913.78 0.72 1 135
molybdopterin molybdotransferase activity
1,575.36 0.60 1 164
Totals 28 329155

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM nitrite:NADP+ oxidoreductase activity
2020-10-08 Added SYNONYM nitrate reductase (NADPH(2)) activity
2020-10-08 Added SYNONYM NADPH:nitrate oxidoreductase activity
2020-10-08 Added SYNONYM assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity
2020-10-08 Deleted SYNONYM triphosphopyridine nucleotide-nitrate reductase activity
2020-10-08 Deleted SYNONYM nitrate reductase (NADPH(2)) activity
2020-10-08 Deleted SYNONYM assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity
2020-10-08 Deleted SYNONYM assimilatory NADPH-nitrate reductase activity
2020-10-08 Deleted SYNONYM NADPH:nitrate reductase activity
2020-10-08 Deleted SYNONYM NADPH:nitrate oxidoreductase activity
Timestamp Action Category Detail
2003-09-03 Added TERM nitrate reductase (NADPH) activity
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM nitrite:NADP+ oxidoreductase activity
2020-10-08 Added SYNONYM nitrate reductase (NADPH(2)) activity
2020-10-08 Added SYNONYM NADPH:nitrate oxidoreductase activity
2020-10-08 Added SYNONYM assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity
2020-10-08 Deleted SYNONYM triphosphopyridine nucleotide-nitrate reductase activity
2020-10-08 Deleted SYNONYM nitrate reductase (NADPH(2)) activity
2020-10-08 Deleted SYNONYM assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity
2020-10-08 Deleted SYNONYM assimilatory NADPH-nitrate reductase activity
2020-10-08 Deleted SYNONYM NADPH:nitrate reductase activity
2020-10-08 Deleted SYNONYM NADPH:nitrate oxidoreductase activity
2020-10-08 Added SYNONYM nitrate reductase (NADPH2)
2020-10-08 Deleted SYNONYM nitrate reductase (NADPH2)
2020-10-08 Added SYNONYM assimilatory NADPH-nitrate reductase activity
2020-10-08 Added SYNONYM NADPH-nitrate reductase activity
2020-10-08 Added SYNONYM NADPH:nitrate reductase activity
2020-10-08 Added SYNONYM nitrite:NADP+ oxidoreductase activity
2020-10-08 Deleted SYNONYM NADPH-nitrate reductase activity
2020-10-08 Added SYNONYM triphosphopyridine nucleotide-nitrate reductase activity
2010-09-15 Deleted DEFINITION Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+.
2010-09-15 Added DEFINITION Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+.
2007-11-08 Added SYNONYM nitrate reductase (NADPH2)
2007-11-08 Added SYNONYM nitrite:NADP+ oxidoreductase activity
2007-09-06 Added SYNONYM NADPH-nitrate reductase activity
2007-09-06 Added SYNONYM NADPH:nitrate oxidoreductase activity
2007-09-06 Added SYNONYM NADPH:nitrate reductase activity
2007-09-06 Added SYNONYM assimilatory NADPH-nitrate reductase activity
2007-09-06 Added SYNONYM assimilatory nitrate reductase activity
2007-09-06 Added SYNONYM assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity
2007-09-06 Added SYNONYM triphosphopyridine nucleotide-nitrate reductase activity
2007-09-06 Added SYNONYM nitrate reductase (NADPH(2)) activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+.
2003-10-30 Updated DEFINITION Catalysis of the reaction: NO2(-) (nitrite) + NADP+ + H2O = NO3(-) (nitrate) + NADPH + H+.
2003-09-03 Added DEFINITION Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+.
Timestamp Action Category Detail
2019-07-13 Deleted RELATION is a GO:0008940 (nitrate reductase activity)
2019-07-13 Deleted RELATION is a GO:0046857 (oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor)
2019-07-13 Added RELATION is a GO:0050463 (nitrate reductase [NAD(P)H] activity)
2008-04-01 Updated RELATION is a GO:0046857 (oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor)
2008-04-01 Updated RELATION is a GO:0008940 (nitrate reductase activity)
Timestamp Action Category Detail
2018-07-13 Deleted XREF RHEA:19064
2018-07-13 Added XREF RHEA:19061
2011-09-16 Added XREF RHEA:19064
2009-05-21 Deleted XREF MetaCyc:NITRATE-REDUCTASE-(NADPH)-RXN
2009-05-21 Added XREF MetaCyc:NITRATE-REDUCTASE-NADPH-RXN
2003-10-27 Added XREF MetaCyc:NITRATE-REDUCTASE-(NADPH)-RXN
2003-09-03 Added XREF EC:1.7.1.3
Timestamp Action Category Detail
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