GO:0050518
JSON
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Molecular Function
Definition (GO:0050518 GONUTS page)
Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate.
Secondary IDs
GO:0008699
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
MEP cytidylyltransferase activity | exact |
CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity | exact |
4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity | exact |
MCT activity | related |
4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q4H4F3 | 1397 | BTRD_NIACI | GO:0016779 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17226887 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.7.60 | |
InterPro | IPR001228 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
KEGG_REACTION | R05633 | |
MetaCyc | 2.7.7.60-RXN | |
RHEA | 13429 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:58262 | 2-C-methyl-D-erythritol 4-phosphate(2-) |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:37563 | CTP(4-) |
has_participant | CHEBI | CHEBI:57823 | 4-CDP-2-C-methyl-D-erythritol(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0050518 based on ALL annotations
The top 100 of 127 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
|
5,094.44 | 100.00 | 38,265 | 38,265 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
|
682.78 | 13.07 | 32,160 | 239,956 |
cytidylyltransferase activity
|
2,985.33 | 12.25 | 5,131 | 8,756 |
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
|
1,043.97 | 10.98 | 7,317 | 35,706 |
isoprenoid biosynthetic process
|
395.22 | 7.72 | 36,113 | 465,500 |
terpenoid biosynthetic process
|
181.01 | 3.09 | 7,273 | 204,698 |
D-ribitol-5-phosphate cytidylyltransferase activity
|
1,980.90 | 2.04 | 808 | 2,078 |
nucleotidyltransferase activity
|
100.39 | 1.97 | 38,248 | 1,940,928 |
poly(ribitol phosphate) teichoic acid biosynthetic process
|
2,613.41 | 1.37 | 533 | 1,039 |
teichoic acid biosynthetic process
|
152.56 | 1.15 | 701 | 23,408 |
Totals | 183439 | 158636008 |
No co-occurrence statistics for GO:0050518 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
|
16,351.89 | 100.00 | 79 | 79 |
CTP binding
|
1,816.88 | 1.15 | 1 | 9 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
|
172.13 | 0.58 | 1 | 95 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
|
132.94 | 0.50 | 1 | 123 |
apicoplast
|
43.84 | 0.22 | 1 | 373 |
manganese ion binding
|
14.91 | 0.09 | 1 | 1,097 |
magnesium ion binding
|
11.16 | 0.07 | 2 | 2,931 |
chloroplast stroma
|
6.62 | 0.04 | 1 | 2,469 |
zinc ion binding
|
2.58 | 0.02 | 1 | 6,330 |
identical protein binding
|
1.86 | 0.01 | 1 | 8,780 |
Totals | 93 | 289110 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity |
2020-10-08 | Added | SYNONYM | 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity |
2019-06-20 | Deleted | XREF | KEGG:R05633 |
2019-06-20 | Added | XREF | KEGG_REACTION:R05633 |
2018-07-13 | Deleted | XREF | RHEA:13432 |
2018-07-13 | Added | XREF | RHEA:13429 |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. |
2010-10-11 | Added | XREF | RHEA:13432 |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate. |
2010-10-11 | Added | XREF | KEGG:R05633 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-25 | Added | TERM | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity |
2020-10-08 | Added | SYNONYM | 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. |
2007-09-06 | Added | SYNONYM | 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity |
2007-09-06 | Added | SYNONYM | MCT activity |
2007-08-09 | Added | SYNONYM | MEP cytidylyltransferase activity |
2007-08-09 | Added | SYNONYM | CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
2007-08-09 | Added | SYNONYM | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity |
2007-08-09 | Deleted | SYNONYM | MEP cytidylyltransferase activity |
2007-08-09 | Deleted | SYNONYM | CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
2007-08-09 | Deleted | SYNONYM | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity |
2007-01-22 | Added | SYNONYM | MEP cytidylyltransferase activity |
2006-01-22 | Added | SYNONYM | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity |
2005-10-24 | Added | SYNONYM | CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
2003-09-25 | Added | DEFINITION | Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-04-29 | Deleted | RELATION | is a GO:0016779 (nucleotidyltransferase activity) |
2009-04-29 | Added | RELATION | is a GO:0070567 (cytidylyltransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016779 (nucleotidyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R05633 |
2019-06-20 | Added | XREF | KEGG_REACTION:R05633 |
2018-07-13 | Deleted | XREF | RHEA:13432 |
2018-07-13 | Added | XREF | RHEA:13429 |
2010-10-11 | Added | XREF | RHEA:13432 |
2010-10-11 | Added | XREF | KEGG:R05633 |
2003-10-27 | Added | XREF | MetaCyc:2.7.7.60-RXN |
2003-09-25 | Added | XREF | EC:2.7.7.60 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-01-22 | Added | SECONDARY | GO:0008699 (4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity) |
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