This term is obsolete.

GO:0050518 JSON

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

Molecular Function

Definition (GO:0050518 GONUTS page)

Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate.

Secondary IDs

GO:0008699

38,341 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
MEP cytidylyltransferase activity exact
CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity exact
4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity exact
MCT activity related
4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity related

Ancestor Chart

Ancestor chart for GO:0050518
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q4H4F3 1397 BTRD_NIACI GO:0016779 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17226887
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.7.7.60
InterPro IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
KEGG_REACTION R05633
MetaCyc 2.7.7.60-RXN
RHEA 13429

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:58262 2-C-methyl-D-erythritol 4-phosphate(2-)
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:37563 CTP(4-)
has_participant CHEBI CHEBI:57823 4-CDP-2-C-methyl-D-erythritol(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0050518 based on ALL annotations
The top 100 of 127 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
5,094.44 100.00 38,265 38,265
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
682.78 13.07 32,160 239,956
cytidylyltransferase activity
2,985.33 12.25 5,131 8,756
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
1,043.97 10.98 7,317 35,706
isoprenoid biosynthetic process
395.22 7.72 36,113 465,500
terpenoid biosynthetic process
181.01 3.09 7,273 204,698
D-ribitol-5-phosphate cytidylyltransferase activity
1,980.90 2.04 808 2,078
nucleotidyltransferase activity
100.39 1.97 38,248 1,940,928
poly(ribitol phosphate) teichoic acid biosynthetic process
2,613.41 1.37 533 1,039
teichoic acid biosynthetic process
152.56 1.15 701 23,408
Totals 183439 158636008
No co-occurrence statistics for GO:0050518 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
16,351.89 100.00 79 79
CTP binding
1,816.88 1.15 1 9
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
172.13 0.58 1 95
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
132.94 0.50 1 123
apicoplast
43.84 0.22 1 373
manganese ion binding
14.91 0.09 1 1,097
magnesium ion binding
11.16 0.07 2 2,931
chloroplast stroma
6.62 0.04 1 2,469
zinc ion binding
2.58 0.02 1 6,330
identical protein binding
1.86 0.01 1 8,780
Totals 93 289110

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity
2020-10-08 Added SYNONYM 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity
2019-06-20 Deleted XREF KEGG:R05633
2019-06-20 Added XREF KEGG_REACTION:R05633
2018-07-13 Deleted XREF RHEA:13432
2018-07-13 Added XREF RHEA:13429
2010-10-11 Deleted DEFINITION Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
2010-10-11 Added XREF RHEA:13432
2010-10-11 Added DEFINITION Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate.
2010-10-11 Added XREF KEGG:R05633
Timestamp Action Category Detail
2003-09-25 Added TERM 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity
2020-10-08 Added SYNONYM 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
2010-10-11 Added DEFINITION Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate.
2008-05-13 Added DEFINITION Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
2007-09-06 Added SYNONYM 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity
2007-09-06 Added SYNONYM MCT activity
2007-08-09 Added SYNONYM MEP cytidylyltransferase activity
2007-08-09 Added SYNONYM CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
2007-08-09 Added SYNONYM 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity
2007-08-09 Deleted SYNONYM MEP cytidylyltransferase activity
2007-08-09 Deleted SYNONYM CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
2007-08-09 Deleted SYNONYM 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity
2007-01-22 Added SYNONYM MEP cytidylyltransferase activity
2006-01-22 Added SYNONYM 4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity
2005-10-24 Added SYNONYM CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
2003-09-25 Added DEFINITION Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
Timestamp Action Category Detail
2009-04-29 Deleted RELATION is a GO:0016779 (nucleotidyltransferase activity)
2009-04-29 Added RELATION is a GO:0070567 (cytidylyltransferase activity)
2008-04-01 Updated RELATION is a GO:0016779 (nucleotidyltransferase activity)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R05633
2019-06-20 Added XREF KEGG_REACTION:R05633
2018-07-13 Deleted XREF RHEA:13432
2018-07-13 Added XREF RHEA:13429
2010-10-11 Added XREF RHEA:13432
2010-10-11 Added XREF KEGG:R05633
2003-10-27 Added XREF MetaCyc:2.7.7.60-RXN
2003-09-25 Added XREF EC:2.7.7.60
Timestamp Action Category Detail
2006-01-22 Added SECONDARY GO:0008699 (4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity)
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