GO:0050614
JSON
delta24-sterol reductase activity
Molecular Function
Definition (GO:0050614 GONUTS page)
Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
lanosterol Delta(24)-reductase activity | narrow |
D24-sterol reductase activity | exact |
lanosterol delta24-reductase activity | related |
sterol:NADP+ delta24-oxidoreductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.3.1.72 | |
MetaCyc | RXN66-321 | |
RHEA | 13685 | |
Reactome | R-HSA-196417 | |
Reactome | R-HSA-6807064 | |
Reactome | R-HSA-9755937 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:16290 | 5alpha-cholesta-7,24-dien-3beta-ol |
has_participant | CHEBI | CHEBI:17168 | 5alpha-cholest-7-en-3beta-ol |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0050614 based on ALL annotations
The top 100 of 101 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
delta24-sterol reductase activity
|
44,762.07 | 100.00 | 4,355 | 4,355 |
delta24(24-1) sterol reductase activity
|
16,307.45 | 27.47 | 2,297 | 6,305 |
steroid metabolic process
|
2,803.86 | 6.01 | 2,588 | 41,316 |
cholesterol biosynthetic process via desmosterol
|
26,254.67 | 1.39 | 61 | 104 |
male genitalia development
|
1,916.01 | 1.03 | 58 | 1,355 |
plasminogen activation
|
880.37 | 0.80 | 58 | 2,949 |
amyloid precursor protein catabolic process
|
617.41 | 0.68 | 58 | 4,205 |
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
|
458.80 | 0.61 | 64 | 6,244 |
skin development
|
462.35 | 0.59 | 59 | 5,712 |
FAD binding
|
238.76 | 0.53 | 4,196 | 786,652 |
Totals | 24390 | 261680690 |
No co-occurrence statistics for GO:0050614 based on MANUAL annotations
The top 29 of 29 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
delta24-sterol reductase activity
|
430,599.70 | 100.00 | 3 | 3 |
cholesterol biosynthetic process via desmosterol
|
172,239.88 | 33.33 | 2 | 5 |
delta24(24-1) sterol reductase activity
|
19,873.83 | 4.62 | 3 | 65 |
cholesterol biosynthetic process via lathosterol
|
15,378.56 | 3.33 | 1 | 28 |
amyloid precursor protein catabolic process
|
6,834.92 | 1.54 | 1 | 63 |
plasminogen activation
|
6,332.35 | 1.43 | 1 | 68 |
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
|
4,731.86 | 1.09 | 2 | 182 |
male genitalia development
|
4,784.44 | 1.09 | 1 | 90 |
skin development
|
3,043.11 | 0.70 | 2 | 283 |
cholesterol biosynthetic process
|
2,641.72 | 0.61 | 2 | 326 |
Totals | 46 | 539928 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Deleted | XREF | MetaCyc:1.3.1.72-RXN |
2023-08-11 | Added | XREF | MetaCyc:RXN66-321 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9755937 |
2020-10-08 | Deleted | SYNONYM | lanosterol delta24-reductase activity |
2020-10-08 | Added | SYNONYM | lanosterol delta24-reductase activity |
2020-10-08 | Deleted | SYNONYM | sterol:NADP+ delta24-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | sterol:NADP+ delta24-oxidoreductase activity |
2019-04-01 | Added | XREF | Reactome:R-HSA-6807064 |
2019-04-01 | Added | XREF | Reactome:R-HSA-196417 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6807064 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-25 | Added | TERM | delta24-sterol reductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | lanosterol delta24-reductase activity |
2020-10-08 | Added | SYNONYM | lanosterol delta24-reductase activity |
2020-10-08 | Deleted | SYNONYM | sterol:NADP+ delta24-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | sterol:NADP+ delta24-oxidoreductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. |
2007-11-08 | Added | SYNONYM | lanosterol delta24-reductase activity |
2007-11-08 | Added | SYNONYM | sterol:NADP+ delta24-oxidoreductase activity |
2007-09-06 | Added | SYNONYM | lanosterol Delta(24)-reductase activity |
2007-08-09 | Added | SYNONYM | D24-sterol reductase activity |
2007-08-09 | Deleted | SYNONYM | D24-sterol reductase activity |
2004-04-19 | Added | SYNONYM | D24-sterol reductase activity |
2004-04-16 | Deleted | SYNONYM | D24-sterol reductase activity |
2003-10-27 | Added | SYNONYM | D24-sterol reductase activity |
2003-09-25 | Added | DEFINITION | Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Deleted | XREF | MetaCyc:1.3.1.72-RXN |
2023-08-11 | Added | XREF | MetaCyc:RXN66-321 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9755937 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6807064 |
2019-04-01 | Added | XREF | Reactome:R-HSA-196417 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6807064 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-196417 |
2018-12-11 | Added | XREF | reactome:R-HSA-6807064 |
2018-12-11 | Added | XREF | reactome:R-HSA-196417 |
2018-07-13 | Deleted | XREF | RHEA:13688 |
2018-07-13 | Added | XREF | RHEA:13685 |
2011-09-16 | Added | XREF | RHEA:13688 |
2003-10-27 | Added | XREF | MetaCyc:1.3.1.72-RXN |
2003-09-25 | Added | XREF | EC:1.3.1.72 |
Timestamp | Action | Category | Detail |
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