This term is obsolete.

GO:0050614 JSON

delta24-sterol reductase activity

Molecular Function

Definition (GO:0050614 GONUTS page)

Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.

4,359 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
lanosterol Delta(24)-reductase activity narrow
D24-sterol reductase activity exact
lanosterol delta24-reductase activity related
sterol:NADP+ delta24-oxidoreductase activity related

Ancestor Chart

Ancestor chart for GO:0050614
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.3.1.72
MetaCyc RXN66-321
RHEA 13685
Reactome R-HSA-196417
Reactome R-HSA-6807064
Reactome R-HSA-9755937

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:16290 5alpha-cholesta-7,24-dien-3beta-ol
has_participant CHEBI CHEBI:17168 5alpha-cholest-7-en-3beta-ol
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57783 NADPH(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0050614 based on ALL annotations
The top 100 of 101 co-occurring terms
Co-occurring Term PR S% #Together #Compared
delta24-sterol reductase activity
44,762.07 100.00 4,355 4,355
delta24(24-1) sterol reductase activity
16,307.45 27.47 2,297 6,305
steroid metabolic process
2,803.86 6.01 2,588 41,316
cholesterol biosynthetic process via desmosterol
26,254.67 1.39 61 104
male genitalia development
1,916.01 1.03 58 1,355
plasminogen activation
880.37 0.80 58 2,949
amyloid precursor protein catabolic process
617.41 0.68 58 4,205
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
458.80 0.61 64 6,244
skin development
462.35 0.59 59 5,712
FAD binding
238.76 0.53 4,196 786,652
Totals 24390 261680690
No co-occurrence statistics for GO:0050614 based on MANUAL annotations
The top 29 of 29 co-occurring terms
Co-occurring Term PR S% #Together #Compared
delta24-sterol reductase activity
430,599.70 100.00 3 3
cholesterol biosynthetic process via desmosterol
172,239.88 33.33 2 5
delta24(24-1) sterol reductase activity
19,873.83 4.62 3 65
cholesterol biosynthetic process via lathosterol
15,378.56 3.33 1 28
amyloid precursor protein catabolic process
6,834.92 1.54 1 63
plasminogen activation
6,332.35 1.43 1 68
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
4,731.86 1.09 2 182
male genitalia development
4,784.44 1.09 1 90
skin development
3,043.11 0.70 2 283
cholesterol biosynthetic process
2,641.72 0.61 2 326
Totals 46 539928

Change Log

Timestamp Action Category Detail
2023-08-11 Deleted XREF MetaCyc:1.3.1.72-RXN
2023-08-11 Added XREF MetaCyc:RXN66-321
2023-04-02 Added XREF Reactome:R-HSA-9755937
2020-10-08 Deleted SYNONYM lanosterol delta24-reductase activity
2020-10-08 Added SYNONYM lanosterol delta24-reductase activity
2020-10-08 Deleted SYNONYM sterol:NADP+ delta24-oxidoreductase activity
2020-10-08 Added SYNONYM sterol:NADP+ delta24-oxidoreductase activity
2019-04-01 Added XREF Reactome:R-HSA-6807064
2019-04-01 Added XREF Reactome:R-HSA-196417
2019-04-01 Deleted XREF reactome:R-HSA-6807064
Timestamp Action Category Detail
2003-09-25 Added TERM delta24-sterol reductase activity
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM lanosterol delta24-reductase activity
2020-10-08 Added SYNONYM lanosterol delta24-reductase activity
2020-10-08 Deleted SYNONYM sterol:NADP+ delta24-oxidoreductase activity
2020-10-08 Added SYNONYM sterol:NADP+ delta24-oxidoreductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.
2007-11-08 Added SYNONYM lanosterol delta24-reductase activity
2007-11-08 Added SYNONYM sterol:NADP+ delta24-oxidoreductase activity
2007-09-06 Added SYNONYM lanosterol Delta(24)-reductase activity
2007-08-09 Added SYNONYM D24-sterol reductase activity
2007-08-09 Deleted SYNONYM D24-sterol reductase activity
2004-04-19 Added SYNONYM D24-sterol reductase activity
2004-04-16 Deleted SYNONYM D24-sterol reductase activity
2003-10-27 Added SYNONYM D24-sterol reductase activity
2003-09-25 Added DEFINITION Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2023-08-11 Deleted XREF MetaCyc:1.3.1.72-RXN
2023-08-11 Added XREF MetaCyc:RXN66-321
2023-04-02 Added XREF Reactome:R-HSA-9755937
2019-04-01 Added XREF Reactome:R-HSA-6807064
2019-04-01 Added XREF Reactome:R-HSA-196417
2019-04-01 Deleted XREF reactome:R-HSA-6807064
2019-04-01 Deleted XREF reactome:R-HSA-196417
2018-12-11 Added XREF reactome:R-HSA-6807064
2018-12-11 Added XREF reactome:R-HSA-196417
2018-07-13 Deleted XREF RHEA:13688
2018-07-13 Added XREF RHEA:13685
2011-09-16 Added XREF RHEA:13688
2003-10-27 Added XREF MetaCyc:1.3.1.72-RXN
2003-09-25 Added XREF EC:1.3.1.72
Timestamp Action Category Detail
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