This term is obsolete.

GO:0050637 JSON

lovastatin nonaketide synthase activity

Molecular Function

Definition (GO:0050637 GONUTS page)

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+.

63 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) related

Ancestor Chart

Ancestor chart for GO:0050637
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.3.1.161
KEGG_REACTION R07251
MetaCyc 2.3.1.161-RXN
RHEA 18565

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:64479 O-(pantetheine-4'-phosphoryl)serine(1-) residue
has_participant CHEBI CHEBI:59789 S-adenosyl-L-methionine zwitterion
has_participant CHEBI CHEBI:79032 O-[S-(dihydromonacolin L carboxy)pantetheine-4'-phosphoryl]-L-serine(1-) residue
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:16526 carbon dioxide
has_participant CHEBI CHEBI:57384 malonyl-CoA(5-)
has_participant CHEBI CHEBI:57856 S-adenosyl-L-homocysteine zwitterion

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0050637 based on ALL annotations
The top 43 of 43 co-occurring terms
Co-occurring Term PR S% #Together #Compared
lovastatin nonaketide synthase activity
3,248,440.50 100.00 61 61
mycocerosate synthase activity
249,880.02 6.77 22 286
lovastatin biosynthetic process
1,082,813.40 5.80 4 12
erythronolide synthase activity
76,433.89 2.26 22 935
polyketide synthase activity
151,090.23 1.96 2 43
malonyl-CoA metabolic process
812,110.06 1.56 1 4
6-methylsalicylic acid synthase activity
85,485.27 1.02 1 38
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity
51,562.54 0.81 1 63
long-chain fatty acid [acyl-carrier-protein] ligase activity
18,658.99 0.57 21 3,656
phenylalanine racemase (ATP-hydrolyzing) activity
13,423.31 0.37 2 484
Totals 614 108034507
No co-occurrence statistics for GO:0050637 based on MANUAL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term PR S% #Together #Compared
lovastatin nonaketide synthase activity
1,411,533.00 100.00 1 1
malonyl-CoA metabolic process
352,883.25 25.00 1 4
lovastatin biosynthetic process
117,627.75 8.33 1 12
polyketide synthase activity
32,826.35 2.33 1 43
NADPH oxidation
21,067.66 1.49 1 67
S-adenosylmethionine metabolic process
20,457.00 1.45 1 69
polyketide biosynthetic process
2,145.19 0.15 1 658
methylation
583.04 0.04 1 2,421
S-adenosylmethionine-dependent methyltransferase activity
441.52 0.03 1 3,197
acyltransferase activity, transferring groups other than amino-acyl groups
358.89 0.03 1 3,933
Totals 12 27265

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+).
2020-10-08 Added SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
2020-10-08 Deleted SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
2019-06-20 Deleted XREF KEGG:R07251
2019-06-20 Added XREF KEGG_REACTION:R07251
2018-07-13 Deleted XREF RHEA:18568
2018-07-13 Added XREF RHEA:18565
2010-10-11 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O.
2010-10-11 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+).
Timestamp Action Category Detail
2003-09-25 Added TERM lovastatin nonaketide synthase activity
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+).
2020-10-08 Added SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
2020-10-08 Deleted SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
2010-10-11 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O.
2010-10-11 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O.
2007-11-08 Added SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O.
2003-09-25 Added DEFINITION Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + H+ + 10 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R07251
2019-06-20 Added XREF KEGG_REACTION:R07251
2018-07-13 Deleted XREF RHEA:18568
2018-07-13 Added XREF RHEA:18565
2010-10-11 Added XREF KEGG:R07251
2010-10-11 Added XREF RHEA:18568
2003-10-27 Added XREF MetaCyc:2.3.1.161-RXN
2003-09-25 Added XREF EC:2.3.1.161
Timestamp Action Category Detail
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