GO:0050637
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lovastatin nonaketide synthase activity
Molecular Function
Definition (GO:0050637 GONUTS page)
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.3.1.161 | |
KEGG_REACTION | R07251 | |
MetaCyc | 2.3.1.161-RXN | |
RHEA | 18565 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:64479 | O-(pantetheine-4'-phosphoryl)serine(1-) residue |
has_participant | CHEBI | CHEBI:59789 | S-adenosyl-L-methionine zwitterion |
has_participant | CHEBI | CHEBI:79032 | O-[S-(dihydromonacolin L carboxy)pantetheine-4'-phosphoryl]-L-serine(1-) residue |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:16526 | carbon dioxide |
has_participant | CHEBI | CHEBI:57384 | malonyl-CoA(5-) |
has_participant | CHEBI | CHEBI:57856 | S-adenosyl-L-homocysteine zwitterion |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0050637 based on ALL annotations
The top 43 of 43 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
lovastatin nonaketide synthase activity
|
3,248,440.50 | 100.00 | 61 | 61 |
mycocerosate synthase activity
|
249,880.02 | 6.77 | 22 | 286 |
lovastatin biosynthetic process
|
1,082,813.40 | 5.80 | 4 | 12 |
erythronolide synthase activity
|
76,433.89 | 2.26 | 22 | 935 |
polyketide synthase activity
|
151,090.23 | 1.96 | 2 | 43 |
malonyl-CoA metabolic process
|
812,110.06 | 1.56 | 1 | 4 |
6-methylsalicylic acid synthase activity
|
85,485.27 | 1.02 | 1 | 38 |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity
|
51,562.54 | 0.81 | 1 | 63 |
long-chain fatty acid [acyl-carrier-protein] ligase activity
|
18,658.99 | 0.57 | 21 | 3,656 |
phenylalanine racemase (ATP-hydrolyzing) activity
|
13,423.31 | 0.37 | 2 | 484 |
Totals | 614 | 108034507 |
No co-occurrence statistics for GO:0050637 based on MANUAL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
lovastatin nonaketide synthase activity
|
1,411,533.00 | 100.00 | 1 | 1 |
malonyl-CoA metabolic process
|
352,883.25 | 25.00 | 1 | 4 |
lovastatin biosynthetic process
|
117,627.75 | 8.33 | 1 | 12 |
polyketide synthase activity
|
32,826.35 | 2.33 | 1 | 43 |
NADPH oxidation
|
21,067.66 | 1.49 | 1 | 67 |
S-adenosylmethionine metabolic process
|
20,457.00 | 1.45 | 1 | 69 |
polyketide biosynthetic process
|
2,145.19 | 0.15 | 1 | 658 |
methylation
|
583.04 | 0.04 | 1 | 2,421 |
S-adenosylmethionine-dependent methyltransferase activity
|
441.52 | 0.03 | 1 | 3,197 |
acyltransferase activity, transferring groups other than amino-acyl groups
|
358.89 | 0.03 | 1 | 3,933 |
Totals | 12 | 27265 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+). |
2020-10-08 | Added | SYNONYM | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) |
2020-10-08 | Deleted | SYNONYM | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) |
2019-06-20 | Deleted | XREF | KEGG:R07251 |
2019-06-20 | Added | XREF | KEGG_REACTION:R07251 |
2018-07-13 | Deleted | XREF | RHEA:18568 |
2018-07-13 | Added | XREF | RHEA:18565 |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-25 | Added | TERM | lovastatin nonaketide synthase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+). |
2020-10-08 | Added | SYNONYM | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) |
2020-10-08 | Deleted | SYNONYM | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O. |
2007-11-08 | Added | SYNONYM | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) |
2006-02-04 | Updated | DEFINITION | Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O. |
2003-09-25 | Added | DEFINITION | Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + H+ + 10 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R07251 |
2019-06-20 | Added | XREF | KEGG_REACTION:R07251 |
2018-07-13 | Deleted | XREF | RHEA:18568 |
2018-07-13 | Added | XREF | RHEA:18565 |
2010-10-11 | Added | XREF | KEGG:R07251 |
2010-10-11 | Added | XREF | RHEA:18568 |
2003-10-27 | Added | XREF | MetaCyc:2.3.1.161-RXN |
2003-09-25 | Added | XREF | EC:2.3.1.161 |
Timestamp | Action | Category | Detail |
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