This term is obsolete.

GO:0050860 JSON

negative regulation of T cell receptor signaling pathway

Biological Process

Definition (GO:0050860 GONUTS page)

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.

2,929 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
down regulation of T cell receptor signaling pathway exact
down-regulation of T cell receptor signaling pathway exact
downregulation of T cell receptor signaling pathway exact
negative regulation of TCR signaling pathway exact
negative regulation of T-lymphocyte receptor signalling pathway exact
inhibition of T cell receptor signaling pathway narrow
negative regulation of T-cell receptor signaling pathway exact
negative regulation of T lymphocyte receptor signalling pathway exact
negative regulation of T lymphocyte receptor signaling pathway exact
negative regulation of T cell receptor signalling pathway exact

Ancestor Chart

Ancestor chart for GO:0050860
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0050860

Child Term Relationship to
GO:0050860
termination of T cell signal transduction
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Cross-references

Database ID Description
InterPro IPR034452 Transmembrane protein PVRIG

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0050860 based on ALL annotations
The top 100 of 782 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of T cell receptor signaling pathway
68,160.41 100.00 2,860 2,860
negative regulation of JNK cascade
10,885.14 10.09 615 3,851
negative regulation of T cell activation
9,724.74 9.72 669 4,689
positive regulation of mitotic cell cycle
9,154.54 9.01 615 4,579
negative regulation of ERK1 and ERK2 cascade
5,893.21 7.19 857 9,912
MAP kinase phosphatase activity
5,217.01 5.98 615 8,035
leading edge of lamellipodium
48,641.75 5.37 157 220
negative regulation of chemotaxis
62,953.72 4.63 133 144
natural killer cell mediated cytotoxicity
7,573.38 4.17 179 1,611
negative regulation of interleukin-2 production
5,652.33 4.17 221 2,665
Totals 15936 157222
No co-occurrence statistics for GO:0050860 based on MANUAL annotations
The top 100 of 703 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of T cell receptor signaling pathway
8,611.99 100.00 150 150
negative regulation of T cell activation
1,623.98 11.30 33 175
negative regulation of activated T cell proliferation
2,496.23 10.05 20 69
negative regulation of interleukin-2 production
1,403.44 8.37 22 135
protein phosphorylated amino acid binding
4,736.60 6.92 11 20
positive regulation of T cell anergy
3,189.63 5.99 10 27
signaling receptor inhibitor activity
3,075.71 5.95 10 28
negative regulation of chemotaxis
5,167.20 5.77 9 15
negative regulation of axonogenesis
1,691.64 5.64 11 56
branching involved in mammary gland duct morphogenesis
1,633.31 5.58 11 58
Totals 1156 12779

Change Log

Timestamp Action Category Detail
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2008-04-01 Updated RELATION is a GO:0050856 (regulation of T cell receptor signaling pathway)
2008-04-01 Added RELATION negatively regulates GO:0050852 (T cell receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0050858 (negative regulation of antigen receptor-mediated signaling pathway)
2007-08-09 Added SYNONYM negative regulation of T-cell receptor signaling pathway
2007-08-09 Added SYNONYM negative regulation of T-lymphocyte receptor signaling pathway
2007-08-09 Added SYNONYM negative regulation of T-lymphocyte receptor signalling pathway
Timestamp Action Category Detail
2005-06-02 Updated TERM negative regulation of T cell receptor signaling pathway
2004-02-12 Added TERM negative regulation of T-cell receptor signaling pathway
Timestamp Action Category Detail
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2007-08-09 Added SYNONYM negative regulation of T-cell receptor signaling pathway
2007-08-09 Added SYNONYM negative regulation of T-lymphocyte receptor signaling pathway
2007-08-09 Added SYNONYM negative regulation of T-lymphocyte receptor signalling pathway
2007-08-09 Added SYNONYM negative regulation of TCR signaling pathway
2007-08-09 Deleted SYNONYM negative regulation of T cell receptor signalling pathway
2007-08-09 Deleted SYNONYM negative regulation of T lymphocyte receptor signaling pathway
2007-08-09 Deleted SYNONYM negative regulation of T lymphocyte receptor signalling pathway
2007-08-09 Deleted SYNONYM negative regulation of T-cell receptor signaling pathway
2007-08-09 Deleted SYNONYM negative regulation of T-lymphocyte receptor signaling pathway
2007-08-09 Added SYNONYM negative regulation of T lymphocyte receptor signalling pathway
2007-08-09 Added SYNONYM negative regulation of T lymphocyte receptor signaling pathway
2007-08-09 Added SYNONYM negative regulation of T cell receptor signalling pathway
2007-08-09 Added SYNONYM inhibition of T cell receptor signaling pathway
2007-08-09 Added SYNONYM downregulation of T cell receptor signaling pathway
2007-08-09 Added SYNONYM down-regulation of T cell receptor signaling pathway
2007-08-09 Added SYNONYM down regulation of T cell receptor signaling pathway
2007-08-09 Deleted SYNONYM negative regulation of T-lymphocyte receptor signalling pathway
2007-08-09 Deleted SYNONYM inhibition of T cell receptor signaling pathway
2007-08-09 Deleted SYNONYM downregulation of T cell receptor signaling pathway
2007-08-09 Deleted SYNONYM down-regulation of T cell receptor signaling pathway
2007-08-09 Deleted SYNONYM down regulation of T cell receptor signaling pathway
2007-08-09 Deleted SYNONYM negative regulation of TCR signaling pathway
2007-02-23 Added SYNONYM down regulation of T cell receptor signaling pathway
2007-02-23 Added SYNONYM down-regulation of T cell receptor signaling pathway
2007-02-23 Added SYNONYM downregulation of T cell receptor signaling pathway
2007-02-23 Added SYNONYM inhibition of T cell receptor signaling pathway
2006-11-25 Added SYNONYM negative regulation of TCR signaling pathway
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2005-06-02 Added SYNONYM negative regulation of T-lymphocyte receptor signalling pathway
2005-06-02 Added SYNONYM negative regulation of T-lymphocyte receptor signaling pathway
2005-06-02 Added SYNONYM negative regulation of T-cell receptor signaling pathway
2005-06-02 Added SYNONYM negative regulation of T lymphocyte receptor signalling pathway
2005-06-02 Added SYNONYM negative regulation of T lymphocyte receptor signaling pathway
2005-06-02 Added SYNONYM negative regulation of T cell receptor signalling pathway
2005-06-02 Deleted SYNONYM negative regulation of T-cell receptor signalling pathway
2005-05-26 Updated DEFINITION Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
2004-10-08 Added SYNONYM negative regulation of T-cell receptor signalling pathway
2004-02-12 Added DEFINITION Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a T-cell.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0050856 (regulation of T cell receptor signaling pathway)
2008-04-01 Added RELATION negatively regulates GO:0050852 (T cell receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0050858 (negative regulation of antigen receptor-mediated signaling pathway)
Timestamp Action Category Detail
Timestamp Action Category Detail
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