GO:0050860
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negative regulation of T cell receptor signaling pathway
Biological Process
Definition (GO:0050860 GONUTS page)
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
down regulation of T cell receptor signaling pathway | exact |
down-regulation of T cell receptor signaling pathway | exact |
downregulation of T cell receptor signaling pathway | exact |
negative regulation of TCR signaling pathway | exact |
negative regulation of T-lymphocyte receptor signalling pathway | exact |
inhibition of T cell receptor signaling pathway | narrow |
negative regulation of T-cell receptor signaling pathway | exact |
negative regulation of T lymphocyte receptor signalling pathway | exact |
negative regulation of T lymphocyte receptor signaling pathway | exact |
negative regulation of T cell receptor signalling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0050860
Child Term | Relationship to GO:0050860 |
---|---|
termination of T cell signal transduction
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR034452 | Transmembrane protein PVRIG |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0050860 based on ALL annotations
The top 100 of 782 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of T cell receptor signaling pathway
|
68,160.41 | 100.00 | 2,860 | 2,860 |
negative regulation of JNK cascade
|
10,885.14 | 10.09 | 615 | 3,851 |
negative regulation of T cell activation
|
9,724.74 | 9.72 | 669 | 4,689 |
positive regulation of mitotic cell cycle
|
9,154.54 | 9.01 | 615 | 4,579 |
negative regulation of ERK1 and ERK2 cascade
|
5,893.21 | 7.19 | 857 | 9,912 |
MAP kinase phosphatase activity
|
5,217.01 | 5.98 | 615 | 8,035 |
leading edge of lamellipodium
|
48,641.75 | 5.37 | 157 | 220 |
negative regulation of chemotaxis
|
62,953.72 | 4.63 | 133 | 144 |
natural killer cell mediated cytotoxicity
|
7,573.38 | 4.17 | 179 | 1,611 |
negative regulation of interleukin-2 production
|
5,652.33 | 4.17 | 221 | 2,665 |
Totals | 15936 | 157222 |
No co-occurrence statistics for GO:0050860 based on MANUAL annotations
The top 100 of 703 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of T cell receptor signaling pathway
|
8,611.99 | 100.00 | 150 | 150 |
negative regulation of T cell activation
|
1,623.98 | 11.30 | 33 | 175 |
negative regulation of activated T cell proliferation
|
2,496.23 | 10.05 | 20 | 69 |
negative regulation of interleukin-2 production
|
1,403.44 | 8.37 | 22 | 135 |
protein phosphorylated amino acid binding
|
4,736.60 | 6.92 | 11 | 20 |
positive regulation of T cell anergy
|
3,189.63 | 5.99 | 10 | 27 |
signaling receptor inhibitor activity
|
3,075.71 | 5.95 | 10 | 28 |
negative regulation of chemotaxis
|
5,167.20 | 5.77 | 9 | 15 |
negative regulation of axonogenesis
|
1,691.64 | 5.64 | 11 | 56 |
branching involved in mammary gland duct morphogenesis
|
1,633.31 | 5.58 | 11 | 58 |
Totals | 1156 | 12779 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2008-04-01 | Updated | RELATION | is a GO:0050856 (regulation of T cell receptor signaling pathway) |
2008-04-01 | Added | RELATION | negatively regulates GO:0050852 (T cell receptor signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0050858 (negative regulation of antigen receptor-mediated signaling pathway) |
2007-08-09 | Added | SYNONYM | negative regulation of T-cell receptor signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of T-lymphocyte receptor signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of T-lymphocyte receptor signalling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-06-02 | Updated | TERM | negative regulation of T cell receptor signaling pathway |
2004-02-12 | Added | TERM | negative regulation of T-cell receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2007-08-09 | Added | SYNONYM | negative regulation of T-cell receptor signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of T-lymphocyte receptor signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of T-lymphocyte receptor signalling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of TCR signaling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of T cell receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of T lymphocyte receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of T lymphocyte receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of T-cell receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of T-lymphocyte receptor signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of T lymphocyte receptor signalling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of T lymphocyte receptor signaling pathway |
2007-08-09 | Added | SYNONYM | negative regulation of T cell receptor signalling pathway |
2007-08-09 | Added | SYNONYM | inhibition of T cell receptor signaling pathway |
2007-08-09 | Added | SYNONYM | downregulation of T cell receptor signaling pathway |
2007-08-09 | Added | SYNONYM | down-regulation of T cell receptor signaling pathway |
2007-08-09 | Added | SYNONYM | down regulation of T cell receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of T-lymphocyte receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | inhibition of T cell receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | downregulation of T cell receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | down-regulation of T cell receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | down regulation of T cell receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | negative regulation of TCR signaling pathway |
2007-02-23 | Added | SYNONYM | down regulation of T cell receptor signaling pathway |
2007-02-23 | Added | SYNONYM | down-regulation of T cell receptor signaling pathway |
2007-02-23 | Added | SYNONYM | downregulation of T cell receptor signaling pathway |
2007-02-23 | Added | SYNONYM | inhibition of T cell receptor signaling pathway |
2006-11-25 | Added | SYNONYM | negative regulation of TCR signaling pathway |
2006-05-04 | Updated | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2005-10-21 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2005-06-02 | Added | SYNONYM | negative regulation of T-lymphocyte receptor signalling pathway |
2005-06-02 | Added | SYNONYM | negative regulation of T-lymphocyte receptor signaling pathway |
2005-06-02 | Added | SYNONYM | negative regulation of T-cell receptor signaling pathway |
2005-06-02 | Added | SYNONYM | negative regulation of T lymphocyte receptor signalling pathway |
2005-06-02 | Added | SYNONYM | negative regulation of T lymphocyte receptor signaling pathway |
2005-06-02 | Added | SYNONYM | negative regulation of T cell receptor signalling pathway |
2005-06-02 | Deleted | SYNONYM | negative regulation of T-cell receptor signalling pathway |
2005-05-26 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
2004-10-08 | Added | SYNONYM | negative regulation of T-cell receptor signalling pathway |
2004-02-12 | Added | DEFINITION | Any process that stops, prevents or reduces the rate of signaling pathways initiated by the cross-linking of an antigen receptor on a T-cell. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0050856 (regulation of T cell receptor signaling pathway) |
2008-04-01 | Added | RELATION | negatively regulates GO:0050852 (T cell receptor signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0050858 (negative regulation of antigen receptor-mediated signaling pathway) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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