This term is obsolete.

GO:0051346 JSON

negative regulation of hydrolase activity

Biological Process

Definition (GO:0051346 GONUTS page)

Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.

Restrictions

This term should not be used for direct annotation.

247 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
downregulation of hydrolase activity exact
down-regulation of hydrolase activity exact
down regulation of hydrolase activity exact
inhibition of hydrolase activity narrow
hydrolase inhibitor exact

Ancestor Chart

Ancestor chart for GO:0051346
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0051346

Child Term Relationship to
GO:0051346
negative regulation of exo-alpha-sialidase activity
is_a
negative regulation of nuclease activity
is_a
negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
is_a
negative regulation of cyclic-nucleotide phosphodiesterase activity
is_a
negative regulation of lipase activity
is_a
negative regulation of beta-galactosidase activity
is_a
negative regulation of peptidase activity
is_a
negative regulation of GTPase activity
is_a
negative regulation of phosphatase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Describing enzyme functions that catalyse multi-stage reactions Link

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0051346 based on ALL annotations
The top 100 of 115 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of hydrolase activity
18,014,078.00 100.00 11 11
negative regulation of mitochondrial ATP synthesis coupled proton transport
10,007,822.00 33.33 5 9
peptidyl-threonine autophosphorylation
12,009,386.00 30.77 4 6
regulation of synaptic vesicle docking
3,002,346.50 9.52 2 12
regulation of endocannabinoid signaling pathway
661,067.10 3.45 4 109
mitochondrial proton-transporting ATP synthase complex binding
444,792.06 2.37 4 162
regulation of ATP metabolic process
428,906.62 2.29 4 168
calcium- and calmodulin-dependent protein kinase complex
280,374.78 1.52 4 257
angiostatin binding
263,363.72 1.44 5 342
protein C inhibitor-coagulation factor Xa complex
268,866.84 1.30 1 67
Totals 265 4686629
No co-occurrence statistics for GO:0051346 based on MANUAL annotations
The top 100 of 109 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of hydrolase activity
128,321.19 100.00 11 11
negative regulation of mitochondrial ATP synthesis coupled proton transport
71,289.55 33.33 5 9
peptidyl-threonine autophosphorylation
85,547.45 30.77 4 6
regulation of endocannabinoid signaling pathway
57,031.64 25.00 4 9
angiostatin binding
42,773.73 23.81 5 15
calcium- and calmodulin-dependent protein kinase complex
42,773.73 21.05 4 12
regulation of ATP metabolic process
42,773.73 13.33 2 6
mitochondrial proton-transporting ATP synthase complex binding
25,664.24 10.53 2 10
regulation of synaptic vesicle docking
23,331.13 10.00 2 11
regulation of mitochondrial membrane permeability involved in apoptotic process
12,418.18 7.69 3 31
Totals 241 188647

Change Log

Timestamp Action Category Detail
2024-07-26 Deleted SUBSET gocheck_do_not_annotate
2024-07-26 Added SUBSET gocheck_obsoletion_candidate
2023-06-13 Added SUBSET gocheck_do_not_annotate
2010-06-15 Added RELATION negatively regulates GO:0016787 (hydrolase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0016787 (hydrolase activity)
2010-06-09 Updated TERM negative regulation of hydrolase activity
2010-06-08 Updated TERM negative regulation of hydrolase activity
2010-06-08 Added RELATION negatively regulates GO:0016787 (hydrolase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0016787 (hydrolase activity)
2009-02-25 Updated TERM negative regulation of hydrolase activity
Timestamp Action Category Detail
2010-06-09 Updated TERM negative regulation of hydrolase activity
2010-06-08 Updated TERM negative regulation of hydrolase activity
2009-02-25 Updated TERM negative regulation of hydrolase activity
2009-02-22 Updated TERM negative regulation of hydrolase activity
2005-02-24 Added TERM negative regulation of hydrolase activity
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
2008-05-12 Deleted DEFINITION Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
2007-08-09 Added SYNONYM hydrolase inhibitor
2007-08-09 Added SYNONYM down-regulation of hydrolase activity
2007-08-09 Added SYNONYM downregulation of hydrolase activity
2007-08-09 Added SYNONYM down regulation of hydrolase activity
2007-08-09 Added SYNONYM inhibition of hydrolase activity
2007-08-09 Deleted SYNONYM inhibition of hydrolase activity
2007-08-09 Deleted SYNONYM downregulation of hydrolase activity
2007-08-09 Deleted SYNONYM down-regulation of hydrolase activity
2007-08-09 Deleted SYNONYM down regulation of hydrolase activity
2007-08-09 Deleted SYNONYM hydrolase inhibitor
2007-02-23 Added SYNONYM down regulation of hydrolase activity
2007-02-23 Added SYNONYM down-regulation of hydrolase activity
2007-02-23 Added SYNONYM downregulation of hydrolase activity
2007-02-23 Added SYNONYM inhibition of hydrolase activity
2005-02-25 Added DEFINITION Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
2005-02-24 Added SYNONYM hydrolase inhibitor
Timestamp Action Category Detail
2010-06-15 Added RELATION negatively regulates GO:0016787 (hydrolase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0016787 (hydrolase activity)
2010-06-08 Added RELATION negatively regulates GO:0016787 (hydrolase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0016787 (hydrolase activity)
2009-02-22 Added RELATION negatively regulates GO:0016787 (hydrolase activity)
2008-04-01 Updated RELATION is a GO:0051336 (regulation of hydrolase activity)
2008-04-01 Updated RELATION is a GO:0043086 (negative regulation of catalytic activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-07-26 Deleted SUBSET gocheck_do_not_annotate
2024-07-26 Added SUBSET gocheck_obsoletion_candidate
2023-06-13 Added SUBSET gocheck_do_not_annotate
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