GO:0051346
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negative regulation of hydrolase activity
Biological Process
Definition (GO:0051346 GONUTS page)
Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
Restrictions
This term should not be used for direct annotation.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
downregulation of hydrolase activity | exact |
down-regulation of hydrolase activity | exact |
down regulation of hydrolase activity | exact |
inhibition of hydrolase activity | narrow |
hydrolase inhibitor | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0051346
Child Term | Relationship to GO:0051346 |
---|---|
negative regulation of exo-alpha-sialidase activity
|
is_a |
negative regulation of nuclease activity
|
is_a |
negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
|
is_a |
negative regulation of cyclic-nucleotide phosphodiesterase activity
|
is_a |
negative regulation of lipase activity
|
is_a |
negative regulation of beta-galactosidase activity
|
is_a |
negative regulation of peptidase activity
|
is_a |
negative regulation of GTPase activity
|
is_a |
negative regulation of phosphatase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Describing enzyme functions that catalyse multi-stage reactions | Link |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0051346 based on ALL annotations
The top 100 of 115 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of hydrolase activity
|
18,014,078.00 | 100.00 | 11 | 11 |
negative regulation of mitochondrial ATP synthesis coupled proton transport
|
10,007,822.00 | 33.33 | 5 | 9 |
peptidyl-threonine autophosphorylation
|
12,009,386.00 | 30.77 | 4 | 6 |
regulation of synaptic vesicle docking
|
3,002,346.50 | 9.52 | 2 | 12 |
regulation of endocannabinoid signaling pathway
|
661,067.10 | 3.45 | 4 | 109 |
mitochondrial proton-transporting ATP synthase complex binding
|
444,792.06 | 2.37 | 4 | 162 |
regulation of ATP metabolic process
|
428,906.62 | 2.29 | 4 | 168 |
calcium- and calmodulin-dependent protein kinase complex
|
280,374.78 | 1.52 | 4 | 257 |
angiostatin binding
|
263,363.72 | 1.44 | 5 | 342 |
protein C inhibitor-coagulation factor Xa complex
|
268,866.84 | 1.30 | 1 | 67 |
Totals | 265 | 4686629 |
No co-occurrence statistics for GO:0051346 based on MANUAL annotations
The top 100 of 109 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of hydrolase activity
|
128,321.19 | 100.00 | 11 | 11 |
negative regulation of mitochondrial ATP synthesis coupled proton transport
|
71,289.55 | 33.33 | 5 | 9 |
peptidyl-threonine autophosphorylation
|
85,547.45 | 30.77 | 4 | 6 |
regulation of endocannabinoid signaling pathway
|
57,031.64 | 25.00 | 4 | 9 |
angiostatin binding
|
42,773.73 | 23.81 | 5 | 15 |
calcium- and calmodulin-dependent protein kinase complex
|
42,773.73 | 21.05 | 4 | 12 |
regulation of ATP metabolic process
|
42,773.73 | 13.33 | 2 | 6 |
mitochondrial proton-transporting ATP synthase complex binding
|
25,664.24 | 10.53 | 2 | 10 |
regulation of synaptic vesicle docking
|
23,331.13 | 10.00 | 2 | 11 |
regulation of mitochondrial membrane permeability involved in apoptotic process
|
12,418.18 | 7.69 | 3 | 31 |
Totals | 241 | 188647 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-26 | Deleted | SUBSET | gocheck_do_not_annotate |
2024-07-26 | Added | SUBSET | gocheck_obsoletion_candidate |
2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
2010-06-15 | Added | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2010-06-14 | Deleted | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2010-06-09 | Updated | TERM | negative regulation of hydrolase activity |
2010-06-08 | Updated | TERM | negative regulation of hydrolase activity |
2010-06-08 | Added | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2009-02-25 | Deleted | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2009-02-25 | Updated | TERM | negative regulation of hydrolase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-09 | Updated | TERM | negative regulation of hydrolase activity |
2010-06-08 | Updated | TERM | negative regulation of hydrolase activity |
2009-02-25 | Updated | TERM | negative regulation of hydrolase activity |
2009-02-22 | Updated | TERM | negative regulation of hydrolase activity |
2005-02-24 | Added | TERM | negative regulation of hydrolase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. |
2008-05-12 | Deleted | DEFINITION | Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. |
2007-08-09 | Added | SYNONYM | hydrolase inhibitor |
2007-08-09 | Added | SYNONYM | down-regulation of hydrolase activity |
2007-08-09 | Added | SYNONYM | downregulation of hydrolase activity |
2007-08-09 | Added | SYNONYM | down regulation of hydrolase activity |
2007-08-09 | Added | SYNONYM | inhibition of hydrolase activity |
2007-08-09 | Deleted | SYNONYM | inhibition of hydrolase activity |
2007-08-09 | Deleted | SYNONYM | downregulation of hydrolase activity |
2007-08-09 | Deleted | SYNONYM | down-regulation of hydrolase activity |
2007-08-09 | Deleted | SYNONYM | down regulation of hydrolase activity |
2007-08-09 | Deleted | SYNONYM | hydrolase inhibitor |
2007-02-23 | Added | SYNONYM | down regulation of hydrolase activity |
2007-02-23 | Added | SYNONYM | down-regulation of hydrolase activity |
2007-02-23 | Added | SYNONYM | downregulation of hydrolase activity |
2007-02-23 | Added | SYNONYM | inhibition of hydrolase activity |
2005-02-25 | Added | DEFINITION | Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. |
2005-02-24 | Added | SYNONYM | hydrolase inhibitor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-15 | Added | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2010-06-14 | Deleted | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2010-06-08 | Added | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2009-02-25 | Deleted | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2009-02-22 | Added | RELATION | negatively regulates GO:0016787 (hydrolase activity) |
2008-04-01 | Updated | RELATION | is a GO:0051336 (regulation of hydrolase activity) |
2008-04-01 | Updated | RELATION | is a GO:0043086 (negative regulation of catalytic activity) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-26 | Deleted | SUBSET | gocheck_do_not_annotate |
2024-07-26 | Added | SUBSET | gocheck_obsoletion_candidate |
2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
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