This term is obsolete.

GO:0051380 JSON

norepinephrine binding

Molecular Function

Definition (GO:0051380 GONUTS page)

Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.

1,480 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
noradrenaline binding exact

Ancestor Chart

Ancestor chart for GO:0051380
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:72587 (R)-noradrenaline(1+)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0051380 based on ALL annotations
The top 100 of 252 co-occurring terms
Co-occurring Term PR S% #Together #Compared
norepinephrine binding
134,255.36 100.00 1,452 1,452
beta2-adrenergic receptor activity
122,527.31 76.05 1,191 1,305
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
66,480.48 46.50 1,284 2,593
regulation of smooth muscle contraction
19,501.54 13.19 856 5,893
adrenergic receptor activity
19,588.16 10.51 397 2,721
heat generation
63,088.48 10.02 164 349
diet induced thermogenesis
28,894.85 8.00 164 762
blood vessel diameter maintenance
11,117.94 7.75 794 9,588
fear response
31,319.29 7.71 150 643
negative regulation of multicellular organism growth
19,297.00 6.75 164 1,141
Totals 21444 3094977
No co-occurrence statistics for GO:0051380 based on MANUAL annotations
The top 100 of 229 co-occurring terms
Co-occurring Term PR S% #Together #Compared
norepinephrine binding
26,363.25 100.00 49 49
beta2-adrenergic receptor activity
23,261.69 56.60 30 34
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
12,357.77 36.14 30 64
beta-adrenergic receptor activity
24,605.70 28.00 14 15
beta3-adrenergic receptor activity
12,727.09 21.88 14 29
positive regulation of lipophagy
9,090.77 14.71 10 29
negative regulation of G protein-coupled receptor signaling pathway
5,478.08 14.55 16 77
epinephrine binding
3,721.87 9.84 12 85
adenylate cyclase-activating adrenergic receptor signaling pathway
2,080.12 7.85 46 583
positive regulation of autophagosome maturation
2,929.25 7.75 10 90
Totals 481 11930

Change Log

Timestamp Action Category Detail
2022-07-04 Added RELATION is a GO:0043169 (cation binding)
2021-05-24 Added DEFINITION Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2012-10-29 Deleted RELATION is a GO:0043176 (amine binding)
2012-10-04 Deleted RELATION is a GO:0043178 (alcohol binding)
2012-09-07 Added RELATION is a GO:1901338 (catecholamine binding)
2009-07-06 Added RELATION is a GO:0043178 (alcohol binding)
2009-07-03 Deleted DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2008-10-02 Deleted RELATION is a GO:0042562 (hormone binding)
Timestamp Action Category Detail
2005-06-27 Added TERM norepinephrine binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2009-07-03 Deleted DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2008-05-13 Added DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2008-05-12 Deleted DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2007-08-09 Added SYNONYM noradrenaline binding
2007-08-09 Deleted SYNONYM noradrenaline binding
2005-06-27 Added DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2005-06-27 Added SYNONYM noradrenaline binding
Timestamp Action Category Detail
2022-07-04 Added RELATION is a GO:0043169 (cation binding)
2012-10-29 Deleted RELATION is a GO:0043176 (amine binding)
2012-10-04 Deleted RELATION is a GO:0043178 (alcohol binding)
2012-09-07 Added RELATION is a GO:1901338 (catecholamine binding)
2009-07-06 Added RELATION is a GO:0043178 (alcohol binding)
2008-10-02 Deleted RELATION is a GO:0042562 (hormone binding)
2008-10-02 Deleted RELATION is a GO:0042165 (obsolete neurotransmitter binding)
2008-04-01 Updated RELATION is a GO:0042165 (obsolete neurotransmitter binding)
2008-04-01 Updated RELATION is a GO:0042562 (hormone binding)
2008-04-01 Updated RELATION is a GO:0043176 (amine binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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