This term is obsolete.

GO:0051380 JSON

norepinephrine binding

Molecular Function

Definition (GO:0051380 GONUTS page)

Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.

1,495 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
noradrenaline binding exact

Ancestor Chart

Ancestor chart for GO:0051380
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:72587 (R)-noradrenaline(1+)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0051380 based on ALL annotations
The top 100 of 254 co-occurring terms
Co-occurring Term PR S% #Together #Compared
norepinephrine binding
135,536.84 100.00 1,462 1,462
beta2-adrenergic receptor activity
123,589.83 76.05 1,200 1,316
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
66,457.77 46.08 1,293 2,637
regulation of smooth muscle contraction
19,514.77 13.08 860 5,973
adrenergic receptor activity
19,529.38 10.43 401 2,783
heat generation
63,690.66 9.96 164 349
diet induced thermogenesis
29,170.66 7.96 164 762
fear response
31,618.24 7.67 150 643
blood vessel diameter maintenance
11,104.56 7.67 798 9,740
negative regulation of multicellular organism growth
19,396.20 6.71 164 1,146
Totals 21692 3200342
No co-occurrence statistics for GO:0051380 based on MANUAL annotations
The top 100 of 231 co-occurring terms
Co-occurring Term PR S% #Together #Compared
norepinephrine binding
27,677.12 100.00 51 51
beta2-adrenergic receptor activity
24,601.89 58.18 32 36
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
12,132.44 34.78 32 73
beta-adrenergic receptor activity
25,831.98 26.92 14 15
beta3-adrenergic receptor activity
12,499.34 20.59 14 31
positive regulation of lipophagy
9,543.83 14.29 10 29
negative regulation of G protein-coupled receptor signaling pathway
5,467.09 13.79 16 81
adenylate cyclase-activating adrenergic receptor signaling pathway
2,983.54 10.68 47 436
epinephrine binding
3,423.97 8.82 12 97
positive regulation of autophagosome maturation
2,853.31 7.25 10 97
Totals 486 12060

Change Log

Timestamp Action Category Detail
2022-07-04 Added RELATION is a GO:0043169 (cation binding)
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2021-05-24 Added DEFINITION Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2012-10-29 Deleted RELATION is a GO:0043176 (amine binding)
2012-10-04 Deleted RELATION is a GO:0043178 (alcohol binding)
2012-09-07 Added RELATION is a GO:1901338 (catecholamine binding)
2009-07-06 Added RELATION is a GO:0043178 (alcohol binding)
2009-07-03 Deleted DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2008-10-02 Deleted RELATION is a GO:0042165 (obsolete neurotransmitter binding)
Timestamp Action Category Detail
2005-06-27 Added TERM norepinephrine binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2021-05-24 Added DEFINITION Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2009-07-03 Deleted DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2008-05-13 Added DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2008-05-12 Deleted DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2007-08-09 Deleted SYNONYM noradrenaline binding
2007-08-09 Added SYNONYM noradrenaline binding
2005-06-27 Added SYNONYM noradrenaline binding
2005-06-27 Added DEFINITION Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
Timestamp Action Category Detail
2022-07-04 Added RELATION is a GO:0043169 (cation binding)
2012-10-29 Deleted RELATION is a GO:0043176 (amine binding)
2012-10-04 Deleted RELATION is a GO:0043178 (alcohol binding)
2012-09-07 Added RELATION is a GO:1901338 (catecholamine binding)
2009-07-06 Added RELATION is a GO:0043178 (alcohol binding)
2008-10-02 Deleted RELATION is a GO:0042165 (obsolete neurotransmitter binding)
2008-10-02 Deleted RELATION is a GO:0042562 (hormone binding)
2008-04-01 Updated RELATION is a GO:0043176 (amine binding)
2008-04-01 Updated RELATION is a GO:0042562 (hormone binding)
2008-04-01 Updated RELATION is a GO:0042165 (obsolete neurotransmitter binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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