GO:0051717
JSON
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
Molecular Function
Definition (GO:0051717 GONUTS page)
Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity | related |
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity | related |
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0051717
Child Term | Relationship to GO:0051717 |
---|---|
PTEN phosphatase complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | A0A087QTQ7 | 9233 | A0A087QTQ7_APTFO | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A087VMI5 | 100784 | A0A087VMI5_BALRE | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091CMN8 | 885580 | A0A091CMN8_FUKDA | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091HHI2 | 9244 | A0A091HHI2_CALAN | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091JLW6 | 188379 | A0A091JLW6_EGRGA | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091L9X5 | 187382 | A0A091L9X5_9AVES | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091P439 | 57397 | A0A091P439_APAVI | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091SAD7 | 54374 | A0A091SAD7_9AVES | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091SQ34 | 176057 | A0A091SQ34_NESNO | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A093DPA0 | 121530 | A0A093DPA0_TAUER | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR017361 | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN |
MetaCyc | 3.1.3.62-RXN | |
RHEA | 77155 | |
Reactome | R-HSA-1855200 | |
Reactome | R-HSA-1855205 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:203600 | 1D-myo-inositol 1,4,5-trisphosphate(6-) |
has_participant | CHEBI | CHEBI:57895 | 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-) |
has_participant | CHEBI | CHEBI:15377 | water |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0051717 based on ALL annotations
The top 100 of 280 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
|
161,239.69 | 100.00 | 1,209 | 1,209 |
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
|
160,839.58 | 99.50 | 1,206 | 1,209 |
phosphatidylinositol phosphate phosphatase activity
|
27,717.23 | 17.02 | 1,144 | 6,655 |
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
|
26,454.81 | 16.29 | 1,159 | 7,064 |
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
|
24,965.34 | 15.48 | 1,206 | 7,789 |
cell motility
|
11,038.86 | 6.83 | 1,159 | 16,929 |
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
|
70,414.81 | 5.32 | 69 | 158 |
negative regulation of keratinocyte migration
|
154,020.00 | 5.28 | 64 | 67 |
phosphatidylinositol 3-kinase/protein kinase B signal transduction
|
8,285.92 | 5.13 | 1,160 | 22,573 |
negative regulation of wound healing, spreading of epidermal cells
|
45,660.80 | 4.67 | 64 | 226 |
Totals | 31516 | 4721720 |
No co-occurrence statistics for GO:0051717 based on MANUAL annotations
The top 100 of 210 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
|
143,533.22 | 100.00 | 9 | 9 |
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
|
107,649.91 | 54.55 | 6 | 8 |
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
|
91,339.32 | 53.85 | 7 | 11 |
negative regulation of synaptic vesicle clustering
|
143,533.23 | 33.33 | 3 | 3 |
regulation of macrophage apoptotic process
|
143,533.22 | 22.22 | 2 | 2 |
regulation of cellular component size
|
71,766.61 | 18.18 | 2 | 4 |
rhythmic synaptic transmission
|
39,145.43 | 17.65 | 3 | 11 |
negative regulation of keratinocyte migration
|
57,413.29 | 16.67 | 2 | 5 |
regulation of B cell apoptotic process
|
57,413.29 | 16.67 | 2 | 5 |
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
|
57,413.29 | 16.67 | 2 | 5 |
Totals | 241 | 8127 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-20 | Added | XREF | RHEA:77155 |
2024-06-20 | Deleted | DEFINITION | Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. |
2024-06-20 | Added | DEFINITION | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate. |
2020-10-08 | Deleted | SYNONYM | inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity |
2020-10-08 | Deleted | SYNONYM | inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity |
2020-10-08 | Added | SYNONYM | inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity |
2020-10-08 | Deleted | SYNONYM | inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity |
2020-10-08 | Added | SYNONYM | inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity |
2020-10-08 | Added | SYNONYM | inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1855200 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-12-16 | Added | TERM | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-20 | Deleted | DEFINITION | Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. |
2024-06-20 | Added | DEFINITION | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate. |
2020-10-08 | Deleted | SYNONYM | inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity |
2020-10-08 | Deleted | SYNONYM | inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity |
2020-10-08 | Added | SYNONYM | inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity |
2020-10-08 | Deleted | SYNONYM | inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity |
2020-10-08 | Added | SYNONYM | inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity |
2020-10-08 | Added | SYNONYM | inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. |
2007-09-06 | Added | SYNONYM | inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity |
2007-09-06 | Added | SYNONYM | inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity |
2007-09-06 | Added | SYNONYM | inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity |
2005-12-16 | Added | DEFINITION | Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-09-16 | Added | RELATION | is a GO:0052743 (inositol tetrakisphosphate phosphatase activity) |
2011-09-16 | Deleted | RELATION | is a GO:0004437 (obsolete inositol or phosphatidylinositol phosphatase activity) |
2008-04-01 | Updated | RELATION | is a GO:0004437 (obsolete inositol or phosphatidylinositol phosphatase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-20 | Added | XREF | RHEA:77155 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1855200 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1855205 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1855200 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1855205 |
2018-12-11 | Added | XREF | reactome:R-HSA-1855205 |
2018-12-11 | Added | XREF | reactome:R-HSA-1855200 |
2005-12-16 | Added | XREF | MetaCyc:3.1.3.62-RXN |
Timestamp | Action | Category | Detail |
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