Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism.
GO:0051920
JSON
peroxiredoxin activity
Molecular Function
Definition (GO:0051920 GONUTS page)
Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
Comments
Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
PRDX activity | exact |
Prx activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0051920
Child Term | Relationship to GO:0051920 |
---|---|
NADH-dependent peroxiredoxin activity
|
is_a |
thioredoxin-dependent peroxiredoxin activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I5Y865 | 10116 | A0A8I5Y865_RAT | GO:0098869 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8J8YB21 | 10116 | A0A8J8YB21_RAT | GO:0098869 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR003779 | Carboxymuconolactone decarboxylase-like |
InterPro | IPR004674 | Alkylhydroperoxidase AhpD |
InterPro | IPR004675 | Alkylhydroperoxidase AhpD core |
InterPro | IPR017559 | Alkyl hydroperoxide reductase subunit C |
InterPro | IPR019479 | Peroxiredoxin, C-terminal |
InterPro | IPR022915 | Peroxiredoxin, TDXH subfamily |
InterPro | IPR045020 | 1-Cys peroxiredoxin |
RHEA | 10008 | |
Reactome | R-HSA-1222431 | |
Reactome | R-HSA-1222755 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:35924 | peroxol |
has_participant | CHEBI | CHEBI:30879 | alcohol |
has_participant | CHEBI | CHEBI:50058 | L-cystine residue |
has_participant | CHEBI | CHEBI:29950 | L-cysteine residue |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0051920 based on ALL annotations
The top 100 of 864 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
peroxiredoxin activity
|
1,154.41 | 100.00 | 171,651 | 171,651 |
cellular oxidant detoxification
|
231.31 | 19.98 | 169,141 | 844,124 |
cellular response to stress
|
491.51 | 16.87 | 37,476 | 88,019 |
thioredoxin peroxidase activity
|
316.62 | 14.03 | 38,292 | 139,612 |
peroxidase activity
|
166.82 | 12.12 | 73,717 | 510,126 |
cell redox homeostasis
|
174.39 | 11.28 | 52,845 | 349,807 |
hydrogen peroxide catabolic process
|
215.83 | 11.25 | 37,802 | 202,194 |
response to oxidative stress
|
113.68 | 7.62 | 43,234 | 439,037 |
NADH-dependent peroxiredoxin activity
|
526.01 | 4.40 | 7,974 | 17,500 |
thioredoxin-dependent peroxiredoxin activity
|
302.54 | 3.15 | 5,941 | 22,669 |
Totals | 777812 | 68209221 |
No co-occurrence statistics for GO:0051920 based on MANUAL annotations
The top 100 of 222 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
peroxiredoxin activity
|
45,533.32 | 100.00 | 31 | 31 |
thioredoxin-dependent peroxiredoxin activity
|
18,213.33 | 10.81 | 4 | 10 |
protein deglycase activity
|
15,177.77 | 10.26 | 4 | 12 |
positive regulation of mitochondrial electron transport, NADH to ubiquinone
|
11,383.33 | 7.50 | 3 | 12 |
methylglyoxal metabolic process
|
7,588.89 | 6.52 | 3 | 18 |
glycolate biosynthetic process
|
4,792.98 | 6.15 | 4 | 38 |
cellular response to glyoxal
|
18,213.33 | 5.88 | 2 | 5 |
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
|
15,177.77 | 5.71 | 2 | 6 |
glyoxalase (glycolic acid-forming) activity
|
13,009.52 | 5.56 | 2 | 7 |
positive regulation of NAD(P)H oxidase activity
|
13,009.52 | 5.56 | 2 | 7 |
Totals | 256 | 11002 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-26 | Deleted | XREF | MetaCyc:1.11.1.15-RXN |
2022-05-26 | Deleted | XREF | EC:1.11.1.24 |
2022-05-26 | Deleted | RELATION | is a GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor) |
2022-05-26 | Deleted | SYNONYM | AhpC activity |
2022-05-26 | Deleted | SYNONYM | alkyl hydroperoxide reductase C22 activity |
2022-05-26 | Added | RELATION | is a GO:0004601 (peroxidase activity) |
2022-05-26 | Deleted | RELATION | is a GO:0016209 (antioxidant activity) |
2022-05-07 | Deleted | DEFINITION | Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
2022-05-07 | Deleted | SYNONYM | thiol-containing-reductant:hydroperoxide oxidoreductase activity |
2022-05-07 | Added | DEFINITION | Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-03-11 | Added | TERM | peroxiredoxin activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-26 | Deleted | SYNONYM | AhpC activity |
2022-05-26 | Deleted | SYNONYM | alkyl hydroperoxide reductase C22 activity |
2022-05-07 | Deleted | DEFINITION | Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
2022-05-07 | Deleted | SYNONYM | thiol-containing-reductant:hydroperoxide oxidoreductase activity |
2022-05-07 | Added | DEFINITION | Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. |
2020-10-08 | Added | SYNONYM | thiol-containing-reductant:hydroperoxide oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | thiol-containing-reductant:hydroperoxide oxidoreductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
2007-11-08 | Added | SYNONYM | thiol-containing-reductant:hydroperoxide oxidoreductase activity |
2007-08-09 | Added | SYNONYM | AhpC activity |
2007-08-09 | Added | SYNONYM | PRDX activity |
2007-08-09 | Added | SYNONYM | Prx activity |
2007-08-09 | Added | SYNONYM | alkyl hydroperoxide reductase C22 activity |
2007-08-09 | Deleted | SYNONYM | alkyl hydroperoxide reductase C22 activity |
2007-08-09 | Deleted | SYNONYM | Prx activity |
2007-08-09 | Deleted | SYNONYM | PRDX activity |
2007-08-09 | Deleted | SYNONYM | AhpC activity |
2007-05-12 | Deleted | SYNONYM | TrxPx activity |
2007-05-12 | Deleted | SYNONYM | tryparedoxin peroxidase activity |
2007-05-12 | Deleted | SYNONYM | TXNPx activity |
2007-05-12 | Deleted | SYNONYM | thioredoxin peroxidase activity |
2006-03-11 | Added | SYNONYM | PRDX activity |
2006-03-11 | Added | SYNONYM | Prx activity |
2006-03-11 | Added | SYNONYM | TXNPx activity |
2006-03-11 | Added | SYNONYM | TrxPx activity |
2006-03-11 | Added | SYNONYM | alkyl hydroperoxide reductase C22 activity |
2006-03-11 | Added | DEFINITION | Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
2006-03-11 | Added | SYNONYM | AhpC activity |
2006-03-11 | Added | SYNONYM | tryparedoxin peroxidase activity |
2006-03-11 | Added | SYNONYM | thioredoxin peroxidase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-26 | Deleted | RELATION | is a GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor) |
2022-05-26 | Added | RELATION | is a GO:0004601 (peroxidase activity) |
2022-05-26 | Deleted | RELATION | is a GO:0016209 (antioxidant activity) |
2014-07-23 | Added | RELATION | is a GO:0016209 (antioxidant activity) |
2014-07-23 | Added | RELATION | is a GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor) |
2014-07-23 | Deleted | RELATION | is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen) |
2010-02-04 | Deleted | RELATION | is a GO:0004601 (peroxidase activity) |
2010-02-04 | Added | RELATION | is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen) |
2008-04-01 | Updated | RELATION | is a GO:0004601 (peroxidase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-26 | Deleted | XREF | MetaCyc:1.11.1.15-RXN |
2022-05-26 | Deleted | XREF | EC:1.11.1.24 |
2021-04-24 | Added | XREF | EC:1.11.1.24 |
2021-04-24 | Deleted | XREF | EC:1.11.1.15 |
2019-12-12 | Added | XREF | RHEA:10008 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1222431 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1222755 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1222431 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1500804 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1500804 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1222755 |
2018-12-11 | Added | XREF | reactome:R-HSA-1222431 |
2018-12-11 | Added | XREF | reactome:R-HSA-1222755 |
2018-12-11 | Added | XREF | reactome:R-HSA-1500804 |
2009-05-21 | Added | XREF | MetaCyc:1.11.1.15-RXN |
2006-03-11 | Added | XREF | EC:1.11.1.15 |
Timestamp | Action | Category | Detail |
---|
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