This term is obsolete.
Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism.

GO:0051920 JSON

peroxiredoxin activity

Molecular Function

Definition (GO:0051920 GONUTS page)

Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Comments

Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism.

351,814 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
PRDX activity exact
Prx activity exact

Ancestor Chart

Ancestor chart for GO:0051920
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0051920

Child Term Relationship to
GO:0051920
NADH-dependent peroxiredoxin activity
is_a
thioredoxin-dependent peroxiredoxin activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I5Y865 10116 A0A8I5Y865_RAT GO:0098869 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J8YB21 10116 A0A8J8YB21_RAT GO:0098869 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
InterPro IPR003779 Carboxymuconolactone decarboxylase-like
InterPro IPR004674 Alkylhydroperoxidase AhpD
InterPro IPR004675 Alkylhydroperoxidase AhpD core
InterPro IPR017559 Alkyl hydroperoxide reductase subunit C
InterPro IPR019479 Peroxiredoxin, C-terminal
InterPro IPR022915 Peroxiredoxin, TDXH subfamily
InterPro IPR045020 1-Cys peroxiredoxin
RHEA 10008
Reactome R-HSA-1222431
Reactome R-HSA-1222755

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:35924 peroxol
has_participant CHEBI CHEBI:30879 alcohol
has_participant CHEBI CHEBI:50058 L-cystine residue
has_participant CHEBI CHEBI:29950 L-cysteine residue

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0051920 based on ALL annotations
The top 100 of 864 co-occurring terms
Co-occurring Term PR S% #Together #Compared
peroxiredoxin activity
1,154.41 100.00 171,651 171,651
cellular oxidant detoxification
231.31 19.98 169,141 844,124
cellular response to stress
491.51 16.87 37,476 88,019
thioredoxin peroxidase activity
316.62 14.03 38,292 139,612
peroxidase activity
166.82 12.12 73,717 510,126
cell redox homeostasis
174.39 11.28 52,845 349,807
hydrogen peroxide catabolic process
215.83 11.25 37,802 202,194
response to oxidative stress
113.68 7.62 43,234 439,037
NADH-dependent peroxiredoxin activity
526.01 4.40 7,974 17,500
thioredoxin-dependent peroxiredoxin activity
302.54 3.15 5,941 22,669
Totals 777812 68209221
No co-occurrence statistics for GO:0051920 based on MANUAL annotations
The top 100 of 222 co-occurring terms
Co-occurring Term PR S% #Together #Compared
peroxiredoxin activity
45,533.32 100.00 31 31
thioredoxin-dependent peroxiredoxin activity
18,213.33 10.81 4 10
protein deglycase activity
15,177.77 10.26 4 12
positive regulation of mitochondrial electron transport, NADH to ubiquinone
11,383.33 7.50 3 12
methylglyoxal metabolic process
7,588.89 6.52 3 18
glycolate biosynthetic process
4,792.98 6.15 4 38
cellular response to glyoxal
18,213.33 5.88 2 5
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
15,177.77 5.71 2 6
glyoxalase (glycolic acid-forming) activity
13,009.52 5.56 2 7
positive regulation of NAD(P)H oxidase activity
13,009.52 5.56 2 7
Totals 256 11002

Change Log

Timestamp Action Category Detail
2022-05-26 Deleted XREF MetaCyc:1.11.1.15-RXN
2022-05-26 Deleted XREF EC:1.11.1.24
2022-05-26 Deleted RELATION is a GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor)
2022-05-26 Deleted SYNONYM AhpC activity
2022-05-26 Deleted SYNONYM alkyl hydroperoxide reductase C22 activity
2022-05-26 Added RELATION is a GO:0004601 (peroxidase activity)
2022-05-26 Deleted RELATION is a GO:0016209 (antioxidant activity)
2022-05-07 Deleted DEFINITION Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
2022-05-07 Deleted SYNONYM thiol-containing-reductant:hydroperoxide oxidoreductase activity
2022-05-07 Added DEFINITION Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
Timestamp Action Category Detail
2006-03-11 Added TERM peroxiredoxin activity
Timestamp Action Category Detail
2022-05-26 Deleted SYNONYM AhpC activity
2022-05-26 Deleted SYNONYM alkyl hydroperoxide reductase C22 activity
2022-05-07 Deleted DEFINITION Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
2022-05-07 Deleted SYNONYM thiol-containing-reductant:hydroperoxide oxidoreductase activity
2022-05-07 Added DEFINITION Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
2020-10-08 Added SYNONYM thiol-containing-reductant:hydroperoxide oxidoreductase activity
2020-10-08 Deleted SYNONYM thiol-containing-reductant:hydroperoxide oxidoreductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
2007-11-08 Added SYNONYM thiol-containing-reductant:hydroperoxide oxidoreductase activity
2007-08-09 Added SYNONYM AhpC activity
2007-08-09 Added SYNONYM PRDX activity
2007-08-09 Added SYNONYM Prx activity
2007-08-09 Added SYNONYM alkyl hydroperoxide reductase C22 activity
2007-08-09 Deleted SYNONYM alkyl hydroperoxide reductase C22 activity
2007-08-09 Deleted SYNONYM Prx activity
2007-08-09 Deleted SYNONYM PRDX activity
2007-08-09 Deleted SYNONYM AhpC activity
2007-05-12 Deleted SYNONYM TrxPx activity
2007-05-12 Deleted SYNONYM tryparedoxin peroxidase activity
2007-05-12 Deleted SYNONYM TXNPx activity
2007-05-12 Deleted SYNONYM thioredoxin peroxidase activity
2006-03-11 Added SYNONYM PRDX activity
2006-03-11 Added SYNONYM Prx activity
2006-03-11 Added SYNONYM TXNPx activity
2006-03-11 Added SYNONYM TrxPx activity
2006-03-11 Added SYNONYM alkyl hydroperoxide reductase C22 activity
2006-03-11 Added DEFINITION Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
2006-03-11 Added SYNONYM AhpC activity
2006-03-11 Added SYNONYM tryparedoxin peroxidase activity
2006-03-11 Added SYNONYM thioredoxin peroxidase activity
Timestamp Action Category Detail
2022-05-26 Deleted RELATION is a GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor)
2022-05-26 Added RELATION is a GO:0004601 (peroxidase activity)
2022-05-26 Deleted RELATION is a GO:0016209 (antioxidant activity)
2014-07-23 Added RELATION is a GO:0016209 (antioxidant activity)
2014-07-23 Added RELATION is a GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor)
2014-07-23 Deleted RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2010-02-04 Deleted RELATION is a GO:0004601 (peroxidase activity)
2010-02-04 Added RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2008-04-01 Updated RELATION is a GO:0004601 (peroxidase activity)
Timestamp Action Category Detail
2022-05-26 Deleted XREF MetaCyc:1.11.1.15-RXN
2022-05-26 Deleted XREF EC:1.11.1.24
2021-04-24 Added XREF EC:1.11.1.24
2021-04-24 Deleted XREF EC:1.11.1.15
2019-12-12 Added XREF RHEA:10008
2019-04-01 Deleted XREF reactome:R-HSA-1222431
2019-04-01 Deleted XREF reactome:R-HSA-1222755
2019-04-01 Added XREF Reactome:R-HSA-1222431
2019-04-01 Added XREF Reactome:R-HSA-1500804
2019-04-01 Deleted XREF reactome:R-HSA-1500804
2019-04-01 Added XREF Reactome:R-HSA-1222755
2018-12-11 Added XREF reactome:R-HSA-1222431
2018-12-11 Added XREF reactome:R-HSA-1222755
2018-12-11 Added XREF reactome:R-HSA-1500804
2009-05-21 Added XREF MetaCyc:1.11.1.15-RXN
2006-03-11 Added XREF EC:1.11.1.15
Timestamp Action Category Detail
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