This term is obsolete.

GO:0051932 JSON

synaptic transmission, GABAergic

Biological Process

Definition (GO:0051932 GONUTS page)

The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.

1,542 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
synaptic transmission, gamma-aminobutyric acid-ergic exact
synaptic transmission, gamma-aminobutyric acid mediated exact
synaptic transmission, GABA mediated exact
GABAergic synaptic transmission exact

Ancestor Chart

Ancestor chart for GO:0051932
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0051932

Child Term Relationship to
GO:0051932
positive regulation of synaptic transmission, GABAergic
positively_regulates
GABA-ergic synapse
capable_of
symmetric, GABA-ergic, inhibitory synapse
capable_of
negative regulation of synaptic transmission, GABAergic
negatively_regulates
gamma-aminobutyric acid secretion, neurotransmission
part_of
regulation of synaptic transmission, GABAergic
regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0051932 synaptic transmission, GABAergic Only in Taxon 33208 Metazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein D4A055 10116 CACB4_RAT GO:0051932 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P05067-PRO_0000000092 9606 A4_HUMAN GO:0007268 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18216187
NOT-qualified manual protein P54282 10116 CAC1A_RAT GO:0051932 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P97445 10090 CAC1A_MOUSE GO:0051932 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10322048
NOT-qualified manual protein Q8R0S4 10090 CACB4_MOUSE GO:0051932 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10322048
NOT-qualified manual protein Q9NFU0 7227 FMR1_DROME GO:0007268 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:12086643

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:59888 gamma-aminobutyric acid zwitterion
has_participant CL CL:0000617 GABAergic neuron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0051932 based on ALL annotations
The top 100 of 830 co-occurring terms
Co-occurring Term PR S% #Together #Compared
synaptic transmission, GABAergic
145,476.70 100.00 1,340 1,340
GABA-A receptor complex
46,769.83 16.93 353 1,098
inhibitory synapse assembly
33,622.16 16.81 511 2,211
GABA-gated chloride ion channel activity
41,615.59 15.84 351 1,227
neurotransmitter-gated ion channel clustering
143,635.22 11.62 156 158
positive regulation of protein localization to synapse
120,472.90 11.58 159 192
benzodiazepine receptor activity
84,777.81 11.57 169 290
gephyrin clustering involved in postsynaptic density assembly
66,164.33 10.22 156 343
cellular response to progesterone stimulus
115,694.07 7.39 101 127
post-embryonic forelimb morphogenesis
78,995.42 7.09 101 186
Totals 13527 295604
No co-occurrence statistics for GO:0051932 based on MANUAL annotations
The top 100 of 723 co-occurring terms
Co-occurring Term PR S% #Together #Compared
synaptic transmission, GABAergic
5,229.96 100.00 247 247
benzodiazepine receptor activity
4,441.52 61.01 169 199
GABA-gated chloride ion channel activity
4,116.17 58.02 170 216
inhibitory synapse assembly
3,851.35 56.77 176 239
regulation of postsynaptic membrane potential
4,093.01 55.48 162 207
GABA-A receptor complex
2,444.44 38.83 172 368
GABA-A receptor activity
2,213.15 36.46 179 423
gamma-aminobutyric acid signaling pathway
1,921.61 33.39 194 528
dendrite membrane
1,892.19 30.32 161 445
postsynapse
758.23 13.54 166 1,145
Totals 3321 33160

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
2022-11-22 Deleted DEFINITION The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2022-11-22 Added DEFINITION The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2020-02-10 Added SYNONYM GABAergic synaptic transmission
2017-07-07 Deleted DEFINITION The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
2017-07-07 Added DEFINITION The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2017-07-07 Added RELATION is a GO:0007268 (chemical synaptic transmission)
2017-07-07 Deleted RELATION is a GO:0007270 (neuron-neuron synaptic transmission)
2008-05-13 Added DEFINITION The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
2008-05-12 Deleted DEFINITION The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
Timestamp Action Category Detail
2006-03-12 Added TERM synaptic transmission, GABAergic
Timestamp Action Category Detail
2022-11-22 Deleted DEFINITION The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2022-11-22 Added DEFINITION The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2020-02-10 Added SYNONYM GABAergic synaptic transmission
2017-07-07 Deleted DEFINITION The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
2017-07-07 Added DEFINITION The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2008-05-13 Added DEFINITION The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
2008-05-12 Deleted DEFINITION The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
2007-08-09 Deleted SYNONYM synaptic transmission, gamma-aminobutyric acid mediated
2007-08-09 Deleted SYNONYM synaptic transmission, gamma-aminobutyric acid-ergic
2007-08-09 Added SYNONYM synaptic transmission, GABA mediated
2007-08-09 Added SYNONYM synaptic transmission, gamma-aminobutyric acid mediated
2007-08-09 Added SYNONYM synaptic transmission, gamma-aminobutyric acid-ergic
2007-08-09 Deleted SYNONYM synaptic transmission, GABA mediated
2006-03-12 Added DEFINITION The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
2006-03-12 Added SYNONYM synaptic transmission, gamma-aminobutyric acid-ergic
2006-03-12 Added SYNONYM synaptic transmission, GABA mediated
2006-03-12 Added SYNONYM synaptic transmission, gamma-aminobutyric acid mediated
Timestamp Action Category Detail
2017-07-07 Added RELATION is a GO:0007268 (chemical synaptic transmission)
2017-07-07 Deleted RELATION is a GO:0007270 (neuron-neuron synaptic transmission)
2008-04-01 Updated RELATION is a GO:0007270 (neuron-neuron synaptic transmission)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
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