GO:0051932
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synaptic transmission, GABAergic
Biological Process
Definition (GO:0051932 GONUTS page)
The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
synaptic transmission, gamma-aminobutyric acid-ergic | exact |
synaptic transmission, gamma-aminobutyric acid mediated | exact |
synaptic transmission, GABA mediated | exact |
GABAergic synaptic transmission | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0051932
Child Term | Relationship to GO:0051932 |
---|---|
positive regulation of synaptic transmission, GABAergic
|
positively_regulates |
GABA-ergic synapse
|
capable_of |
symmetric, GABA-ergic, inhibitory synapse
|
capable_of |
negative regulation of synaptic transmission, GABAergic
|
negatively_regulates |
gamma-aminobutyric acid secretion, neurotransmission
|
part_of |
regulation of synaptic transmission, GABAergic
|
regulates |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0051932 | synaptic transmission, GABAergic | Only in Taxon | 33208 | Metazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | D4A055 | 10116 | CACB4_RAT | GO:0051932 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P05067-PRO_0000000092 | 9606 | A4_HUMAN | GO:0007268 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18216187 | |
NOT-qualified manual | protein | P54282 | 10116 | CAC1A_RAT | GO:0051932 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P97445 | 10090 | CAC1A_MOUSE | GO:0051932 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10322048 | |
NOT-qualified manual | protein | Q8R0S4 | 10090 | CACB4_MOUSE | GO:0051932 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10322048 | |
NOT-qualified manual | protein | Q9NFU0 | 7227 | FMR1_DROME | GO:0007268 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:12086643 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:59888 | gamma-aminobutyric acid zwitterion |
has_participant | CL | CL:0000617 | GABAergic neuron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0051932 based on ALL annotations
The top 100 of 830 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
synaptic transmission, GABAergic
|
145,476.70 | 100.00 | 1,340 | 1,340 |
GABA-A receptor complex
|
46,769.83 | 16.93 | 353 | 1,098 |
inhibitory synapse assembly
|
33,622.16 | 16.81 | 511 | 2,211 |
GABA-gated chloride ion channel activity
|
41,615.59 | 15.84 | 351 | 1,227 |
neurotransmitter-gated ion channel clustering
|
143,635.22 | 11.62 | 156 | 158 |
positive regulation of protein localization to synapse
|
120,472.90 | 11.58 | 159 | 192 |
benzodiazepine receptor activity
|
84,777.81 | 11.57 | 169 | 290 |
gephyrin clustering involved in postsynaptic density assembly
|
66,164.33 | 10.22 | 156 | 343 |
cellular response to progesterone stimulus
|
115,694.07 | 7.39 | 101 | 127 |
post-embryonic forelimb morphogenesis
|
78,995.42 | 7.09 | 101 | 186 |
Totals | 13527 | 295604 |
No co-occurrence statistics for GO:0051932 based on MANUAL annotations
The top 100 of 723 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
synaptic transmission, GABAergic
|
5,229.96 | 100.00 | 247 | 247 |
benzodiazepine receptor activity
|
4,441.52 | 61.01 | 169 | 199 |
GABA-gated chloride ion channel activity
|
4,116.17 | 58.02 | 170 | 216 |
inhibitory synapse assembly
|
3,851.35 | 56.77 | 176 | 239 |
regulation of postsynaptic membrane potential
|
4,093.01 | 55.48 | 162 | 207 |
GABA-A receptor complex
|
2,444.44 | 38.83 | 172 | 368 |
GABA-A receptor activity
|
2,213.15 | 36.46 | 179 | 423 |
gamma-aminobutyric acid signaling pathway
|
1,921.61 | 33.39 | 194 | 528 |
dendrite membrane
|
1,892.19 | 30.32 | 161 | 445 |
postsynapse
|
758.23 | 13.54 | 166 | 1,145 |
Totals | 3321 | 33160 |
Change Log
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- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
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- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2022-11-22 | Deleted | DEFINITION | The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
2022-11-22 | Added | DEFINITION | The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
2020-02-10 | Added | SYNONYM | GABAergic synaptic transmission |
2017-07-07 | Deleted | DEFINITION | The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
2017-07-07 | Added | DEFINITION | The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
2017-07-07 | Added | RELATION | is a GO:0007268 (chemical synaptic transmission) |
2017-07-07 | Deleted | RELATION | is a GO:0007270 (neuron-neuron synaptic transmission) |
2008-05-13 | Added | DEFINITION | The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
2008-05-12 | Deleted | DEFINITION | The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-03-12 | Added | TERM | synaptic transmission, GABAergic |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-22 | Deleted | DEFINITION | The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
2022-11-22 | Added | DEFINITION | The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
2020-02-10 | Added | SYNONYM | GABAergic synaptic transmission |
2017-07-07 | Deleted | DEFINITION | The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
2017-07-07 | Added | DEFINITION | The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
2008-05-13 | Added | DEFINITION | The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
2008-05-12 | Deleted | DEFINITION | The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
2007-08-09 | Deleted | SYNONYM | synaptic transmission, gamma-aminobutyric acid mediated |
2007-08-09 | Deleted | SYNONYM | synaptic transmission, gamma-aminobutyric acid-ergic |
2007-08-09 | Added | SYNONYM | synaptic transmission, GABA mediated |
2007-08-09 | Added | SYNONYM | synaptic transmission, gamma-aminobutyric acid mediated |
2007-08-09 | Added | SYNONYM | synaptic transmission, gamma-aminobutyric acid-ergic |
2007-08-09 | Deleted | SYNONYM | synaptic transmission, GABA mediated |
2006-03-12 | Added | DEFINITION | The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
2006-03-12 | Added | SYNONYM | synaptic transmission, gamma-aminobutyric acid-ergic |
2006-03-12 | Added | SYNONYM | synaptic transmission, GABA mediated |
2006-03-12 | Added | SYNONYM | synaptic transmission, gamma-aminobutyric acid mediated |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-07-07 | Added | RELATION | is a GO:0007268 (chemical synaptic transmission) |
2017-07-07 | Deleted | RELATION | is a GO:0007270 (neuron-neuron synaptic transmission) |
2008-04-01 | Updated | RELATION | is a GO:0007270 (neuron-neuron synaptic transmission) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
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