GO:0052656
JSON
L-isoleucine-2-oxoglutarate transaminase activity
Molecular Function
Definition (GO:0052656 GONUTS page)
Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
L-isoleucine aminotransferase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
KEGG_REACTION | R02199 | |
MetaCyc | BRANCHED-CHAINAMINOTRANSFERILEU-RXN | |
RHEA | 24801 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:35146 | (S)-3-methyl-2-oxovalerate |
has_participant | CHEBI | CHEBI:16810 | 2-oxoglutarate(2-) |
has_participant | CHEBI | CHEBI:58045 | L-isoleucine zwitterion |
has_participant | CHEBI | CHEBI:29985 | L-glutamate(1-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0052656 based on ALL annotations
The top 100 of 128 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-valine-2-oxoglutarate transaminase activity
|
7,311.76 | 100.00 | 26,661 | 26,661 |
L-isoleucine-2-oxoglutarate transaminase activity
|
7,311.76 | 100.00 | 26,661 | 26,661 |
branched-chain amino acid metabolic process
|
3,413.53 | 46.09 | 25,945 | 55,574 |
branched-chain-amino-acid transaminase activity
|
3,356.70 | 45.47 | 26,114 | 56,883 |
carboxylic acid biosynthetic process
|
1,403.61 | 15.96 | 12,970 | 67,564 |
branched-chain amino acid biosynthetic process
|
810.15 | 11.04 | 25,883 | 233,599 |
aspartate biosynthetic process
|
2,173.45 | 10.43 | 3,691 | 12,417 |
L-leucine biosynthetic process
|
760.67 | 10.32 | 24,720 | 237,614 |
L-valine biosynthetic process
|
637.23 | 8.66 | 24,720 | 283,644 |
isoleucine biosynthetic process
|
392.34 | 5.31 | 22,444 | 418,276 |
Totals | 295698 | 49416388 |
No co-occurrence statistics for GO:0052656 based on MANUAL annotations
The top 33 of 33 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-valine-2-oxoglutarate transaminase activity
|
143,533.22 | 100.00 | 9 | 9 |
L-isoleucine-2-oxoglutarate transaminase activity
|
143,533.22 | 100.00 | 9 | 9 |
L-leucine-2-oxoglutarate transaminase activity
|
129,179.90 | 90.00 | 9 | 10 |
branched-chain amino acid metabolic process
|
28,706.65 | 11.76 | 2 | 10 |
valine metabolic process
|
23,922.21 | 10.53 | 2 | 12 |
L-leucine metabolic process
|
23,922.21 | 10.53 | 2 | 12 |
isoleucine metabolic process
|
71,766.61 | 10.00 | 1 | 2 |
glucosinolate biosynthetic process from homomethionine
|
47,844.41 | 9.09 | 1 | 3 |
methionine-oxo-acid transaminase activity
|
35,883.31 | 8.33 | 1 | 4 |
isoleucine catabolic process
|
14,353.32 | 7.41 | 2 | 20 |
Totals | 93 | 648584 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-03 | Deleted | XREF | EC:2.6.1.42 |
2024-09-03 | Updated | TERM | L-isoleucine-2-oxoglutarate transaminase activity |
2020-06-22 | Added | XREF | RHEA:24801 |
2019-06-20 | Deleted | XREF | KEGG:R02199 |
2019-06-20 | Added | XREF | KEGG_REACTION:R02199 |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2011-09-16 | Deleted | DEFINITION | Catalysis of the reaction: 2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. |
2011-09-16 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-03 | Updated | TERM | L-isoleucine-2-oxoglutarate transaminase activity |
2010-10-08 | Added | TERM | L-isoleucine transaminase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-09-16 | Deleted | DEFINITION | Catalysis of the reaction: 2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. |
2011-09-16 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. |
2010-10-08 | Added | DEFINITION | Catalysis of the reaction: 2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. |
2010-10-08 | Added | SYNONYM | L-isoleucine aminotransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-08 | Added | RELATION | is a GO:0004084 (branched-chain-amino-acid transaminase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-03 | Deleted | XREF | EC:2.6.1.42 |
2020-06-22 | Added | XREF | RHEA:24801 |
2019-06-20 | Deleted | XREF | KEGG:R02199 |
2019-06-20 | Added | XREF | KEGG_REACTION:R02199 |
2010-10-08 | Added | XREF | EC:2.6.1.42 |
2010-10-08 | Added | XREF | KEGG:R02199 |
2010-10-08 | Added | XREF | MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
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