This term is obsolete.

GO:0052656 JSON

L-isoleucine-2-oxoglutarate transaminase activity

Molecular Function

Definition (GO:0052656 GONUTS page)

Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.

27,846 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
L-isoleucine aminotransferase activity exact

Ancestor Chart

Ancestor chart for GO:0052656
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Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
KEGG_REACTION R02199
MetaCyc BRANCHED-CHAINAMINOTRANSFERILEU-RXN
RHEA 24801

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29985 L-glutamate(1-)
has_participant CHEBI CHEBI:35146 (S)-3-methyl-2-oxovalerate
has_participant CHEBI CHEBI:58045 L-isoleucine zwitterion
has_participant CHEBI CHEBI:16810 2-oxoglutarate(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0052656 based on ALL annotations
The top 100 of 133 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0052655
L-valine-2-oxoglutarate transaminase activity
7,118.40 100.00 27,837 27,837
GO:0052656
L-isoleucine-2-oxoglutarate transaminase activity
7,118.40 100.00 27,837 27,837
GO:0052654
L-leucine-2-oxoglutarate transaminase activity
7,118.14 100.00 27,837 27,838
GO:0009081
branched-chain amino acid metabolic process
3,223.50 43.54 25,571 56,468
GO:0004084
branched-chain-amino-acid transaminase activity
3,163.54 42.84 25,678 57,779
GO:0046394
carboxylic acid biosynthetic process
1,513.79 17.93 14,844 69,802
GO:0009082
branched-chain amino acid biosynthetic process
798.75 11.18 26,890 239,643
GO:0009098
L-leucine biosynthetic process
720.69 9.98 24,362 240,627
GO:0006532
aspartate biosynthetic process
2,071.54 9.97 3,665 12,594
GO:0009099
L-valine biosynthetic process
602.35 8.36 24,362 287,905
Totals 331112 47700640
No co-occurrence statistics for GO:0052656 based on MANUAL annotations
The top 33 of 33 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0052655
L-valine-2-oxoglutarate transaminase activity
156,837.00 100.00 9 9
GO:0052656
L-isoleucine-2-oxoglutarate transaminase activity
156,837.00 100.00 9 9
GO:0052654
L-leucine-2-oxoglutarate transaminase activity
141,153.30 90.00 9 10
GO:0009081
branched-chain amino acid metabolic process
31,367.40 11.76 2 10
GO:0006573
valine metabolic process
26,139.50 10.53 2 12
GO:0006551
L-leucine metabolic process
26,139.50 10.53 2 12
GO:0006549
isoleucine metabolic process
78,418.50 10.00 1 2
GO:0033506
glucosinolate biosynthetic process from homomethionine
52,279.00 9.09 1 3
GO:0010326
methionine-oxo-acid transaminase activity
39,209.25 8.33 1 4
GO:0006550
isoleucine catabolic process
15,683.70 7.41 2 20
Totals 93 693445

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2024-09-03 Deleted XREF EC:2.6.1.42
2024-09-03 Updated TERM L-isoleucine-2-oxoglutarate transaminase activity
2020-06-22 Added XREF RHEA:24801
2019-06-20 Added XREF KEGG_REACTION:R02199
2019-06-20 Deleted XREF KEGG:R02199
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2011-09-16 Deleted DEFINITION Catalysis of the reaction: 2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
2011-09-16 Added DEFINITION Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
Timestamp Action Category Detail
2024-09-03 Updated TERM L-isoleucine-2-oxoglutarate transaminase activity
2010-10-08 Added TERM L-isoleucine transaminase activity
Timestamp Action Category Detail
2011-09-16 Deleted DEFINITION Catalysis of the reaction: 2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
2011-09-16 Added DEFINITION Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
2010-10-08 Added DEFINITION Catalysis of the reaction: 2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
2010-10-08 Added SYNONYM L-isoleucine aminotransferase activity
Timestamp Action Category Detail
2010-10-08 Added RELATION is a GO:0004084 (branched-chain-amino-acid transaminase activity)
Timestamp Action Category Detail
2024-09-03 Deleted XREF EC:2.6.1.42
2020-06-22 Added XREF RHEA:24801
2019-06-20 Added XREF KEGG_REACTION:R02199
2019-06-20 Deleted XREF KEGG:R02199
2010-10-08 Added XREF EC:2.6.1.42
2010-10-08 Added XREF KEGG:R02199
2010-10-08 Added XREF MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN
Timestamp Action Category Detail
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
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