GO:0052734
JSON
shikimate 3-dehydrogenase (NAD+) activity
Molecular Function
Definition (GO:0052734 GONUTS page)
Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
3-dehydroshikimic reductase activity | related |
shikimate:NAD(P)(+) oxidoreductase activity | broad |
shikimate oxidoreductase activity | broad |
shikimate:NAD(P)(+) 3-oxidoreductase activity | related |
dehydroshikimic reductase activity | broad |
3-dehydroshikimate reductase activity | related |
DHS reductase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4KZV0 | 6945 | A0A1S4KZV0_IXOSC | GO:0016616 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.1.282 | |
InterPro | IPR022872 | Quinate/Shikimate dehydrogenase |
KEGG_REACTION | R06847 | |
RHEA | 17741 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:36208 | shikimate |
has_participant | CHEBI | CHEBI:16630 | 3-dehydroshikimate |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0033706 | obsolete quinate/shikimate dehydrogenase activity | consider GO:0052734 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0052734 based on ALL annotations
The top 16 of 16 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
shikimate 3-dehydrogenase (NAD+) activity
|
303,170.72 | 100.00 | 643 | 643 |
quinate 3-dehydrogenase (NADP+) activity
|
303,170.75 | 99.53 | 640 | 640 |
quinate 3-dehydrogenase (NAD+) activity
|
296,259.56 | 97.72 | 643 | 658 |
shikimate metabolic process
|
3,159.61 | 1.04 | 625 | 59,970 |
shikimate 3-dehydrogenase (NADP+) activity
|
3,071.50 | 1.01 | 643 | 63,467 |
chorismate biosynthetic process
|
631.14 | 0.21 | 625 | 300,220 |
aromatic amino acid family biosynthetic process
|
477.17 | 0.16 | 588 | 373,587 |
amino acid biosynthetic process
|
228.99 | 0.08 | 588 | 778,477 |
NADP binding
|
30.76 | 0.01 | 88 | 867,427 |
oxidoreductase activity
|
16.37 | 0.01 | 643 | 11,906,003 |
Totals | 5825 | 104995854 |
No co-occurrence statistics for GO:0052734 based on MANUAL annotations
The top 7 of 7 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
shikimate 3-dehydrogenase (NAD+) activity
|
1,291,799.00 | 100.00 | 1 | 1 |
quinate 3-dehydrogenase (NAD+) activity
|
258,359.80 | 20.00 | 1 | 5 |
shikimate 3-dehydrogenase (NADP+) activity
|
6,728.12 | 0.52 | 1 | 192 |
shikimate metabolic process
|
6,557.36 | 0.51 | 1 | 197 |
chorismate biosynthetic process
|
2,896.41 | 0.22 | 1 | 446 |
protein homodimerization activity
|
242.87 | 0.02 | 1 | 5,319 |
protein binding
|
30.89 | 0.00 | 1 | 41,817 |
Totals | 7 | 47977 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | 3-dehydroshikimate reductase activity |
2020-10-08 | Added | SYNONYM | shikimate:NAD(P)(+) 3-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 3-dehydroshikimic reductase activity |
2020-10-08 | Deleted | SYNONYM | 3-dehydroshikimate reductase activity |
2020-10-08 | Deleted | SYNONYM | shikimate:NAD(P)(+) 3-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 3-dehydroshikimic reductase activity |
2019-06-20 | Added | XREF | KEGG_REACTION:R06847 |
2019-06-20 | Deleted | XREF | KEGG:R06847 |
2018-07-13 | Added | XREF | RHEA:17741 |
2018-07-13 | Deleted | XREF | RHEA:17744 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-08-19 | Added | TERM | shikimate 3-dehydrogenase (NAD+) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | 3-dehydroshikimate reductase activity |
2020-10-08 | Added | SYNONYM | shikimate:NAD(P)(+) 3-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 3-dehydroshikimic reductase activity |
2020-10-08 | Deleted | SYNONYM | 3-dehydroshikimate reductase activity |
2020-10-08 | Deleted | SYNONYM | shikimate:NAD(P)(+) 3-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 3-dehydroshikimic reductase activity |
2011-08-19 | Added | SYNONYM | shikimate:NAD(P)(+) oxidoreductase activity |
2011-08-19 | Added | SYNONYM | shikimate oxidoreductase activity |
2011-08-19 | Added | SYNONYM | 3-dehydroshikimic reductase activity |
2011-08-19 | Added | SYNONYM | DHS reductase activity |
2011-08-19 | Added | DEFINITION | Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+. |
2011-08-19 | Added | SYNONYM | 3-dehydroshikimate reductase activity |
2011-08-19 | Added | SYNONYM | shikimate:NAD(P)(+) 3-oxidoreductase activity |
2011-08-19 | Added | SYNONYM | dehydroshikimic reductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-08-19 | Added | RELATION | is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R06847 |
2019-06-20 | Deleted | XREF | KEGG:R06847 |
2018-07-13 | Added | XREF | RHEA:17741 |
2018-07-13 | Deleted | XREF | RHEA:17744 |
2011-08-19 | Added | XREF | RHEA:17744 |
2011-08-19 | Added | XREF | EC:1.1.1.282 |
2011-08-19 | Added | XREF | KEGG:R06847 |
Timestamp | Action | Category | Detail |
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