GO:0052925
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dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
Molecular Function
Definition (GO:0052925 GONUTS page)
Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity | related |
man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016757 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A6KJI3 | 10116 | A6KJI3_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D6WQD5 | 7070 | D6WQD5_TRICA | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q6AYL7 | 10116 | Q6AYL7_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7JRM5 | 7227 | Q7JRM5_DROME | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.4.1.258 | |
KEGG_REACTION | R06258 | |
MetaCyc | RXN-5466 | |
RHEA | 29527 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:132516 | alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc(PP-Dol)(2-) |
has_participant | CHEBI | CHEBI:57683 | dolichyl phosphate(2-) |
has_participant | CHEBI | CHEBI:58211 | dolichyl beta-D-mannosyl phosphate(1-) |
has_participant | CHEBI | CHEBI:132515 | alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc(PP-Dol)(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0004584 | obsolete dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity | consider GO:0052925 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0052925 based on ALL annotations
The top 100 of 137 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
|
46,008.68 | 100.00 | 4,237 | 4,237 |
mannosyltransferase activity
|
2,079.03 | 4.52 | 4,236 | 93,742 |
protein glycosylation
|
609.22 | 1.32 | 4,235 | 319,828 |
dolichol-linked oligosaccharide biosynthetic process
|
304.00 | 0.60 | 282 | 42,679 |
endoplasmic reticulum membrane
|
153.50 | 0.33 | 4,200 | 1,258,864 |
alpha-1,3-mannosyltransferase activity
|
232.27 | 0.32 | 38 | 7,527 |
endoplasmic reticulum
|
114.31 | 0.25 | 4,214 | 1,696,157 |
negative regulation of tumor necrosis factor-mediated signaling pathway
|
297.27 | 0.21 | 13 | 2,012 |
D-amino-acid oxidase activity
|
93.04 | 0.16 | 31 | 15,329 |
protein N-linked glycosylation
|
56.56 | 0.12 | 247 | 200,936 |
Totals | 28988 | 91843306 |
No co-occurrence statistics for GO:0052925 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
|
13,597.88 | 100.00 | 95 | 95 |
protein glycosylation
|
927.58 | 6.82 | 94 | 1,378 |
dolichol-linked oligosaccharide biosynthetic process
|
135.38 | 0.91 | 9 | 904 |
alpha-1,3-mannosyltransferase activity
|
181.31 | 0.82 | 2 | 150 |
negative regulation of tumor necrosis factor-mediated signaling pathway
|
110.55 | 0.46 | 1 | 123 |
endoplasmic reticulum
|
51.06 | 0.38 | 94 | 25,031 |
lumenal side of endoplasmic reticulum membrane
|
49.81 | 0.31 | 2 | 546 |
protein N-linked glycosylation
|
42.18 | 0.30 | 8 | 2,579 |
protein N-linked glycosylation via asparagine
|
18.43 | 0.12 | 1 | 738 |
endoplasmic reticulum membrane
|
6.48 | 0.05 | 8 | 16,799 |
Totals | 323 | 338097 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
2020-10-08 | Deleted | SYNONYM | man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity |
2020-10-08 | Added | SYNONYM | man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity |
2020-10-08 | Added | SYNONYM | dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity |
2019-06-20 | Deleted | XREF | KEGG:R06258 |
2019-06-20 | Added | XREF | KEGG_REACTION:R06258 |
2018-07-13 | Deleted | XREF | RHEA:29530 |
2018-07-13 | Added | XREF | RHEA:29527 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-03-01 | Added | TERM | dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
2020-10-08 | Deleted | SYNONYM | man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity |
2020-10-08 | Added | SYNONYM | man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity |
2020-10-08 | Added | SYNONYM | dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity |
2012-03-01 | Added | SYNONYM | dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity |
2012-03-01 | Added | DEFINITION | Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
2012-03-01 | Added | SYNONYM | man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-03-01 | Added | RELATION | is a GO:0000033 (alpha-1,3-mannosyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R06258 |
2019-06-20 | Added | XREF | KEGG_REACTION:R06258 |
2018-07-13 | Deleted | XREF | RHEA:29530 |
2018-07-13 | Added | XREF | RHEA:29527 |
2012-03-01 | Added | XREF | EC:2.4.1.258 |
2012-03-01 | Added | XREF | KEGG:R06258 |
2012-03-01 | Added | XREF | MetaCyc:RXN-5466 |
2012-03-01 | Added | XREF | RHEA:29530 |
Timestamp | Action | Category | Detail |
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