This term is obsolete.

GO:0052925 JSON

dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity

Molecular Function

Definition (GO:0052925 GONUTS page)

Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

4,279 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity related
man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity related

Ancestor Chart

Ancestor chart for GO:0052925
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016757 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A6KJI3 10116 A6KJI3_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D6WQD5 7070 D6WQD5_TRICA GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q6AYL7 10116 Q6AYL7_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7JRM5 7227 Q7JRM5_DROME GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 2.4.1.258
KEGG_REACTION R06258
MetaCyc RXN-5466
RHEA 29527

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:132516 alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc(PP-Dol)(2-)
has_participant CHEBI CHEBI:57683 dolichyl phosphate(2-)
has_participant CHEBI CHEBI:58211 dolichyl beta-D-mannosyl phosphate(1-)
has_participant CHEBI CHEBI:132515 alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc(PP-Dol)(2-)
has_participant CHEBI CHEBI:15378 hydron

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0004584 obsolete dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity consider GO:0052925

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0052925 based on ALL annotations
The top 100 of 137 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
46,008.68 100.00 4,237 4,237
mannosyltransferase activity
2,079.03 4.52 4,236 93,742
protein glycosylation
609.22 1.32 4,235 319,828
dolichol-linked oligosaccharide biosynthetic process
304.00 0.60 282 42,679
endoplasmic reticulum membrane
153.50 0.33 4,200 1,258,864
alpha-1,3-mannosyltransferase activity
232.27 0.32 38 7,527
endoplasmic reticulum
114.31 0.25 4,214 1,696,157
negative regulation of tumor necrosis factor-mediated signaling pathway
297.27 0.21 13 2,012
D-amino-acid oxidase activity
93.04 0.16 31 15,329
protein N-linked glycosylation
56.56 0.12 247 200,936
Totals 28988 91843306
No co-occurrence statistics for GO:0052925 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
13,597.88 100.00 95 95
protein glycosylation
927.58 6.82 94 1,378
dolichol-linked oligosaccharide biosynthetic process
135.38 0.91 9 904
alpha-1,3-mannosyltransferase activity
181.31 0.82 2 150
negative regulation of tumor necrosis factor-mediated signaling pathway
110.55 0.46 1 123
endoplasmic reticulum
51.06 0.38 94 25,031
lumenal side of endoplasmic reticulum membrane
49.81 0.31 2 546
protein N-linked glycosylation
42.18 0.30 8 2,579
protein N-linked glycosylation via asparagine
18.43 0.12 1 738
endoplasmic reticulum membrane
6.48 0.05 8 16,799
Totals 323 338097

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
2022-09-01 Added DEFINITION Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
2020-10-08 Deleted SYNONYM man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity
2020-10-08 Added SYNONYM man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity
2020-10-08 Added SYNONYM dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity
2020-10-08 Deleted SYNONYM dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity
2019-06-20 Deleted XREF KEGG:R06258
2019-06-20 Added XREF KEGG_REACTION:R06258
2018-07-13 Deleted XREF RHEA:29530
2018-07-13 Added XREF RHEA:29527
Timestamp Action Category Detail
2012-03-01 Added TERM dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
2022-09-01 Added DEFINITION Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
2020-10-08 Deleted SYNONYM man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity
2020-10-08 Added SYNONYM man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity
2020-10-08 Added SYNONYM dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity
2020-10-08 Deleted SYNONYM dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity
2012-03-01 Added SYNONYM dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity
2012-03-01 Added DEFINITION Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
2012-03-01 Added SYNONYM man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity
Timestamp Action Category Detail
2012-03-01 Added RELATION is a GO:0000033 (alpha-1,3-mannosyltransferase activity)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R06258
2019-06-20 Added XREF KEGG_REACTION:R06258
2018-07-13 Deleted XREF RHEA:29530
2018-07-13 Added XREF RHEA:29527
2012-03-01 Added XREF EC:2.4.1.258
2012-03-01 Added XREF KEGG:R06258
2012-03-01 Added XREF MetaCyc:RXN-5466
2012-03-01 Added XREF RHEA:29530
Timestamp Action Category Detail
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