This term is obsolete.

GO:0060008 JSON

Sertoli cell differentiation

Biological Process

Definition (GO:0060008 GONUTS page)

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.

1,480 annotations

Ancestor Chart

Ancestor chart for GO:0060008
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0060008

Child Term Relationship to
GO:0060008
Sertoli cell fate commitment
part_of
Sertoli cell development
part_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0060008 Sertoli cell differentiation Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-Ontology Relations

Relation Other Ontology ID Term
results_in_acquisition_of_features_of CL CL:0000216 Sertoli cell

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0060008 based on ALL annotations
The top 100 of 551 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Sertoli cell differentiation
327,078.50 100.00 596 596
positive regulation of male gonad development
152,934.31 30.18 274 586
renal vesicle induction
215,922.92 24.74 169 256
male sex determination
76,578.79 19.97 343 1,465
Sertoli cell development
92,446.98 16.60 171 605
negative regulation of immune system process
320,192.62 15.55 93 95
enzyme activator complex
277,708.16 14.71 90 106
cell proliferation involved in heart morphogenesis
327,078.53 14.60 87 87
regulation of branching involved in lung morphogenesis
327,078.53 14.60 87 87
regulation of epithelial cell proliferation involved in lung morphogenesis
327,078.53 14.60 87 87
Totals 10159 41929
No co-occurrence statistics for GO:0060008 based on MANUAL annotations
The top 100 of 506 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Sertoli cell differentiation
26,912.48 100.00 48 48
renal vesicle induction
19,735.82 21.15 11 15
heart valve morphogenesis
10,092.18 20.55 15 40
epithelial cell proliferation involved in prostatic bud elongation
26,912.48 18.75 9 9
regulation of cell proliferation involved in tissue homeostasis
22,019.30 18.00 9 11
negative regulation of immune system process
22,019.30 18.00 9 11
positive regulation of male gonad development
7,849.47 17.07 14 48
morphogenesis of a branching epithelium
15,138.27 16.36 9 16
positive regulation of mesenchymal stem cell differentiation
15,138.27 16.36 9 16
positive regulation of kidney development
14,247.78 16.07 9 17
Totals 736 5242

Change Log

Timestamp Action Category Detail
2024-03-22 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2024-03-22 Deleted CONSTRAINT in_taxon NCBITaxon:33213 (Bilateria)
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:33213 (Bilateria)
2017-08-13 Deleted RELATION is a GO:0044702 (single organism reproductive process)
2016-08-06 Deleted RELATION is a GO:0044767 (single-organism developmental process)
2016-06-22 Added RELATION is a GO:0044767 (single-organism developmental process)
2014-07-30 Deleted RELATION is a GO:0048610 (obsolete cellular process involved in reproduction)
2013-11-28 Added RELATION is a GO:0044702 (single organism reproductive process)
2013-05-09 Deleted RELATION is a GO:0030154 (cell differentiation)
2013-05-09 Added RELATION is a GO:0030855 (epithelial cell differentiation)
Timestamp Action Category Detail
2006-11-10 Added TERM Sertoli cell differentiation
Timestamp Action Category Detail
2010-12-17 Added DEFINITION The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
2006-11-14 Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
Timestamp Action Category Detail
2017-08-13 Deleted RELATION is a GO:0044702 (single organism reproductive process)
2016-08-06 Deleted RELATION is a GO:0044767 (single-organism developmental process)
2016-06-22 Added RELATION is a GO:0044767 (single-organism developmental process)
2014-07-30 Deleted RELATION is a GO:0048610 (obsolete cellular process involved in reproduction)
2013-11-28 Added RELATION is a GO:0044702 (single organism reproductive process)
2013-05-09 Deleted RELATION is a GO:0030154 (cell differentiation)
2013-05-09 Added RELATION is a GO:0030855 (epithelial cell differentiation)
2010-03-19 Added RELATION is a GO:0003006 (developmental process involved in reproduction)
2010-03-19 Added RELATION is a GO:0048610 (obsolete cellular process involved in reproduction)
2008-04-01 Updated RELATION is a GO:0030154 (cell differentiation)
2008-04-01 Updated RELATION part of GO:0008584 (male gonad development)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-22 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2024-03-22 Deleted CONSTRAINT in_taxon NCBITaxon:33213 (Bilateria)
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:33213 (Bilateria)
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