GO:0060392
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negative regulation of SMAD protein signal transduction
Biological Process
Definition (GO:0060392 GONUTS page)
Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway.
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
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negative regulation of SMAD protein import into nucleus | narrow |
negative regulation of SMAD protein nuclear translocation | narrow |
Ancestor Chart
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
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GO:0010991 | obsolete negative regulation of SMAD protein complex assembly | consider GO:0060392 |
GO:0060394 | obsolete negative regulation of pathway-restricted SMAD protein phosphorylation | consider GO:0060392 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0060392 based on ALL annotations
The top 100 of 976 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of SMAD protein signal transduction
|
102,169.17 | 100.00 | 1,908 | 1,908 |
negative regulation of transforming growth factor beta receptor signaling pathway
|
10,631.39 | 9.81 | 1,203 | 11,561 |
response to laminar fluid shear stress
|
61,097.84 | 8.87 | 180 | 301 |
negative regulation of chondrocyte proliferation
|
49,955.65 | 8.46 | 177 | 362 |
ureteric bud formation
|
38,738.20 | 7.82 | 171 | 451 |
negative regulation of osteoblast differentiation
|
10,779.09 | 7.81 | 441 | 4,180 |
endocardial cushion formation
|
21,877.03 | 7.32 | 191 | 892 |
aortic valve morphogenesis
|
13,352.22 | 7.29 | 270 | 2,066 |
regulation of epithelial to mesenchymal transition
|
19,367.53 | 6.67 | 178 | 939 |
type I transforming growth factor beta receptor binding
|
18,538.76 | 6.62 | 180 | 992 |
Totals | 14405 | 89471 |
No co-occurrence statistics for GO:0060392 based on MANUAL annotations
The top 100 of 903 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of SMAD protein signal transduction
|
11,431.85 | 100.00 | 113 | 113 |
negative regulation of transforming growth factor beta receptor signaling pathway
|
1,749.53 | 14.12 | 73 | 477 |
R-SMAD binding
|
1,289.31 | 6.49 | 15 | 133 |
negative regulation of epithelial to mesenchymal transition
|
1,118.33 | 6.45 | 18 | 184 |
aortic valve morphogenesis
|
1,311.85 | 6.33 | 14 | 122 |
negative regulation of osteoblast differentiation
|
924.28 | 5.78 | 19 | 235 |
negative regulation of activin receptor signaling pathway
|
1,245.05 | 5.42 | 11 | 101 |
tricuspid valve development
|
9,798.73 | 5.26 | 6 | 7 |
EMILIN complex
|
8,573.89 | 5.22 | 6 | 8 |
embryonic heart tube elongation
|
8,573.89 | 5.22 | 6 | 8 |
Totals | 812 | 7588 |
Change Log
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Timestamp | Action | Category | Detail |
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2023-06-13 | Deleted | DEFINITION | Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2023-06-13 | Added | DEFINITION | Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. |
2022-07-30 | Added | RELATION | is a GO:1902532 (negative regulation of intracellular signal transduction) |
2018-03-05 | Added | SYNONYM | negative regulation of SMAD protein import into nucleus |
2018-03-05 | Added | DEFINITION | Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2018-03-05 | Deleted | DEFINITION | Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2018-03-05 | Updated | TERM | negative regulation of SMAD protein signal transduction |
2018-03-05 | Added | RELATION | negatively regulates GO:0060395 (SMAD protein signal transduction) |
2018-03-05 | Deleted | RELATION | negatively regulates GO:0007184 (SMAD protein import into nucleus) |
2018-03-05 | Deleted | RELATION | is a GO:0042308 (negative regulation of protein import into nucleus) |
Timestamp | Action | Category | Detail |
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2018-03-05 | Updated | TERM | negative regulation of SMAD protein signal transduction |
2010-12-24 | Updated | TERM | negative regulation of SMAD protein import into nucleus |
2009-01-12 | Added | TERM | negative regulation of SMAD protein nuclear translocation |
Timestamp | Action | Category | Detail |
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2023-06-13 | Deleted | DEFINITION | Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2023-06-13 | Added | DEFINITION | Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. |
2018-03-05 | Added | SYNONYM | negative regulation of SMAD protein import into nucleus |
2018-03-05 | Added | DEFINITION | Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2018-03-05 | Deleted | DEFINITION | Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2011-01-02 | Added | DEFINITION | Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2011-01-02 | Deleted | DEFINITION | Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movoment of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2010-12-24 | Added | SYNONYM | negative regulation of SMAD protein nuclear translocation |
2010-12-24 | Added | DEFINITION | Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movoment of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2010-12-24 | Deleted | DEFINITION | Any process that decreases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
2009-01-12 | Added | DEFINITION | Any process that decreases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
Timestamp | Action | Category | Detail |
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2022-07-30 | Added | RELATION | is a GO:1902532 (negative regulation of intracellular signal transduction) |
2018-03-05 | Added | RELATION | negatively regulates GO:0060395 (SMAD protein signal transduction) |
2018-03-05 | Deleted | RELATION | negatively regulates GO:0007184 (SMAD protein import into nucleus) |
2018-03-05 | Deleted | RELATION | is a GO:0042308 (negative regulation of protein import into nucleus) |
2010-12-24 | Added | RELATION | is a GO:0042308 (negative regulation of protein import into nucleus) |
2010-12-24 | Deleted | RELATION | is a GO:0033159 (obsolete negative regulation of protein import into nucleus, translocation) |
2009-11-15 | Added | RELATION | is a GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway) |
2009-01-12 | Added | RELATION | is a GO:0060390 (regulation of SMAD protein signal transduction) |
2009-01-12 | Added | RELATION | is a GO:0033159 (obsolete negative regulation of protein import into nucleus, translocation) |
2009-01-12 | Added | RELATION | negatively regulates GO:0007184 (SMAD protein import into nucleus) |
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