This term is obsolete.

GO:0060392 JSON

negative regulation of SMAD protein signal transduction

Biological Process

Definition (GO:0060392 GONUTS page)

Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway.

Acknowledgement

This term was created by the GO Consortium with support from: BHF image

1,959 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
negative regulation of SMAD protein import into nucleus narrow
negative regulation of SMAD protein nuclear translocation narrow

Ancestor Chart

Ancestor chart for GO:0060392
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Ancestor chart

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0010991 obsolete negative regulation of SMAD protein complex assembly consider GO:0060392
GO:0060394 obsolete negative regulation of pathway-restricted SMAD protein phosphorylation consider GO:0060392

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0060392 based on ALL annotations
The top 100 of 976 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of SMAD protein signal transduction
102,169.17 100.00 1,908 1,908
negative regulation of transforming growth factor beta receptor signaling pathway
10,631.39 9.81 1,203 11,561
response to laminar fluid shear stress
61,097.84 8.87 180 301
negative regulation of chondrocyte proliferation
49,955.65 8.46 177 362
ureteric bud formation
38,738.20 7.82 171 451
negative regulation of osteoblast differentiation
10,779.09 7.81 441 4,180
endocardial cushion formation
21,877.03 7.32 191 892
aortic valve morphogenesis
13,352.22 7.29 270 2,066
regulation of epithelial to mesenchymal transition
19,367.53 6.67 178 939
type I transforming growth factor beta receptor binding
18,538.76 6.62 180 992
Totals 14405 89471
No co-occurrence statistics for GO:0060392 based on MANUAL annotations
The top 100 of 903 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of SMAD protein signal transduction
11,431.85 100.00 113 113
negative regulation of transforming growth factor beta receptor signaling pathway
1,749.53 14.12 73 477
R-SMAD binding
1,289.31 6.49 15 133
negative regulation of epithelial to mesenchymal transition
1,118.33 6.45 18 184
aortic valve morphogenesis
1,311.85 6.33 14 122
negative regulation of osteoblast differentiation
924.28 5.78 19 235
negative regulation of activin receptor signaling pathway
1,245.05 5.42 11 101
tricuspid valve development
9,798.73 5.26 6 7
EMILIN complex
8,573.89 5.22 6 8
embryonic heart tube elongation
8,573.89 5.22 6 8
Totals 812 7588

Change Log

Timestamp Action Category Detail
2023-06-13 Deleted DEFINITION Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2023-06-13 Added DEFINITION Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway.
2022-07-30 Added RELATION is a GO:1902532 (negative regulation of intracellular signal transduction)
2018-03-05 Added SYNONYM negative regulation of SMAD protein import into nucleus
2018-03-05 Added DEFINITION Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2018-03-05 Deleted DEFINITION Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2018-03-05 Updated TERM negative regulation of SMAD protein signal transduction
2018-03-05 Added RELATION negatively regulates GO:0060395 (SMAD protein signal transduction)
2018-03-05 Deleted RELATION negatively regulates GO:0007184 (SMAD protein import into nucleus)
2018-03-05 Deleted RELATION is a GO:0042308 (negative regulation of protein import into nucleus)
Timestamp Action Category Detail
2018-03-05 Updated TERM negative regulation of SMAD protein signal transduction
2010-12-24 Updated TERM negative regulation of SMAD protein import into nucleus
2009-01-12 Added TERM negative regulation of SMAD protein nuclear translocation
Timestamp Action Category Detail
2023-06-13 Deleted DEFINITION Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2023-06-13 Added DEFINITION Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway.
2018-03-05 Added SYNONYM negative regulation of SMAD protein import into nucleus
2018-03-05 Added DEFINITION Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2018-03-05 Deleted DEFINITION Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2011-01-02 Added DEFINITION Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2011-01-02 Deleted DEFINITION Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movoment of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2010-12-24 Added SYNONYM negative regulation of SMAD protein nuclear translocation
2010-12-24 Added DEFINITION Any process that decreases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movoment of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2010-12-24 Deleted DEFINITION Any process that decreases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2009-01-12 Added DEFINITION Any process that decreases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
Timestamp Action Category Detail
2022-07-30 Added RELATION is a GO:1902532 (negative regulation of intracellular signal transduction)
2018-03-05 Added RELATION negatively regulates GO:0060395 (SMAD protein signal transduction)
2018-03-05 Deleted RELATION negatively regulates GO:0007184 (SMAD protein import into nucleus)
2018-03-05 Deleted RELATION is a GO:0042308 (negative regulation of protein import into nucleus)
2010-12-24 Added RELATION is a GO:0042308 (negative regulation of protein import into nucleus)
2010-12-24 Deleted RELATION is a GO:0033159 (obsolete negative regulation of protein import into nucleus, translocation)
2009-11-15 Added RELATION is a GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway)
2009-01-12 Added RELATION is a GO:0060390 (regulation of SMAD protein signal transduction)
2009-01-12 Added RELATION is a GO:0033159 (obsolete negative regulation of protein import into nucleus, translocation)
2009-01-12 Added RELATION negatively regulates GO:0007184 (SMAD protein import into nucleus)
Timestamp Action Category Detail
Timestamp Action Category Detail
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