This term is obsolete.
Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.

GO:0060395 JSON

SMAD protein signal transduction

Biological Process

Definition (GO:0060395 GONUTS page)

An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes.

Comments

Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.

Acknowledgement

This term was created by the GO Consortium with support from: BHF image

15,370 annotations

Ancestor Chart

Ancestor chart for GO:0060395
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0060395

Child Term Relationship to
GO:0060395
negative regulation of SMAD protein signal transduction
negatively_regulates
positive regulation of SMAD protein signal transduction
positively_regulates
regulation of SMAD protein signal transduction
regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2JUU0 10116 A0A0G2JUU0_RAT GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZRF9 10116 A0A8I5ZRF9_RAT GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IKT5 10116 A6IKT5_RAT GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IKT6 10116 A6IKT6_RAT GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein G3V9C9 10116 G3V9C9_RAT GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O75928-2 9606 PIAS2_HUMAN GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16777850
NOT-qualified manual protein Q4FZS4 10116 Q4FZS4_RAT GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q68FR4 10116 Q68FR4_RAT GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q8NF64 9606 ZMIZ2_HUMAN GO:0060395 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16777850

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0007182 obsolete common-partner SMAD protein phosphorylation consider GO:0060395
GO:0007183 obsolete SMAD protein complex assembly consider GO:0060395
GO:0060389 obsolete pathway-restricted SMAD protein phosphorylation consider GO:0060395

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0060395 based on ALL annotations
The top 100 of 1,152 co-occurring terms
Co-occurring Term PR S% #Together #Compared
SMAD protein signal transduction
12,819.02 100.00 15,207 15,207
heteromeric SMAD protein complex
12,819.02 93.17 14,168 14,168
I-SMAD binding
10,563.55 77.69 14,163 17,187
transforming growth factor beta receptor signaling pathway
3,533.43 22.17 8,079 29,310
BMP signaling pathway
3,127.52 20.62 8,686 35,602
transcription regulator inhibitor activity
7,073.42 14.71 2,541 4,605
regulation of multicellular organismal process
5,464.91 14.31 2,696 6,324
activin receptor signaling pathway
2,570.89 12.59 3,843 19,162
anatomical structure morphogenesis
1,337.87 10.36 14,173 135,801
regulation of developmental process
2,095.19 9.01 2,544 15,565
Totals 166323 4600760
No co-occurrence statistics for GO:0060395 based on MANUAL annotations
The top 100 of 995 co-occurring terms
Co-occurring Term PR S% #Together #Compared
SMAD protein signal transduction
4,306.00 100.00 300 300
heteromeric SMAD protein complex
4,306.00 70.33 211 211
I-SMAD binding
3,398.60 58.03 206 261
anatomical structure morphogenesis
766.42 16.48 207 1,163
BMP signaling pathway
729.66 14.26 142 838
transforming growth factor beta receptor signaling pathway
660.40 13.25 148 965
activin receptor signaling pathway
950.08 11.95 62 281
transcription regulator inhibitor activity
1,342.13 11.82 48 154
SMAD protein complex
2,492.95 6.96 22 38
co-SMAD binding
1,640.38 4.91 16 42
Totals 2391 28019

Change Log

Timestamp Action Category Detail
2023-12-15 Deleted DEFINITION An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes.
2023-12-15 Added RELATION is a GO:0141124 (intracellular signaling cassette)
2023-12-15 Added DEFINITION An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes.
2023-12-15 Deleted RELATION is a GO:0035556 (intracellular signal transduction)
2023-07-06 Deleted CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2023-06-13 Deleted DEFINITION An intracellular signal transduction process that starts with the activation of a SMAD protein, and ultimately effecting a change in the functioning of the cell, for e. g. transcription. SMAD proteins are activated by protein serine/threonine kinase cell surface receptors.
2023-06-13 Added DEFINITION An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes.
2022-07-30 Added RELATION is a GO:0035556 (intracellular signal transduction)
2022-07-30 Deleted RELATION is a GO:0007165 (signal transduction)
2022-07-30 Added DEFINITION An intracellular signal transduction process that starts with the activation of a SMAD protein, and ultimately effecting a change in the functioning of the cell, for e. g. transcription. SMAD proteins are activated by protein serine/threonine kinase cell surface receptors.
Timestamp Action Category Detail
2009-01-12 Added TERM SMAD protein signal transduction
Timestamp Action Category Detail
2023-12-15 Deleted DEFINITION An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes.
2023-12-15 Added DEFINITION An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes.
2023-06-13 Deleted DEFINITION An intracellular signal transduction process that starts with the activation of a SMAD protein, and ultimately effecting a change in the functioning of the cell, for e. g. transcription. SMAD proteins are activated by protein serine/threonine kinase cell surface receptors.
2023-06-13 Added DEFINITION An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes.
2022-07-30 Added DEFINITION An intracellular signal transduction process that starts with the activation of a SMAD protein, and ultimately effecting a change in the functioning of the cell, for e. g. transcription. SMAD proteins are activated by protein serine/threonine kinase cell surface receptors.
2022-07-30 Deleted DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
2009-01-30 Deleted DEFINITION x.
2009-01-30 Added DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
2009-01-12 Added DEFINITION x.
Timestamp Action Category Detail
2023-12-15 Added RELATION is a GO:0141124 (intracellular signaling cassette)
2023-12-15 Deleted RELATION is a GO:0035556 (intracellular signal transduction)
2022-07-30 Added RELATION is a GO:0035556 (intracellular signal transduction)
2022-07-30 Deleted RELATION is a GO:0007165 (signal transduction)
2009-06-11 Added RELATION part of GO:0007178 (cell surface receptor protein serine/threonine kinase signaling pathway)
2009-06-11 Deleted RELATION part of GO:0007179 (transforming growth factor beta receptor signaling pathway)
2009-01-12 Added RELATION part of GO:0007179 (transforming growth factor beta receptor signaling pathway)
2009-01-12 Added RELATION is a GO:0007165 (signal transduction)
Timestamp Action Category Detail
Timestamp Action Category Detail
2023-07-06 Deleted CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2017-04-01 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
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