Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.
GO:0060395
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SMAD protein signal transduction
Biological Process
Definition (GO:0060395 GONUTS page)
An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes.
Comments
Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.
Acknowledgement
This term was created by the GO Consortium with support from:
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0060395
Child Term | Relationship to GO:0060395 |
---|---|
negative regulation of SMAD protein signal transduction
|
negatively_regulates |
positive regulation of SMAD protein signal transduction
|
positively_regulates |
regulation of SMAD protein signal transduction
|
regulates |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2JUU0 | 10116 | A0A0G2JUU0_RAT | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZRF9 | 10116 | A0A8I5ZRF9_RAT | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IKT5 | 10116 | A6IKT5_RAT | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IKT6 | 10116 | A6IKT6_RAT | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | G3V9C9 | 10116 | G3V9C9_RAT | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O75928-2 | 9606 | PIAS2_HUMAN | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16777850 | |
NOT-qualified manual | protein | Q4FZS4 | 10116 | Q4FZS4_RAT | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q68FR4 | 10116 | Q68FR4_RAT | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q8NF64 | 9606 | ZMIZ2_HUMAN | GO:0060395 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16777850 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0007182 | obsolete common-partner SMAD protein phosphorylation | consider GO:0060395 |
GO:0007183 | obsolete SMAD protein complex assembly | consider GO:0060395 |
GO:0060389 | obsolete pathway-restricted SMAD protein phosphorylation | consider GO:0060395 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0060395 based on ALL annotations
The top 100 of 1,152 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
SMAD protein signal transduction
|
12,819.02 | 100.00 | 15,207 | 15,207 |
heteromeric SMAD protein complex
|
12,819.02 | 93.17 | 14,168 | 14,168 |
I-SMAD binding
|
10,563.55 | 77.69 | 14,163 | 17,187 |
transforming growth factor beta receptor signaling pathway
|
3,533.43 | 22.17 | 8,079 | 29,310 |
BMP signaling pathway
|
3,127.52 | 20.62 | 8,686 | 35,602 |
transcription regulator inhibitor activity
|
7,073.42 | 14.71 | 2,541 | 4,605 |
regulation of multicellular organismal process
|
5,464.91 | 14.31 | 2,696 | 6,324 |
activin receptor signaling pathway
|
2,570.89 | 12.59 | 3,843 | 19,162 |
anatomical structure morphogenesis
|
1,337.87 | 10.36 | 14,173 | 135,801 |
regulation of developmental process
|
2,095.19 | 9.01 | 2,544 | 15,565 |
Totals | 166323 | 4600760 |
No co-occurrence statistics for GO:0060395 based on MANUAL annotations
The top 100 of 995 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
SMAD protein signal transduction
|
4,306.00 | 100.00 | 300 | 300 |
heteromeric SMAD protein complex
|
4,306.00 | 70.33 | 211 | 211 |
I-SMAD binding
|
3,398.60 | 58.03 | 206 | 261 |
anatomical structure morphogenesis
|
766.42 | 16.48 | 207 | 1,163 |
BMP signaling pathway
|
729.66 | 14.26 | 142 | 838 |
transforming growth factor beta receptor signaling pathway
|
660.40 | 13.25 | 148 | 965 |
activin receptor signaling pathway
|
950.08 | 11.95 | 62 | 281 |
transcription regulator inhibitor activity
|
1,342.13 | 11.82 | 48 | 154 |
SMAD protein complex
|
2,492.95 | 6.96 | 22 | 38 |
co-SMAD binding
|
1,640.38 | 4.91 | 16 | 42 |
Totals | 2391 | 28019 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | DEFINITION | An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes. |
2023-12-15 | Added | RELATION | is a GO:0141124 (intracellular signaling cassette) |
2023-12-15 | Added | DEFINITION | An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes. |
2023-12-15 | Deleted | RELATION | is a GO:0035556 (intracellular signal transduction) |
2023-07-06 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2023-06-13 | Deleted | DEFINITION | An intracellular signal transduction process that starts with the activation of a SMAD protein, and ultimately effecting a change in the functioning of the cell, for e. g. transcription. SMAD proteins are activated by protein serine/threonine kinase cell surface receptors. |
2023-06-13 | Added | DEFINITION | An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes. |
2022-07-30 | Added | RELATION | is a GO:0035556 (intracellular signal transduction) |
2022-07-30 | Deleted | RELATION | is a GO:0007165 (signal transduction) |
2022-07-30 | Added | DEFINITION | An intracellular signal transduction process that starts with the activation of a SMAD protein, and ultimately effecting a change in the functioning of the cell, for e. g. transcription. SMAD proteins are activated by protein serine/threonine kinase cell surface receptors. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-01-12 | Added | TERM | SMAD protein signal transduction |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | DEFINITION | An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes. |
2023-12-15 | Added | DEFINITION | An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes. |
2023-06-13 | Deleted | DEFINITION | An intracellular signal transduction process that starts with the activation of a SMAD protein, and ultimately effecting a change in the functioning of the cell, for e. g. transcription. SMAD proteins are activated by protein serine/threonine kinase cell surface receptors. |
2023-06-13 | Added | DEFINITION | An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes. |
2022-07-30 | Added | DEFINITION | An intracellular signal transduction process that starts with the activation of a SMAD protein, and ultimately effecting a change in the functioning of the cell, for e. g. transcription. SMAD proteins are activated by protein serine/threonine kinase cell surface receptors. |
2022-07-30 | Deleted | DEFINITION | The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. |
2009-01-30 | Deleted | DEFINITION | x. |
2009-01-30 | Added | DEFINITION | The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. |
2009-01-12 | Added | DEFINITION | x. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Added | RELATION | is a GO:0141124 (intracellular signaling cassette) |
2023-12-15 | Deleted | RELATION | is a GO:0035556 (intracellular signal transduction) |
2022-07-30 | Added | RELATION | is a GO:0035556 (intracellular signal transduction) |
2022-07-30 | Deleted | RELATION | is a GO:0007165 (signal transduction) |
2009-06-11 | Added | RELATION | part of GO:0007178 (cell surface receptor protein serine/threonine kinase signaling pathway) |
2009-06-11 | Deleted | RELATION | part of GO:0007179 (transforming growth factor beta receptor signaling pathway) |
2009-01-12 | Added | RELATION | part of GO:0007179 (transforming growth factor beta receptor signaling pathway) |
2009-01-12 | Added | RELATION | is a GO:0007165 (signal transduction) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-07-06 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2017-04-01 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
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