Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
GO:0061542
JSON
3-demethylubiquinol-n 3-O-methyltransferase activity
Molecular Function
Definition (GO:0061542 GONUTS page)
Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol. PMID:10777520 PMID:23190198
Comments
Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
5-demethylubiquinone-10 methyltransferase | narrow |
S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase | related |
2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase | narrow |
OMHMB-methyltransferase | related |
5-demethylubiquinone-9 methyltransferase | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6JFH4 | 10116 | A6JFH4_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JFH5 | 10116 | A6JFH5_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7XRZ1 | 227321 | TDIE_EMENI | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773 | |
NOT-qualified manual | protein | D3Z930 | 10116 | D3Z930_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A629 | 10116 | D4A629_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.1.1.64 | |
InterPro | IPR010233 | Ubiquinone biosynthesis O-methyltransferase |
RHEA | 44380 | |
Reactome | R-HSA-2162186 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57856 | S-adenosyl-L-homocysteine zwitterion |
has_participant | CHEBI | CHEBI:17976 | ubiquinol |
has_participant | CHEBI | CHEBI:59789 | S-adenosyl-L-methionine zwitterion |
has_participant | CHEBI | CHEBI:84422 | 3-demethylubiquinol |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0008689 | obsolete 3-demethylubiquinone-9 3-O-methyltransferase activity | replaced_by GO:0061542 |
GO:0043431 | obsolete 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity | replaced_by GO:0061542 |
GO:0044596 | obsolete 3-demethylubiquinol-10 3-O-methyltransferase activity | replaced_by GO:0061542 |
GO:0061543 | obsolete 3-demethylubiquinol-6 3-O-methyltransferase activity | replaced_by GO:0061542 |
GO:0099119 | obsolete 3-demethylubiquinol-8 3-O-methyltransferase activity | replaced_by GO:0061542 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0061542 based on ALL annotations
The top 100 of 241 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
3-demethylubiquinol-n 3-O-methyltransferase activity
|
10,000.96 | 100.00 | 19,492 | 19,492 |
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
|
8,072.55 | 78.40 | 18,804 | 23,296 |
2-polyprenyl-6-hydroxyphenol methylase activity
|
8,847.33 | 50.33 | 10,499 | 11,868 |
extrinsic component of mitochondrial inner membrane
|
1,943.12 | 9.37 | 2,989 | 15,384 |
ubiquinone biosynthetic process
|
925.69 | 9.26 | 19,483 | 210,491 |
methylation
|
53.64 | 0.54 | 19,328 | 3,603,867 |
methyltransferase activity
|
51.74 | 0.52 | 19,345 | 3,739,251 |
ubiquinone biosynthesis complex
|
1,666.83 | 0.48 | 96 | 576 |
mitochondrial inner membrane
|
10.02 | 0.10 | 2,994 | 2,988,420 |
mitochondrion
|
7.76 | 0.08 | 4,081 | 5,259,736 |
Totals | 118078 | 28174133 |
No co-occurrence statistics for GO:0061542 based on MANUAL annotations
The top 21 of 21 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
3-demethylubiquinol-n 3-O-methyltransferase activity
|
39,145.42 | 100.00 | 33 | 33 |
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
|
7,931.43 | 20.00 | 31 | 153 |
ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
|
7,443.14 | 18.24 | 27 | 142 |
ubiquinone biosynthesis complex
|
6,263.27 | 7.41 | 4 | 25 |
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
|
1,186.23 | 2.48 | 4 | 132 |
phosphatidylglycerol binding
|
2,302.67 | 2.04 | 1 | 17 |
extrinsic component of mitochondrial inner membrane
|
1,505.59 | 1.72 | 1 | 26 |
ubiquinone biosynthetic process
|
196.29 | 0.49 | 7 | 1,396 |
hyperosmotic salinity response
|
151.73 | 0.34 | 1 | 258 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
134.21 | 0.33 | 3 | 875 |
Totals | 163 | 191651 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Added | RELATION | part of GO:0006744 (ubiquinone biosynthetic process) |
2023-12-26 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n. |
2023-12-26 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol. |
2023-12-26 | Added | XREF | Reactome:R-HSA-2162186 |
2023-10-10 | Added | RELATION | is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity) |
2023-10-10 | Added | XREF | RHEA:44380 |
2023-10-10 | Added | XREF | EC:2.1.1.64 |
2020-01-10 | Updated | TERM | 3-demethylubiquinol-n 3-O-methyltransferase activity |
2020-01-10 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. |
2020-01-10 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-01-10 | Updated | TERM | 3-demethylubiquinol-n 3-O-methyltransferase activity |
2013-06-27 | Added | TERM | 3-demethylubiquinone-n 3-O-methyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n. |
2023-12-26 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol. |
2020-01-10 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. |
2020-01-10 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n. |
2015-04-10 | Deleted | SYNONYM | S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase |
2015-04-10 | Deleted | SYNONYM | OMHMB-methyltransferase |
2015-04-10 | Added | SYNONYM | S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase |
2015-04-10 | Deleted | SYNONYM | 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase |
2015-04-10 | Added | SYNONYM | 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase |
2015-04-10 | Added | SYNONYM | OMHMB-methyltransferase |
2014-09-11 | Deleted | SYNONYM | demethoxyubiquinone monooxygenase |
2014-09-11 | Deleted | SYNONYM | demethoxy-ubiquinone hydroxylase |
2014-09-07 | Added | SYNONYM | demethoxy-ubiquinone hydroxylase |
2014-09-05 | Added | SYNONYM | demethoxyubiquinone monooxygenase |
2014-09-05 | Added | SYNONYM | 5-demethylubiquinone-10 methyltransferase |
2014-09-05 | Added | SYNONYM | 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase |
2014-09-05 | Added | SYNONYM | 5-demethylubiquinone-9 methyltransferase |
2014-09-05 | Added | SYNONYM | OMHMB-methyltransferase |
2014-09-05 | Added | SYNONYM | S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase |
2013-06-27 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Added | RELATION | part of GO:0006744 (ubiquinone biosynthetic process) |
2023-10-10 | Added | RELATION | is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity) |
2013-06-27 | Added | RELATION | is a GO:0008171 (O-methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Added | XREF | Reactome:R-HSA-2162186 |
2023-10-10 | Added | XREF | RHEA:44380 |
2023-10-10 | Added | XREF | EC:2.1.1.64 |
Timestamp | Action | Category | Detail |
---|
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