This term is obsolete.
Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.

GO:0061542 JSON

3-demethylubiquinol-n 3-O-methyltransferase activity

Molecular Function

Definition (GO:0061542 GONUTS page)

Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol. PMID:10777520 PMID:23190198

Comments

Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.

19,516 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
5-demethylubiquinone-10 methyltransferase narrow
S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase related
2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase narrow
OMHMB-methyltransferase related
5-demethylubiquinone-9 methyltransferase narrow

Ancestor Chart

Ancestor chart for GO:0061542
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A8I5YBY9 10116 A0A8I5YBY9_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A2VDP2 9913 PCMD1_BOVIN GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6JFH4 10116 A6JFH4_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JFH5 10116 A6JFH5_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7XRZ1 227321 TDIE_EMENI GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773
NOT-qualified manual protein D3Z930 10116 D3Z930_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A629 10116 D4A629_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 2.1.1.64
InterPro IPR010233 Ubiquinone biosynthesis O-methyltransferase
RHEA 44380
Reactome R-HSA-2162186

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57856 S-adenosyl-L-homocysteine zwitterion
has_participant CHEBI CHEBI:17976 ubiquinol
has_participant CHEBI CHEBI:59789 S-adenosyl-L-methionine zwitterion
has_participant CHEBI CHEBI:84422 3-demethylubiquinol
has_participant CHEBI CHEBI:15378 hydron

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0008689 obsolete 3-demethylubiquinone-9 3-O-methyltransferase activity replaced_by GO:0061542
GO:0043431 obsolete 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity replaced_by GO:0061542
GO:0044596 obsolete 3-demethylubiquinol-10 3-O-methyltransferase activity replaced_by GO:0061542
GO:0061543 obsolete 3-demethylubiquinol-6 3-O-methyltransferase activity replaced_by GO:0061542
GO:0099119 obsolete 3-demethylubiquinol-8 3-O-methyltransferase activity replaced_by GO:0061542

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0061542 based on ALL annotations
The top 100 of 241 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3-demethylubiquinol-n 3-O-methyltransferase activity
10,000.96 100.00 19,492 19,492
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
8,072.55 78.40 18,804 23,296
2-polyprenyl-6-hydroxyphenol methylase activity
8,847.33 50.33 10,499 11,868
extrinsic component of mitochondrial inner membrane
1,943.12 9.37 2,989 15,384
ubiquinone biosynthetic process
925.69 9.26 19,483 210,491
methylation
53.64 0.54 19,328 3,603,867
methyltransferase activity
51.74 0.52 19,345 3,739,251
ubiquinone biosynthesis complex
1,666.83 0.48 96 576
mitochondrial inner membrane
10.02 0.10 2,994 2,988,420
mitochondrion
7.76 0.08 4,081 5,259,736
Totals 118078 28174133
No co-occurrence statistics for GO:0061542 based on MANUAL annotations
The top 21 of 21 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3-demethylubiquinol-n 3-O-methyltransferase activity
39,145.42 100.00 33 33
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
7,931.43 20.00 31 153
ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
7,443.14 18.24 27 142
ubiquinone biosynthesis complex
6,263.27 7.41 4 25
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
1,186.23 2.48 4 132
phosphatidylglycerol binding
2,302.67 2.04 1 17
extrinsic component of mitochondrial inner membrane
1,505.59 1.72 1 26
ubiquinone biosynthetic process
196.29 0.49 7 1,396
hyperosmotic salinity response
151.73 0.34 1 258
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
134.21 0.33 3 875
Totals 163 191651

Change Log

Timestamp Action Category Detail
2023-12-26 Added RELATION part of GO:0006744 (ubiquinone biosynthetic process)
2023-12-26 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n.
2023-12-26 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol.
2023-12-26 Added XREF Reactome:R-HSA-2162186
2023-10-10 Added RELATION is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
2023-10-10 Added XREF RHEA:44380
2023-10-10 Added XREF EC:2.1.1.64
2020-01-10 Updated TERM 3-demethylubiquinol-n 3-O-methyltransferase activity
2020-01-10 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.
2020-01-10 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n.
Timestamp Action Category Detail
2020-01-10 Updated TERM 3-demethylubiquinol-n 3-O-methyltransferase activity
2013-06-27 Added TERM 3-demethylubiquinone-n 3-O-methyltransferase activity
Timestamp Action Category Detail
2023-12-26 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n.
2023-12-26 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol.
2020-01-10 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.
2020-01-10 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n.
2015-04-10 Deleted SYNONYM S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase
2015-04-10 Deleted SYNONYM OMHMB-methyltransferase
2015-04-10 Added SYNONYM S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase
2015-04-10 Deleted SYNONYM 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase
2015-04-10 Added SYNONYM 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase
2015-04-10 Added SYNONYM OMHMB-methyltransferase
2014-09-11 Deleted SYNONYM demethoxyubiquinone monooxygenase
2014-09-11 Deleted SYNONYM demethoxy-ubiquinone hydroxylase
2014-09-07 Added SYNONYM demethoxy-ubiquinone hydroxylase
2014-09-05 Added SYNONYM demethoxyubiquinone monooxygenase
2014-09-05 Added SYNONYM 5-demethylubiquinone-10 methyltransferase
2014-09-05 Added SYNONYM 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase
2014-09-05 Added SYNONYM 5-demethylubiquinone-9 methyltransferase
2014-09-05 Added SYNONYM OMHMB-methyltransferase
2014-09-05 Added SYNONYM S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase
2013-06-27 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.
Timestamp Action Category Detail
2023-12-26 Added RELATION part of GO:0006744 (ubiquinone biosynthetic process)
2023-10-10 Added RELATION is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
2013-06-27 Added RELATION is a GO:0008171 (O-methyltransferase activity)
Timestamp Action Category Detail
2023-12-26 Added XREF Reactome:R-HSA-2162186
2023-10-10 Added XREF RHEA:44380
2023-10-10 Added XREF EC:2.1.1.64
Timestamp Action Category Detail
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