GO:0061663
JSON
NEDD8 ligase activity
Molecular Function
Definition (GO:0061663 GONUTS page)
Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
E3 | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.3.2.32 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0061663 based on ALL annotations
The top 100 of 190 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NEDD8 ligase activity
|
755,576.70 | 100.00 | 258 | 258 |
cellular response to actinomycin D
|
274,371.40 | 17.47 | 65 | 179 |
positive regulation of protein autoubiquitination
|
192,413.94 | 16.47 | 82 | 322 |
negative regulation of response to oxidative stress
|
154,893.22 | 14.24 | 82 | 400 |
Cul7-RING ubiquitin ligase complex
|
122,725.77 | 12.10 | 83 | 511 |
Cul5-RING ubiquitin ligase complex
|
97,291.88 | 12.08 | 171 | 1,328 |
Cul4B-RING E3 ubiquitin ligase complex
|
109,637.88 | 11.11 | 83 | 572 |
positive regulation of muscle cell differentiation
|
90,325.11 | 8.73 | 63 | 527 |
atrial septum development
|
73,572.38 | 7.48 | 63 | 647 |
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
|
72,651.60 | 7.48 | 65 | 676 |
Totals | 5355 | 861810 |
No co-occurrence statistics for GO:0061663 based on MANUAL annotations
The top 100 of 178 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NEDD8 ligase activity
|
53,824.96 | 100.00 | 24 | 24 |
cellular response to actinomycin D
|
29,359.07 | 20.69 | 6 | 11 |
response to formaldehyde
|
38,446.40 | 19.23 | 5 | 7 |
cellular response to vitamin B1
|
38,446.40 | 19.23 | 5 | 7 |
Cul7-RING ubiquitin ligase complex
|
13,890.31 | 17.02 | 8 | 31 |
positive regulation of protein autoubiquitination
|
15,378.56 | 15.38 | 6 | 21 |
response to water-immersion restraint stress
|
19,223.20 | 15.15 | 5 | 14 |
response to ether
|
19,223.20 | 15.15 | 5 | 14 |
negative regulation of response to oxidative stress
|
12,917.99 | 13.95 | 6 | 25 |
regulation of protein catabolic process at postsynapse, modulating synaptic transmission
|
12,232.94 | 12.20 | 5 | 22 |
Totals | 543 | 20779 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Added | SYNONYM | E3 |
2023-06-13 | Deleted | SYNONYM | E3 |
2023-03-14 | Deleted | DEFINITION | Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. |
2023-03-14 | Added | DEFINITION | Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. |
2023-03-14 | Added | XREF | EC:2.3.2.32 |
2014-11-08 | Added | RELATION | is a GO:0061659 (ubiquitin-like protein ligase activity) |
2014-11-08 | Added | DEFINITION | Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. |
2014-11-08 | Added | RELATION | is a GO:0019788 (NEDD8 transferase activity) |
2014-11-08 | Added | SYNONYM | E3 |
2014-11-08 | Added | TERM | NEDD8 ligase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-11-08 | Added | TERM | NEDD8 ligase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Added | SYNONYM | E3 |
2023-06-13 | Deleted | SYNONYM | E3 |
2023-03-14 | Deleted | DEFINITION | Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. |
2023-03-14 | Added | DEFINITION | Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. |
2014-11-08 | Added | DEFINITION | Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. |
2014-11-08 | Added | SYNONYM | E3 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-11-08 | Added | RELATION | is a GO:0061659 (ubiquitin-like protein ligase activity) |
2014-11-08 | Added | RELATION | is a GO:0019788 (NEDD8 transferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-03-14 | Added | XREF | EC:2.3.2.32 |
Timestamp | Action | Category | Detail |
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