This term is obsolete.

GO:0061663 JSON

NEDD8 ligase activity

Molecular Function

Definition (GO:0061663 GONUTS page)

Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.

264 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
E3 broad

Ancestor Chart

Ancestor chart for GO:0061663
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.3.2.32

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0061663 based on ALL annotations
The top 100 of 192 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NEDD8 ligase activity
768,042.10 100.00 258 258
cellular response to actinomycin D
278,897.97 17.47 65 179
positive regulation of protein autoubiquitination
195,588.36 16.47 82 322
negative regulation of response to oxidative stress
156,665.30 14.19 82 402
Cul5-RING ubiquitin ligase complex
99,345.84 12.14 171 1,322
Cul7-RING ubiquitin ligase complex
123,302.70 11.99 83 517
Cul4B-RING E3 ubiquitin ligase complex
110,480.93 11.04 83 577
positive regulation of muscle cell differentiation
91,815.28 8.73 63 527
atrial septum development
74,901.94 7.49 63 646
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
73,959.61 7.49 65 675
Totals 5196 774758
No co-occurrence statistics for GO:0061663 based on MANUAL annotations
The top 100 of 181 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NEDD8 ligase activity
58,813.88 100.00 24 24
cellular response to actinomycin D
32,080.30 20.69 6 11
response to formaldehyde
42,009.91 19.23 5 7
cellular response to vitamin B1
42,009.91 19.23 5 7
Cul7-RING ubiquitin ligase complex
14,703.47 16.67 8 32
positive regulation of protein autoubiquitination
16,803.97 15.38 6 21
response to water-immersion restraint stress
21,004.96 15.15 5 14
response to ether
21,004.96 15.15 5 14
negative regulation of response to oxidative stress
14,703.47 14.29 6 24
regulation of protein catabolic process at postsynapse, modulating synaptic transmission
13,366.79 12.20 5 22
Totals 537 20209

Change Log

Timestamp Action Category Detail
2023-06-13 Added SYNONYM E3
2023-06-13 Deleted SYNONYM E3
2023-03-14 Added DEFINITION Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.
2023-03-14 Deleted DEFINITION Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.
2023-03-14 Added XREF EC:2.3.2.32
2014-11-08 Added SYNONYM E3
2014-11-08 Added RELATION is a GO:0019788 (NEDD8 transferase activity)
2014-11-08 Added RELATION is a GO:0061659 (ubiquitin-like protein ligase activity)
2014-11-08 Added TERM NEDD8 ligase activity
2014-11-08 Added DEFINITION Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.
Timestamp Action Category Detail
2014-11-08 Added TERM NEDD8 ligase activity
Timestamp Action Category Detail
2023-06-13 Added SYNONYM E3
2023-06-13 Deleted SYNONYM E3
2023-03-14 Added DEFINITION Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.
2023-03-14 Deleted DEFINITION Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.
2014-11-08 Added SYNONYM E3
2014-11-08 Added DEFINITION Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.
Timestamp Action Category Detail
2014-11-08 Added RELATION is a GO:0019788 (NEDD8 transferase activity)
2014-11-08 Added RELATION is a GO:0061659 (ubiquitin-like protein ligase activity)
Timestamp Action Category Detail
2023-03-14 Added XREF EC:2.3.2.32
Timestamp Action Category Detail
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