GO:0061710
JSON
L-threonylcarbamoyladenylate synthase
Molecular Function
Definition (GO:0061710 GONUTS page)
Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O.
Ancestor Chart
Ancestor chart for GO:0061710
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q4H4F3 | 1397 | BTRD_NIACI | GO:0016779 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17226887 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.7.87 | |
MetaCyc | RXN-14569 | |
RHEA | 36407 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:73682 | L-threonylcarbamoyladenylate(2-) |
has_participant | CHEBI | CHEBI:17544 | hydrogencarbonate |
has_participant | CHEBI | CHEBI:57926 | L-threonine zwitterion |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0061710 based on ALL annotations
The top 100 of 101 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-threonylcarbamoyladenylate synthase
|
10,121.96 | 100.00 | 19,259 | 19,259 |
regulation of translational fidelity
|
1,900.03 | 18.71 | 18,917 | 100,776 |
double-stranded RNA binding
|
987.74 | 9.76 | 19,216 | 196,918 |
tRNA threonylcarbamoyladenosine modification
|
352.56 | 3.16 | 4,891 | 140,419 |
tRNA binding
|
148.17 | 1.46 | 18,912 | 1,291,960 |
tRNA processing
|
107.67 | 1.06 | 18,596 | 1,748,269 |
nucleotidyltransferase activity
|
100.27 | 0.99 | 19,227 | 1,940,928 |
single-stranded telomeric DNA binding
|
128.07 | 0.58 | 201 | 15,886 |
negative regulation of transport
|
749.13 | 0.42 | 86 | 1,162 |
tRNA threonylcarbamoyladenosine metabolic process
|
59.09 | 0.38 | 201 | 34,429 |
Totals | 158135 | 294806114 |
No co-occurrence statistics for GO:0061710 based on MANUAL annotations
The top 16 of 16 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-threonylcarbamoyladenylate synthase
|
184,542.70 | 100.00 | 7 | 7 |
negative regulation of transport
|
21,293.39 | 10.00 | 3 | 26 |
tRNA threonylcarbamoyladenosine modification
|
7,097.80 | 3.85 | 7 | 182 |
regulation of translational fidelity
|
5,102.56 | 2.75 | 6 | 217 |
nucleotidyltransferase activity
|
2,283.00 | 1.23 | 6 | 485 |
tRNA threonylcarbamoyladenosine metabolic process
|
798.89 | 0.42 | 1 | 231 |
tRNA binding
|
460.02 | 0.25 | 6 | 2,407 |
single-stranded telomeric DNA binding
|
168.22 | 0.09 | 1 | 1,097 |
telomere maintenance
|
147.75 | 0.08 | 1 | 1,249 |
double-stranded RNA binding
|
117.54 | 0.06 | 1 | 1,570 |
Totals | 59 | 426271 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-22 | Deleted | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O. |
2022-11-22 | Added | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O. |
2018-07-13 | Deleted | XREF | RHEA:36410 |
2018-07-13 | Added | XREF | RHEA:36407 |
2015-06-25 | Added | XREF | RHEA:36410 |
2015-06-25 | Added | XREF | EC:2.7.7.87 |
2015-06-25 | Added | XREF | MetaCyc:RXN-14569 |
2015-06-25 | Added | TERM | L-threonylcarbamoyladenylate synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-06-25 | Added | TERM | L-threonylcarbamoyladenylate synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-22 | Deleted | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O. |
2022-11-22 | Added | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O. |
2015-06-25 | Added | DEFINITION | Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-06-25 | Added | RELATION | is a GO:0016779 (nucleotidyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-13 | Deleted | XREF | RHEA:36410 |
2018-07-13 | Added | XREF | RHEA:36407 |
2015-06-25 | Added | XREF | RHEA:36410 |
2015-06-25 | Added | XREF | EC:2.7.7.87 |
2015-06-25 | Added | XREF | MetaCyc:RXN-14569 |
Timestamp | Action | Category | Detail |
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