GO:0061763
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multivesicular body-lysosome fusion
Biological Process
Definition (GO:0061763 GONUTS page)
The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle. PMID:21118109
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
late endosome-lysosome fusion | related |
endosome-lysosome fusion | related |
MVB-lysosome fusion | exact |
fusion of MVB to lysosome | exact |
fusion of multivesicular body to lysosome | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0061763 | multivesicular body-lysosome fusion | Never in Taxon | 4751 | Fungi | |
GO:0061763 | multivesicular body-lysosome fusion | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2K1K3 | 10116 | A0A0G2K1K3_RAT | GO:0061025 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8948454 | |
NOT-qualified manual | protein | A0A8I6A5G9 | 10116 | A0A8I6A5G9_RAT | GO:0061025 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8948454 | |
NOT-qualified manual | protein | Q5I0J5 | 10116 | MITD1_RAT | GO:0071985 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q5PQN6 | 10116 | SPE39_RAT | GO:0008333 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q63616 | 10116 | VP33B_RAT | GO:0008333 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q6IN37 | 10116 | Q6IN37_RAT | GO:0061025 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8948454 | |
NOT-qualified manual | protein | Q8CJH4 | 10116 | Q8CJH4_RAT | GO:0061025 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8948454 | |
NOT-qualified manual | protein | Q8WV92 | 9606 | MITD1_HUMAN | GO:0071985 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000315 from these references: PMID:23015756, PMID:23045692 | |
NOT-qualified manual | protein | Q9ES54 | 10116 | NPL4_RAT | GO:0061025 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10811609 | |
NOT-qualified manual | protein | Q9H267 | 9606 | VP33B_HUMAN | GO:0008333 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25783203 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0061763 based on ALL annotations
The top 100 of 139 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
multivesicular body-lysosome fusion
|
1,740,524.90 | 100.00 | 112 | 112 |
vesicle fusion with vacuole
|
448,588.88 | 13.59 | 25 | 97 |
amphisome membrane
|
141,226.80 | 8.11 | 111 | 1,368 |
late endosome to lysosome transport
|
100,676.52 | 5.78 | 111 | 1,919 |
ubiquitin-specific protease binding
|
97,932.34 | 5.54 | 88 | 1,564 |
midbody abscission
|
73,236.64 | 4.21 | 111 | 2,638 |
suppression of viral release by host
|
69,305.97 | 3.94 | 88 | 2,210 |
ESCRT III complex disassembly
|
97,599.52 | 2.82 | 6 | 107 |
regulation of exosomal secretion
|
870,262.44 | 2.61 | 3 | 6 |
kinetochore microtubule
|
41,071.06 | 2.36 | 111 | 4,704 |
Totals | 4105 | 5977778 |
No co-occurrence statistics for GO:0061763 based on MANUAL annotations
The top 100 of 125 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
multivesicular body-lysosome fusion
|
47,844.41 | 100.00 | 27 | 27 |
vesicle fusion with vacuole
|
41,245.18 | 80.65 | 25 | 29 |
amphisome membrane
|
25,915.72 | 53.06 | 26 | 48 |
viral budding via host ESCRT complex
|
17,770.78 | 36.62 | 26 | 70 |
viral budding from plasma membrane
|
17,277.15 | 35.62 | 26 | 72 |
late endosome to lysosome transport
|
15,746.26 | 32.50 | 26 | 79 |
multivesicular body membrane
|
14,298.33 | 29.55 | 26 | 87 |
multivesicular body sorting pathway
|
13,375.86 | 27.66 | 26 | 93 |
midbody abscission
|
10,113.45 | 20.97 | 26 | 123 |
membrane fission
|
8,667.47 | 17.86 | 25 | 138 |
Totals | 860 | 61665 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2024-01-30 | Added | SYNONYM | late endosome-lysosome fusion |
2024-01-30 | Added | SYNONYM | endosome-lysosome fusion |
2021-03-12 | Added | RELATION | is a GO:0097212 (lysosomal membrane organization) |
2021-03-02 | Deleted | RELATION | is a GO:0090174 (organelle membrane fusion) |
2021-03-02 | Added | RELATION | is a GO:0006906 (vesicle fusion) |
2017-01-21 | Added | RELATION | is a GO:0090174 (organelle membrane fusion) |
2017-01-21 | Deleted | RELATION | is a GO:0051469 (vesicle fusion with vacuole) |
2016-10-22 | Deleted | RELATION | is a GO:0097576 (vacuole fusion) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-04-17 | Added | TERM | multivesicular body-lysosome fusion |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-01-30 | Added | SYNONYM | late endosome-lysosome fusion |
2024-01-30 | Added | SYNONYM | endosome-lysosome fusion |
2016-04-17 | Added | SYNONYM | fusion of MVB to lysosome |
2016-04-17 | Added | SYNONYM | MVB-lysosome fusion |
2016-04-17 | Added | SYNONYM | fusion of multivesicular body to lysosome |
2016-04-17 | Added | DEFINITION | The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-03-12 | Added | RELATION | is a GO:0097212 (lysosomal membrane organization) |
2021-03-02 | Deleted | RELATION | is a GO:0090174 (organelle membrane fusion) |
2021-03-02 | Added | RELATION | is a GO:0006906 (vesicle fusion) |
2017-01-21 | Added | RELATION | is a GO:0090174 (organelle membrane fusion) |
2017-01-21 | Deleted | RELATION | is a GO:0051469 (vesicle fusion with vacuole) |
2016-10-22 | Deleted | RELATION | is a GO:0097576 (vacuole fusion) |
2016-10-22 | Added | RELATION | is a GO:0051469 (vesicle fusion with vacuole) |
2016-10-22 | Deleted | RELATION | is a GO:0090174 (organelle membrane fusion) |
2016-04-17 | Added | RELATION | part of GO:0032510 (endosome to lysosome transport via multivesicular body sorting pathway) |
2016-04-17 | Added | RELATION | is a GO:0090174 (organelle membrane fusion) |
2016-04-17 | Added | RELATION | is a GO:0097576 (vacuole fusion) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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