This term is obsolete.

GO:0061763 JSON

multivesicular body-lysosome fusion

Biological Process

Definition (GO:0061763 GONUTS page)

The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle. PMID:21118109

Acknowledgement

This term was created by the GO Consortium with support from: PARK image

119 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
late endosome-lysosome fusion related
endosome-lysosome fusion related
MVB-lysosome fusion exact
fusion of MVB to lysosome exact
fusion of multivesicular body to lysosome exact

Ancestor Chart

Ancestor chart for GO:0061763
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0061763 multivesicular body-lysosome fusion Never in Taxon 4751 Fungi
GO:0061763 multivesicular body-lysosome fusion Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2K1K3 10116 A0A0G2K1K3_RAT GO:0061025 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8948454
NOT-qualified manual protein A0A8I6A5G9 10116 A0A8I6A5G9_RAT GO:0061025 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8948454
NOT-qualified manual protein Q5I0J5 10116 MITD1_RAT GO:0071985 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q5PQN6 10116 SPE39_RAT GO:0008333 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q63616 10116 VP33B_RAT GO:0008333 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q6IN37 10116 Q6IN37_RAT GO:0061025 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8948454
NOT-qualified manual protein Q8CJH4 10116 Q8CJH4_RAT GO:0061025 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8948454
NOT-qualified manual protein Q8WV92 9606 MITD1_HUMAN GO:0071985 2 NOT-qualified manual annotations exist with evidence code ECO:0000315 from these references: PMID:23015756, PMID:23045692
NOT-qualified manual protein Q9ES54 10116 NPL4_RAT GO:0061025 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10811609
NOT-qualified manual protein Q9H267 9606 VP33B_HUMAN GO:0008333 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25783203

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0061763 based on ALL annotations
The top 100 of 139 co-occurring terms
Co-occurring Term PR S% #Together #Compared
multivesicular body-lysosome fusion
1,740,524.90 100.00 112 112
vesicle fusion with vacuole
448,588.88 13.59 25 97
amphisome membrane
141,226.80 8.11 111 1,368
late endosome to lysosome transport
100,676.52 5.78 111 1,919
ubiquitin-specific protease binding
97,932.34 5.54 88 1,564
midbody abscission
73,236.64 4.21 111 2,638
suppression of viral release by host
69,305.97 3.94 88 2,210
ESCRT III complex disassembly
97,599.52 2.82 6 107
regulation of exosomal secretion
870,262.44 2.61 3 6
kinetochore microtubule
41,071.06 2.36 111 4,704
Totals 4105 5977778
No co-occurrence statistics for GO:0061763 based on MANUAL annotations
The top 100 of 125 co-occurring terms
Co-occurring Term PR S% #Together #Compared
multivesicular body-lysosome fusion
47,844.41 100.00 27 27
vesicle fusion with vacuole
41,245.18 80.65 25 29
amphisome membrane
25,915.72 53.06 26 48
viral budding via host ESCRT complex
17,770.78 36.62 26 70
viral budding from plasma membrane
17,277.15 35.62 26 72
late endosome to lysosome transport
15,746.26 32.50 26 79
multivesicular body membrane
14,298.33 29.55 26 87
multivesicular body sorting pathway
13,375.86 27.66 26 93
midbody abscission
10,113.45 20.97 26 123
membrane fission
8,667.47 17.86 25 138
Totals 860 61665

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2024-01-30 Added SYNONYM late endosome-lysosome fusion
2024-01-30 Added SYNONYM endosome-lysosome fusion
2021-03-12 Added RELATION is a GO:0097212 (lysosomal membrane organization)
2021-03-02 Deleted RELATION is a GO:0090174 (organelle membrane fusion)
2021-03-02 Added RELATION is a GO:0006906 (vesicle fusion)
2017-01-21 Added RELATION is a GO:0090174 (organelle membrane fusion)
2017-01-21 Deleted RELATION is a GO:0051469 (vesicle fusion with vacuole)
2016-10-22 Deleted RELATION is a GO:0097576 (vacuole fusion)
Timestamp Action Category Detail
2016-04-17 Added TERM multivesicular body-lysosome fusion
Timestamp Action Category Detail
2024-01-30 Added SYNONYM late endosome-lysosome fusion
2024-01-30 Added SYNONYM endosome-lysosome fusion
2016-04-17 Added SYNONYM fusion of MVB to lysosome
2016-04-17 Added SYNONYM MVB-lysosome fusion
2016-04-17 Added SYNONYM fusion of multivesicular body to lysosome
2016-04-17 Added DEFINITION The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle.
Timestamp Action Category Detail
2021-03-12 Added RELATION is a GO:0097212 (lysosomal membrane organization)
2021-03-02 Deleted RELATION is a GO:0090174 (organelle membrane fusion)
2021-03-02 Added RELATION is a GO:0006906 (vesicle fusion)
2017-01-21 Added RELATION is a GO:0090174 (organelle membrane fusion)
2017-01-21 Deleted RELATION is a GO:0051469 (vesicle fusion with vacuole)
2016-10-22 Deleted RELATION is a GO:0097576 (vacuole fusion)
2016-10-22 Added RELATION is a GO:0051469 (vesicle fusion with vacuole)
2016-10-22 Deleted RELATION is a GO:0090174 (organelle membrane fusion)
2016-04-17 Added RELATION part of GO:0032510 (endosome to lysosome transport via multivesicular body sorting pathway)
2016-04-17 Added RELATION is a GO:0090174 (organelle membrane fusion)
2016-04-17 Added RELATION is a GO:0097576 (vacuole fusion)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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