This term is obsolete.

GO:0070040 JSON

rRNA (adenine(2503)-C2-)-methyltransferase activity

Molecular Function

Definition (GO:0070040 GONUTS page)

Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine. PMID:20007606 PMID:20184321 PMID:21368151 PMID:21415317 PMID:21527678

35,846 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
rRNA (adenine-C2-)-methyltransferase activity broad

Ancestor Chart

Ancestor chart for GO:0070040
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A8I5YBY9 10116 A0A8I5YBY9_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A2VDP2 9913 PCMD1_BOVIN GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6JFH4 10116 A6JFH4_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JFH5 10116 A6JFH5_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7XRZ1 227321 TDIE_EMENI GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773
NOT-qualified manual protein D3Z930 10116 D3Z930_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A629 10116 D4A629_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 2.1.1.192
MetaCyc RXN-11586
RHEA 42916

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:74497 2-methyladenosine 5'-monophosphate(1-) residue
has_participant CHEBI CHEBI:57844 L-methionine zwitterion
has_participant CHEBI CHEBI:33738 di-mu-sulfido-diiron(1+)
has_participant CHEBI CHEBI:33737 di-mu-sulfido-diiron(2+)
has_participant CHEBI CHEBI:74411 adenosine 5'-monophosphate(1-) residue
has_participant CHEBI CHEBI:17319 5'-deoxyadenosine
has_participant CHEBI CHEBI:59789 S-adenosyl-L-methionine zwitterion
has_participant CHEBI CHEBI:57856 S-adenosyl-L-homocysteine zwitterion

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070040 based on ALL annotations
The top 63 of 63 co-occurring terms
Co-occurring Term PR S% #Together #Compared
rRNA (adenine(2503)-C2-)-methyltransferase activity
5,438.53 100.00 35,844 35,844
tRNA (adenine(37)-C2)-methyltransferase activity
5,438.53 99.92 35,815 35,815
rRNA base methylation
839.62 15.44 35,800 231,889
tRNA methylation
606.75 11.16 35,800 320,887
RNA methyltransferase activity
580.03 10.66 35,575 333,562
rRNA processing
175.40 3.22 35,694 1,106,747
tRNA binding
147.06 2.70 34,936 1,291,960
iron-sulfur cluster binding
118.44 2.18 35,759 1,641,943
tRNA processing
109.77 2.02 35,286 1,748,269
rRNA binding
93.57 1.72 35,037 2,036,482
Totals 534949 267352275
No co-occurrence statistics for GO:0070040 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term PR S% #Together #Compared
rRNA (adenine(2503)-C2-)-methyltransferase activity
1,291,799.00 100.00 1 1
tRNA (adenine(37)-C2)-methyltransferase activity
1,291,799.00 100.00 1 1
rRNA base methylation
1,172.23 0.09 1 1,102
4 iron, 4 sulfur cluster binding
874.61 0.07 1 1,477
tRNA methylation
711.34 0.06 1 1,816
tRNA binding
536.68 0.04 1 2,407
protein binding
30.89 0.00 1 41,817
cytosol
15.34 0.00 1 84,217
Totals 8 132838

Change Log

Timestamp Action Category Detail
2024-06-19 Deleted XREF MetaCyc:RXN0-7007
2023-09-23 Added XREF RHEA:42916
2023-09-23 Updated TERM rRNA (adenine(2503)-C2-)-methyltransferase activity
2023-09-23 Added SYNONYM rRNA (adenine-C2-)-methyltransferase activity
2023-09-23 Deleted DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA.
2023-09-23 Added DEFINITION Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine.
2023-09-23 Added XREF MetaCyc:RXN0-7007
2011-06-19 Added DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA.
2011-06-19 Added XREF MetaCyc:RXN-11586
2011-06-19 Added XREF EC:2.1.1.192
Timestamp Action Category Detail
2023-09-23 Updated TERM rRNA (adenine(2503)-C2-)-methyltransferase activity
2008-10-02 Added TERM rRNA (adenine-C2-)-methyltransferase activity
Timestamp Action Category Detail
2023-09-23 Added SYNONYM rRNA (adenine-C2-)-methyltransferase activity
2023-09-23 Deleted DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA.
2023-09-23 Added DEFINITION Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine.
2011-06-19 Added DEFINITION Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA.
2011-06-19 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C2-methyladenine.
2008-10-02 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C2-methyladenine.
Timestamp Action Category Detail
2008-10-02 Added RELATION is a GO:0016433 (rRNA (adenine) methyltransferase activity)
2008-10-02 Added RELATION is a GO:0008169 (C-methyltransferase activity)
Timestamp Action Category Detail
2024-06-19 Deleted XREF MetaCyc:RXN0-7007
2023-09-23 Added XREF RHEA:42916
2023-09-23 Added XREF MetaCyc:RXN0-7007
2011-06-19 Added XREF MetaCyc:RXN-11586
2011-06-19 Added XREF EC:2.1.1.192
Timestamp Action Category Detail
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