GO:0070040
JSON
rRNA (adenine(2503)-C2-)-methyltransferase activity
Molecular Function
Definition (GO:0070040 GONUTS page)
Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine. PMID:20007606 PMID:20184321 PMID:21368151 PMID:21415317 PMID:21527678
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
rRNA (adenine-C2-)-methyltransferase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6JFH4 | 10116 | A6JFH4_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JFH5 | 10116 | A6JFH5_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7XRZ1 | 227321 | TDIE_EMENI | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773 | |
NOT-qualified manual | protein | D3Z930 | 10116 | D3Z930_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A629 | 10116 | D4A629_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.1.1.192 | |
MetaCyc | RXN-11586 | |
RHEA | 42916 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:74497 | 2-methyladenosine 5'-monophosphate(1-) residue |
has_participant | CHEBI | CHEBI:57844 | L-methionine zwitterion |
has_participant | CHEBI | CHEBI:33738 | di-mu-sulfido-diiron(1+) |
has_participant | CHEBI | CHEBI:33737 | di-mu-sulfido-diiron(2+) |
has_participant | CHEBI | CHEBI:74411 | adenosine 5'-monophosphate(1-) residue |
has_participant | CHEBI | CHEBI:17319 | 5'-deoxyadenosine |
has_participant | CHEBI | CHEBI:59789 | S-adenosyl-L-methionine zwitterion |
has_participant | CHEBI | CHEBI:57856 | S-adenosyl-L-homocysteine zwitterion |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070040 based on ALL annotations
The top 63 of 63 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
rRNA (adenine(2503)-C2-)-methyltransferase activity
|
5,438.53 | 100.00 | 35,844 | 35,844 |
tRNA (adenine(37)-C2)-methyltransferase activity
|
5,438.53 | 99.92 | 35,815 | 35,815 |
rRNA base methylation
|
839.62 | 15.44 | 35,800 | 231,889 |
tRNA methylation
|
606.75 | 11.16 | 35,800 | 320,887 |
RNA methyltransferase activity
|
580.03 | 10.66 | 35,575 | 333,562 |
rRNA processing
|
175.40 | 3.22 | 35,694 | 1,106,747 |
tRNA binding
|
147.06 | 2.70 | 34,936 | 1,291,960 |
iron-sulfur cluster binding
|
118.44 | 2.18 | 35,759 | 1,641,943 |
tRNA processing
|
109.77 | 2.02 | 35,286 | 1,748,269 |
rRNA binding
|
93.57 | 1.72 | 35,037 | 2,036,482 |
Totals | 534949 | 267352275 |
No co-occurrence statistics for GO:0070040 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
rRNA (adenine(2503)-C2-)-methyltransferase activity
|
1,291,799.00 | 100.00 | 1 | 1 |
tRNA (adenine(37)-C2)-methyltransferase activity
|
1,291,799.00 | 100.00 | 1 | 1 |
rRNA base methylation
|
1,172.23 | 0.09 | 1 | 1,102 |
4 iron, 4 sulfur cluster binding
|
874.61 | 0.07 | 1 | 1,477 |
tRNA methylation
|
711.34 | 0.06 | 1 | 1,816 |
tRNA binding
|
536.68 | 0.04 | 1 | 2,407 |
protein binding
|
30.89 | 0.00 | 1 | 41,817 |
cytosol
|
15.34 | 0.00 | 1 | 84,217 |
Totals | 8 | 132838 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-19 | Deleted | XREF | MetaCyc:RXN0-7007 |
2023-09-23 | Added | XREF | RHEA:42916 |
2023-09-23 | Updated | TERM | rRNA (adenine(2503)-C2-)-methyltransferase activity |
2023-09-23 | Added | SYNONYM | rRNA (adenine-C2-)-methyltransferase activity |
2023-09-23 | Deleted | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA. |
2023-09-23 | Added | DEFINITION | Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine. |
2023-09-23 | Added | XREF | MetaCyc:RXN0-7007 |
2011-06-19 | Added | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA. |
2011-06-19 | Added | XREF | MetaCyc:RXN-11586 |
2011-06-19 | Added | XREF | EC:2.1.1.192 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Updated | TERM | rRNA (adenine(2503)-C2-)-methyltransferase activity |
2008-10-02 | Added | TERM | rRNA (adenine-C2-)-methyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Added | SYNONYM | rRNA (adenine-C2-)-methyltransferase activity |
2023-09-23 | Deleted | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA. |
2023-09-23 | Added | DEFINITION | Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine. |
2011-06-19 | Added | DEFINITION | Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA. |
2011-06-19 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C2-methyladenine. |
2008-10-02 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C2-methyladenine. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-10-02 | Added | RELATION | is a GO:0016433 (rRNA (adenine) methyltransferase activity) |
2008-10-02 | Added | RELATION | is a GO:0008169 (C-methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-19 | Deleted | XREF | MetaCyc:RXN0-7007 |
2023-09-23 | Added | XREF | RHEA:42916 |
2023-09-23 | Added | XREF | MetaCyc:RXN0-7007 |
2011-06-19 | Added | XREF | MetaCyc:RXN-11586 |
2011-06-19 | Added | XREF | EC:2.1.1.192 |
Timestamp | Action | Category | Detail |
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