This term is obsolete.

GO:0070080 JSON

titin Z domain binding

Molecular Function

Definition (GO:0070080 GONUTS page)

Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.

810 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
Z repeat domain binding exact

Ancestor Chart

Ancestor chart for GO:0070080
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070080 based on ALL annotations
The top 94 of 94 co-occurring terms
Co-occurring Term PR S% #Together #Compared
titin Z domain binding
241,859.55 100.00 806 806
skeletal muscle myosin thick filament assembly
204,096.00 75.56 708 839
sarcomerogenesis
195,698.90 72.76 708 875
detection of muscle stretch
184,721.19 69.07 708 927
titin binding
143,126.86 59.18 806 1,362
skeletal muscle thin filament assembly
137,539.39 52.72 708 1,245
cardiac muscle tissue morphogenesis
92,760.86 36.42 708 1,846
cardiac myofibril assembly
49,821.52 20.03 708 3,437
actin filament uncapping
241,859.52 12.16 98 98
negative regulation of potassium ion transport
84,650.84 9.92 98 280
Totals 13716 158800255
No co-occurrence statistics for GO:0070080 based on MANUAL annotations
The top 74 of 74 co-occurring terms
Co-occurring Term PR S% #Together #Compared
titin Z domain binding
161,474.88 100.00 8 8
actin filament uncapping
161,474.88 62.50 5 5
phospholipase C-activating angiotensin-activated signaling pathway
73,397.66 35.71 5 11
microspike assembly
50,460.90 26.32 5 16
negative regulation of potassium ion transport
32,294.98 17.86 5 25
positive regulation of endocytic recycling
23,746.31 13.51 5 34
positive regulation of potassium ion transport
23,067.84 13.16 5 35
titin binding
18,721.73 11.59 8 69
FATZ binding
18,721.73 11.59 8 69
detection of muscle stretch
13,456.24 7.32 3 36
Totals 281 333500

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2009-07-03 Deleted DEFINITION Interacting selectively with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2008-11-07 Deleted DEFINITION Interacting selectively with the titin Z domain, which recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2008-11-07 Added DEFINITION Interacting selectively with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2008-10-21 Added TERM titin Z domain binding
2008-10-21 Added DEFINITION Interacting selectively with the titin Z domain, which recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2008-10-21 Added RELATION is a GO:0019904 (protein domain specific binding)
2008-10-21 Added SYNONYM Z repeat domain binding
Timestamp Action Category Detail
2008-10-21 Added TERM titin Z domain binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2009-07-03 Deleted DEFINITION Interacting selectively with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2008-11-07 Deleted DEFINITION Interacting selectively with the titin Z domain, which recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2008-11-07 Added DEFINITION Interacting selectively with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2008-10-21 Added DEFINITION Interacting selectively with the titin Z domain, which recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.
2008-10-21 Added SYNONYM Z repeat domain binding
Timestamp Action Category Detail
2008-10-21 Added RELATION is a GO:0019904 (protein domain specific binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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