This term is obsolete.

GO:0070123 JSON

transforming growth factor beta receptor activity, type III

Molecular Function

Definition (GO:0070123 GONUTS page)

Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. PMID:9759503

Acknowledgement

This term was created by the GO Consortium with support from: BHF image

13,111 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
endoglin narrow
type III transforming growth factor beta receptor activity exact
type III TGFbeta receptor activity exact
type III TGF-beta receptor activity exact
transforming growth factor beta ligand binding to type III receptor related
betaglycan narrow

Ancestor Chart

Ancestor chart for GO:0070123
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0B4K7S5 7227 A0A0B4K7S5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A0G2QC55 10116 A0A0G2QC55_RAT GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A126GUQ5 7227 A0A126GUQ5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8GLD7 8355 A0A1L8GLD7_XENLA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A287AG10 9823 A0A287AG10_PIG GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2I2UNM6 9685 A0A2I2UNM6_FELCA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5VFW3 9541 A0A2K5VFW3_MACFA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18508765

Cross-references

Database ID Description
EC 2.7.11.30

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070123 based on ALL annotations
The top 100 of 746 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transforming growth factor beta receptor activity, type III
14,876.28 100.00 13,104 13,104
activin receptor activity, type II
14,790.59 95.62 12,600 12,673
activin receptor activity, type I
14,707.03 95.10 12,600 12,745
transforming growth factor beta receptor activity, type I
14,106.05 94.13 13,003 13,713
transforming growth factor beta receptor activity, type II
14,096.63 94.05 13,000 13,719
BMP receptor activity
14,421.88 93.33 12,600 12,997
activin receptor signaling pathway
9,742.33 63.65 12,549 19,162
transmembrane receptor protein serine/threonine kinase activity
8,301.21 52.80 11,893 21,313
cell surface receptor protein serine/threonine kinase signaling pathway
7,796.71 52.20 13,003 24,810
cellular response to growth factor stimulus
6,687.15 43.28 12,070 26,851
Totals 203037 3074689
No co-occurrence statistics for GO:0070123 based on MANUAL annotations
The top 100 of 105 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transforming growth factor beta receptor activity, type III
129,179.90 100.00 10 10
epicardium-derived cardiac fibroblast cell development
86,119.94 18.18 2 3
inhibin-betaglycan-ActRII complex
43,059.97 14.29 2 6
transforming growth factor beta receptor complex assembly
43,059.97 14.29 2 6
response to follicle-stimulating hormone
22,796.46 12.50 3 17
response to luteinizing hormone
21,529.98 10.00 2 12
negative regulation of apoptotic process involved in morphogenesis
64,589.95 9.09 1 2
definitive erythrocyte differentiation
17,223.99 8.70 2 15
negative regulation of cell-cell adhesion
11,163.69 8.33 7 81
muscular septum morphogenesis
16,147.49 8.33 2 16
Totals 325 217028

Change Log

Timestamp Action Category Detail
2024-08-16 Added XREF EC:2.7.11.30
2008-11-22 Added SYNONYM betaglycan
2008-11-22 Added SYNONYM endoglin
2008-11-22 Added SYNONYM type III transforming growth factor beta receptor activity
2008-11-22 Added SYNONYM transforming growth factor beta ligand binding to type III receptor
2008-11-22 Added SYNONYM type III TGFbeta receptor activity
2008-11-22 Added SYNONYM type III TGF-beta receptor activity
2008-11-22 Added TERM transforming growth factor beta receptor activity, type III
2008-11-22 Added RELATION is a GO:0005024 (transforming growth factor beta receptor activity)
2008-11-22 Added DEFINITION Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.
Timestamp Action Category Detail
2008-11-22 Added TERM transforming growth factor beta receptor activity, type III
Timestamp Action Category Detail
2008-11-22 Added SYNONYM betaglycan
2008-11-22 Added SYNONYM endoglin
2008-11-22 Added SYNONYM type III transforming growth factor beta receptor activity
2008-11-22 Added SYNONYM transforming growth factor beta ligand binding to type III receptor
2008-11-22 Added SYNONYM type III TGFbeta receptor activity
2008-11-22 Added SYNONYM type III TGF-beta receptor activity
2008-11-22 Added DEFINITION Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.
Timestamp Action Category Detail
2008-11-22 Added RELATION is a GO:0005024 (transforming growth factor beta receptor activity)
Timestamp Action Category Detail
2024-08-16 Added XREF EC:2.7.11.30
Timestamp Action Category Detail
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