GO:0070123
JSON
transforming growth factor beta receptor activity, type III
Molecular Function
Definition (GO:0070123 GONUTS page)
Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. PMID:9759503
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
endoglin | narrow |
type III transforming growth factor beta receptor activity | exact |
type III TGFbeta receptor activity | exact |
type III TGF-beta receptor activity | exact |
transforming growth factor beta ligand binding to type III receptor | related |
betaglycan | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0B4K7S5 | 7227 | A0A0B4K7S5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
NOT-qualified manual | protein | A0A0G2QC55 | 10116 | A0A0G2QC55_RAT | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A126GUQ5 | 7227 | A0A126GUQ5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8GLD7 | 8355 | A0A1L8GLD7_XENLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A287AG10 | 9823 | A0A287AG10_PIG | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2I2UNM6 | 9685 | A0A2I2UNM6_FELCA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5VFW3 | 9541 | A0A2K5VFW3_MACFA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18508765 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.11.30 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070123 based on ALL annotations
The top 100 of 746 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
transforming growth factor beta receptor activity, type III
|
14,876.28 | 100.00 | 13,104 | 13,104 |
activin receptor activity, type II
|
14,790.59 | 95.62 | 12,600 | 12,673 |
activin receptor activity, type I
|
14,707.03 | 95.10 | 12,600 | 12,745 |
transforming growth factor beta receptor activity, type I
|
14,106.05 | 94.13 | 13,003 | 13,713 |
transforming growth factor beta receptor activity, type II
|
14,096.63 | 94.05 | 13,000 | 13,719 |
BMP receptor activity
|
14,421.88 | 93.33 | 12,600 | 12,997 |
activin receptor signaling pathway
|
9,742.33 | 63.65 | 12,549 | 19,162 |
transmembrane receptor protein serine/threonine kinase activity
|
8,301.21 | 52.80 | 11,893 | 21,313 |
cell surface receptor protein serine/threonine kinase signaling pathway
|
7,796.71 | 52.20 | 13,003 | 24,810 |
cellular response to growth factor stimulus
|
6,687.15 | 43.28 | 12,070 | 26,851 |
Totals | 203037 | 3074689 |
No co-occurrence statistics for GO:0070123 based on MANUAL annotations
The top 100 of 105 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
transforming growth factor beta receptor activity, type III
|
129,179.90 | 100.00 | 10 | 10 |
epicardium-derived cardiac fibroblast cell development
|
86,119.94 | 18.18 | 2 | 3 |
inhibin-betaglycan-ActRII complex
|
43,059.97 | 14.29 | 2 | 6 |
transforming growth factor beta receptor complex assembly
|
43,059.97 | 14.29 | 2 | 6 |
response to follicle-stimulating hormone
|
22,796.46 | 12.50 | 3 | 17 |
response to luteinizing hormone
|
21,529.98 | 10.00 | 2 | 12 |
negative regulation of apoptotic process involved in morphogenesis
|
64,589.95 | 9.09 | 1 | 2 |
definitive erythrocyte differentiation
|
17,223.99 | 8.70 | 2 | 15 |
negative regulation of cell-cell adhesion
|
11,163.69 | 8.33 | 7 | 81 |
muscular septum morphogenesis
|
16,147.49 | 8.33 | 2 | 16 |
Totals | 325 | 217028 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:2.7.11.30 |
2008-11-22 | Added | SYNONYM | betaglycan |
2008-11-22 | Added | SYNONYM | endoglin |
2008-11-22 | Added | SYNONYM | type III transforming growth factor beta receptor activity |
2008-11-22 | Added | SYNONYM | transforming growth factor beta ligand binding to type III receptor |
2008-11-22 | Added | SYNONYM | type III TGFbeta receptor activity |
2008-11-22 | Added | SYNONYM | type III TGF-beta receptor activity |
2008-11-22 | Added | TERM | transforming growth factor beta receptor activity, type III |
2008-11-22 | Added | RELATION | is a GO:0005024 (transforming growth factor beta receptor activity) |
2008-11-22 | Added | DEFINITION | Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-11-22 | Added | TERM | transforming growth factor beta receptor activity, type III |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-11-22 | Added | SYNONYM | betaglycan |
2008-11-22 | Added | SYNONYM | endoglin |
2008-11-22 | Added | SYNONYM | type III transforming growth factor beta receptor activity |
2008-11-22 | Added | SYNONYM | transforming growth factor beta ligand binding to type III receptor |
2008-11-22 | Added | SYNONYM | type III TGFbeta receptor activity |
2008-11-22 | Added | SYNONYM | type III TGF-beta receptor activity |
2008-11-22 | Added | DEFINITION | Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-11-22 | Added | RELATION | is a GO:0005024 (transforming growth factor beta receptor activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:2.7.11.30 |
Timestamp | Action | Category | Detail |
---|
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