This term is obsolete.

GO:0070402 JSON

NADPH binding

Molecular Function

Definition (GO:0070402 GONUTS page)

Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

141,932 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
reduced NADP binding exact
NADP (reduced) binding exact
reduced nicotinamide adenine dinucleotide phosphate binding exact

Ancestor Chart

Ancestor chart for GO:0070402
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8J8XB91 10116 A0A8J8XB91_RAT GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HAS1 10116 A6HAS1_RAT GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B5DF61 10116 B5DF61_RAT GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O06553 83332 F420R_MYCTU GO:0070402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25644473
NOT-qualified manual protein Q28283 9615 TRIB2_CANLF GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9342215
NOT-qualified manual protein Q5AU62 227321 NMRA_EMENI GO:0070402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12764138
NOT-qualified manual protein Q5GLH2 9913 TRIB2_BOVIN GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q5R669 9601 TRIB2_PONAB GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q7Z7A4 9606 PXK_HUMAN GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:16142408
NOT-qualified manual protein Q8K4K3 10090 TRIB2_MOUSE GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
InterPro IPR011859 Dihydrodipicolinate reductase, plant-type
InterPro IPR013512 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:57783 NADPH(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070402 based on ALL annotations
The top 100 of 825 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NADPH binding
1,397.68 100.00 141,774 141,774
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
1,390.97 26.70 37,903 38,086
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
1,397.61 26.64 37,766 37,768
NADPH:quinone reductase activity
1,296.97 21.44 30,909 33,309
mRNA 3'-UTR AU-rich region binding
782.11 16.27 26,459 47,284
thymidylate synthase (FAD) activity
1,280.30 13.64 19,579 21,374
oxidoreductase activity, acting on NAD(P)H
201.65 10.71 41,585 288,228
thymidylate synthase activity
445.87 10.67 19,579 61,375
dTMP biosynthetic process
435.20 10.58 19,579 62,880
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
204.18 10.17 35,546 243,320
Totals 872143 103906146
No co-occurrence statistics for GO:0070402 based on MANUAL annotations
The top 100 of 493 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NADPH binding
2,215.91 100.00 637 637
NADPH:quinone reductase activity
2,144.81 28.15 181 187
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
2,172.88 15.81 101 103
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
2,172.46 15.65 100 102
oxidoreductase activity, acting on NAD(P)H
690.12 15.28 147 472
NADH binding
1,527.47 10.61 71 103
mRNA 3'-UTR AU-rich region binding
307.41 8.68 120 865
6,7-dihydropteridine reductase activity
2,101.29 8.59 55 58
tetrahydrobiopterin biosynthetic process
451.10 6.63 57 280
manganese ion binding
190.31 5.90 101 1,176
Totals 2330 32807

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2016-11-28 Added RELATION is a GO:0043168 (anion binding)
2016-06-22 Deleted RELATION is a GO:0043168 (anion binding)
2012-11-02 Added RELATION is a GO:0043168 (anion binding)
2009-07-03 Deleted DEFINITION Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-02-25 Added TERM NADPH binding
2009-02-25 Added SYNONYM reduced nicotinamide adenine dinucleotide phosphate binding
2009-02-25 Added DEFINITION Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
Timestamp Action Category Detail
2009-02-25 Added TERM NADPH binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-07-03 Deleted DEFINITION Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-02-25 Added SYNONYM reduced nicotinamide adenine dinucleotide phosphate binding
2009-02-25 Added DEFINITION Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-02-25 Added SYNONYM NADP (reduced) binding
2009-02-25 Added SYNONYM reduced NADP binding
Timestamp Action Category Detail
2016-11-28 Added RELATION is a GO:0043168 (anion binding)
2016-06-22 Deleted RELATION is a GO:0043168 (anion binding)
2012-11-02 Added RELATION is a GO:0043168 (anion binding)
2009-02-25 Added RELATION is a GO:0050661 (NADP binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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