GO:0070402
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NADPH binding
Molecular Function
Definition (GO:0070402 GONUTS page)
Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
reduced nicotinamide adenine dinucleotide phosphate binding | exact |
reduced NADP binding | exact |
NADP (reduced) binding | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | O06553 | 83332 | F420R_MYCTU | GO:0070402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25644473 | |
NOT-qualified manual | protein | Q28283 | 9615 | TRIB2_CANLF | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9342215 | |
NOT-qualified manual | protein | Q5AU62 | 227321 | NMRA_EMENI | GO:0070402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12764138 | |
NOT-qualified manual | protein | Q5GLH2 | 9913 | TRIB2_BOVIN | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q5R669 | 9601 | TRIB2_PONAB | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q7Z7A4 | 9606 | PXK_HUMAN | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:16142408 | |
NOT-qualified manual | protein | Q8K4K3 | 10090 | TRIB2_MOUSE | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q92519 | 9606 | TRIB2_HUMAN | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9PT37 | 8022 | Q9PT37_ONCMY | GO:0070402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10725344 | |
NOT-qualified manual | protein | Q9YGD6 | 8022 | Q9YGD6_ONCMY | GO:0070402 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10725344 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR011859 | Dihydrodipicolinate reductase, plant-type |
InterPro | IPR013512 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CHEBI | CHEBI:57783 | NADPH(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070402 based on ALL annotations
The top 100 of 805 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NADPH binding
|
1,405.46 | 100.00 | 138,701 | 138,701 |
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
|
1,398.54 | 26.92 | 37,390 | 37,575 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
|
1,405.39 | 26.86 | 37,250 | 37,252 |
NADPH:quinone reductase activity
|
1,300.53 | 21.25 | 29,995 | 32,415 |
mRNA 3'-UTR AU-rich region binding
|
786.13 | 16.13 | 25,638 | 45,836 |
thymidylate synthase (FAD) activity
|
1,289.48 | 13.74 | 19,289 | 21,024 |
thymidylate synthase activity
|
449.78 | 10.73 | 19,289 | 60,274 |
oxidoreductase activity, acting on NAD(P)H
|
201.86 | 10.66 | 40,564 | 282,429 |
dTMP biosynthetic process
|
439.57 | 10.65 | 19,289 | 61,674 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
|
206.49 | 10.27 | 35,254 | 239,956 |
Totals | 852310 | 101908110 |
No co-occurrence statistics for GO:0070402 based on MANUAL annotations
The top 100 of 481 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NADPH binding
|
2,196.94 | 100.00 | 588 | 588 |
NADPH:quinone reductase activity
|
2,117.05 | 26.77 | 159 | 165 |
oxidoreductase activity, acting on NAD(P)H
|
751.86 | 16.41 | 141 | 412 |
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
|
2,128.99 | 15.91 | 94 | 97 |
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
|
2,150.69 | 15.76 | 93 | 95 |
NADH binding
|
1,449.04 | 10.00 | 62 | 94 |
mRNA 3'-UTR AU-rich region binding
|
296.96 | 8.44 | 108 | 799 |
6,7-dihydropteridine reductase activity
|
2,062.43 | 7.78 | 46 | 49 |
tetrahydrobiopterin biosynthetic process
|
416.81 | 6.05 | 48 | 253 |
manganese ion binding
|
188.25 | 5.91 | 94 | 1,097 |
Totals | 2151 | 29097 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2016-11-28 | Added | RELATION | is a GO:0043168 (anion binding) |
2016-06-22 | Deleted | RELATION | is a GO:0043168 (anion binding) |
2012-11-02 | Added | RELATION | is a GO:0043168 (anion binding) |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2009-02-25 | Added | SYNONYM | reduced nicotinamide adenine dinucleotide phosphate binding |
2009-02-25 | Added | RELATION | is a GO:0050661 (NADP binding) |
2009-02-25 | Added | TERM | NADPH binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-25 | Added | TERM | NADPH binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2009-02-25 | Added | SYNONYM | reduced nicotinamide adenine dinucleotide phosphate binding |
2009-02-25 | Added | DEFINITION | Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2009-02-25 | Added | SYNONYM | NADP (reduced) binding |
2009-02-25 | Added | SYNONYM | reduced NADP binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-11-28 | Added | RELATION | is a GO:0043168 (anion binding) |
2016-06-22 | Deleted | RELATION | is a GO:0043168 (anion binding) |
2012-11-02 | Added | RELATION | is a GO:0043168 (anion binding) |
2009-02-25 | Added | RELATION | is a GO:0050661 (NADP binding) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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