This term is obsolete.

GO:0070402 JSON

NADPH binding

Molecular Function

Definition (GO:0070402 GONUTS page)

Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

138,844 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
reduced nicotinamide adenine dinucleotide phosphate binding exact
reduced NADP binding exact
NADP (reduced) binding exact

Ancestor Chart

Ancestor chart for GO:0070402
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein O06553 83332 F420R_MYCTU GO:0070402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25644473
NOT-qualified manual protein Q28283 9615 TRIB2_CANLF GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9342215
NOT-qualified manual protein Q5AU62 227321 NMRA_EMENI GO:0070402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12764138
NOT-qualified manual protein Q5GLH2 9913 TRIB2_BOVIN GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q5R669 9601 TRIB2_PONAB GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q7Z7A4 9606 PXK_HUMAN GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:16142408
NOT-qualified manual protein Q8K4K3 10090 TRIB2_MOUSE GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q92519 9606 TRIB2_HUMAN GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9PT37 8022 Q9PT37_ONCMY GO:0070402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10725344
NOT-qualified manual protein Q9YGD6 8022 Q9YGD6_ONCMY GO:0070402 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10725344

Cross-references

Database ID Description
InterPro IPR011859 Dihydrodipicolinate reductase, plant-type
InterPro IPR013512 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:57783 NADPH(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070402 based on ALL annotations
The top 100 of 805 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NADPH binding
1,405.46 100.00 138,701 138,701
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
1,398.54 26.92 37,390 37,575
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
1,405.39 26.86 37,250 37,252
NADPH:quinone reductase activity
1,300.53 21.25 29,995 32,415
mRNA 3'-UTR AU-rich region binding
786.13 16.13 25,638 45,836
thymidylate synthase (FAD) activity
1,289.48 13.74 19,289 21,024
thymidylate synthase activity
449.78 10.73 19,289 60,274
oxidoreductase activity, acting on NAD(P)H
201.86 10.66 40,564 282,429
dTMP biosynthetic process
439.57 10.65 19,289 61,674
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
206.49 10.27 35,254 239,956
Totals 852310 101908110
No co-occurrence statistics for GO:0070402 based on MANUAL annotations
The top 100 of 481 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NADPH binding
2,196.94 100.00 588 588
NADPH:quinone reductase activity
2,117.05 26.77 159 165
oxidoreductase activity, acting on NAD(P)H
751.86 16.41 141 412
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
2,128.99 15.91 94 97
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
2,150.69 15.76 93 95
NADH binding
1,449.04 10.00 62 94
mRNA 3'-UTR AU-rich region binding
296.96 8.44 108 799
6,7-dihydropteridine reductase activity
2,062.43 7.78 46 49
tetrahydrobiopterin biosynthetic process
416.81 6.05 48 253
manganese ion binding
188.25 5.91 94 1,097
Totals 2151 29097

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2016-11-28 Added RELATION is a GO:0043168 (anion binding)
2016-06-22 Deleted RELATION is a GO:0043168 (anion binding)
2012-11-02 Added RELATION is a GO:0043168 (anion binding)
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-07-03 Deleted DEFINITION Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-02-25 Added SYNONYM reduced nicotinamide adenine dinucleotide phosphate binding
2009-02-25 Added RELATION is a GO:0050661 (NADP binding)
2009-02-25 Added TERM NADPH binding
Timestamp Action Category Detail
2009-02-25 Added TERM NADPH binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-07-03 Deleted DEFINITION Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-02-25 Added SYNONYM reduced nicotinamide adenine dinucleotide phosphate binding
2009-02-25 Added DEFINITION Interacting selectively with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2009-02-25 Added SYNONYM NADP (reduced) binding
2009-02-25 Added SYNONYM reduced NADP binding
Timestamp Action Category Detail
2016-11-28 Added RELATION is a GO:0043168 (anion binding)
2016-06-22 Deleted RELATION is a GO:0043168 (anion binding)
2012-11-02 Added RELATION is a GO:0043168 (anion binding)
2009-02-25 Added RELATION is a GO:0050661 (NADP binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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