GO:0070694
JSON
5-hydroxymethyl-dUMP N-hydrolase activity
Molecular Function
Definition (GO:0070694 GONUTS page)
Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil. PMID:17234634
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
deoxynucleoside 5'-monophosphate N-glycosidase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q93Y07 | 3702 | SFR2_ARATH | GO:0016798 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25100720 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR028607 | 2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 |
RHEA | 77099 | |
Reactome | R-HSA-8953339 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:90409 | 5-hydroxymethyluridine-2'-deoxy-5'-phosphate(2-) |
has_participant | CHEBI | CHEBI:62877 | 2-deoxy-D-ribofuranose 5-phosphate(2-) |
has_participant | CHEBI | CHEBI:16964 | 5-hydroxymethyluracil |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070694 based on ALL annotations
The top 75 of 75 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
5-hydroxymethyl-dUMP N-hydrolase activity
|
36,818.07 | 100.00 | 5,382 | 5,382 |
deoxyribonucleoside monophosphate catabolic process
|
36,714.05 | 98.09 | 5,294 | 5,309 |
nucleoside salvage
|
21,790.29 | 2.65 | 145 | 245 |
hydrolase activity, hydrolyzing N-glycosyl compounds
|
437.28 | 1.13 | 1,066 | 89,756 |
nucleoside deoxyribosyltransferase activity
|
13,216.74 | 1.02 | 56 | 156 |
nucleoside metabolic process
|
252.80 | 0.67 | 1,066 | 155,254 |
nucleotide metabolic process
|
129.70 | 0.35 | 1,095 | 310,832 |
dCMP deaminase activity
|
117.03 | 0.27 | 86 | 27,055 |
epithelial cell differentiation
|
109.86 | 0.23 | 53 | 17,762 |
cytidine deamination
|
46.50 | 0.12 | 77 | 60,974 |
Totals | 20257 | 243910297 |
No co-occurrence statistics for GO:0070694 based on MANUAL annotations
The top 25 of 25 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
5-hydroxymethyl-dUMP N-hydrolase activity
|
30,032.62 | 100.00 | 47 | 47 |
deoxyribonucleoside monophosphate catabolic process
|
26,837.66 | 80.77 | 42 | 47 |
nucleoside salvage
|
15,731.37 | 19.30 | 11 | 21 |
dGMP catabolic process
|
2,730.24 | 2.99 | 2 | 22 |
allantoin metabolic process
|
1,766.62 | 2.53 | 2 | 34 |
nucleoside deoxyribosyltransferase activity
|
30,032.62 | 2.13 | 1 | 1 |
purine nucleotide catabolic process
|
3,754.08 | 1.85 | 1 | 8 |
positive regulation of cell growth
|
417.12 | 1.30 | 8 | 576 |
pyrimidine nucleotide metabolic process
|
750.82 | 1.16 | 1 | 40 |
dCMP deaminase activity
|
382.58 | 0.99 | 2 | 157 |
Totals | 178 | 755206 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-02 | Updated | TERM | 5-hydroxymethyl-dUMP N-hydrolase activity |
2024-11-02 | Deleted | DEFINITION | Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. |
2024-11-02 | Added | DEFINITION | Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil. |
2024-11-02 | Deleted | SYNONYM | deoxynucleoside 5'-monophosphate N-glycosidase activity |
2024-11-02 | Added | XREF | RHEA:77099 |
2024-11-02 | Added | SYNONYM | deoxynucleoside 5'-monophosphate N-glycosidase activity |
2021-05-15 | Deleted | XREF | EC:3.2.2.- |
2021-01-04 | Deleted | XREF | EC:3.2.2 |
2021-01-04 | Added | XREF | EC:3.2.2.- |
2020-01-26 | Deleted | XREF | IMG:03312 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-02 | Updated | TERM | 5-hydroxymethyl-dUMP N-hydrolase activity |
2009-06-11 | Added | TERM | deoxyribonucleoside 5'-monophosphate N-glycosidase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-02 | Deleted | DEFINITION | Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. |
2024-11-02 | Added | DEFINITION | Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil. |
2024-11-02 | Deleted | SYNONYM | deoxynucleoside 5'-monophosphate N-glycosidase activity |
2024-11-02 | Added | SYNONYM | deoxynucleoside 5'-monophosphate N-glycosidase activity |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H20 = deoxyribose 5-monophosphate + a purine or pyrimidine base. |
2009-07-12 | Added | SYNONYM | deoxynucleoside 5'-monophosphate N-glycosidase activity |
2009-06-11 | Added | DEFINITION | Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H20 = deoxyribose 5-monophosphate + a purine or pyrimidine base. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-06-11 | Added | RELATION | is a GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-02 | Added | XREF | RHEA:77099 |
2021-05-15 | Deleted | XREF | EC:3.2.2.- |
2021-01-04 | Deleted | XREF | EC:3.2.2 |
2021-01-04 | Added | XREF | EC:3.2.2.- |
2020-01-26 | Deleted | XREF | IMG:03312 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8953339 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8953339 |
2018-12-11 | Added | XREF | reactome:R-HSA-8953339 |
2016-10-03 | Deleted | XREF | EC:3.2.2.- |
2016-10-03 | Added | XREF | EC:3.2.2 |
2009-07-12 | Added | XREF | IMG:03312 |
2009-06-11 | Added | XREF | EC:3.2.2.- |
Timestamp | Action | Category | Detail |
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