This term is obsolete.

GO:0070694 JSON

5-hydroxymethyl-dUMP N-hydrolase activity

Molecular Function

Definition (GO:0070694 GONUTS page)

Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil. PMID:17234634

5,434 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
deoxynucleoside 5'-monophosphate N-glycosidase activity broad

Ancestor Chart

Ancestor chart for GO:0070694
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q93Y07 3702 SFR2_ARATH GO:0016798 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25100720

Cross-references

Database ID Description
InterPro IPR028607 2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1
RHEA 77099
Reactome R-HSA-8953339

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:90409 5-hydroxymethyluridine-2'-deoxy-5'-phosphate(2-)
has_participant CHEBI CHEBI:62877 2-deoxy-D-ribofuranose 5-phosphate(2-)
has_participant CHEBI CHEBI:16964 5-hydroxymethyluracil

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070694 based on ALL annotations
The top 75 of 75 co-occurring terms
Co-occurring Term PR S% #Together #Compared
5-hydroxymethyl-dUMP N-hydrolase activity
36,818.07 100.00 5,382 5,382
deoxyribonucleoside monophosphate catabolic process
36,714.05 98.09 5,294 5,309
nucleoside salvage
21,790.29 2.65 145 245
hydrolase activity, hydrolyzing N-glycosyl compounds
437.28 1.13 1,066 89,756
nucleoside deoxyribosyltransferase activity
13,216.74 1.02 56 156
nucleoside metabolic process
252.80 0.67 1,066 155,254
nucleotide metabolic process
129.70 0.35 1,095 310,832
dCMP deaminase activity
117.03 0.27 86 27,055
epithelial cell differentiation
109.86 0.23 53 17,762
cytidine deamination
46.50 0.12 77 60,974
Totals 20257 243910297
No co-occurrence statistics for GO:0070694 based on MANUAL annotations
The top 25 of 25 co-occurring terms
Co-occurring Term PR S% #Together #Compared
5-hydroxymethyl-dUMP N-hydrolase activity
30,032.62 100.00 47 47
deoxyribonucleoside monophosphate catabolic process
26,837.66 80.77 42 47
nucleoside salvage
15,731.37 19.30 11 21
dGMP catabolic process
2,730.24 2.99 2 22
allantoin metabolic process
1,766.62 2.53 2 34
nucleoside deoxyribosyltransferase activity
30,032.62 2.13 1 1
purine nucleotide catabolic process
3,754.08 1.85 1 8
positive regulation of cell growth
417.12 1.30 8 576
pyrimidine nucleotide metabolic process
750.82 1.16 1 40
dCMP deaminase activity
382.58 0.99 2 157
Totals 178 755206

Change Log

Timestamp Action Category Detail
2024-11-02 Updated TERM 5-hydroxymethyl-dUMP N-hydrolase activity
2024-11-02 Deleted DEFINITION Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base.
2024-11-02 Added DEFINITION Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil.
2024-11-02 Deleted SYNONYM deoxynucleoside 5'-monophosphate N-glycosidase activity
2024-11-02 Added XREF RHEA:77099
2024-11-02 Added SYNONYM deoxynucleoside 5'-monophosphate N-glycosidase activity
2021-05-15 Deleted XREF EC:3.2.2.-
2021-01-04 Deleted XREF EC:3.2.2
2021-01-04 Added XREF EC:3.2.2.-
2020-01-26 Deleted XREF IMG:03312
Timestamp Action Category Detail
2024-11-02 Updated TERM 5-hydroxymethyl-dUMP N-hydrolase activity
2009-06-11 Added TERM deoxyribonucleoside 5'-monophosphate N-glycosidase activity
Timestamp Action Category Detail
2024-11-02 Deleted DEFINITION Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base.
2024-11-02 Added DEFINITION Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil.
2024-11-02 Deleted SYNONYM deoxynucleoside 5'-monophosphate N-glycosidase activity
2024-11-02 Added SYNONYM deoxynucleoside 5'-monophosphate N-glycosidase activity
2010-09-03 Added DEFINITION Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H20 = deoxyribose 5-monophosphate + a purine or pyrimidine base.
2009-07-12 Added SYNONYM deoxynucleoside 5'-monophosphate N-glycosidase activity
2009-06-11 Added DEFINITION Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H20 = deoxyribose 5-monophosphate + a purine or pyrimidine base.
Timestamp Action Category Detail
2009-06-11 Added RELATION is a GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds)
Timestamp Action Category Detail
2024-11-02 Added XREF RHEA:77099
2021-05-15 Deleted XREF EC:3.2.2.-
2021-01-04 Deleted XREF EC:3.2.2
2021-01-04 Added XREF EC:3.2.2.-
2020-01-26 Deleted XREF IMG:03312
2019-04-01 Deleted XREF reactome:R-HSA-8953339
2019-04-01 Added XREF Reactome:R-HSA-8953339
2018-12-11 Added XREF reactome:R-HSA-8953339
2016-10-03 Deleted XREF EC:3.2.2.-
2016-10-03 Added XREF EC:3.2.2
2009-07-12 Added XREF IMG:03312
2009-06-11 Added XREF EC:3.2.2.-
Timestamp Action Category Detail
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