Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.
GO:0070743
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interleukin-23 complex
Cellular Component
Definition (GO:0070743 GONUTS page)
A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. PMID:11114383 PMID:15999093
Comments
Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
IL12B | narrow |
IL-23 complex | exact |
p19 | narrow |
p40 | narrow |
IL23A | narrow |
Ancestor Chart
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q99470 | 9606 | SDF2_HUMAN | GO:0005576 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0G2JY81 | 10116 | A0A0G2JY81_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A7U3L4H9 | 10116 | A0A7U3L4H9_RAT | GO:0005576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AAN5 | 10116 | A0A8I6AAN5_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A1Z7L0 | 7227 | A1Z7L0_DROME | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:35714143 | |
NOT-qualified manual | protein | A4QNU9 | 7955 | A4QNU9_DANRE | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22292055 | |
NOT-qualified manual | protein | A6HTD8 | 10116 | A6HTD8_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HWX9 | 10116 | A6HWX9_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K8X7 | 10116 | A6K8X7_RAT | GO:0005576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B1WC21 | 10116 | B1WC21_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070743 based on ALL annotations
The top 89 of 89 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
interleukin-23 complex
|
667,598.56 | 100.00 | 292 | 292 |
interleukin-23 receptor binding
|
660,342.06 | 61.90 | 182 | 184 |
positive regulation of NK T cell activation
|
455,067.22 | 48.28 | 182 | 267 |
positive regulation of T-helper 17 cell lineage commitment
|
269,821.12 | 33.56 | 194 | 480 |
interleukin-12 alpha subunit binding
|
654,246.60 | 33.33 | 98 | 100 |
positive regulation of NK T cell proliferation
|
227,108.31 | 28.22 | 182 | 535 |
interleukin-12 complex
|
355,568.80 | 25.93 | 98 | 184 |
positive regulation of natural killer cell proliferation
|
195,972.48 | 24.93 | 182 | 620 |
positive regulation of T-helper 1 type immune response
|
173,291.55 | 22.48 | 183 | 705 |
positive regulation of smooth muscle cell apoptotic process
|
224,827.02 | 20.21 | 98 | 291 |
Totals | 9869 | 100326759 |
No co-occurrence statistics for GO:0070743 based on MANUAL annotations
The top 82 of 82 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
interleukin-23 complex
|
75,988.18 | 100.00 | 17 | 17 |
interleukin-23 receptor binding
|
60,790.54 | 42.11 | 8 | 10 |
positive regulation of T-helper 1 type immune response
|
29,359.07 | 38.64 | 17 | 44 |
interleukin-12 alpha subunit binding
|
56,991.13 | 31.58 | 6 | 8 |
positive regulation of NK T cell activation
|
35,461.15 | 28.00 | 7 | 15 |
positive regulation of T-helper 17 cell lineage commitment
|
19,823.00 | 23.53 | 12 | 46 |
interleukin-12 complex
|
28,495.57 | 22.22 | 6 | 16 |
positive regulation of NK T cell proliferation
|
17,158.62 | 17.07 | 7 | 31 |
T-helper cell differentiation
|
18,237.16 | 16.67 | 6 | 25 |
positive regulation of mononuclear cell proliferation
|
19,996.89 | 16.13 | 5 | 19 |
Totals | 455 | 419757 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0044421 (obsolete extracellular region part) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2009-06-26 | Added | SYNONYM | p19 |
2009-06-26 | Added | SYNONYM | IL-23 complex |
2009-06-26 | Added | TERM | interleukin-23 complex |
2009-06-26 | Added | DEFINITION | A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. |
2009-06-26 | Added | RELATION | part of GO:0005615 (extracellular space) |
2009-06-26 | Added | RELATION | is a GO:0043234 (protein complex) |
2009-06-26 | Added | RELATION | is a GO:0044421 (obsolete extracellular region part) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-06-26 | Added | TERM | interleukin-23 complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-06-26 | Added | SYNONYM | p19 |
2009-06-26 | Added | SYNONYM | IL-23 complex |
2009-06-26 | Added | DEFINITION | A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. |
2009-06-26 | Added | SYNONYM | IL12B |
2009-06-26 | Added | SYNONYM | IL23A |
2009-06-26 | Added | SYNONYM | p40 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0044421 (obsolete extracellular region part) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2009-06-26 | Added | RELATION | part of GO:0005615 (extracellular space) |
2009-06-26 | Added | RELATION | is a GO:0043234 (protein complex) |
2009-06-26 | Added | RELATION | is a GO:0044421 (obsolete extracellular region part) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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