This term is obsolete.
Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.

GO:0070743 JSON

interleukin-23 complex

Cellular Component

Definition (GO:0070743 GONUTS page)

A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. PMID:11114383 PMID:15999093

Comments

Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.

316 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
IL-23 complex exact
IL23A narrow
IL12B narrow
p19 narrow
p40 narrow

Ancestor Chart

Ancestor chart for GO:0070743
Chart options
Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q99470 9606 SDF2_HUMAN GO:0005576 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0G2JY81 10116 A0A0G2JY81_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A7U3L4H9 10116 A0A7U3L4H9_RAT GO:0005576 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AAN5 10116 A0A8I6AAN5_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A1Z7L0 7227 A1Z7L0_DROME GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:35714143
NOT-qualified manual protein A4QNU9 7955 A4QNU9_DANRE GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22292055
NOT-qualified manual protein A6HTD8 10116 A6HTD8_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HWX9 10116 A6HWX9_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K8X7 10116 A6K8X7_RAT GO:0005576 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B1WC21 10116 B1WC21_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070743 based on ALL annotations
The top 84 of 84 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-23 complex
676,296.44 100.00 293 293
interleukin-23 receptor binding
668,945.44 61.69 182 184
positive regulation of NK T cell activation
460,996.10 48.15 182 267
positive regulation of T-helper 17 cell lineage commitment
275,008.53 33.85 196 482
interleukin-12 alpha subunit binding
586,522.60 31.82 98 113
positive regulation of NK T cell proliferation
230,498.05 28.22 182 534
positive regulation of natural killer cell proliferation
198,846.45 24.93 182 619
interleukin-12 complex
314,109.25 24.14 98 211
positive regulation of T-helper 1 type immune response
175,798.64 22.48 183 704
positive regulation of smooth muscle cell apoptotic process
230,128.66 20.29 98 288
Totals 9852 101794163
No co-occurrence statistics for GO:0070743 based on MANUAL annotations
The top 76 of 76 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-23 complex
74,291.21 100.00 19 19
positive regulation of T-helper 1 type immune response
31,367.40 42.22 19 45
interleukin-23 receptor binding
59,432.97 38.10 8 10
positive regulation of T-helper 17 cell lineage commitment
21,668.27 26.42 14 48
positive regulation of NK T cell activation
34,669.23 25.93 7 15
T-helper cell differentiation
22,287.36 18.18 6 20
positive regulation of NK T cell proliferation
16,775.43 16.28 7 31
positive regulation of mononuclear cell proliferation
19,550.32 15.15 5 19
positive regulation of granulocyte macrophage colony-stimulating factor production
14,445.51 14.58 7 36
interleukin-12 alpha subunit binding
13,929.60 13.33 6 32
Totals 439 437824

Change Log

Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044421 (obsolete extracellular region part)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2009-06-26 Added SYNONYM p40
2009-06-26 Added DEFINITION A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
2009-06-26 Added TERM interleukin-23 complex
2009-06-26 Added SYNONYM IL-23 complex
2009-06-26 Added RELATION part of GO:0005615 (extracellular space)
2009-06-26 Added RELATION is a GO:0043234 (protein complex)
2009-06-26 Added RELATION is a GO:0044421 (obsolete extracellular region part)
Timestamp Action Category Detail
2009-06-26 Added TERM interleukin-23 complex
Timestamp Action Category Detail
2009-06-26 Added SYNONYM p40
2009-06-26 Added DEFINITION A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
2009-06-26 Added SYNONYM IL-23 complex
2009-06-26 Added SYNONYM IL23A
2009-06-26 Added SYNONYM IL12B
2009-06-26 Added SYNONYM p19
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044421 (obsolete extracellular region part)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2009-06-26 Added RELATION part of GO:0005615 (extracellular space)
2009-06-26 Added RELATION is a GO:0043234 (protein complex)
2009-06-26 Added RELATION is a GO:0044421 (obsolete extracellular region part)
Timestamp Action Category Detail
Timestamp Action Category Detail
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