This term is obsolete.
Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.

GO:0070743 JSON

interleukin-23 complex

Cellular Component

Definition (GO:0070743 GONUTS page)

A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. PMID:11114383 PMID:15999093

Comments

Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.

313 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
IL12B narrow
IL-23 complex exact
p19 narrow
p40 narrow
IL23A narrow

Ancestor Chart

Ancestor chart for GO:0070743
Chart options
Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q99470 9606 SDF2_HUMAN GO:0005576 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0G2JY81 10116 A0A0G2JY81_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A7U3L4H9 10116 A0A7U3L4H9_RAT GO:0005576 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AAN5 10116 A0A8I6AAN5_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A1Z7L0 7227 A1Z7L0_DROME GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:35714143
NOT-qualified manual protein A4QNU9 7955 A4QNU9_DANRE GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22292055
NOT-qualified manual protein A6HTD8 10116 A6HTD8_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HWX9 10116 A6HWX9_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K8X7 10116 A6K8X7_RAT GO:0005576 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B1WC21 10116 B1WC21_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070743 based on ALL annotations
The top 89 of 89 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-23 complex
667,598.56 100.00 292 292
interleukin-23 receptor binding
660,342.06 61.90 182 184
positive regulation of NK T cell activation
455,067.22 48.28 182 267
positive regulation of T-helper 17 cell lineage commitment
269,821.12 33.56 194 480
interleukin-12 alpha subunit binding
654,246.60 33.33 98 100
positive regulation of NK T cell proliferation
227,108.31 28.22 182 535
interleukin-12 complex
355,568.80 25.93 98 184
positive regulation of natural killer cell proliferation
195,972.48 24.93 182 620
positive regulation of T-helper 1 type immune response
173,291.55 22.48 183 705
positive regulation of smooth muscle cell apoptotic process
224,827.02 20.21 98 291
Totals 9869 100326759
No co-occurrence statistics for GO:0070743 based on MANUAL annotations
The top 82 of 82 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-23 complex
75,988.18 100.00 17 17
interleukin-23 receptor binding
60,790.54 42.11 8 10
positive regulation of T-helper 1 type immune response
29,359.07 38.64 17 44
interleukin-12 alpha subunit binding
56,991.13 31.58 6 8
positive regulation of NK T cell activation
35,461.15 28.00 7 15
positive regulation of T-helper 17 cell lineage commitment
19,823.00 23.53 12 46
interleukin-12 complex
28,495.57 22.22 6 16
positive regulation of NK T cell proliferation
17,158.62 17.07 7 31
T-helper cell differentiation
18,237.16 16.67 6 25
positive regulation of mononuclear cell proliferation
19,996.89 16.13 5 19
Totals 455 419757

Change Log

Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044421 (obsolete extracellular region part)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2009-06-26 Added SYNONYM p19
2009-06-26 Added SYNONYM IL-23 complex
2009-06-26 Added TERM interleukin-23 complex
2009-06-26 Added DEFINITION A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
2009-06-26 Added RELATION part of GO:0005615 (extracellular space)
2009-06-26 Added RELATION is a GO:0043234 (protein complex)
2009-06-26 Added RELATION is a GO:0044421 (obsolete extracellular region part)
Timestamp Action Category Detail
2009-06-26 Added TERM interleukin-23 complex
Timestamp Action Category Detail
2009-06-26 Added SYNONYM p19
2009-06-26 Added SYNONYM IL-23 complex
2009-06-26 Added DEFINITION A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
2009-06-26 Added SYNONYM IL12B
2009-06-26 Added SYNONYM IL23A
2009-06-26 Added SYNONYM p40
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044421 (obsolete extracellular region part)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2009-06-26 Added RELATION part of GO:0005615 (extracellular space)
2009-06-26 Added RELATION is a GO:0043234 (protein complex)
2009-06-26 Added RELATION is a GO:0044421 (obsolete extracellular region part)
Timestamp Action Category Detail
Timestamp Action Category Detail
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