This term is obsolete.

GO:0070847 JSON

core mediator complex

Cellular Component

Definition (GO:0070847 GONUTS page)

A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. PMID:11454195 PMID:16168358 PMID:17870225

24,562 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
C mediator complex exact
S mediator complex exact

Ancestor Chart

Ancestor chart for GO:0070847
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0070847 core mediator complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A0E5 10116 A0A8I6A0E5_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070847 based on ALL annotations
The top 100 of 343 co-occurring terms
Co-occurring Term PR S% #Together #Compared
core mediator complex
7,993.23 100.00 24,388 24,388
mediator complex
1,721.77 21.52 24,284 112,737
transcription coregulator activity
1,066.80 13.31 23,878 178,911
termination of RNA polymerase II transcription
1,448.28 7.32 2,668 14,725
positive regulation of transcription initiation by RNA polymerase II
750.78 3.35 1,208 12,861
somatic stem cell population maintenance
1,321.43 2.62 736 4,452
nuclear thyroid hormone receptor binding
845.04 1.96 573 5,420
positive regulation of gene expression
205.96 1.92 1,717 66,636
regulation of transcription by RNA polymerase II
84.34 1.05 23,687 2,244,948
transcription coactivator binding
395.47 0.90 264 5,336
Totals 142507 16431471
No co-occurrence statistics for GO:0070847 based on MANUAL annotations
The top 100 of 183 co-occurring terms
Co-occurring Term PR S% #Together #Compared
core mediator complex
1,484.83 100.00 870 870
mediator complex
444.63 28.74 763 2,548
positive regulation of transcription initiation by RNA polymerase II
650.24 17.34 194 443
transcription coregulator activity
163.68 10.11 477 4,327
somatic stem cell population maintenance
228.09 4.43 51 332
transcription coactivator activity
63.45 3.71 192 4,493
RNA polymerase II preinitiation complex assembly
89.80 3.64 73 1,207
positive regulation of transcription elongation by RNA polymerase II
78.89 3.36 73 1,374
nuclear thyroid hormone receptor binding
246.01 2.77 28 169
transcription coactivator binding
112.40 1.72 19 251
Totals 4415 174990

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2020-04-25 Added RELATION part of GO:0005634 (nucleus)
2018-07-12 Deleted RELATION part of GO:0016591 (RNA polymerase II, holoenzyme)
2018-07-12 Deleted RELATION is a GO:0044451 (obsolete nucleoplasm part)
2014-11-28 Added RELATION is a GO:0090575 (RNA polymerase II transcription regulator complex)
2014-11-28 Deleted RELATION is a GO:0043234 (protein complex)
2010-06-15 Added RELATION has part GO:0016592 (mediator complex)
2010-06-14 Deleted RELATION has part GO:0016592 (mediator complex)
2010-06-08 Added RELATION has part GO:0016592 (mediator complex)
Timestamp Action Category Detail
2009-08-06 Added TERM core mediator complex
Timestamp Action Category Detail
2009-08-06 Added SYNONYM C mediator complex
2009-08-06 Added DEFINITION A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
2009-08-06 Added SYNONYM S mediator complex
Timestamp Action Category Detail
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2020-04-25 Added RELATION part of GO:0005634 (nucleus)
2018-07-12 Deleted RELATION part of GO:0016591 (RNA polymerase II, holoenzyme)
2018-07-12 Deleted RELATION is a GO:0044451 (obsolete nucleoplasm part)
2014-11-28 Added RELATION is a GO:0090575 (RNA polymerase II transcription regulator complex)
2014-11-28 Deleted RELATION is a GO:0043234 (protein complex)
2010-06-15 Added RELATION has part GO:0016592 (mediator complex)
2010-06-14 Deleted RELATION has part GO:0016592 (mediator complex)
2010-06-08 Added RELATION has part GO:0016592 (mediator complex)
2009-08-06 Added RELATION part of GO:0016591 (RNA polymerase II, holoenzyme)
2009-08-06 Added RELATION is a GO:0043234 (protein complex)
2009-08-06 Added RELATION is a GO:0044451 (obsolete nucleoplasm part)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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