GO:0070847
JSON
core mediator complex
Cellular Component
Definition (GO:0070847 GONUTS page)
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. PMID:11454195 PMID:16168358 PMID:17870225
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
C mediator complex | exact |
S mediator complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0070847 | core mediator complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A0E5 | 10116 | A0A8I6A0E5_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070847 based on ALL annotations
The top 100 of 343 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
core mediator complex
|
7,993.23 | 100.00 | 24,388 | 24,388 |
mediator complex
|
1,721.77 | 21.52 | 24,284 | 112,737 |
transcription coregulator activity
|
1,066.80 | 13.31 | 23,878 | 178,911 |
termination of RNA polymerase II transcription
|
1,448.28 | 7.32 | 2,668 | 14,725 |
positive regulation of transcription initiation by RNA polymerase II
|
750.78 | 3.35 | 1,208 | 12,861 |
somatic stem cell population maintenance
|
1,321.43 | 2.62 | 736 | 4,452 |
nuclear thyroid hormone receptor binding
|
845.04 | 1.96 | 573 | 5,420 |
positive regulation of gene expression
|
205.96 | 1.92 | 1,717 | 66,636 |
regulation of transcription by RNA polymerase II
|
84.34 | 1.05 | 23,687 | 2,244,948 |
transcription coactivator binding
|
395.47 | 0.90 | 264 | 5,336 |
Totals | 142507 | 16431471 |
No co-occurrence statistics for GO:0070847 based on MANUAL annotations
The top 100 of 183 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
core mediator complex
|
1,484.83 | 100.00 | 870 | 870 |
mediator complex
|
444.63 | 28.74 | 763 | 2,548 |
positive regulation of transcription initiation by RNA polymerase II
|
650.24 | 17.34 | 194 | 443 |
transcription coregulator activity
|
163.68 | 10.11 | 477 | 4,327 |
somatic stem cell population maintenance
|
228.09 | 4.43 | 51 | 332 |
transcription coactivator activity
|
63.45 | 3.71 | 192 | 4,493 |
RNA polymerase II preinitiation complex assembly
|
89.80 | 3.64 | 73 | 1,207 |
positive regulation of transcription elongation by RNA polymerase II
|
78.89 | 3.36 | 73 | 1,374 |
nuclear thyroid hormone receptor binding
|
246.01 | 2.77 | 28 | 169 |
transcription coactivator binding
|
112.40 | 1.72 | 19 | 251 |
Totals | 4415 | 174990 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2020-04-25 | Added | RELATION | part of GO:0005634 (nucleus) |
2018-07-12 | Deleted | RELATION | part of GO:0016591 (RNA polymerase II, holoenzyme) |
2018-07-12 | Deleted | RELATION | is a GO:0044451 (obsolete nucleoplasm part) |
2014-11-28 | Added | RELATION | is a GO:0090575 (RNA polymerase II transcription regulator complex) |
2014-11-28 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2010-06-15 | Added | RELATION | has part GO:0016592 (mediator complex) |
2010-06-14 | Deleted | RELATION | has part GO:0016592 (mediator complex) |
2010-06-08 | Added | RELATION | has part GO:0016592 (mediator complex) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-08-06 | Added | TERM | core mediator complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-08-06 | Added | SYNONYM | C mediator complex |
2009-08-06 | Added | DEFINITION | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
2009-08-06 | Added | SYNONYM | S mediator complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2020-04-25 | Added | RELATION | part of GO:0005634 (nucleus) |
2018-07-12 | Deleted | RELATION | part of GO:0016591 (RNA polymerase II, holoenzyme) |
2018-07-12 | Deleted | RELATION | is a GO:0044451 (obsolete nucleoplasm part) |
2014-11-28 | Added | RELATION | is a GO:0090575 (RNA polymerase II transcription regulator complex) |
2014-11-28 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2010-06-15 | Added | RELATION | has part GO:0016592 (mediator complex) |
2010-06-14 | Deleted | RELATION | has part GO:0016592 (mediator complex) |
2010-06-08 | Added | RELATION | has part GO:0016592 (mediator complex) |
2009-08-06 | Added | RELATION | part of GO:0016591 (RNA polymerase II, holoenzyme) |
2009-08-06 | Added | RELATION | is a GO:0043234 (protein complex) |
2009-08-06 | Added | RELATION | is a GO:0044451 (obsolete nucleoplasm part) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link