This term is obsolete.

GO:0070888 JSON

E-box binding

Molecular Function

Definition (GO:0070888 GONUTS page)

Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. PMID:11812799

Acknowledgement

This term was created by the GO Consortium with support from: BHF image

19,441 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
E-box promoter binding exact

Ancestor Chart

Ancestor chart for GO:0070888
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0070888

Child Term Relationship to
GO:0070888
CLOCK-BMAL transcription complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link
Considerations when annotating from ChiP assay results Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein P40999 284812 PMT1M_SCHPO GO:0003677 To remove over-annotation from InterPro entries IPR001525 and IPR018117; for this particular C5-methyltransferase family member, there is a Ser residue in the active site that may be responsible. Reported by InterPro on 19-10-2012
NOT-qualified manual protein A0A0G2JVM9 10116 A0A0G2JVM9_RAT GO:0000978 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A0G2K0G0 10116 A0A0G2K0G0_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K6Q9 10116 A0A0G2K6Q9_RAT GO:0003690 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GWQ8 10116 A0A1B0GWQ8_RAT GO:0003677 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1D8PIK2 237561 A0A1D8PIK2_CANAL GO:0000976 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20008550
NOT-qualified manual protein A0A287AGK9 9823 A0A287AGK9_PIG GO:0000978 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2I2ZSU6 9595 A0A2I2ZSU6_GORGO GO:0000978 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A337SMT8 9685 A0A337SMT8_FELCA GO:0000978 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A3Q2H1G8 9796 A0A3Q2H1G8_HORSE GO:0000978 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070888 based on ALL annotations
The top 100 of 1,457 co-occurring terms
Co-occurring Term PR S% #Together #Compared
E-box binding
10,175.32 100.00 19,158 19,158
sensory organ development
8,557.03 55.09 11,781 14,009
axon development
6,604.82 48.03 12,429 19,148
CLOCK-BMAL transcription complex
4,929.14 9.94 2,130 4,397
circadian regulation of gene expression
828.32 5.53 2,821 34,654
bHLH transcription factor binding
4,480.88 4.93 1,008 2,289
camera-type eye development
1,137.63 3.75 1,024 9,159
sequence-specific double-stranded DNA binding
453.94 3.59 2,980 66,798
forebrain development
1,153.83 3.51 927 8,175
oligodendrocyte differentiation
1,341.13 3.19 775 5,880
Totals 150950 5075769
No co-occurrence statistics for GO:0070888 based on MANUAL annotations
The top 100 of 1,350 co-occurring terms
Co-occurring Term PR S% #Together #Compared
E-box binding
2,174.75 100.00 594 594
axon development
1,324.54 37.76 296 486
sensory organ development
997.20 30.42 282 615
neuron fate commitment
1,096.36 17.09 122 242
circadian regulation of gene expression
244.35 6.90 90 801
bHLH transcription factor binding
714.10 6.43 44 134
CLOCK-BMAL transcription complex
994.17 5.06 32 70
forebrain development
205.42 4.44 46 487
positive regulation of neuron differentiation
202.85 4.25 43 461
negative regulation of monocyte differentiation
1,208.19 4.07 25 45
Totals 4002 64855

Change Log

Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
2021-05-24 Added DEFINITION Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
2017-11-25 Added RELATION is a GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
2017-11-25 Deleted RELATION is a GO:0000976 (transcription cis-regulatory region binding)
2017-11-03 Added RELATION is a GO:0000976 (transcription cis-regulatory region binding)
2017-11-03 Deleted RELATION is a GO:0044212 (transcription regulatory region DNA binding)
2011-05-13 Deleted RELATION is a GO:0010843 (obsolete promoter binding)
2011-05-13 Added RELATION is a GO:0044212 (transcription regulatory region DNA binding)
2010-09-09 Deleted DEFINITION Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes in neurons, muscle and other tissues.
2010-09-09 Added DEFINITION Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
Timestamp Action Category Detail
2009-08-31 Added TERM E-box binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
2021-05-24 Added DEFINITION Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
2010-09-09 Deleted DEFINITION Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes in neurons, muscle and other tissues.
2010-09-09 Added DEFINITION Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
2009-08-31 Added DEFINITION Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes in neurons, muscle and other tissues.
2009-08-31 Added SYNONYM E-box promoter binding
Timestamp Action Category Detail
2017-11-25 Added RELATION is a GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
2017-11-25 Deleted RELATION is a GO:0000976 (transcription cis-regulatory region binding)
2017-11-03 Added RELATION is a GO:0000976 (transcription cis-regulatory region binding)
2017-11-03 Deleted RELATION is a GO:0044212 (transcription regulatory region DNA binding)
2011-05-13 Deleted RELATION is a GO:0010843 (obsolete promoter binding)
2011-05-13 Added RELATION is a GO:0044212 (transcription regulatory region DNA binding)
2009-08-31 Added RELATION is a GO:0010843 (obsolete promoter binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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