GO:0070888
JSON
E-box binding
Molecular Function
Definition (GO:0070888 GONUTS page)
Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. PMID:11812799
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
E-box promoter binding | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0070888
Child Term | Relationship to GO:0070888 |
---|---|
CLOCK-BMAL transcription complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Considerations when annotating from ChiP assay results | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | P40999 | 284812 | PMT1M_SCHPO | GO:0003677 | To remove over-annotation from InterPro entries IPR001525 and IPR018117; for this particular C5-methyltransferase family member, there is a Ser residue in the active site that may be responsible. Reported by InterPro on 19-10-2012 | |
NOT-qualified manual | protein | A0A0G2JVM9 | 10116 | A0A0G2JVM9_RAT | GO:0000978 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A0G2K0G0 | 10116 | A0A0G2K0G0_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K6Q9 | 10116 | A0A0G2K6Q9_RAT | GO:0003690 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GWQ8 | 10116 | A0A1B0GWQ8_RAT | GO:0003677 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1D8PIK2 | 237561 | A0A1D8PIK2_CANAL | GO:0000976 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20008550 | |
NOT-qualified manual | protein | A0A287AGK9 | 9823 | A0A287AGK9_PIG | GO:0000978 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2I2ZSU6 | 9595 | A0A2I2ZSU6_GORGO | GO:0000978 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A337SMT8 | 9685 | A0A337SMT8_FELCA | GO:0000978 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A3Q2H1G8 | 9796 | A0A3Q2H1G8_HORSE | GO:0000978 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070888 based on ALL annotations
The top 100 of 1,457 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
E-box binding
|
10,175.32 | 100.00 | 19,158 | 19,158 |
sensory organ development
|
8,557.03 | 55.09 | 11,781 | 14,009 |
axon development
|
6,604.82 | 48.03 | 12,429 | 19,148 |
CLOCK-BMAL transcription complex
|
4,929.14 | 9.94 | 2,130 | 4,397 |
circadian regulation of gene expression
|
828.32 | 5.53 | 2,821 | 34,654 |
bHLH transcription factor binding
|
4,480.88 | 4.93 | 1,008 | 2,289 |
camera-type eye development
|
1,137.63 | 3.75 | 1,024 | 9,159 |
sequence-specific double-stranded DNA binding
|
453.94 | 3.59 | 2,980 | 66,798 |
forebrain development
|
1,153.83 | 3.51 | 927 | 8,175 |
oligodendrocyte differentiation
|
1,341.13 | 3.19 | 775 | 5,880 |
Totals | 150950 | 5075769 |
No co-occurrence statistics for GO:0070888 based on MANUAL annotations
The top 100 of 1,350 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
E-box binding
|
2,174.75 | 100.00 | 594 | 594 |
axon development
|
1,324.54 | 37.76 | 296 | 486 |
sensory organ development
|
997.20 | 30.42 | 282 | 615 |
neuron fate commitment
|
1,096.36 | 17.09 | 122 | 242 |
circadian regulation of gene expression
|
244.35 | 6.90 | 90 | 801 |
bHLH transcription factor binding
|
714.10 | 6.43 | 44 | 134 |
CLOCK-BMAL transcription complex
|
994.17 | 5.06 | 32 | 70 |
forebrain development
|
205.42 | 4.44 | 46 | 487 |
positive regulation of neuron differentiation
|
202.85 | 4.25 | 43 | 461 |
negative regulation of monocyte differentiation
|
1,208.19 | 4.07 | 25 | 45 |
Totals | 4002 | 64855 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
2021-05-24 | Added | DEFINITION | Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
2017-11-25 | Added | RELATION | is a GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding) |
2017-11-25 | Deleted | RELATION | is a GO:0000976 (transcription cis-regulatory region binding) |
2017-11-03 | Added | RELATION | is a GO:0000976 (transcription cis-regulatory region binding) |
2017-11-03 | Deleted | RELATION | is a GO:0044212 (transcription regulatory region DNA binding) |
2011-05-13 | Deleted | RELATION | is a GO:0010843 (obsolete promoter binding) |
2011-05-13 | Added | RELATION | is a GO:0044212 (transcription regulatory region DNA binding) |
2010-09-09 | Deleted | DEFINITION | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes in neurons, muscle and other tissues. |
2010-09-09 | Added | DEFINITION | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-08-31 | Added | TERM | E-box binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
2021-05-24 | Added | DEFINITION | Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
2010-09-09 | Deleted | DEFINITION | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes in neurons, muscle and other tissues. |
2010-09-09 | Added | DEFINITION | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
2009-08-31 | Added | DEFINITION | Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes in neurons, muscle and other tissues. |
2009-08-31 | Added | SYNONYM | E-box promoter binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-11-25 | Added | RELATION | is a GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding) |
2017-11-25 | Deleted | RELATION | is a GO:0000976 (transcription cis-regulatory region binding) |
2017-11-03 | Added | RELATION | is a GO:0000976 (transcription cis-regulatory region binding) |
2017-11-03 | Deleted | RELATION | is a GO:0044212 (transcription regulatory region DNA binding) |
2011-05-13 | Deleted | RELATION | is a GO:0010843 (obsolete promoter binding) |
2011-05-13 | Added | RELATION | is a GO:0044212 (transcription regulatory region DNA binding) |
2009-08-31 | Added | RELATION | is a GO:0010843 (obsolete promoter binding) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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