This term is obsolete.
Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.

GO:0070987 JSON

error-free translesion synthesis

Biological Process

Definition (GO:0070987 GONUTS page)

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.

Comments

Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.

21,207 annotations

Ancestor Chart

Ancestor chart for GO:0070987
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Guidance for interpreting DNA repair investigations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A6K9T7 10116 A6K9T7_RAT GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K9T7 10116 A6K9T7_RAT GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8VU90 10090 ANKL1_MOUSE GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503
NOT-qualified manual protein A8VU90 10090 ANKL1_MOUSE GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503
NOT-qualified manual protein D4A332 10116 D4A332_RAT GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A332 10116 D4A332_RAT GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein H2R4I1 9598 H2R4I1_PANTR GO:0006301 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein L0T864 83332 FPG2_MYCTU GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20031487
NOT-qualified manual protein O89042 10116 DPOLA_RAT GO:0006281 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein P09884 9606 DPOLA_HUMAN GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:3335506

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0045021 obsolete error-free DNA repair consider GO:0070987

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070987 based on ALL annotations
The top 100 of 356 co-occurring terms
Co-occurring Term PR S% #Together #Compared
error-free translesion synthesis
9,209.13 100.00 21,168 21,168
deoxycytidyl transferase activity
9,193.82 25.53 5,407 5,416
error-prone translesion synthesis
888.42 8.52 8,940 92,670
response to radiation
2,767.49 6.53 1,630 5,424
mitochondrial nucleoid
746.79 4.52 1,960 24,170
replication fork
663.71 4.05 1,794 24,892
translesion synthesis
671.55 3.42 1,283 17,594
site of double-strand break
271.68 2.25 1,819 61,659
damaged DNA binding
209.19 2.20 8,424 370,855
DNA-directed DNA polymerase activity
150.27 1.60 9,635 590,457
Totals 106949 23695632
No co-occurrence statistics for GO:0070987 based on MANUAL annotations
The top 100 of 155 co-occurring terms
Co-occurring Term PR S% #Together #Compared
error-free translesion synthesis
8,175.94 100.00 158 158
deoxycytidyl transferase activity
8,000.12 56.88 91 93
error-prone translesion synthesis
1,463.51 16.38 104 581
DNA-directed DNA polymerase activity
540.21 6.39 104 1,574
mitochondrial nucleoid
457.40 4.58 32 572
fatty acid homeostasis
648.88 2.31 5 63
error-free postreplication DNA repair
1,557.32 2.29 4 21
DNA biosynthetic process
726.75 2.01 4 45
mitochondrial chromosome
1,167.99 1.70 3 21
DNA synthesis involved in DNA repair
183.43 1.51 7 312
Totals 703 41171

Change Log

Timestamp Action Category Detail
2009-10-30 Added DEFINITION The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
2009-10-30 Added RELATION is a GO:0019985 (translesion synthesis)
2009-10-30 Added TERM error-free translesion synthesis
Timestamp Action Category Detail
2009-10-30 Added TERM error-free translesion synthesis
Timestamp Action Category Detail
2009-10-30 Added DEFINITION The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
Timestamp Action Category Detail
2009-10-30 Added RELATION is a GO:0019985 (translesion synthesis)
Timestamp Action Category Detail
Timestamp Action Category Detail
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