Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
GO:0070987
JSON
error-free translesion synthesis
Biological Process
Definition (GO:0070987 GONUTS page)
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
Comments
Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
Ancestor Chart
Ancestor chart for GO:0070987
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Guidance for interpreting DNA repair investigations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | A6K9T7 | 10116 | A6K9T7_RAT | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6K9T7 | 10116 | A6K9T7_RAT | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A8VU90 | 10090 | ANKL1_MOUSE | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503 | |
| NOT-qualified manual | protein | A8VU90 | 10090 | ANKL1_MOUSE | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503 | |
| NOT-qualified manual | protein | D4A332 | 10116 | D4A332_RAT | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | D4A332 | 10116 | D4A332_RAT | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | H2R4I1 | 9598 | H2R4I1_PANTR | GO:0006301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | L0T864 | 83332 | FPG2_MYCTU | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20031487 | |
| NOT-qualified manual | protein | O89042 | 10116 | DPOLA_RAT | GO:0006281 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
| NOT-qualified manual | protein | P09884 | 9606 | DPOLA_HUMAN | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:3335506 |
Cross-references
| Database | ID | Description |
|---|---|---|
| Reactome | R-HSA-110320 |
Replaces
This term can be used instead of these obsolete terms:
| GO Identifier | GO Term Name | Reason |
|---|---|---|
| GO:0045021 | obsolete error-free DNA repair | consider GO:0070987 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070987 based on ALL annotations
The top 100 of 357 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
error-free translesion synthesis
|
9,180.22 | 100.00 | 21,687 | 21,687 |
|
deoxycytidyl transferase activity
|
9,173.68 | 25.88 | 5,613 | 5,617 |
|
error-prone translesion synthesis
|
882.39 | 8.50 | 9,172 | 95,424 |
|
response to radiation
|
2,669.93 | 6.41 | 1,647 | 5,663 |
|
mitochondrial nucleoid
|
759.57 | 4.62 | 2,055 | 24,837 |
|
replication fork
|
641.91 | 3.96 | 1,811 | 25,900 |
|
translesion synthesis
|
644.57 | 3.32 | 1,287 | 18,330 |
|
site of double-strand break
|
264.74 | 2.20 | 1,836 | 63,665 |
|
damaged DNA binding
|
207.73 | 2.19 | 8,625 | 381,160 |
|
DNA-directed DNA polymerase activity
|
142.30 | 1.52 | 9,871 | 636,816 |
| Totals | 114891 | 27740954 | ||
No co-occurrence statistics for GO:0070987 based on MANUAL annotations
The top 100 of 152 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
error-free translesion synthesis
|
8,015.97 | 100.00 | 176 | 176 |
|
deoxycytidyl transferase activity
|
7,861.82 | 57.30 | 102 | 104 |
|
error-prone translesion synthesis
|
1,484.44 | 16.86 | 115 | 621 |
|
DNA-directed DNA polymerase activity
|
528.27 | 6.37 | 115 | 1,745 |
|
mitochondrial nucleoid
|
508.33 | 5.19 | 39 | 615 |
|
fatty acid homeostasis
|
616.61 | 2.12 | 5 | 65 |
|
error-free postreplication DNA repair
|
1,526.85 | 2.07 | 4 | 21 |
|
DNA biosynthetic process
|
712.53 | 1.84 | 4 | 45 |
|
mitochondrial chromosome
|
1,145.14 | 1.55 | 3 | 21 |
|
DNA synthesis involved in DNA repair
|
171.07 | 1.41 | 7 | 328 |
| Totals | 759 | 43784 | ||
Change Log
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-12-05 | Added | XREF | Reactome:R-HSA-110320 |
| 2009-10-30 | Added | RELATION | is a GO:0019985 (translesion synthesis) |
| 2009-10-30 | Added | TERM | error-free translesion synthesis |
| 2009-10-30 | Added | DEFINITION | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2009-10-30 | Added | TERM | error-free translesion synthesis |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2009-10-30 | Added | DEFINITION | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2009-10-30 | Added | RELATION | is a GO:0019985 (translesion synthesis) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-12-05 | Added | XREF | Reactome:R-HSA-110320 |
| Timestamp | Action | Category | Detail |
|---|
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