This term is obsolete.
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

GO:0070991 JSON

medium-chain fatty acyl-CoA dehydrogenase activity

Molecular Function

Definition (GO:0070991 GONUTS page)

Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.

Comments

While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

10,691 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
MCAD activity exact

Ancestor Chart

Ancestor chart for GO:0070991
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.3.8.7
InterPro IPR034180 Medium-chain specific acyl-CoA dehydrogenase
MetaCyc RXN-11734
RHEA 14477

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:83723 medium-chain 3-substituted propanoyl-CoA(4-)
has_participant CHEBI CHEBI:57692 FAD(3-)
has_participant CHEBI CHEBI:83726 medium-chain 2,3-trans-enoyl CoA(4-)
has_participant CHEBI CHEBI:58307 FADH2(2-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070991 based on ALL annotations
The top 100 of 127 co-occurring terms
Co-occurring Term PR S% #Together #Compared
medium-chain fatty acyl-CoA dehydrogenase activity
18,592.13 100.00 10,658 10,658
long-chain fatty acyl-CoA dehydrogenase activity
14,911.33 52.99 6,498 8,102
medium-chain fatty acid catabolic process
5,571.69 15.97 2,716 9,063
fatty acid beta-oxidation using acyl-CoA dehydrogenase
752.74 3.97 7,056 174,277
acyl-CoA dehydrogenase activity
478.48 2.56 9,397 365,134
fatty acid beta-oxidation
373.49 1.99 7,257 361,245
medium-chain fatty acid metabolic process
7,948.48 1.60 174 407
very-long-chain fatty acyl-CoA dehydrogenase activity
641.34 0.71 94 2,725
carboxylic acid catabolic process
2,140.54 0.63 70 608
flavin adenine dinucleotide binding
112.59 0.61 10,276 1,696,922
Totals 88764 162425768
No co-occurrence statistics for GO:0070991 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term PR S% #Together #Compared
medium-chain fatty acyl-CoA dehydrogenase activity
22,405.29 100.00 63 63
medium-chain fatty acid catabolic process
7,259.81 31.52 58 179
medium-chain fatty acid metabolic process
7,001.65 6.76 5 16
long-chain fatty acyl-CoA dehydrogenase activity
2,635.92 4.30 4 34
carnitine metabolic process, CoA-linked
829.83 2.13 3 81
very-long-chain fatty acyl-CoA dehydrogenase activity
1,018.42 1.90 2 44
acyl-CoA dehydrogenase activity
411.53 1.65 9 490
regulation of gluconeogenesis
430.87 1.21 2 104
negative regulation of cellular response to oxidative stress
772.60 1.10 1 29
fatty acid beta-oxidation using acyl-CoA dehydrogenase
237.63 0.98 7 660
Totals 349 718815

Change Log

Timestamp Action Category Detail
2024-06-22 Added XREF MetaCyc:RXN-11734
2023-12-15 Added DEFINITION Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
2023-12-15 Updated TERM medium-chain fatty acyl-CoA dehydrogenase activity
2023-12-15 Deleted DEFINITION Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
2022-06-20 Added XREF EC:1.3.8.7
2022-06-20 Added XREF RHEA:14477
2022-06-20 Added DEFINITION Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
2022-06-20 Deleted XREF EC:1.3.99.-
2022-06-20 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
2021-01-04 Deleted XREF EC:1.3.99
Timestamp Action Category Detail
2023-12-15 Updated TERM medium-chain fatty acyl-CoA dehydrogenase activity
2009-10-30 Added TERM medium-chain-acyl-CoA dehydrogenase activity
Timestamp Action Category Detail
2023-12-15 Added DEFINITION Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
2023-12-15 Deleted DEFINITION Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
2022-06-20 Added DEFINITION Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
2022-06-20 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
2012-02-04 Added DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
2012-02-04 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue.
2009-10-30 Added DEFINITION Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue.
2009-10-30 Added SYNONYM MCAD activity
Timestamp Action Category Detail
2009-10-30 Added RELATION is a GO:0003995 (acyl-CoA dehydrogenase activity)
Timestamp Action Category Detail
2024-06-22 Added XREF MetaCyc:RXN-11734
2022-06-20 Added XREF EC:1.3.8.7
2022-06-20 Added XREF RHEA:14477
2022-06-20 Deleted XREF EC:1.3.99.-
2021-01-04 Deleted XREF EC:1.3.99
2021-01-04 Added XREF EC:1.3.99.-
2016-10-03 Deleted XREF EC:1.3.99.-
2016-10-03 Added XREF EC:1.3.99
2009-10-30 Added XREF EC:1.3.99.-
Timestamp Action Category Detail
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