While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
GO:0070991
JSON
medium-chain fatty acyl-CoA dehydrogenase activity
Molecular Function
Definition (GO:0070991 GONUTS page)
Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
Comments
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
MCAD activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.3.8.7 | |
InterPro | IPR034180 | Medium-chain specific acyl-CoA dehydrogenase |
MetaCyc | RXN-11734 | |
RHEA | 14477 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57692 | FAD(3-) |
has_participant | CHEBI | CHEBI:58307 | FADH2(2-) |
has_participant | CHEBI | CHEBI:83723 | medium-chain 3-substituted propanoyl-CoA(4-) |
has_participant | CHEBI | CHEBI:83726 | medium-chain 2,3-trans-enoyl CoA(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070991 based on ALL annotations
The top 100 of 127 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
medium-chain fatty acyl-CoA dehydrogenase activity
|
18,295.52 | 100.00 | 10,655 | 10,655 |
long-chain fatty acyl-CoA dehydrogenase activity
|
14,765.60 | 53.84 | 6,584 | 8,158 |
medium-chain fatty acid catabolic process
|
5,453.27 | 15.57 | 2,620 | 8,790 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase
|
765.78 | 4.10 | 7,138 | 170,536 |
acyl-CoA dehydrogenase activity
|
483.29 | 2.63 | 9,403 | 355,959 |
fatty acid beta-oxidation
|
379.93 | 2.06 | 7,338 | 353,360 |
medium-chain fatty acid metabolic process
|
7,821.67 | 1.60 | 174 | 407 |
very-long-chain fatty acyl-CoA dehydrogenase activity
|
647.02 | 0.71 | 94 | 2,658 |
flavin adenine dinucleotide binding
|
113.31 | 0.62 | 10,284 | 1,660,475 |
carnitine metabolic process, CoA-linked
|
338.22 | 0.56 | 85 | 4,598 |
Totals | 83100 | 158654135 |
No co-occurrence statistics for GO:0070991 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
medium-chain fatty acyl-CoA dehydrogenase activity
|
23,487.25 | 100.00 | 55 | 55 |
medium-chain fatty acid catabolic process
|
7,527.97 | 31.06 | 50 | 156 |
medium-chain fatty acid metabolic process
|
7,339.77 | 7.58 | 5 | 16 |
long-chain fatty acyl-CoA dehydrogenase activity
|
3,131.63 | 4.94 | 4 | 30 |
carnitine metabolic process, CoA-linked
|
992.42 | 2.44 | 3 | 71 |
very-long-chain fatty acyl-CoA dehydrogenase activity
|
1,145.72 | 2.13 | 2 | 41 |
acyl-CoA dehydrogenase activity
|
495.51 | 1.93 | 10 | 474 |
regulation of gluconeogenesis
|
474.49 | 1.32 | 2 | 99 |
negative regulation of cellular response to oxidative stress
|
809.91 | 1.20 | 1 | 29 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase
|
299.68 | 1.19 | 8 | 627 |
Totals | 319 | 671483 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-22 | Added | XREF | MetaCyc:RXN-11734 |
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. |
2023-12-15 | Updated | TERM | medium-chain fatty acyl-CoA dehydrogenase activity |
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
2022-06-20 | Added | DEFINITION | Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
2022-06-20 | Deleted | XREF | EC:1.3.99.- |
2022-06-20 | Added | XREF | RHEA:14477 |
2022-06-20 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
2022-06-20 | Added | XREF | EC:1.3.8.7 |
2021-01-04 | Added | XREF | EC:1.3.99.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Updated | TERM | medium-chain fatty acyl-CoA dehydrogenase activity |
2009-10-30 | Added | TERM | medium-chain-acyl-CoA dehydrogenase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. |
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
2022-06-20 | Added | DEFINITION | Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
2022-06-20 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
2012-02-04 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. |
2012-02-04 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. |
2009-10-30 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. |
2009-10-30 | Added | SYNONYM | MCAD activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-10-30 | Added | RELATION | is a GO:0003995 (acyl-CoA dehydrogenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-22 | Added | XREF | MetaCyc:RXN-11734 |
2022-06-20 | Deleted | XREF | EC:1.3.99.- |
2022-06-20 | Added | XREF | RHEA:14477 |
2022-06-20 | Added | XREF | EC:1.3.8.7 |
2021-01-04 | Added | XREF | EC:1.3.99.- |
2021-01-04 | Deleted | XREF | EC:1.3.99 |
2016-10-03 | Deleted | XREF | EC:1.3.99.- |
2016-10-03 | Added | XREF | EC:1.3.99 |
2009-10-30 | Added | XREF | EC:1.3.99.- |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link