GO:0071253
JSON
connexin binding
Molecular Function
Definition (GO:0071253 GONUTS page)
Binding to a connexin, any of a group of related proteins that assemble to form gap junctions. PMID:19864490
Ancestor Chart
Ancestor chart for GO:0071253
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Binding term considerations | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
| Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
|---|---|---|---|---|---|
| GO:0071253 | connexin binding | Never in Taxon | 4751 | Fungi |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
| NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
| NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Cross-references
| Database | ID | Description |
|---|---|---|
| InterPro | IPR028129 | Consortin, C-terminal domain |
| InterPro | IPR042318 | Consortin |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0071253 based on ALL annotations
The top 100 of 517 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
connexin binding
|
115,549.30 | 100.00 | 1,723 | 1,723 |
|
positive regulation of Golgi to plasma membrane protein transport
|
85,373.26 | 65.69 | 1,474 | 1,995 |
|
transport vesicle
|
9,349.88 | 7.94 | 1,398 | 17,277 |
|
regulation of signal transduction by receptor internalization
|
115,549.31 | 5.46 | 94 | 94 |
|
negative regulation of sarcomere organization
|
113,142.02 | 5.45 | 94 | 96 |
|
regulation of caveolin-mediated endocytosis
|
111,975.62 | 5.45 | 94 | 97 |
|
negative regulation of membrane depolarization during cardiac muscle cell action potential
|
115,549.30 | 5.40 | 93 | 93 |
|
positive regulation of dephosphorylation
|
79,864.95 | 5.33 | 94 | 136 |
|
regulation of toll-like receptor 3 signaling pathway
|
58,083.61 | 5.18 | 94 | 187 |
|
positive regulation of platelet-derived growth factor receptor-beta signaling pathway
|
36,944.34 | 4.89 | 94 | 294 |
| Totals | 14626 | 503719 | ||
No co-occurrence statistics for GO:0071253 based on MANUAL annotations
The top 100 of 454 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
connexin binding
|
30,017.25 | 100.00 | 47 | 47 |
|
positive regulation of Golgi to plasma membrane protein transport
|
14,472.61 | 35.53 | 27 | 56 |
|
AV node cell to bundle of His cell communication
|
23,090.20 | 20.00 | 10 | 13 |
|
transport vesicle
|
2,486.09 | 7.80 | 27 | 326 |
|
gamma-delta T cell activation
|
6,525.49 | 7.69 | 5 | 23 |
|
regulation of AV node cell action potential
|
7,504.31 | 6.78 | 4 | 16 |
|
regulation of ventricular cardiac muscle cell membrane depolarization
|
6,670.50 | 6.56 | 4 | 18 |
|
regulation of signal transduction by receptor internalization
|
30,017.25 | 6.38 | 3 | 3 |
|
AV node cell-bundle of His cell adhesion involved in cell communication
|
30,017.25 | 6.38 | 3 | 3 |
|
apicolateral plasma membrane
|
2,375.47 | 6.29 | 11 | 139 |
| Totals | 352 | 4604 | ||
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
- Other
- Other
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions. |
| 2021-05-24 | Added | DEFINITION | Binding to a connexin, any of a group of related proteins that assemble to form gap junctions. |
| 2018-08-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
| 2009-12-06 | Added | TERM | connexin binding |
| 2009-12-06 | Added | RELATION | is a GO:0005515 (protein binding) |
| 2009-12-06 | Added | DEFINITION | Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2009-12-06 | Added | TERM | connexin binding |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions. |
| 2021-05-24 | Added | DEFINITION | Binding to a connexin, any of a group of related proteins that assemble to form gap junctions. |
| 2009-12-06 | Added | DEFINITION | Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2009-12-06 | Added | RELATION | is a GO:0005515 (protein binding) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2018-08-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
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