GO:0071424
JSON
rRNA (cytosine-N4-)-methyltransferase activity
Molecular Function
Definition (GO:0071424 GONUTS page)
Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. PMID:19965768
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6JFH4 | 10116 | A6JFH4_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JFH5 | 10116 | A6JFH5_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7XRZ1 | 227321 | TDIE_EMENI | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773 | |
NOT-qualified manual | protein | D3Z930 | 10116 | D3Z930_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A629 | 10116 | D4A629_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
RHEA | 62520 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:82748 | cytidine 5'-monophosphate(1-) residue |
has_participant | CHEBI | CHEBI:74506 | N(4)-methylcytidine 5'-monophosphate(1-) residue |
has_participant | CHEBI | CHEBI:57856 | S-adenosyl-L-homocysteine zwitterion |
has_participant | CHEBI | CHEBI:59789 | S-adenosyl-L-methionine zwitterion |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0071424 based on ALL annotations
The top 100 of 114 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
rRNA (cytosine-N4-)-methyltransferase activity
|
4,119.73 | 100.00 | 48,099 | 48,099 |
rRNA base methylation
|
839.53 | 20.38 | 48,099 | 236,031 |
rRNA processing
|
160.98 | 3.89 | 43,918 | 1,123,906 |
methylation
|
54.15 | 1.31 | 47,878 | 3,642,626 |
methyltransferase activity
|
52.27 | 1.27 | 48,099 | 3,790,987 |
cytoplasm
|
7.30 | 0.18 | 45,162 | 25,503,657 |
mitochondrial matrix
|
1.98 | 0.04 | 106 | 220,932 |
biological_process
|
0.74 | 0.01 | 12 | 66,641 |
rRNA 5'-end processing
|
0.51 | 0.01 | 5 | 40,615 |
tRNA methyltransferase activity
|
0.27 | 0.00 | 4 | 60,581 |
Totals | 281922 | 236887105 |
No co-occurrence statistics for GO:0071424 based on MANUAL annotations
The top 13 of 13 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
rRNA (cytosine-N4-)-methyltransferase activity
|
11,762.77 | 100.00 | 120 | 120 |
rRNA base methylation
|
1,157.94 | 9.84 | 120 | 1,219 |
mitochondrial matrix
|
13.92 | 0.12 | 5 | 4,225 |
methyltransferase activity
|
5.67 | 0.05 | 1 | 2,076 |
protein homodimerization activity
|
2.24 | 0.02 | 1 | 5,255 |
cytoplasm
|
2.14 | 0.02 | 36 | 197,513 |
mitochondrion
|
1.20 | 0.01 | 5 | 48,955 |
biological_process
|
0.71 | 0.01 | 4 | 66,641 |
cellular_component
|
0.38 | 0.00 | 2 | 62,590 |
molecular_function
|
0.34 | 0.00 | 2 | 69,334 |
Totals | 299 | 734339 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-22 | Added | DEFINITION | Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. |
2022-01-22 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine. |
2022-01-22 | Added | XREF | RHEA:62520 |
2018-03-18 | Deleted | XREF | EC:2.1.1 |
2016-10-03 | Added | XREF | EC:2.1.1 |
2016-10-03 | Deleted | XREF | EC:2.1.1.- |
2009-12-17 | Added | XREF | EC:2.1.1.- |
2009-12-17 | Added | RELATION | is a GO:0008170 (N-methyltransferase activity) |
2009-12-17 | Added | TERM | rRNA (cytosine-N4-)-methyltransferase activity |
2009-12-17 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-12-17 | Added | TERM | rRNA (cytosine-N4-)-methyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-22 | Added | DEFINITION | Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. |
2022-01-22 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine. |
2009-12-17 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-12-17 | Added | RELATION | is a GO:0008170 (N-methyltransferase activity) |
2009-12-17 | Added | RELATION | is a GO:0016434 (rRNA (cytosine) methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-22 | Added | XREF | RHEA:62520 |
2018-03-18 | Deleted | XREF | EC:2.1.1 |
2016-10-03 | Added | XREF | EC:2.1.1 |
2016-10-03 | Deleted | XREF | EC:2.1.1.- |
2009-12-17 | Added | XREF | EC:2.1.1.- |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link