This term is obsolete.

GO:0071424 JSON

rRNA (cytosine-N4-)-methyltransferase activity

Molecular Function

Definition (GO:0071424 GONUTS page)

Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. PMID:19965768

48,155 annotations

Ancestor Chart

Ancestor chart for GO:0071424
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A8I5YBY9 10116 A0A8I5YBY9_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A2VDP2 9913 PCMD1_BOVIN GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6JFH4 10116 A6JFH4_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JFH5 10116 A6JFH5_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7XRZ1 227321 TDIE_EMENI GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773
NOT-qualified manual protein D3Z930 10116 D3Z930_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A629 10116 D4A629_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
RHEA 62520

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:82748 cytidine 5'-monophosphate(1-) residue
has_participant CHEBI CHEBI:74506 N(4)-methylcytidine 5'-monophosphate(1-) residue
has_participant CHEBI CHEBI:57856 S-adenosyl-L-homocysteine zwitterion
has_participant CHEBI CHEBI:59789 S-adenosyl-L-methionine zwitterion
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0071424 based on ALL annotations
The top 100 of 114 co-occurring terms
Co-occurring Term PR S% #Together #Compared
rRNA (cytosine-N4-)-methyltransferase activity
4,119.73 100.00 48,099 48,099
rRNA base methylation
839.53 20.38 48,099 236,031
rRNA processing
160.98 3.89 43,918 1,123,906
methylation
54.15 1.31 47,878 3,642,626
methyltransferase activity
52.27 1.27 48,099 3,790,987
cytoplasm
7.30 0.18 45,162 25,503,657
mitochondrial matrix
1.98 0.04 106 220,932
biological_process
0.74 0.01 12 66,641
rRNA 5'-end processing
0.51 0.01 5 40,615
tRNA methyltransferase activity
0.27 0.00 4 60,581
Totals 281922 236887105
No co-occurrence statistics for GO:0071424 based on MANUAL annotations
The top 13 of 13 co-occurring terms
Co-occurring Term PR S% #Together #Compared
rRNA (cytosine-N4-)-methyltransferase activity
11,762.77 100.00 120 120
rRNA base methylation
1,157.94 9.84 120 1,219
mitochondrial matrix
13.92 0.12 5 4,225
methyltransferase activity
5.67 0.05 1 2,076
protein homodimerization activity
2.24 0.02 1 5,255
cytoplasm
2.14 0.02 36 197,513
mitochondrion
1.20 0.01 5 48,955
biological_process
0.71 0.01 4 66,641
cellular_component
0.38 0.00 2 62,590
molecular_function
0.34 0.00 2 69,334
Totals 299 734339

Change Log

Timestamp Action Category Detail
2022-01-22 Added DEFINITION Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine.
2022-01-22 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine.
2022-01-22 Added XREF RHEA:62520
2018-03-18 Deleted XREF EC:2.1.1
2016-10-03 Added XREF EC:2.1.1
2016-10-03 Deleted XREF EC:2.1.1.-
2009-12-17 Added XREF EC:2.1.1.-
2009-12-17 Added RELATION is a GO:0008170 (N-methyltransferase activity)
2009-12-17 Added TERM rRNA (cytosine-N4-)-methyltransferase activity
2009-12-17 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine.
Timestamp Action Category Detail
2009-12-17 Added TERM rRNA (cytosine-N4-)-methyltransferase activity
Timestamp Action Category Detail
2022-01-22 Added DEFINITION Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine.
2022-01-22 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine.
2009-12-17 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine.
Timestamp Action Category Detail
2009-12-17 Added RELATION is a GO:0008170 (N-methyltransferase activity)
2009-12-17 Added RELATION is a GO:0016434 (rRNA (cytosine) methyltransferase activity)
Timestamp Action Category Detail
2022-01-22 Added XREF RHEA:62520
2018-03-18 Deleted XREF EC:2.1.1
2016-10-03 Added XREF EC:2.1.1
2016-10-03 Deleted XREF EC:2.1.1.-
2009-12-17 Added XREF EC:2.1.1.-
Timestamp Action Category Detail
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