GO:0071885
JSON
N-terminal protein N-methyltransferase activity
Molecular Function
Definition (GO:0071885 GONUTS page)
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. PMID:20481588
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
X-Pro-Lys N-terminal methyltransferase | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6JFH4 | 10116 | A6JFH4_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JFH5 | 10116 | A6JFH5_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7XRZ1 | 227321 | TDIE_EMENI | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773 | |
NOT-qualified manual | protein | D3Z930 | 10116 | D3Z930_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A629 | 10116 | D4A629_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.1.1.244 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0071885 based on ALL annotations
The top 100 of 106 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
N-terminal protein N-methyltransferase activity
|
37,657.71 | 100.00 | 5,262 | 5,262 |
protein methyltransferase activity
|
1,212.82 | 3.19 | 4,096 | 127,180 |
protein-lysine N-methyltransferase activity
|
594.11 | 1.50 | 1,178 | 74,667 |
rDNA heterochromatin formation
|
1,045.67 | 1.45 | 155 | 5,582 |
spindle organization
|
183.09 | 0.40 | 111 | 22,830 |
S-adenosylmethionine-dependent methyltransferase activity
|
68.45 | 0.18 | 1,106 | 608,428 |
N-terminal peptidyl-glycine methylation
|
37,657.71 | 0.17 | 9 | 9 |
N-terminal peptidyl-proline dimethylation
|
37,657.71 | 0.17 | 9 | 9 |
N-terminal peptidyl-serine dimethylation
|
37,657.71 | 0.17 | 9 | 9 |
N-terminal peptidyl-serine trimethylation
|
37,657.71 | 0.17 | 9 | 9 |
Totals | 29885 | 246093780 |
No co-occurrence statistics for GO:0071885 based on MANUAL annotations
The top 21 of 21 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
N-terminal protein N-methyltransferase activity
|
19,336.07 | 100.00 | 73 | 73 |
N-terminal peptidyl-serine dimethylation
|
19,336.07 | 12.33 | 9 | 9 |
N-terminal peptidyl-serine trimethylation
|
19,336.07 | 12.33 | 9 | 9 |
N-terminal peptidyl-glycine methylation
|
19,336.07 | 12.33 | 9 | 9 |
N-terminal peptidyl-proline dimethylation
|
19,336.07 | 12.33 | 9 | 9 |
spindle organization
|
1,530.19 | 6.69 | 22 | 278 |
N-terminal protein amino acid methylation
|
19,336.07 | 5.48 | 4 | 4 |
N-terminal peptidyl-alanine trimethylation
|
19,336.07 | 1.37 | 1 | 1 |
protein methyltransferase activity
|
193.36 | 0.94 | 10 | 1,000 |
histone methyltransferase activity
|
153.34 | 0.76 | 10 | 1,261 |
Totals | 273 | 569934 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-26 | Added | XREF | EC:2.1.1.244 |
2022-02-17 | Added | RELATION | is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity) |
2010-09-15 | Added | DEFINITION | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. |
2010-09-15 | Added | SYNONYM | X-Pro-Lys N-terminal methyltransferase |
2010-09-15 | Added | TERM | N-terminal protein N-methyltransferase activity |
2010-09-15 | Added | RELATION | is a GO:0008276 (protein methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-09-15 | Added | TERM | N-terminal protein N-methyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-09-15 | Added | DEFINITION | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. |
2010-09-15 | Added | SYNONYM | X-Pro-Lys N-terminal methyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Added | RELATION | is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity) |
2010-09-15 | Added | RELATION | is a GO:0008276 (protein methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-26 | Added | XREF | EC:2.1.1.244 |
Timestamp | Action | Category | Detail |
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