This term is obsolete.

GO:0071885 JSON

N-terminal protein N-methyltransferase activity

Molecular Function

Definition (GO:0071885 GONUTS page)

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. PMID:20481588

5,326 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
X-Pro-Lys N-terminal methyltransferase narrow

Ancestor Chart

Ancestor chart for GO:0071885
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A8I5YBY9 10116 A0A8I5YBY9_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A2VDP2 9913 PCMD1_BOVIN GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6JFH4 10116 A6JFH4_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JFH5 10116 A6JFH5_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7XRZ1 227321 TDIE_EMENI GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773
NOT-qualified manual protein D3Z930 10116 D3Z930_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A629 10116 D4A629_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 2.1.1.244

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0071885 based on ALL annotations
The top 100 of 106 co-occurring terms
Co-occurring Term PR S% #Together #Compared
N-terminal protein N-methyltransferase activity
37,657.71 100.00 5,262 5,262
protein methyltransferase activity
1,212.82 3.19 4,096 127,180
protein-lysine N-methyltransferase activity
594.11 1.50 1,178 74,667
rDNA heterochromatin formation
1,045.67 1.45 155 5,582
spindle organization
183.09 0.40 111 22,830
S-adenosylmethionine-dependent methyltransferase activity
68.45 0.18 1,106 608,428
N-terminal peptidyl-glycine methylation
37,657.71 0.17 9 9
N-terminal peptidyl-proline dimethylation
37,657.71 0.17 9 9
N-terminal peptidyl-serine dimethylation
37,657.71 0.17 9 9
N-terminal peptidyl-serine trimethylation
37,657.71 0.17 9 9
Totals 29885 246093780
No co-occurrence statistics for GO:0071885 based on MANUAL annotations
The top 21 of 21 co-occurring terms
Co-occurring Term PR S% #Together #Compared
N-terminal protein N-methyltransferase activity
19,336.07 100.00 73 73
N-terminal peptidyl-serine dimethylation
19,336.07 12.33 9 9
N-terminal peptidyl-serine trimethylation
19,336.07 12.33 9 9
N-terminal peptidyl-glycine methylation
19,336.07 12.33 9 9
N-terminal peptidyl-proline dimethylation
19,336.07 12.33 9 9
spindle organization
1,530.19 6.69 22 278
N-terminal protein amino acid methylation
19,336.07 5.48 4 4
N-terminal peptidyl-alanine trimethylation
19,336.07 1.37 1 1
protein methyltransferase activity
193.36 0.94 10 1,000
histone methyltransferase activity
153.34 0.76 10 1,261
Totals 273 569934

Change Log

Timestamp Action Category Detail
2022-05-26 Added XREF EC:2.1.1.244
2022-02-17 Added RELATION is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
2010-09-15 Added DEFINITION Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
2010-09-15 Added SYNONYM X-Pro-Lys N-terminal methyltransferase
2010-09-15 Added TERM N-terminal protein N-methyltransferase activity
2010-09-15 Added RELATION is a GO:0008276 (protein methyltransferase activity)
Timestamp Action Category Detail
2010-09-15 Added TERM N-terminal protein N-methyltransferase activity
Timestamp Action Category Detail
2010-09-15 Added DEFINITION Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
2010-09-15 Added SYNONYM X-Pro-Lys N-terminal methyltransferase
Timestamp Action Category Detail
2022-02-17 Added RELATION is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
2010-09-15 Added RELATION is a GO:0008276 (protein methyltransferase activity)
Timestamp Action Category Detail
2022-05-26 Added XREF EC:2.1.1.244
Timestamp Action Category Detail
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