While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
GO:0080019
JSON
alcohol-forming very long-chain fatty acyl-CoA reductase activity
Molecular Function
Definition (GO:0080019 GONUTS page)
Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. PMID:16980563
Comments
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
fatty acyl CoA reductase (alcohol-forming) activity | exact |
fatty-acyl-CoA reductase (alcohol-forming) activity | related |
fatty acyl-CoA reductase (alcohol-forming) activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR026055 | Fatty acyl-CoA reductase |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0080019 based on ALL annotations
The top 100 of 175 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
alcohol-forming very long-chain fatty acyl-CoA reductase activity
|
10,149.82 | 100.00 | 19,523 | 19,523 |
long-chain fatty-acyl-CoA metabolic process
|
7,065.00 | 66.24 | 18,196 | 26,141 |
fatty acid derivative metabolic process
|
10,149.82 | 48.52 | 9,473 | 9,473 |
alcohol-forming long-chain fatty acyl-CoA reductase activity
|
10,093.47 | 40.28 | 7,882 | 7,926 |
suberin biosynthetic process
|
9,894.10 | 26.77 | 5,262 | 5,398 |
peroxisome
|
394.70 | 3.76 | 10,543 | 271,113 |
peroxisomal membrane
|
175.35 | 1.50 | 1,991 | 115,244 |
lipid metabolic process
|
138.82 | 1.36 | 15,417 | 1,127,241 |
intracellular membrane-bounded organelle
|
82.42 | 0.80 | 6,756 | 831,948 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
|
81.96 | 0.78 | 3,713 | 459,801 |
Totals | 121803 | 101207060 |
No co-occurrence statistics for GO:0080019 based on MANUAL annotations
The top 35 of 35 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
alcohol-forming very long-chain fatty acyl-CoA reductase activity
|
2,613.95 | 100.00 | 540 | 540 |
long-chain fatty-acyl-CoA metabolic process
|
2,119.10 | 79.97 | 531 | 655 |
suberin biosynthetic process
|
2,497.93 | 65.71 | 366 | 383 |
alcohol-forming long-chain fatty acyl-CoA reductase activity
|
2,495.13 | 3.88 | 21 | 22 |
peroxisome
|
92.13 | 3.25 | 161 | 4,568 |
intracellular membrane-bounded organelle
|
78.48 | 2.96 | 372 | 12,391 |
wax biosynthetic process
|
196.94 | 1.63 | 11 | 146 |
ether lipid biosynthetic process
|
170.47 | 0.96 | 6 | 92 |
peroxisomal membrane
|
12.97 | 0.41 | 13 | 2,619 |
pollen exine formation
|
145.22 | 0.35 | 2 | 36 |
Totals | 2062 | 519439 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons. |
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. |
2023-01-18 | Updated | TERM | alcohol-forming very long-chain fatty acyl-CoA reductase activity |
2023-01-18 | Deleted | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. |
2023-01-18 | Added | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons. |
2023-01-18 | Added | SYNONYM | fatty-acyl-CoA reductase (alcohol-forming) activity |
2011-09-16 | Deleted | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA. |
2011-09-16 | Added | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. |
2011-01-13 | Added | SYNONYM | fatty acyl CoA reductase (alcohol-forming) activity |
2010-04-03 | Added | SYNONYM | fatty acyl-CoA reductase (alcohol-forming) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-18 | Updated | TERM | alcohol-forming very long-chain fatty acyl-CoA reductase activity |
2010-04-03 | Updated | TERM | fatty-acyl-CoA reductase (alcohol-forming) activity |
2008-10-09 | Added | TERM | fatty acyl-CoA reductase (alcohol-forming) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons. |
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. |
2023-01-18 | Deleted | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. |
2023-01-18 | Added | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons. |
2023-01-18 | Added | SYNONYM | fatty-acyl-CoA reductase (alcohol-forming) activity |
2011-09-16 | Deleted | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA. |
2011-09-16 | Added | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. |
2011-01-13 | Added | SYNONYM | fatty acyl CoA reductase (alcohol-forming) activity |
2010-04-03 | Added | SYNONYM | fatty acyl-CoA reductase (alcohol-forming) activity |
2008-10-09 | Added | DEFINITION | Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-10-09 | Added | RELATION | is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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