This term is obsolete.
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

GO:0080019 JSON

alcohol-forming very long-chain fatty acyl-CoA reductase activity

Molecular Function

Definition (GO:0080019 GONUTS page)

Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. PMID:16980563

Comments

While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

20,077 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
fatty acyl CoA reductase (alcohol-forming) activity exact
fatty-acyl-CoA reductase (alcohol-forming) activity related
fatty acyl-CoA reductase (alcohol-forming) activity exact

Ancestor Chart

Ancestor chart for GO:0080019
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
InterPro IPR026055 Fatty acyl-CoA reductase

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0080019 based on ALL annotations
The top 100 of 175 co-occurring terms
Co-occurring Term PR S% #Together #Compared
alcohol-forming very long-chain fatty acyl-CoA reductase activity
10,149.82 100.00 19,523 19,523
long-chain fatty-acyl-CoA metabolic process
7,065.00 66.24 18,196 26,141
fatty acid derivative metabolic process
10,149.82 48.52 9,473 9,473
alcohol-forming long-chain fatty acyl-CoA reductase activity
10,093.47 40.28 7,882 7,926
suberin biosynthetic process
9,894.10 26.77 5,262 5,398
peroxisome
394.70 3.76 10,543 271,113
peroxisomal membrane
175.35 1.50 1,991 115,244
lipid metabolic process
138.82 1.36 15,417 1,127,241
intracellular membrane-bounded organelle
82.42 0.80 6,756 831,948
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
81.96 0.78 3,713 459,801
Totals 121803 101207060
No co-occurrence statistics for GO:0080019 based on MANUAL annotations
The top 35 of 35 co-occurring terms
Co-occurring Term PR S% #Together #Compared
alcohol-forming very long-chain fatty acyl-CoA reductase activity
2,613.95 100.00 540 540
long-chain fatty-acyl-CoA metabolic process
2,119.10 79.97 531 655
suberin biosynthetic process
2,497.93 65.71 366 383
alcohol-forming long-chain fatty acyl-CoA reductase activity
2,495.13 3.88 21 22
peroxisome
92.13 3.25 161 4,568
intracellular membrane-bounded organelle
78.48 2.96 372 12,391
wax biosynthetic process
196.94 1.63 11 146
ether lipid biosynthetic process
170.47 0.96 6 92
peroxisomal membrane
12.97 0.41 13 2,619
pollen exine formation
145.22 0.35 2 36
Totals 2062 519439

Change Log

Timestamp Action Category Detail
2023-12-15 Deleted DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons.
2023-12-15 Added DEFINITION Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
2023-01-18 Updated TERM alcohol-forming very long-chain fatty acyl-CoA reductase activity
2023-01-18 Deleted DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.
2023-01-18 Added DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons.
2023-01-18 Added SYNONYM fatty-acyl-CoA reductase (alcohol-forming) activity
2011-09-16 Deleted DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA.
2011-09-16 Added DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.
2011-01-13 Added SYNONYM fatty acyl CoA reductase (alcohol-forming) activity
2010-04-03 Added SYNONYM fatty acyl-CoA reductase (alcohol-forming) activity
Timestamp Action Category Detail
2023-01-18 Updated TERM alcohol-forming very long-chain fatty acyl-CoA reductase activity
2010-04-03 Updated TERM fatty-acyl-CoA reductase (alcohol-forming) activity
2008-10-09 Added TERM fatty acyl-CoA reductase (alcohol-forming) activity
Timestamp Action Category Detail
2023-12-15 Deleted DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons.
2023-12-15 Added DEFINITION Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.
2023-01-18 Added DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. A very long chain fatty acid (VLCFA) is a fatty acid with an aliphatic tail of 22 or more carbons.
2023-01-18 Added SYNONYM fatty-acyl-CoA reductase (alcohol-forming) activity
2011-09-16 Deleted DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA.
2011-09-16 Added DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.
2011-01-13 Added SYNONYM fatty acyl CoA reductase (alcohol-forming) activity
2010-04-03 Added SYNONYM fatty acyl-CoA reductase (alcohol-forming) activity
2008-10-09 Added DEFINITION Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA.
Timestamp Action Category Detail
2008-10-09 Added RELATION is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.