This term is obsolete.

GO:0085034 JSON

symbiont-mediated suppression of host NF-kappaB cascade

Biological Process

Definition (GO:0085034 GONUTS page)

A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. PMID:18250452 PMID:22442494 PMID:24648522 PMID:33567255

7,659 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade exact
suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade exact
disruption of host I-kappaB kinase/NF-kappaB cascade exact
disruption of host canonical NF-kappaB cascade related
symbiont-mediated suppression of host canonical NF-kappaB cascade related

Ancestor Chart

Ancestor chart for GO:0085034
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade Never in Taxon 33090 Viridiplantae
GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade Never in Taxon 4895 Schizosaccharomyces
GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade Never in Taxon 7742 Vertebrata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q2TH00 623 OSPZ2_SHIFL GO:0085034 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20485572

Cross-references

Database ID Description
UniProtKB-KW KW-1100 Inhibition of host NF-kappa-B by virus
VZ 695

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0039644 obsolete suppression by virus of host NF-kappaB cascade replaced_by GO:0085034
GO:0061765 obsolete perturbation by virus of host non-canonical NF-kappaB signal transduction replaced_by GO:0085034

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0085034 based on ALL annotations
The top 100 of 217 co-occurring terms
Co-occurring Term PR S% #Together #Compared
symbiont-mediated suppression of host NF-kappaB cascade
25,488.86 100.00 7,648 7,648
symbiont-mediated degradation of host mRNA
12,910.28 28.36 2,997 5,917
symbiont-mediated perturbation of host ubiquitin-like protein modification
8,952.36 27.66 4,325 12,314
host cell endoplasmic reticulum-Golgi intermediate compartment
7,354.92 20.29 3,106 10,764
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
10,099.92 18.89 2,028 5,118
symbiont-mediated suppression of host ISG15-protein conjugation
5,786.87 17.48 3,302 14,544
G-quadruplex RNA binding
5,550.55 15.68 2,746 12,610
omega peptidase activity
4,640.17 14.38 3,109 17,078
host cytoskeleton
4,812.08 12.39 2,028 10,742
host cell perinuclear region of cytoplasm
3,581.51 11.86 3,305 23,521
Totals 187704 90303995
No co-occurrence statistics for GO:0085034 based on MANUAL annotations
The top 47 of 47 co-occurring terms
Co-occurring Term PR S% #Together #Compared
symbiont-mediated suppression of host NF-kappaB cascade
46,135.68 100.00 28 28
host cell cytoplasm
3,571.79 7.02 12 155
host cell nucleus
3,355.32 6.63 12 165
symbiont-mediated suppression of host inflammatory response
15,378.56 6.25 2 6
protein-arginine N-acetylglucosaminyltransferase activity
11,533.92 5.88 2 8
protein-cysteine methyltransferase activity
8,388.31 5.41 2 11
symbiont-mediated perturbation of host defense response
23,067.84 3.45 1 2
symbiont-mediated suppression of host defense-related programmed cell death
15,378.56 3.33 1 3
symbiont-mediated suppression of host apoptosis
2,713.86 3.33 2 34
symbiont-mediated perturbation of host defense-related programmed cell death
11,533.92 3.23 1 4
Totals 116 320541

Change Log

Timestamp Action Category Detail
2024-09-11 Added RELATION is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:7742 (Vertebrata)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:33090 (Viridiplantae)
2024-02-24 Added SYNONYM suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Added SYNONYM negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Added SYNONYM disruption of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Deleted SYNONYM disruption of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Deleted SYNONYM negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Deleted SYNONYM suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
Timestamp Action Category Detail
2023-12-26 Updated TERM symbiont-mediated suppression of host NF-kappaB cascade
2023-07-12 Updated TERM symbiont-mediated suppression of host canonical NF-kappaB cascade
2023-07-06 Updated TERM disruption of host canonical NF-kappaB cascade
2023-05-20 Updated TERM disruption of host I-kappaB kinase/NF-kappaB cascade
2019-12-12 Updated TERM suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
2010-08-03 Added TERM negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
Timestamp Action Category Detail
2024-02-24 Added SYNONYM suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Added SYNONYM negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Added SYNONYM disruption of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Deleted SYNONYM disruption of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Deleted SYNONYM negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
2024-02-24 Deleted SYNONYM suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
2024-01-15 Added DEFINITION A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2024-01-15 Deleted DEFINITION A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-12-26 Added SYNONYM disruption of host I-kappaB kinase/NF-kappaB cascade
2023-12-26 Deleted DEFINITION A process in which a symbiont interferes with, inhibits or disrupts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-12-26 Added SYNONYM symbiont-mediated suppression of host canonical NF-kappaB cascade
2023-12-26 Added SYNONYM suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
2023-12-26 Deleted SYNONYM disruption of host I-kappaB kinase/NF-kappaB cascade
2023-12-26 Deleted SYNONYM suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
2023-12-26 Deleted SYNONYM negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
2023-12-26 Added SYNONYM disruption of host canonical NF-kappaB cascade
2023-12-26 Added DEFINITION A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-12-26 Added SYNONYM negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
2023-12-26 Deleted SYNONYM disruption of host canonical NF-kappaB cascade
2023-07-12 Added SYNONYM disruption of host canonical NF-kappaB cascade
2023-07-12 Deleted DEFINITION A process that interferes with a host canonical NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-07-12 Added DEFINITION A process in which a symbiont interferes with, inhibits or disrupts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-07-06 Added SYNONYM disruption of host I-kappaB kinase/NF-kappaB cascade
2023-07-06 Deleted DEFINITION A process that interferes with a host I-kappaB kinase/NF-kappaB-mediated signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-07-06 Added DEFINITION A process that interferes with a host canonical NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-06-24 Added DEFINITION A process that interferes with a host I-kappaB kinase/NF-kappaB-mediated signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-06-24 Deleted DEFINITION Any process that interferes with host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-06-13 Added DEFINITION Any process that interferes with host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-06-13 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2023-05-20 Added SYNONYM suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade
2019-12-12 Added SYNONYM negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2010-08-03 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Timestamp Action Category Detail
2024-09-11 Added RELATION is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway)
2023-12-26 Deleted RELATION is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway)
2023-07-12 Added RELATION is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway)
2023-06-24 Deleted RELATION is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway)
2023-06-24 Deleted RELATION is a GO:0043124 (negative regulation of canonical NF-kappaB signal transduction)
2023-06-24 Added RELATION is a GO:0085032 (symbiont-mediated perturbation of host NF-kappaB cascade)
2019-12-12 Added RELATION is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway)
2010-08-03 Added RELATION is a GO:0043124 (negative regulation of canonical NF-kappaB signal transduction)
Timestamp Action Category Detail
2023-12-26 Added XREF VZ:695
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:7742 (Vertebrata)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:33090 (Viridiplantae)
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