GO:0085034
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symbiont-mediated suppression of host NF-kappaB cascade
Biological Process
Definition (GO:0085034 GONUTS page)
A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. PMID:18250452 PMID:22442494 PMID:24648522 PMID:33567255
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade | exact |
suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade | exact |
disruption of host I-kappaB kinase/NF-kappaB cascade | exact |
disruption of host canonical NF-kappaB cascade | related |
symbiont-mediated suppression of host canonical NF-kappaB cascade | related |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0085034 | symbiont-mediated suppression of host NF-kappaB cascade | Never in Taxon | 33090 | Viridiplantae | |
GO:0085034 | symbiont-mediated suppression of host NF-kappaB cascade | Never in Taxon | 4895 | Schizosaccharomyces | |
GO:0085034 | symbiont-mediated suppression of host NF-kappaB cascade | Never in Taxon | 7742 | Vertebrata |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | Q2TH00 | 623 | OSPZ2_SHIFL | GO:0085034 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20485572 |
Cross-references
Database | ID | Description |
---|---|---|
UniProtKB-KW | KW-1100 | Inhibition of host NF-kappa-B by virus |
VZ | 695 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0039644 | obsolete suppression by virus of host NF-kappaB cascade | replaced_by GO:0085034 |
GO:0061765 | obsolete perturbation by virus of host non-canonical NF-kappaB signal transduction | replaced_by GO:0085034 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0085034 based on ALL annotations
The top 100 of 217 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
symbiont-mediated suppression of host NF-kappaB cascade
|
25,488.86 | 100.00 | 7,648 | 7,648 |
symbiont-mediated degradation of host mRNA
|
12,910.28 | 28.36 | 2,997 | 5,917 |
symbiont-mediated perturbation of host ubiquitin-like protein modification
|
8,952.36 | 27.66 | 4,325 | 12,314 |
host cell endoplasmic reticulum-Golgi intermediate compartment
|
7,354.92 | 20.29 | 3,106 | 10,764 |
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
|
10,099.92 | 18.89 | 2,028 | 5,118 |
symbiont-mediated suppression of host ISG15-protein conjugation
|
5,786.87 | 17.48 | 3,302 | 14,544 |
G-quadruplex RNA binding
|
5,550.55 | 15.68 | 2,746 | 12,610 |
omega peptidase activity
|
4,640.17 | 14.38 | 3,109 | 17,078 |
host cytoskeleton
|
4,812.08 | 12.39 | 2,028 | 10,742 |
host cell perinuclear region of cytoplasm
|
3,581.51 | 11.86 | 3,305 | 23,521 |
Totals | 187704 | 90303995 |
No co-occurrence statistics for GO:0085034 based on MANUAL annotations
The top 47 of 47 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
symbiont-mediated suppression of host NF-kappaB cascade
|
46,135.68 | 100.00 | 28 | 28 |
host cell cytoplasm
|
3,571.79 | 7.02 | 12 | 155 |
host cell nucleus
|
3,355.32 | 6.63 | 12 | 165 |
symbiont-mediated suppression of host inflammatory response
|
15,378.56 | 6.25 | 2 | 6 |
protein-arginine N-acetylglucosaminyltransferase activity
|
11,533.92 | 5.88 | 2 | 8 |
protein-cysteine methyltransferase activity
|
8,388.31 | 5.41 | 2 | 11 |
symbiont-mediated perturbation of host defense response
|
23,067.84 | 3.45 | 1 | 2 |
symbiont-mediated suppression of host defense-related programmed cell death
|
15,378.56 | 3.33 | 1 | 3 |
symbiont-mediated suppression of host apoptosis
|
2,713.86 | 3.33 | 2 | 34 |
symbiont-mediated perturbation of host defense-related programmed cell death
|
11,533.92 | 3.23 | 1 | 4 |
Totals | 116 | 320541 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-11 | Added | RELATION | is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:7742 (Vertebrata) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:33090 (Viridiplantae) |
2024-02-24 | Added | SYNONYM | suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Added | SYNONYM | negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Added | SYNONYM | disruption of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Deleted | SYNONYM | disruption of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Deleted | SYNONYM | negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Deleted | SYNONYM | suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Updated | TERM | symbiont-mediated suppression of host NF-kappaB cascade |
2023-07-12 | Updated | TERM | symbiont-mediated suppression of host canonical NF-kappaB cascade |
2023-07-06 | Updated | TERM | disruption of host canonical NF-kappaB cascade |
2023-05-20 | Updated | TERM | disruption of host I-kappaB kinase/NF-kappaB cascade |
2019-12-12 | Updated | TERM | suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2010-08-03 | Added | TERM | negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | SYNONYM | suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Added | SYNONYM | negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Added | SYNONYM | disruption of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Deleted | SYNONYM | disruption of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Deleted | SYNONYM | negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2024-02-24 | Deleted | SYNONYM | suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2024-01-15 | Added | DEFINITION | A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2024-01-15 | Deleted | DEFINITION | A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-12-26 | Added | SYNONYM | disruption of host I-kappaB kinase/NF-kappaB cascade |
2023-12-26 | Deleted | DEFINITION | A process in which a symbiont interferes with, inhibits or disrupts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-12-26 | Added | SYNONYM | symbiont-mediated suppression of host canonical NF-kappaB cascade |
2023-12-26 | Added | SYNONYM | suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2023-12-26 | Deleted | SYNONYM | disruption of host I-kappaB kinase/NF-kappaB cascade |
2023-12-26 | Deleted | SYNONYM | suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2023-12-26 | Deleted | SYNONYM | negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2023-12-26 | Added | SYNONYM | disruption of host canonical NF-kappaB cascade |
2023-12-26 | Added | DEFINITION | A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-12-26 | Added | SYNONYM | negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2023-12-26 | Deleted | SYNONYM | disruption of host canonical NF-kappaB cascade |
2023-07-12 | Added | SYNONYM | disruption of host canonical NF-kappaB cascade |
2023-07-12 | Deleted | DEFINITION | A process that interferes with a host canonical NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-07-12 | Added | DEFINITION | A process in which a symbiont interferes with, inhibits or disrupts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-07-06 | Added | SYNONYM | disruption of host I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Deleted | DEFINITION | A process that interferes with a host I-kappaB kinase/NF-kappaB-mediated signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-07-06 | Added | DEFINITION | A process that interferes with a host canonical NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-06-24 | Added | DEFINITION | A process that interferes with a host I-kappaB kinase/NF-kappaB-mediated signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-06-24 | Deleted | DEFINITION | Any process that interferes with host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-06-13 | Added | DEFINITION | Any process that interferes with host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-06-13 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2023-05-20 | Added | SYNONYM | suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2019-12-12 | Added | SYNONYM | negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2010-08-03 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-11 | Added | RELATION | is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway) |
2023-12-26 | Deleted | RELATION | is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway) |
2023-07-12 | Added | RELATION | is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway) |
2023-06-24 | Deleted | RELATION | is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway) |
2023-06-24 | Deleted | RELATION | is a GO:0043124 (negative regulation of canonical NF-kappaB signal transduction) |
2023-06-24 | Added | RELATION | is a GO:0085032 (symbiont-mediated perturbation of host NF-kappaB cascade) |
2019-12-12 | Added | RELATION | is a GO:0052029 (symbiont-mediated suppression of host signal transduction pathway) |
2010-08-03 | Added | RELATION | is a GO:0043124 (negative regulation of canonical NF-kappaB signal transduction) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Added | XREF | VZ:695 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:7742 (Vertebrata) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:33090 (Viridiplantae) |
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