This term is obsolete.

GO:0090614 JSON

5'-methylthioadenosine deaminase activity

Molecular Function

Definition (GO:0090614 GONUTS page)

Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3. PMID:23968233

7,353 annotations

Ancestor Chart

Ancestor chart for GO:0090614
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein P38150 559292 YB9Z_YEAST GO:0019239 InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013]
IEA Review protein P40361 559292 YJH0_YEAST GO:0019239 InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013]
NOT-qualified manual protein A0A0K1SC59 5849 ADA_PLAGA GO:0090614 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:19728741
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 3.5.4.31
RHEA 25025

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17509 5'-S-methyl-5'-thioadenosine
has_participant CHEBI CHEBI:28938 ammonium
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:48595 5'-S-methyl-5'-thioinosine

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0090614 based on ALL annotations
The top 35 of 35 co-occurring terms
Co-occurring Term PR S% #Together #Compared
5'-methylthioadenosine deaminase activity
26,533.11 100.00 7,347 7,347
S-adenosylhomocysteine deaminase activity
24,209.22 90.27 7,261 7,958
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
7,525.79 28.05 7,064 24,905
deaminase activity
1,459.44 5.49 7,083 128,771
5'-deoxyadenosine deaminase activity
18,233.66 3.88 290 422
2'-deoxyadenosine deaminase activity
214.70 0.68 295 36,457
adenosine deaminase activity
120.96 0.41 298 65,370
S-adenosylmethionine biosynthetic process
118.64 0.40 289 64,631
hydrolase activity
17.00 0.06 7,345 11,461,355
negative regulation of adenosine receptor signaling pathway
49.12 0.06 6 3,241
Totals 44696 112573226
No co-occurrence statistics for GO:0090614 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term PR S% #Together #Compared
5'-methylthioadenosine deaminase activity
161,474.88 100.00 8 8
adenosine deaminase activity
5,331.72 3.29 7 212
negative regulation of adenosine receptor signaling pathway
4,036.87 2.13 1 40
hypoxanthine salvage
2,043.99 1.16 1 79
inosine biosynthetic process
811.43 0.49 1 199
adenosine catabolic process
780.07 0.47 1 207
external side of plasma membrane
27.55 0.02 1 5,862
cytosol
1.92 0.00 1 84,217
Totals 21 90824

Change Log

Timestamp Action Category Detail
2022-10-08 Added RELATION is a GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines)
2020-08-26 Added XREF RHEA:25025
2020-08-26 Added XREF EC:3.5.4.31
2014-10-25 Added TERM 5'-methylthioadenosine deaminase activity
2014-10-25 Added DEFINITION Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3.
2014-10-25 Added RELATION is a GO:0019239 (deaminase activity)
Timestamp Action Category Detail
2014-10-25 Added TERM 5'-methylthioadenosine deaminase activity
Timestamp Action Category Detail
2014-10-25 Added DEFINITION Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3.
Timestamp Action Category Detail
2022-10-08 Added RELATION is a GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines)
2014-10-25 Added RELATION is a GO:0019239 (deaminase activity)
Timestamp Action Category Detail
2020-08-26 Added XREF RHEA:25025
2020-08-26 Added XREF EC:3.5.4.31
Timestamp Action Category Detail
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