GO:0090614
JSON
5'-methylthioadenosine deaminase activity
Molecular Function
Definition (GO:0090614 GONUTS page)
Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3. PMID:23968233
Ancestor Chart
Ancestor chart for GO:0090614
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | P38150 | 559292 | YB9Z_YEAST | GO:0019239 | InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013] | |
IEA Review | protein | P40361 | 559292 | YJH0_YEAST | GO:0019239 | InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013] | |
NOT-qualified manual | protein | A0A0K1SC59 | 5849 | ADA_PLAGA | GO:0090614 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:19728741 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.5.4.31 | |
RHEA | 25025 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17509 | 5'-S-methyl-5'-thioadenosine |
has_participant | CHEBI | CHEBI:28938 | ammonium |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:48595 | 5'-S-methyl-5'-thioinosine |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0090614 based on ALL annotations
The top 35 of 35 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
5'-methylthioadenosine deaminase activity
|
26,533.11 | 100.00 | 7,347 | 7,347 |
S-adenosylhomocysteine deaminase activity
|
24,209.22 | 90.27 | 7,261 | 7,958 |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
|
7,525.79 | 28.05 | 7,064 | 24,905 |
deaminase activity
|
1,459.44 | 5.49 | 7,083 | 128,771 |
5'-deoxyadenosine deaminase activity
|
18,233.66 | 3.88 | 290 | 422 |
2'-deoxyadenosine deaminase activity
|
214.70 | 0.68 | 295 | 36,457 |
adenosine deaminase activity
|
120.96 | 0.41 | 298 | 65,370 |
S-adenosylmethionine biosynthetic process
|
118.64 | 0.40 | 289 | 64,631 |
hydrolase activity
|
17.00 | 0.06 | 7,345 | 11,461,355 |
negative regulation of adenosine receptor signaling pathway
|
49.12 | 0.06 | 6 | 3,241 |
Totals | 44696 | 112573226 |
No co-occurrence statistics for GO:0090614 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
5'-methylthioadenosine deaminase activity
|
161,474.88 | 100.00 | 8 | 8 |
adenosine deaminase activity
|
5,331.72 | 3.29 | 7 | 212 |
negative regulation of adenosine receptor signaling pathway
|
4,036.87 | 2.13 | 1 | 40 |
hypoxanthine salvage
|
2,043.99 | 1.16 | 1 | 79 |
inosine biosynthetic process
|
811.43 | 0.49 | 1 | 199 |
adenosine catabolic process
|
780.07 | 0.47 | 1 | 207 |
external side of plasma membrane
|
27.55 | 0.02 | 1 | 5,862 |
cytosol
|
1.92 | 0.00 | 1 | 84,217 |
Totals | 21 | 90824 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-10-08 | Added | RELATION | is a GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines) |
2020-08-26 | Added | XREF | RHEA:25025 |
2020-08-26 | Added | XREF | EC:3.5.4.31 |
2014-10-25 | Added | TERM | 5'-methylthioadenosine deaminase activity |
2014-10-25 | Added | DEFINITION | Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3. |
2014-10-25 | Added | RELATION | is a GO:0019239 (deaminase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-10-25 | Added | TERM | 5'-methylthioadenosine deaminase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-10-25 | Added | DEFINITION | Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-10-08 | Added | RELATION | is a GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines) |
2014-10-25 | Added | RELATION | is a GO:0019239 (deaminase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-08-26 | Added | XREF | RHEA:25025 |
2020-08-26 | Added | XREF | EC:3.5.4.31 |
Timestamp | Action | Category | Detail |
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