This term is obsolete.

GO:0098631 JSON

cell adhesion mediator activity

Molecular Function

Definition (GO:0098631 GONUTS page)

The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.

49,712 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cell adhesion molecule exact
protein binding involved in cell adhesion exact

Ancestor Chart

Ancestor chart for GO:0098631
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0098631

Child Term Relationship to
GO:0098631
cell-matrix adhesion mediator activity
is_a
laminin receptor activity
is_a
integrin complex
capable_of
cell adhesion receptor activity
is_a
cell-cell adhesion mediator activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P16573-2 10116 CEAM1_RAT GO:0007155 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8454589
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0005194 obsolete cell adhesion molecule activity consider GO:0098631

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0098631 based on ALL annotations
The top 100 of 305 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell adhesion mediator activity
277,295.56 100.00 703 703
establishment of protein localization to juxtaparanode region of axon
277,295.53 13.51 95 95
presynaptic membrane organization
263,430.78 13.42 95 100
clustering of voltage-gated potassium channels
131,715.39 11.76 95 200
protein localization to juxtaparanode region of axon
127,261.25 11.66 95 207
positive regulation of adenosine receptor signaling pathway
101,710.72 10.96 95 259
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
277,295.56 10.81 76 76
regulation of astrocyte differentiation
96,849.55 10.80 95 272
membrane destabilizing activity
119,617.70 10.74 88 204
leukocyte chemotaxis involved in inflammatory response
48,709.38 10.29 140 797
Totals 8713 374680
No co-occurrence statistics for GO:0098631 based on MANUAL annotations
The top 100 of 245 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell adhesion mediator activity
28,082.59 100.00 46 46
cell aggregation
7,488.69 11.76 8 30
epithelium regeneration
15,317.77 11.76 6 11
maintenance of lens transparency
4,759.76 10.53 10 59
ferroptosis
28,082.59 8.70 4 4
leukocyte chemotaxis involved in inflammatory response
5,105.93 8.22 6 33
homotypic cell-cell adhesion
2,674.53 7.09 10 105
membrane destabilizing activity
6,240.58 6.67 4 18
cytolysis
5,912.12 6.56 4 19
negative regulation of CD40 signaling pathway
10,530.97 5.88 3 8
Totals 332 8579

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_prokaryote 97
goslim_generic 141

Change Log

Timestamp Action Category Detail
2023-12-15 Added SUBSET goslim_prokaryote
2022-04-22 Deleted DEFINITION The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell.
2022-04-22 Added DEFINITION The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.
2022-01-12 Added SUBSET goslim_generic
2020-05-22 Added RELATION is a GO:0050839 (cell adhesion molecule binding)
2020-05-22 Deleted RELATION is a GO:0005488 (binding)
2020-05-22 Deleted DEFINITION The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell.
2020-05-22 Added DEFINITION The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell.
2018-03-31 Deleted DEFINITION Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate.
2018-03-31 Added DEFINITION The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell.
Timestamp Action Category Detail
2017-09-30 Updated TERM cell adhesion mediator activity
2014-05-11 Added TERM protein binding involved in cell adhesion
Timestamp Action Category Detail
2022-04-22 Deleted DEFINITION The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell.
2022-04-22 Added DEFINITION The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.
2020-05-22 Deleted DEFINITION The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell.
2020-05-22 Added DEFINITION The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell.
2018-03-31 Deleted DEFINITION Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate.
2018-03-31 Added DEFINITION The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell.
2018-03-30 Added DEFINITION Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate.
2018-03-30 Deleted DEFINITION The binding by a cell-adhesion protein on the cell surface to an extracellular molecule, to meditate adhesion of the cell to the external substrate or to another cell.
2018-03-29 Deleted DEFINITION Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate.
2018-03-29 Added DEFINITION The binding by a cell-adhesion protein on the cell surface to an extracellular molecule, to meditate adhesion of the cell to the external substrate or to another cell.
2017-09-30 Added DEFINITION Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate.
2017-09-30 Deleted DEFINITION Any protein binding that is involved in cell adhesion.
2017-09-30 Added SYNONYM protein binding involved in cell adhesion
2017-09-30 Added SYNONYM cell adhesion molecule
2014-05-11 Added DEFINITION Any protein binding that is involved in cell adhesion.
Timestamp Action Category Detail
2020-05-22 Added RELATION is a GO:0050839 (cell adhesion molecule binding)
2020-05-22 Deleted RELATION is a GO:0005488 (binding)
2017-11-15 Deleted RELATION is a GO:0005515 (protein binding)
2017-11-15 Added RELATION is a GO:0005488 (binding)
2015-04-24 Added RELATION part of GO:0007155 (cell adhesion)
2014-05-11 Added RELATION is a GO:0005515 (protein binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2023-12-15 Added SUBSET goslim_prokaryote
2022-01-12 Added SUBSET goslim_generic
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