GO:0098631
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cell adhesion mediator activity
Molecular Function
Definition (GO:0098631 GONUTS page)
The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cell adhesion molecule | exact |
protein binding involved in cell adhesion | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0098631
Child Term | Relationship to GO:0098631 |
---|---|
cell-matrix adhesion mediator activity
|
is_a |
laminin receptor activity
|
is_a |
integrin complex
|
capable_of |
cell adhesion receptor activity
|
is_a |
cell-cell adhesion mediator activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P16573-2 | 10116 | CEAM1_RAT | GO:0007155 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8454589 | |
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0005194 | obsolete cell adhesion molecule activity | consider GO:0098631 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0098631 based on ALL annotations
The top 100 of 305 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cell adhesion mediator activity
|
277,295.56 | 100.00 | 703 | 703 |
establishment of protein localization to juxtaparanode region of axon
|
277,295.53 | 13.51 | 95 | 95 |
presynaptic membrane organization
|
263,430.78 | 13.42 | 95 | 100 |
clustering of voltage-gated potassium channels
|
131,715.39 | 11.76 | 95 | 200 |
protein localization to juxtaparanode region of axon
|
127,261.25 | 11.66 | 95 | 207 |
positive regulation of adenosine receptor signaling pathway
|
101,710.72 | 10.96 | 95 | 259 |
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
|
277,295.56 | 10.81 | 76 | 76 |
regulation of astrocyte differentiation
|
96,849.55 | 10.80 | 95 | 272 |
membrane destabilizing activity
|
119,617.70 | 10.74 | 88 | 204 |
leukocyte chemotaxis involved in inflammatory response
|
48,709.38 | 10.29 | 140 | 797 |
Totals | 8713 | 374680 |
No co-occurrence statistics for GO:0098631 based on MANUAL annotations
The top 100 of 245 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cell adhesion mediator activity
|
28,082.59 | 100.00 | 46 | 46 |
cell aggregation
|
7,488.69 | 11.76 | 8 | 30 |
epithelium regeneration
|
15,317.77 | 11.76 | 6 | 11 |
maintenance of lens transparency
|
4,759.76 | 10.53 | 10 | 59 |
ferroptosis
|
28,082.59 | 8.70 | 4 | 4 |
leukocyte chemotaxis involved in inflammatory response
|
5,105.93 | 8.22 | 6 | 33 |
homotypic cell-cell adhesion
|
2,674.53 | 7.09 | 10 | 105 |
membrane destabilizing activity
|
6,240.58 | 6.67 | 4 | 18 |
cytolysis
|
5,912.12 | 6.56 | 4 | 19 |
negative regulation of CD40 signaling pathway
|
10,530.97 | 5.88 | 3 | 8 |
Totals | 332 | 8579 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_prokaryote | 97 |
goslim_generic | 141 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2022-04-22 | Deleted | DEFINITION | The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell. |
2022-04-22 | Added | DEFINITION | The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell. |
2022-01-12 | Added | SUBSET | goslim_generic |
2020-05-22 | Added | RELATION | is a GO:0050839 (cell adhesion molecule binding) |
2020-05-22 | Deleted | RELATION | is a GO:0005488 (binding) |
2020-05-22 | Deleted | DEFINITION | The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell. |
2020-05-22 | Added | DEFINITION | The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell. |
2018-03-31 | Deleted | DEFINITION | Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate. |
2018-03-31 | Added | DEFINITION | The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-09-30 | Updated | TERM | cell adhesion mediator activity |
2014-05-11 | Added | TERM | protein binding involved in cell adhesion |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-22 | Deleted | DEFINITION | The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell. |
2022-04-22 | Added | DEFINITION | The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell. |
2020-05-22 | Deleted | DEFINITION | The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell. |
2020-05-22 | Added | DEFINITION | The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell. |
2018-03-31 | Deleted | DEFINITION | Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate. |
2018-03-31 | Added | DEFINITION | The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell. |
2018-03-30 | Added | DEFINITION | Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate. |
2018-03-30 | Deleted | DEFINITION | The binding by a cell-adhesion protein on the cell surface to an extracellular molecule, to meditate adhesion of the cell to the external substrate or to another cell. |
2018-03-29 | Deleted | DEFINITION | Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate. |
2018-03-29 | Added | DEFINITION | The binding by a cell-adhesion protein on the cell surface to an extracellular molecule, to meditate adhesion of the cell to the external substrate or to another cell. |
2017-09-30 | Added | DEFINITION | Any binding by a cell surface protein to a molecule external to the cell, that meditates adhesion of the cell to that external substrate. |
2017-09-30 | Deleted | DEFINITION | Any protein binding that is involved in cell adhesion. |
2017-09-30 | Added | SYNONYM | protein binding involved in cell adhesion |
2017-09-30 | Added | SYNONYM | cell adhesion molecule |
2014-05-11 | Added | DEFINITION | Any protein binding that is involved in cell adhesion. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-05-22 | Added | RELATION | is a GO:0050839 (cell adhesion molecule binding) |
2020-05-22 | Deleted | RELATION | is a GO:0005488 (binding) |
2017-11-15 | Deleted | RELATION | is a GO:0005515 (protein binding) |
2017-11-15 | Added | RELATION | is a GO:0005488 (binding) |
2015-04-24 | Added | RELATION | part of GO:0007155 (cell adhesion) |
2014-05-11 | Added | RELATION | is a GO:0005515 (protein binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2022-01-12 | Added | SUBSET | goslim_generic |
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