This term is obsolete.

GO:0099502 JSON

calcium-dependent activation of synaptic vesicle fusion

Biological Process

Definition (GO:0099502 GONUTS page)

The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. PMID:23060190

693 annotations

Ancestor Chart

Ancestor chart for GO:0099502
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0099502

Child Term Relationship to
GO:0099502
regulation of calcium-dependent activation of synaptic vesicle fusion
regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0099502 calcium-dependent activation of synaptic vesicle fusion Only in Taxon 33208 Metazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein O08625 10116 SYT10_RAT GO:0016079 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein P05067-PRO_0000000092 9606 A4_HUMAN GO:0007268 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18216187
NOT-qualified manual protein P91645 7227 CAC1A_DROME GO:0007269 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25811491
NOT-qualified manual protein P96210 83332 ESPG1_MYCTU GO:0046903 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469
NOT-qualified manual protein P9WJD1 83332 ESPF_MYCTU GO:0046903 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469
NOT-qualified manual protein Q5RCK6 9601 SYT10_PONAB GO:0016079 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q62717 10116 CAPS1_RAT GO:0006887 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q6XYQ8 9606 SYT10_HUMAN GO:0016079 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NFU0 7227 FMR1_DROME GO:0007268 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:12086643
NOT-qualified manual protein Q9R0N4 10090 SYT10_MOUSE GO:0016079 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:21496647

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0099502 based on ALL annotations
The top 100 of 249 co-occurring terms
Co-occurring Term PR S% #Together #Compared
calcium-dependent activation of synaptic vesicle fusion
346,250.06 100.00 563 563
fast, calcium ion-dependent exocytosis of neurotransmitter
346,250.06 16.16 91 91
synchronous neurotransmitter secretion
346,250.06 16.16 91 91
positive regulation of calcium ion-dependent exocytosis of neurotransmitter
342,486.47 16.13 91 92
calcium ion sensor activity
51,704.19 12.94 277 1,855
regulation of calcium ion-dependent exocytosis
31,663.36 9.03 495 5,413
positive regulation of dendrite extension
25,313.32 5.65 112 1,532
spontaneous neurotransmitter secretion
17,471.01 4.74 248 4,915
positive regulation of calcium ion-dependent exocytosis
15,180.42 3.55 89 2,030
regulation of synaptic transmission, glutamatergic
14,827.65 3.50 91 2,125
Totals 6514 1045812
No co-occurrence statistics for GO:0099502 based on MANUAL annotations
The top 100 of 222 co-occurring terms
Co-occurring Term PR S% #Together #Compared
calcium-dependent activation of synaptic vesicle fusion
4,646.76 100.00 278 278
regulation of calcium ion-dependent exocytosis
2,288.70 41.08 198 402
calcium ion sensor activity
1,987.03 35.89 192 449
dense core granule
2,765.25 28.20 97 163
exocytic vesicle
1,329.80 24.55 176 615
positive regulation of calcium ion-dependent exocytosis
2,350.71 23.76 86 170
regulation of synaptic vesicle exocytosis
1,538.24 20.34 96 290
calcium-dependent phospholipid binding
514.90 10.65 204 1,841
extrinsic component of synaptic vesicle membrane
1,674.99 9.31 31 86
synaptic vesicle membrane
383.51 7.24 103 1,248
Totals 2683 53298

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_synapse 357

Change Log

Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
2020-10-08 Deleted RELATION is a GO:0099171 (presynaptic modulation of chemical synaptic transmission)
2018-04-13 Deleted RELATION is a GO:0099531 (presynaptic process involved in chemical synaptic transmission)
2017-11-08 Deleted RELATION positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane)
2017-09-13 Added RELATION is a GO:0099171 (presynaptic modulation of chemical synaptic transmission)
2017-05-22 Added RELATION positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane)
2017-04-06 Deleted RELATION positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane)
2016-03-27 Added SUBSET goslim_synapse
2016-01-20 Added TERM calcium-dependent activation of synaptic vesicle fusion
2016-01-20 Added DEFINITION The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane.
Timestamp Action Category Detail
2016-01-20 Added TERM calcium-dependent activation of synaptic vesicle fusion
Timestamp Action Category Detail
2016-01-20 Added DEFINITION The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane.
Timestamp Action Category Detail
2020-10-08 Deleted RELATION is a GO:0099171 (presynaptic modulation of chemical synaptic transmission)
2018-04-13 Deleted RELATION is a GO:0099531 (presynaptic process involved in chemical synaptic transmission)
2017-11-08 Deleted RELATION positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane)
2017-09-13 Added RELATION is a GO:0099171 (presynaptic modulation of chemical synaptic transmission)
2017-05-22 Added RELATION positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane)
2017-04-06 Deleted RELATION positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane)
2016-01-20 Added RELATION part of GO:0016079 (synaptic vesicle exocytosis)
2016-01-20 Added RELATION positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane)
2016-01-20 Added RELATION is a GO:0031632 (positive regulation of synaptic vesicle fusion to presynaptic active zone membrane)
2016-01-20 Added RELATION is a GO:0099531 (presynaptic process involved in chemical synaptic transmission)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
2016-03-27 Added SUBSET goslim_synapse
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