GO:0099502
JSON
calcium-dependent activation of synaptic vesicle fusion
Biological Process
Definition (GO:0099502 GONUTS page)
The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. PMID:23060190
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0099502
Child Term | Relationship to GO:0099502 |
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regulation of calcium-dependent activation of synaptic vesicle fusion
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regulates |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0099502 | calcium-dependent activation of synaptic vesicle fusion | Only in Taxon | 33208 | Metazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | O08625 | 10116 | SYT10_RAT | GO:0016079 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | P05067-PRO_0000000092 | 9606 | A4_HUMAN | GO:0007268 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18216187 | |
NOT-qualified manual | protein | P91645 | 7227 | CAC1A_DROME | GO:0007269 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25811491 | |
NOT-qualified manual | protein | P96210 | 83332 | ESPG1_MYCTU | GO:0046903 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469 | |
NOT-qualified manual | protein | P9WJD1 | 83332 | ESPF_MYCTU | GO:0046903 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469 | |
NOT-qualified manual | protein | Q5RCK6 | 9601 | SYT10_PONAB | GO:0016079 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q62717 | 10116 | CAPS1_RAT | GO:0006887 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q6XYQ8 | 9606 | SYT10_HUMAN | GO:0016079 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NFU0 | 7227 | FMR1_DROME | GO:0007268 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:12086643 | |
NOT-qualified manual | protein | Q9R0N4 | 10090 | SYT10_MOUSE | GO:0016079 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:21496647 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0099502 based on ALL annotations
The top 100 of 249 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
calcium-dependent activation of synaptic vesicle fusion
|
346,250.06 | 100.00 | 563 | 563 |
fast, calcium ion-dependent exocytosis of neurotransmitter
|
346,250.06 | 16.16 | 91 | 91 |
synchronous neurotransmitter secretion
|
346,250.06 | 16.16 | 91 | 91 |
positive regulation of calcium ion-dependent exocytosis of neurotransmitter
|
342,486.47 | 16.13 | 91 | 92 |
calcium ion sensor activity
|
51,704.19 | 12.94 | 277 | 1,855 |
regulation of calcium ion-dependent exocytosis
|
31,663.36 | 9.03 | 495 | 5,413 |
positive regulation of dendrite extension
|
25,313.32 | 5.65 | 112 | 1,532 |
spontaneous neurotransmitter secretion
|
17,471.01 | 4.74 | 248 | 4,915 |
positive regulation of calcium ion-dependent exocytosis
|
15,180.42 | 3.55 | 89 | 2,030 |
regulation of synaptic transmission, glutamatergic
|
14,827.65 | 3.50 | 91 | 2,125 |
Totals | 6514 | 1045812 |
No co-occurrence statistics for GO:0099502 based on MANUAL annotations
The top 100 of 222 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
calcium-dependent activation of synaptic vesicle fusion
|
4,646.76 | 100.00 | 278 | 278 |
regulation of calcium ion-dependent exocytosis
|
2,288.70 | 41.08 | 198 | 402 |
calcium ion sensor activity
|
1,987.03 | 35.89 | 192 | 449 |
dense core granule
|
2,765.25 | 28.20 | 97 | 163 |
exocytic vesicle
|
1,329.80 | 24.55 | 176 | 615 |
positive regulation of calcium ion-dependent exocytosis
|
2,350.71 | 23.76 | 86 | 170 |
regulation of synaptic vesicle exocytosis
|
1,538.24 | 20.34 | 96 | 290 |
calcium-dependent phospholipid binding
|
514.90 | 10.65 | 204 | 1,841 |
extrinsic component of synaptic vesicle membrane
|
1,674.99 | 9.31 | 31 | 86 |
synaptic vesicle membrane
|
383.51 | 7.24 | 103 | 1,248 |
Totals | 2683 | 53298 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
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goslim_synapse | 357 |
Change Log
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Timestamp | Action | Category | Detail |
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2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2020-10-08 | Deleted | RELATION | is a GO:0099171 (presynaptic modulation of chemical synaptic transmission) |
2018-04-13 | Deleted | RELATION | is a GO:0099531 (presynaptic process involved in chemical synaptic transmission) |
2017-11-08 | Deleted | RELATION | positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane) |
2017-09-13 | Added | RELATION | is a GO:0099171 (presynaptic modulation of chemical synaptic transmission) |
2017-05-22 | Added | RELATION | positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane) |
2017-04-06 | Deleted | RELATION | positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane) |
2016-03-27 | Added | SUBSET | goslim_synapse |
2016-01-20 | Added | TERM | calcium-dependent activation of synaptic vesicle fusion |
2016-01-20 | Added | DEFINITION | The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-01-20 | Added | TERM | calcium-dependent activation of synaptic vesicle fusion |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-01-20 | Added | DEFINITION | The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | RELATION | is a GO:0099171 (presynaptic modulation of chemical synaptic transmission) |
2018-04-13 | Deleted | RELATION | is a GO:0099531 (presynaptic process involved in chemical synaptic transmission) |
2017-11-08 | Deleted | RELATION | positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane) |
2017-09-13 | Added | RELATION | is a GO:0099171 (presynaptic modulation of chemical synaptic transmission) |
2017-05-22 | Added | RELATION | positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane) |
2017-04-06 | Deleted | RELATION | positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane) |
2016-01-20 | Added | RELATION | part of GO:0016079 (synaptic vesicle exocytosis) |
2016-01-20 | Added | RELATION | positively regulates GO:0031629 (synaptic vesicle fusion to presynaptic active zone membrane) |
2016-01-20 | Added | RELATION | is a GO:0031632 (positive regulation of synaptic vesicle fusion to presynaptic active zone membrane) |
2016-01-20 | Added | RELATION | is a GO:0099531 (presynaptic process involved in chemical synaptic transmission) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2016-03-27 | Added | SUBSET | goslim_synapse |
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