This term is obsolete.
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

GO:0102965 JSON

alcohol-forming long-chain fatty acyl-CoA reductase activity

Molecular Function

Definition (GO:0102965 GONUTS page)

Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.

Comments

While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

7,951 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
alcohol-forming fatty acyl-CoA reductase activity broad

Ancestor Chart

Ancestor chart for GO:0102965
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.2.1.84
MetaCyc RXN-9344
RHEA 52716

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57287 coenzyme A(4-)
has_participant CHEBI CHEBI:83139 long-chain fatty acyl-CoA(4-)
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:77396 long-chain primary fatty alcohol
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0102965 based on ALL annotations
The top 100 of 172 co-occurring terms
Co-occurring Term PR S% #Together #Compared
alcohol-forming long-chain fatty acyl-CoA reductase activity
25,000.62 100.00 7,926 7,926
fatty acid derivative metabolic process
13,388.38 41.16 5,073 9,473
alcohol-forming very long-chain fatty acyl-CoA reductase activity
10,093.47 40.28 7,882 19,523
long-chain fatty-acyl-CoA metabolic process
7,131.69 28.02 7,457 26,141
suberin biosynthetic process
8,748.83 16.52 1,889 5,398
peroxisome
501.00 1.99 5,433 271,113
peroxisomal membrane
273.77 1.04 1,262 115,244
wax biosynthetic process
1,401.35 0.99 94 1,677
lipid metabolic process
174.70 0.70 7,877 1,127,241
ether lipid biosynthetic process
397.98 0.68 94 5,905
Totals 60636 78490496
No co-occurrence statistics for GO:0102965 based on MANUAL annotations
The top 18 of 18 co-occurring terms
Co-occurring Term PR S% #Together #Compared
alcohol-forming long-chain fatty acyl-CoA reductase activity
64,160.59 100.00 22 22
ether lipid biosynthetic process
4,184.39 5.56 6 92
wax biosynthetic process
3,515.65 5.00 8 146
alcohol-forming very long-chain fatty acyl-CoA reductase activity
2,495.13 3.88 21 540
long-chain fatty-acyl-CoA metabolic process
2,057.06 3.20 21 655
liquid clearance, open tracheal system
1,688.44 1.69 1 38
positive regulation of lipid storage
1,034.85 1.20 1 62
lumen formation, open tracheal system
720.91 0.91 1 89
glycerophospholipid biosynthetic process
419.35 0.61 2 306
peroxisome
294.96 0.46 21 4,568
Totals 119 268489

Change Log

Timestamp Action Category Detail
2023-12-15 Added DEFINITION Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
2023-12-15 Deleted DEFINITION Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons.
2023-01-18 Added SYNONYM alcohol-forming fatty acyl-CoA reductase activity
2023-01-18 Updated TERM alcohol-forming long-chain fatty acyl-CoA reductase activity
2023-01-18 Added DEFINITION Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol.
2020-06-22 Added XREF RHEA:52716
2020-04-06 Deleted DEFINITION Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol
2020-04-06 Added DEFINITION Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol.
2017-08-13 Added XREF MetaCyc:RXN-9344
Timestamp Action Category Detail
2023-01-18 Updated TERM alcohol-forming long-chain fatty acyl-CoA reductase activity
2017-08-13 Added TERM alcohol-forming fatty acyl-CoA reductase activity
Timestamp Action Category Detail
2023-12-15 Added DEFINITION Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
2023-12-15 Deleted DEFINITION Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons.
2023-01-18 Added SYNONYM alcohol-forming fatty acyl-CoA reductase activity
2023-01-18 Added DEFINITION Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol.
2020-04-06 Deleted DEFINITION Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol
2020-04-06 Added DEFINITION Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol.
2017-08-13 Added DEFINITION Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol
Timestamp Action Category Detail
2017-08-13 Added RELATION is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:52716
2017-08-13 Added XREF MetaCyc:RXN-9344
2017-08-13 Added XREF EC:1.2.1.84
Timestamp Action Category Detail
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