While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
GO:0102965
JSON
alcohol-forming long-chain fatty acyl-CoA reductase activity
Molecular Function
Definition (GO:0102965 GONUTS page)
Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Comments
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
alcohol-forming fatty acyl-CoA reductase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.2.1.84 | |
MetaCyc | RXN-9344 | |
RHEA | 52716 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57287 | coenzyme A(4-) |
has_participant | CHEBI | CHEBI:83139 | long-chain fatty acyl-CoA(4-) |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:77396 | long-chain primary fatty alcohol |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0102965 based on ALL annotations
The top 100 of 172 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
alcohol-forming long-chain fatty acyl-CoA reductase activity
|
25,000.62 | 100.00 | 7,926 | 7,926 |
fatty acid derivative metabolic process
|
13,388.38 | 41.16 | 5,073 | 9,473 |
alcohol-forming very long-chain fatty acyl-CoA reductase activity
|
10,093.47 | 40.28 | 7,882 | 19,523 |
long-chain fatty-acyl-CoA metabolic process
|
7,131.69 | 28.02 | 7,457 | 26,141 |
suberin biosynthetic process
|
8,748.83 | 16.52 | 1,889 | 5,398 |
peroxisome
|
501.00 | 1.99 | 5,433 | 271,113 |
peroxisomal membrane
|
273.77 | 1.04 | 1,262 | 115,244 |
wax biosynthetic process
|
1,401.35 | 0.99 | 94 | 1,677 |
lipid metabolic process
|
174.70 | 0.70 | 7,877 | 1,127,241 |
ether lipid biosynthetic process
|
397.98 | 0.68 | 94 | 5,905 |
Totals | 60636 | 78490496 |
No co-occurrence statistics for GO:0102965 based on MANUAL annotations
The top 18 of 18 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
alcohol-forming long-chain fatty acyl-CoA reductase activity
|
64,160.59 | 100.00 | 22 | 22 |
ether lipid biosynthetic process
|
4,184.39 | 5.56 | 6 | 92 |
wax biosynthetic process
|
3,515.65 | 5.00 | 8 | 146 |
alcohol-forming very long-chain fatty acyl-CoA reductase activity
|
2,495.13 | 3.88 | 21 | 540 |
long-chain fatty-acyl-CoA metabolic process
|
2,057.06 | 3.20 | 21 | 655 |
liquid clearance, open tracheal system
|
1,688.44 | 1.69 | 1 | 38 |
positive regulation of lipid storage
|
1,034.85 | 1.20 | 1 | 62 |
lumen formation, open tracheal system
|
720.91 | 0.91 | 1 | 89 |
glycerophospholipid biosynthetic process
|
419.35 | 0.61 | 2 | 306 |
peroxisome
|
294.96 | 0.46 | 21 | 4,568 |
Totals | 119 | 268489 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. |
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons. |
2023-01-18 | Added | SYNONYM | alcohol-forming fatty acyl-CoA reductase activity |
2023-01-18 | Updated | TERM | alcohol-forming long-chain fatty acyl-CoA reductase activity |
2023-01-18 | Added | DEFINITION | Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons. |
2023-01-18 | Deleted | DEFINITION | Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol. |
2020-06-22 | Added | XREF | RHEA:52716 |
2020-04-06 | Deleted | DEFINITION | Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol |
2020-04-06 | Added | DEFINITION | Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol. |
2017-08-13 | Added | XREF | MetaCyc:RXN-9344 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-18 | Updated | TERM | alcohol-forming long-chain fatty acyl-CoA reductase activity |
2017-08-13 | Added | TERM | alcohol-forming fatty acyl-CoA reductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. |
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons. |
2023-01-18 | Added | SYNONYM | alcohol-forming fatty acyl-CoA reductase activity |
2023-01-18 | Added | DEFINITION | Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid (LCFA) is a fatty acid with an aliphatic tail of 13 to 21 carbons. |
2023-01-18 | Deleted | DEFINITION | Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol. |
2020-04-06 | Deleted | DEFINITION | Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol |
2020-04-06 | Added | DEFINITION | Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol. |
2017-08-13 | Added | DEFINITION | Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-08-13 | Added | RELATION | is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:52716 |
2017-08-13 | Added | XREF | MetaCyc:RXN-9344 |
2017-08-13 | Added | XREF | EC:1.2.1.84 |
Timestamp | Action | Category | Detail |
---|
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