This term is obsolete.

GO:0106019 JSON

phosphatidylinositol-4,5-bisphosphate phosphatase activity

Molecular Function

Definition (GO:0106019 GONUTS page)

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.

34,987 annotations

Ancestor Chart

Ancestor chart for GO:0106019
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0106019

Child Term Relationship to
GO:0106019
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
is_a
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein A0A087QTQ7 9233 A0A087QTQ7_APTFO GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A087VMI5 100784 A0A087VMI5_BALRE GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091CMN8 885580 A0A091CMN8_FUKDA GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091HHI2 9244 A0A091HHI2_CALAN GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091JLW6 188379 A0A091JLW6_EGRGA GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091L9X5 187382 A0A091L9X5_9AVES GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091P439 57397 A0A091P439_APAVI GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091SAD7 54374 A0A091SAD7_9AVES GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091SQ34 176057 A0A091SQ34_NESNO GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A093DPA0 121530 A0A093DPA0_TAUER GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0106019 based on ALL annotations
The top 56 of 56 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphatidylinositol-4,5-bisphosphate phosphatase activity
49,538,716.00 100.00 4 4
symbiont-mediated suppression of host programmed cell death
8,256,452.50 11.11 1 6
symbiont-mediated suppression of host inflammatory response
8,256,452.50 11.11 1 6
response to inositol
417,461.06 0.84 3 356
negative regulation of protein localization to cilium
94,720.31 0.19 3 1,569
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
18,248.55 0.04 3 8,144
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
12,935.52 0.03 3 11,489
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
12,693.56 0.03 3 11,708
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
12,031.75 0.02 3 12,352
inositol-polyphosphate 5-phosphatase activity
9,922.30 0.02 3 14,978
Totals 109 151665455
No co-occurrence statistics for GO:0106019 based on MANUAL annotations
The top 24 of 24 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphatidylinositol-4,5-bisphosphate phosphatase activity
705,766.50 100.00 2 2
symbiont-mediated suppression of host programmed cell death
117,627.75 14.29 1 6
symbiont-mediated suppression of host inflammatory response
117,627.75 14.29 1 6
response to inositol
70,576.65 9.09 1 10
negative regulation of protein localization to cilium
16,413.18 2.27 1 43
inositol-polyphosphate 5-phosphatase activity
7,755.68 1.09 1 91
host cell cytoplasm
3,600.85 0.51 1 196
host cell plasma membrane
3,068.55 0.43 1 230
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
2,673.36 0.38 1 264
phosphatidylinositol-4-phosphate phosphatase activity
2,613.95 0.37 1 270
Totals 25 266932

Change Log

Timestamp Action Category Detail
2022-10-26 Deleted DEFINITION Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
2022-10-26 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
2017-05-12 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
2017-05-12 Added TERM phosphatidylinositol-4,5-bisphosphate phosphatase activity
2017-05-12 Added RELATION is a GO:0034593 (phosphatidylinositol bisphosphate phosphatase activity)
Timestamp Action Category Detail
2017-05-12 Added TERM phosphatidylinositol-4,5-bisphosphate phosphatase activity
Timestamp Action Category Detail
2022-10-26 Deleted DEFINITION Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
2022-10-26 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
2017-05-12 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.
Timestamp Action Category Detail
2017-05-12 Added RELATION is a GO:0034593 (phosphatidylinositol bisphosphate phosphatase activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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